المؤلفون: Bisignano KK, Smith JD, Harrison WW

المصدر: Clinical Optometry, Vol Volume 16, Pp 147-155 (2024)

مصطلحات موضوعية: oximetry, oxygen saturation, prediabetes, refractive error, blood pressure, Ophthalmology, RE1-994

الوصف: Kelly K Bisignano, Jennyffer D Smith, Wendy W Harrison Department of Clinical Sciences College of Optometry, University of Houston, Houston, TX, USACorrespondence: Wendy W Harrison, Email wwharris@central.uh.eduPurpose: Local retinal oxygen saturation is a research technique, which has the potential as a biomarker for diabetes. However, normative data has not been established. This study examined differences in oxygen saturation around the macula and characterizes the relationship between age, race, refractive error (RE), sex, blood pressure (BP), prediabetic status and oxygen saturation.Methods: Fifty-nine subjects aged 22– 69 (38.8 ± 14.7 years) were included who were racially diverse and with equal gender distribution. None had eye disease. Oxygen saturation was taken with the Zilia Ocular in 4 locations around the macula 3.1 degrees from the fovea and they were also averaged. BP, RE, and HbA1c were noted. Regression analyses for oximetry and other factors were completed as were t-tests with multiple comparison corrections.Results: There were significant variations in oximetry measures by race, with higher pigmentation levels associated with lower oximetry values (p < 0.01). There was no relationship between oximetry and sex (p = 0.34), RE (p = 0.67), BP (systolic p = 0.61, diastolic p = 0.71) nor prediabetic status (p = 0.87). Oximetry was associated with age when controlling for race (P < 0.002). Nasal-temporal variations showed nasal oximetry to higher than temporal measures (P < 0.01).Conclusion: This study revealed race/pigmentation is an important influence on oximetry measures. Retinal location also caused variations, likely due to proximity to larger vessels nasally. No differences in sex, RE nor BP were observed to alter local oxygen saturation. However, age was correlated when considered with race. This study will inform our future work in different disease states and is an important first step in evaluating this technology.Plain Language Summary: This study evaluates a new research instrument (Zilia Ocular) which measures how much oxygen is in the very small blood vessels of the retina. Our group wanted to evaluate healthy people to find out if the measurements the instrument takes are different in different sexes, ages, races, glasses prescriptions and blood pressures. We also looked at if they were changed in people with prediabetes and if it is different in different locations on the retina. We found that the measures are different in different races and ages. The measures also change with location in the eye. The other factors did not change the measurements of oxygen saturation on this instrument. We need to know this information because we want to detect changes in the retina in diabetes in diverse patient groups; however, we need to know about normal variations to better understand and collect that data.Keywords: oximetry, oxygen saturation, prediabetes, refractive error, blood pressure

وصف الملف: electronic resource

العلاقة: https://www.dovepress.com/variations-in-retinal-oxygen-saturation-in-a-diverse-healthy-populatio-peer-reviewed-fulltext-article-OPTOTest; https://doaj.org/toc/1179-2752Test

الوصول الحر: https://doaj.org/article/cc78464617314ecaa4496746b23826d3Test

المؤلفون: Donnellan, James M. S., Oliver, Seb J., Bethermin, Matthieu, Bing, Longji, Bolatto, Alberto, Bradford, Charles M., Burgarella, Denis, Ciesla, Laure, Glenn, Jason, Pope, Alexandra, Serjeant, Stephen, Shirley, Raphael, Smith, JD T., Sorrell, Chris

مصطلحات موضوعية: Astrophysics - Instrumentation and Methods for Astrophysics, Astrophysics - Astrophysics of Galaxies

الوصف: The PRobe far-Infrared Mission for Astrophysics (PRIMA) concept aims to perform mapping with spectral coverage and sensitivities inaccessible to previous FIR space telescopes. PRIMA's imaging instrument, PRIMAger, provides unique hyperspectral imaging simultaneously covering 25-235 $\mu$m. We synthesise images representing a deep, 1500 hr deg$^{-2}$ PRIMAger survey, with realistic instrumental and confusion noise. We demonstrate that we can construct catalogues of galaxies with a high purity ($>95$ per cent) at a source density of 42k deg$^{-2}$ using PRIMAger data alone. Using the XID+ deblending tool we show that we measure fluxes with an accuracy better than 20 per cent to flux levels of 0.16, 0.80, 9.7 and 15 mJy at 47.4, 79.7, 172, 235 $\mu$m respectively. These are a factor of $\sim$2 and $\sim$3 fainter than the classical confusion limits for 72-96 $\mu$m and 126-235 $\mu$m, respectively. At $1.5 \leq z \leq 2$, we detect and accurately measure fluxes in 8-10 of the 10 channels covering 47-235 $\mu$m for sources with $2 \leq$ log(SFR) $\leq 2.5$, a 0.5 dex improvement on what might be expected from the classical confusion limit. Recognising that PRIMager will operate in a context where high quality data will be available at other wavelengths, we investigate the benefits of introducing additional prior information. We show that by introducing even weak prior flux information when employing a higher source density catalogue (more than one source per beam) we can obtain accurate fluxes an order of magnitude below the classical confusion limit for 96-235 $\mu$m.
Comment: 14 pages, 11 figures

الوصول الحر: http://arxiv.org/abs/2404.06935Test

المؤلفون: Bien, SA, Su, YR, Conti, DV, Harrison, TA, Qu, CH, Guo, XY, Lu, YC, Albanes, D, Auer, PL, Banbury, BL, Berndt, SI, Bezieau, S, Brenner, H, Buchanan, DD, Caan, BJ, Campbell, PT, Carlson, CS, Chan, AT, Chang-Claude, J, Chen, S, Connolly, CM, Easton, DF, Feskens, EJM, Gallinger, S, Giles, GG, Gunter, MJ, Hampe, J, Huyghe, JR, Hoffmeister, M, Hudson, TJ, Jacobs, EJ, Jenkins, MA, Kampman, E, Kang, HM, Kuhn, T, Kury, S, Lejbkowicz, F, Le Marchand, L, Milne, RL, Li, L, Li, CI, Lindblom, A, Lindor, NM, Martin, V, McNeil, CE, Melas, M, Moreno, V, Newcomb, PA, Offit, K, Pharaoh, PDP, Potter, JD, Qu, CX, Riboli, E, Rennert, G, Sala, N, Schafmayer, C, Scacheri, PC, Schmit, SL, Severi, G, Slattery, ML, Smith, JD, Trichopoulou, A, Tumino, R, Ulrich, CM, van Duijnhoven, FJB, Van Guelpen, B, Weinstein, SJ, White, E, Wolk, A, Woods, MO, Wu, AH, Abecasis, GR, Casey, G, Nickerson, DA, Gruber, SB, Hsu, L, Zheng, W, Peters, U

المصدر: Human genetics. 138(4):307-326

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:140791474Test

المؤلفون: Neevel, AJ, Smith, JD, Morrison, RJ, Hogikyan, ND, Kupfer, RA, Stein, AP

مصطلحات موضوعية: COVID-19, delayed tracheostomy, laryngeal injury, laryngotracheal stenosis, muscle tension dysphonia, postacute COVID-19 syndrome, prolonged intubation

جغرافية الموضوع: United States

الوصف: Objective: Patients with COVID-19 are at risk for laryngeal injury and dysfunction secondary to respiratory failure, prolonged intubation, and other unique facets of this illness. Our goal is to report clinical features and treatment for patients presenting with voice, airway, and/or swallowing concerns postacute COVID-19. Study Design: Case series. Setting: Academic tertiary care center. Methods: Patients presenting with laryngeal issues following recovery from COVID-19 were included after evaluation by our laryngology team. Data were collected via retrospective chart review from March 1, 2020, to April 1, 2021. This included details of the patient’s COVID-19 course, initial presentation to laryngology, and subsequent treatment. Results: Twenty-four patients met inclusion criteria. Twenty (83%) patients were hospitalized, and 18 required endotracheal intubation for a median (range) duration of 14 days (6-31). Ten patients underwent tracheostomy. Patients were evaluated at a median 107 days (32-215) after their positive SARS-CoV-2 test result. The most common presenting concerns were dysphonia (n = 19, 79%), dyspnea (n = 17, 71%), and dysphagia (n = 6, 25%). Vocal fold motion impairment (50%), early glottic injury (39%), subglottic/tracheal stenosis (22%), and posterior glottic stenosis (17%) were identified in patients who required endotracheal intubation. Patients who did not need intubation were most frequently treated for muscle tension dysphonia (67%). Conclusion: Patients may develop significant voice, airway, and/or swallowing issues postacute COVID-19. These complications are not limited to patients requiring intubation or tracheostomy. Multidisciplinary laryngology clinics will continue to play an integral role in diagnosing and treating patients with COVID-19–related laryngeal sequelae. ; http://deepblue.lib.umich.edu/bitstream/2027.42/191985/2/2021_OTOTest Open_Laryngeal Problems After COVID.pdf ; Published version ; Description of 2021_OTO Open_Laryngeal Problems After COVID.pdf : Published version

وصف الملف: Electronic-eCollection; application/pdf

العلاقة: https://www.ncbi.nlm.nih.gov/pubmed/34458661Test; https://hdl.handle.net/2027.42/191985Test; https://dx.doi.org/10.7302/21986Test; OTO Open; orcid:0000-0002-2313-8542; orcid:0000-0003-1783-4338; orcid:0009-0000-0757-8348; 2473974X211041040; Neevel, AJ; Smith, JD; Morrison, RJ; 0000-0002-2313-8542; Hogikyan, ND; 0000-0003-1783-4338; Kupfer, RA; 0009-0000-0757-8348; Stein, AP

الإتاحة: https://doi.org/10.1177/2473974X211041040Test
https://doi.org/10.7302/21986Test
https://hdl.handle.net/2027.42/191985Test
https://www.ncbi.nlm.nih.gov/pubmed/34458661Test

المؤلفون: Bien, SA, Su, YR, Conti, DV, Harrison, TA, Qu, CH, Guo, XY, Lu, YC, Albanes, D, Auer, PL, Banbury, BL, Berndt, SI, Bezieau, S, Brenner, H, Buchanan, DD, Caan, BJ, Campbell, PT, Carlson, CS, Chan, AT, Chang-Claude, J, Chen, S, Connolly, CM, Easton, DF, Feskens, EJM, Gallinger, S, Giles, GG, Gunter, MJ, Hampe, J, Huyghe, JR, Hoffmeister, M, Hudson, TJ, Jacobs, EJ, Jenkins, MA, Kampman, E, Kang, HM, Kuhn, T, Kury, S, Lejbkowicz, F, Le Marchand, L, Milne, RL, Li, L, Li, CI, Lindblom, A, Lindor, NM, Martin, V, McNeil, CE, Melas, M, Moreno, V, Newcomb, PA, Offit, K, Pharaoh, PDP, Potter, JD, Qu, CX, Riboli, E, Rennert, G, Sala, N, Schafmayer, C, Scacheri, PC, Schmit, SL, Severi, G, Slattery, ML, Smith, JD, Trichopoulou, A, Tumino, R, Ulrich, CM, van Duijnhoven, FJB, Van Guelpen, B, Weinstein, SJ, White, E, Wolk, A, Woods, MO, Wu, AH, Abecasis, GR, Casey, G, Nickerson, DA, Gruber, SB, Hsu, L, Zheng, W, Peters, U

المصدر: Human genetics. 138(7):789-791

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:141302526Test

المؤلفون: Teslovich, TM, Musunuru, K, Smith, AV, Edmondson, AC, Stylianou, IM, Koseki, M, Pirruccello, JP, Ripatti, S, Chasman, DI, Willer, CJ, Johansen, CT, Fouchier, SW, Isaacs, A, Peloso, GM, Barbalic, M, Ricketts, SL, Bis, JC, Aulchenko, YS, Thorleifsson, G, Feitosa, MF, Chambers, J, Orho-Melander, M, Melander, O, Johnson, T, Li, XH, Guo, XQ, Li, MY, Cho, YS, Go, MJ, Kim, YJ, Lee, JY, Park, T, Kim, K, Sim, X, Ong, RTH, Croteau-Chonka, DC, Lange, LA, Smith, JD, Song, K, Zhao, JH, Yuan, X, Luan, JA, Lamina, C, Ziegler, A, Zhang, W, Zee, RYL, Wright, AF, Witteman, JCM, Wilson, JF, Willemsen, G, Wichmann, HE, Whitfield, JB, Waterworth, DM, Wareham, NJ, Waeber, G, Vollenweider, P, Voight, BF, Vitart, V, Uitterlinden, AG, Uda, M, Tuomilehto, J, Thompson, JR, Tanaka, T, Surakka, I, Stringham, HM, Spector, TD, Soranzo, N, Smit, JH, Sinisalo, J, Silander, K, Sijbrands, EJG, Scuteri, A, Scott, J, Schlessinger, D, Sanna, S, Salomaa, V, Saharinen, J, Sabatti, C, Ruokonen, A, Rudan, I, Rose, LM, Roberts, R, Rieder, M, Psaty, BM, Pramstaller, PP, Pichler, I, Perola, M, Penninx, BWJH, Pedersen, NL, Pattaro, C, Parker, AN, Pare, G, Oostra, BA, O'Donnell, CJ, Nieminen, MS, Nickerson, DA, Montgomery, GW, Meitinger, T, McPherson, R, McCarthy, MI, McArdle, W, Masson, D, Martin, NG, Marroni, F, Mangino, M, Magnusson, PKE, Lucas, G, Luben, R, Loos, RJF, Lokki, ML, Lettre, G, Langenberg, C, Launer, LJ, Lakatta, EG, Laaksonen, R, Kyvik, KO, Kronenberg, F, Konig, IR, Khaw, KT, Kaprio, J, Kaplan, LM, Johansson, A, Jarvelin, MR, Janssens, ACJW, Ingelsson, E, Igi, W, Hovingh, GK, Hottenga, JJ, Hofman, A, Hicks, AA, Hengstenberg, C, Heid, IM, Hayward, C, Havulinna, AS, Hastie, ND, Harris, TB, Haritunians, T, Hall, AS, Gyllensten, U, Guiducci, C, Groop, LC, Gonzalez, E, Gieger, C, Freimer, NB, Ferrucci, L, Erdmann, J, Elliott, P, Ejebe, KG, Doering, A, Dominiczak, AF, Demissie, S, Deloukas, P, de Geus, EJC, de Faire, U, Crawford, G, Collins, FS, Chen, YDI, Caulfield, MJ, Campbell, H, Burtt, NP, Bonnycastle, LL, Boomsma, DI, Boekholdt, SM, Bergman, RN, Barroso, I, Bandinelli, S, Ballantyne, CM, Assimes, TL, Quertermous, T, Altshuler, D, Seielstad, M, Wong, TY, Tai, ES, Feranil, AB, Kuzawa, CW, Adair, LS, Taylor, HA, Borecki, IB, Gabriel, SB, Wilson, JG, Holm, H, Thorsteinsdottir, U, Gudnason, V, Krauss, RM, Mohlke, KL, Ordovas, JM, Munroe, PB, Kooner, JS, Tall, AR, Hegele, RA, Kastelein, JJP, Schadt, EE, Rotter, JI, Boerwinkle, E, Strachan, DP, Mooser, V, Stefansson, K, Reilly, MP, Samani, NJ, Schunkert, H, Cupples, LA, Sandhu, MS, Ridker, PM, Rader, DJ, van Duijn, CM, Peltonen, L, Abecasis, GR, Boehnke, M, Kathiresan, S

المصدر: Nature. 466(7307):707-713

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:121097165Test

المؤلفون: Theusch, E, Kim, K, Stevens, K, Smith, JD, Chen, Y-DI, Rotter, JI, Nickerson, DA, Medina, MW

المصدر: The Pharmacogenomics Journal. 17(3)

مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Clinical Research, Atherosclerosis, Heart Disease, Genetics, Cardiovascular, 2.1 Biological and endogenous factors, Aetiology, Adult, Aged, Cell Line, Dyslipidemias, Female, Gene Expression Regulation, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Intracellular Signaling Peptides and Proteins, Lymphocytes, Male, Membrane Proteins, Middle Aged, Pharmacogenetics, Pharmacogenomic Variants, Sex Factors, Simvastatin, Treatment Outcome, Triglycerides, Pharmacology & Pharmacy, Pharmacology and pharmaceutical sciences

الوصف: Statins are widely prescribed to lower plasma low-density lipoprotein (LDL) cholesterol levels. They also modestly reduce plasma triglyceride (TG), an independent cardiovascular disease risk factor, in most people. The mechanism and inter-individual variability of TG statin response is poorly understood. We measured statin-induced gene expression changes in lymphoblastoid cell lines derived from 150 participants of a simvastatin clinical trial and identified 23 genes (false discovery rate, FDR=15%) with expression changes correlated with plasma TG response. The correlation of insulin-induced gene 1 (INSIG1) expression changes with TG response (rho=0.32, q=0.11) was driven by men (interaction P=0.0055). rs73161338 was associated with INSIG1 expression changes (P=5.4 × 10-5) and TG response in two statin clinical trials (P=0.0048), predominantly in men. A combined model including INSIG1 expression level and splicing changes accounted for 29.5% of plasma TG statin response variance in men (P=5.6 × 10-6). Our results suggest that INSIG1 variation may contribute to statin-induced changes in plasma TG in a sex-specific manner.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/52d8m9tgTest

المؤلفون: Huyghe, JR, Bien, SA, Harrison, TA, Kang, HM, Chen, S, Schmit, SL, Conti, DV, Qu, CH, Jeon, J, Edlund, CK, Greenside, P, Wainberg, M, Schumacher, FR, Smith, JD, Levine, DM, Nelson, SC, Sinnott-Armstrong, NA, Albanes, D, Alonso, MH, Anderson, K, Arnau-Collell, C, Arndt, V, Bamia, C, Banbury, BL, Baron, JA, Berndt, SI, Bezieau, S, Bishop, DT, Boehm, J, Boeing, H, Brenner, H, Brezina, S, Buch, S, Buchanan, DD, Burnett-Hartman, A, Butterbach, K, Caan, BJ, Campbell, PT, Carlson, CS, Castellvi-Bel, S, Chan, AT, Chang-Claude, J, Chanock, SJ, Chirlaque, MD, Cho, SH, Connolly, CM, Cross, AJ, Cuk, K, Curtis, KR, de la Chapelle, A, Doheny, KF, Duggan, D, Easton, DF, Elias, SG, Elliott, F, English, DR, Feskens, EJM, Figueiredo, JC, Fischer, R, FitzGerald, LM, Forman, D, Gala, M, Gallinger, S, Gauderman, WJ, Giles, GG, Gillanders, E, Gong, J, Goodman, PJ, Grady, WM, Grove, JS, Gsur, A, Gunter, MJ, Haile, RW, Hampe, J, Hampel, H, Harlid, S, Hayes, RB, Hofer, P, Hoffmeister, M, Hopper, JL, Hsu, WL, Huang, WY, Hudson, TJ, Hunter, DJ, Ibanez-Sanz, G, Idos, GE, Ingersoll, R, Jackson, RD, Jacobs, EJ, Jenkins, MA, Joshi, AD, Joshu, CE, Keku, TO, Key, TJ, Kim, HR, Kobayashi, E, Kolonel, LN, Kooperberg, C, Kuhn, T, Kury, S, Kweon, SS, Larsson, SC, Laurie, CA, Le Marchand, L, Leal, SM, Lee, SC, Lejbkowicz, F, Lemire, M, Li, CI, Li, L, Lieb, W, Lin, Y, Lindblom, A, Lindor, NM, Ling, H, Louie, TL, Mannisto, S, Markowitz, SD, Martin, V, Masala, G, McNeil, CE, Melas, M, Milne, RL, Moreno, L, Murphy, N, Myte, R, Naccarati, A, Newcomb, PA, Offit, K, Ogino, S, Onland-Moret, NC, Pardini, B, Parfrey, PS, Pearlman, R, Perduca, V, Pharoah, PDP, Pinchev, M, Platz, EA, Prentice, RL, Pugh, E, Raskin, L, Rennert, G, Rennert, HS, Riboli, E, Rodriguez-Barranco, M, Romm, J, Sakoda, LC, Schafmayer, C, Schoen, RE, Seminara, D, Shah, M, Shelford, T, Shin, MH, Shulman, K, Sieri, S, Slattery, ML, Southey, MC, Stadler, ZK, Stegmaier, C, Su, YR, Tangen, CM, Thibodeau, SN, Thomas, DC, Thomas, SS, Toland, AE, Trichopoulou, A, Ulrich, CM, Van den Berg, DJ, van Duijnhoven, FJB, Van Guelpen, B, van Kranen, H, Vijai, J, Visvanathan, K, Vodicka, P, Vodickova, L, Vymetalkova, V, Weigl, K, Weinstein, SJ, White, E, Win, AK, Wolf, CR, Wolk, A, Woods, MO, Wu, AH, Zaidi, SH, Zanke, BW, Zhang, Q, Zheng, W, Scacheri, PC, Potter, JD, Bassik, MC, Kundaje, A, Casey, G, Moreno, V, Abecasis, GR, Nickerson, DA, Gruber, SB, Hsu, L, Peters, U

المصدر: Nature genetics. 51(1):76

مصطلحات موضوعية: Medicin och hälsovetenskap

الوصول الحر: http://kipublications.ki.se/Default.aspx?queryparsed=id:139855588Test

المؤلفون: Smith JD (collector)

الوصول الحر: https://www.europeana.eu/item/11655/Botany_L_1300913?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCaTest

المؤلفون: Smith JD (collector)

الوصول الحر: https://www.europeana.eu/item/11655/Botany_L_4103958?utm_source=api&utm_medium=api&utm_campaign=YuvuWBeCaTest