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11
المؤلفون: Lifu Deng, Olga Lucia Gamboa, Moritz Dannhauer, Anshu Jonnalagadda, Rena Hamdan, Courtney Crowell, Tory Worth, Angel V. Peterchev, Marc A. Sommer, Roberto Cabeza, Lawrence G. Appelbaum, Simon W. Davis
الوصف: Transcranial magnetic stimulation (TMS) has become an important technique in both scientific and clinical practices, and yet our understanding of how the brain responds to TMS is still limited. Concurrent neuroimaging during TMS may bridge this gap, and emerging evidence suggests widespread that modulatory effects of TMS may be best captured through changes in functional connectivity between distributed networks, rather than local changes in cortical activity. However, the relationship between TMS stimulation parameters and evoked changes in functional connectivity is unknown. In this study, 24 healthy volunteers received concurrent TMS-fMRI while performing a dot-motion direction discrimination task. An MR-compatible coil was used to apply trains of three pulses at 10 Hz rTMS over the primary visual cortex (V1) at the onset of the dot stimuli with four levels of stimulation intensity (20%, 40%, 80%, and 120% of resting motor threshold, RMT). Behavioral results demonstrated impairment of motion discrimination at 80% RMT. FMRI results yielded three findings. First, functional connectivity between visual and non-visual areas increased as a function of rTMS intensity. Second, connectivity within the visual network was positively associated with motion accuracy, while the connectivity between visual and non-visual regions was negatively associated with motion accuracy. Lastly, we found that reductions in the similarity between functional and structural connectivity associated with increasing TMS intensity were constrained to the visual network. These findings demonstrate spatially dependent nonlinear effects of TMS intensity on brain functional connectivity that proceed beyond the site of stimulation and influence associated behavior.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::25e51b4fedda41a1f248f816d73ff9edTest
https://doi.org/10.1101/2022.01.06.475293Test -
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المؤلفون: Moritz Dannhauer, Hannah Palmer, Simon W. Davis, Eleanor Wood, Lawrence G. Appelbaum, Joyce E‐H. Wang, Sarah H. Lisanby, Lysianne Beynel, Courtney A. Crowell, Susan A. Hilbig, Bruce Luber, Roberto Cabeza, Andrew M. Michael, Angel V. Peterchev
المصدر: Brain and Behavior, Vol 11, Iss 11, Pp n/a-n/a (2021)
Brain and Behaviorمصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Psychological intervention, Posterior parietal cortex, Prefrontal Cortex, Stimulation, Neurosciences. Biological psychiatry. Neuropsychiatry, DLPFC, behavioral disciplines and activities, working memory, Behavioral Neuroscience, Dorsolateral Prefrontal Cortex, medicine, Humans, Working memory, repetitive transcranial magnetic stimulation, Original Articles, Transcranial Magnetic Stimulation, Dorsolateral prefrontal cortex, medicine.anatomical_structure, Memory, Short-Term, parietal cortex, Original Article, Psychology, Neuroscience, Internet-Based Intervention, psychological phenomena and processes, RC321-571
الوصف: Background Online repetitive transcranialmagnetic stimulation (rTMS) has been shown to modulate working memory (WM) performance in a site‐specific manner, with behavioral improvements due to stimulation of the dorsolateral prefrontal cortex (DLPFC), and impairment from stimulation to the lateral parietal cortex (LPC). Neurobehavioral studies have demonstrated that subprocesses of WM allowing for the maintenance and manipulation of information in the mind involve unique cortical networks. Despite promising evidence of modulatory effects of rTMS on WM, no studies have yet demonstrated distinct modulatory control of these two subprocesses. The current study therefore sought to explore this possibility through site‐specific stimulation during an online task invoking both skills. Methods Twenty‐nine subjects completed a 4‐day protocol, in which active or sham 5Hz rTMS was applied over the DLPFC and LPC in separate blocks of trials while participants performed tasks that required either maintenance alone, or both maintenance and manipulation (alphabetization) of information. Stimulation targets were defined individually based on fMRI activation and structural network properties. Stimulation amplitude was adjusted using electric field modeling to equate induced current in the target region across participants. Results Despite the use of advanced techniques, no significant differences or interactions between active and sham stimulation were found. Exploratory analyses testing stimulation amplitude, fMRI activation, and modal controllability showed nonsignificant but interesting trends with rTMS effects. Conclusion While this study did not reveal any significant behavioral changes in WM, the results may point to parameters that contribute to positive effects, such as stimulation amplitude and functional activation.
Working memory is a crucial a cognitive ability that declines rapidly with aging. Repetitive transcranial magnetic stimulation (rTMS) has been proposed as an approach to enhance working memory abilities, however effects are often modest. In this study, advanced techniques were used (fMRI, network controllability and electric field modeling) to optimize rTMS effects. However, no significant differences were found between active and sham rTMS, as such the manuscript provides a detailed account of how stimulation and task parameters may have led to the lack of significant rTMS results.الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eab32bbce13d2b5324b71c4e1792df93Test
https://doaj.org/article/c98f85b72ba74c2685bd223596e1dac2Test -
13دورية أكاديمية
المؤلفون: Simon W Davis, Jie Zhuang, Paul Wright, Lorraine Komisarjevsky Tyler, See Profile, Simon W. Davis N, Lorraine K. Tyler
المساهمون: The Pennsylvania State University CiteSeerX Archives
مصطلحات موضوعية: Functional Networks ICA
الوصف: Age-related sensitivity to task-related modulation of language-processing networks
وصف الملف: application/pdf
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المؤلفون: Benjamin R. Geib, Simon W. Davis, Zachary A. Monge, Wei-Chun Wang, Erik A. Wing, Roberto Cabeza
المصدر: J Neurosci
مصطلحات موضوعية: Adult, Male, Statement (logic), media_common.quotation_subject, Repression, Psychology, Hippocampus, Mnemonic, False memory, 050105 experimental psychology, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Memory, Perception, Encoding (memory), Similarity (psychology), Humans, Visual Pathways, 0501 psychology and cognitive sciences, Set (psychology), Research Articles, media_common, Cerebral Cortex, Brain Mapping, General Neuroscience, 05 social sciences, Recognition, Psychology, Magnetic Resonance Imaging, Pattern Recognition, Physiological, Mental Recall, Female, Psychology, Photic Stimulation, 030217 neurology & neurosurgery, Cognitive psychology
الوصف: The declarative memory system allows us to accurately recognize a countless number of items and events, particularly those strengthened by repeated exposure. However, increased familiarity due to repetition can also lead to false recognition of related but new items, particularly when mechanisms supporting fine-grain mnemonic discrimination fail. The hippocampus is thought to be particularly important in separating overlapping cortical inputs during encoding so that similar experiences can be differentiated. In the current study of male and female human subjects, we examine how neural pattern similarity between repeated exemplars of a given concept (e.g., apple) influences true and false memory for target or lure images. Consistent with past work, we found that subsequent true recognition was related to pattern similarity between concept exemplars and the entire encoding set (global encoding similarity), particularly in ventral visual stream. In addition, memory for an individual target exemplar (a specific apple) could be predicted solely by the degree of pattern overlap between the other exemplars (different apple pictures) of that concept (concept-specific encoding similarity). Critically, subsequent false memory for lures was mitigated when high concept-specific similarity in cortical areas was accompanied by differentiated hippocampal representations of the corresponding exemplars. Furthermore, both true and false memory entailed the reinstatement of concept-related information at varying levels of specificity. These results link both true and false memory to a measure of concept strength expressed in the overlap of cortical representations, and importantly, illustrate how the hippocampus serves to separate concurrent cortical overlap in the service of detailed memory.SIGNIFICANCE STATEMENTIn some instances, the same processes that help promote memory for a general idea or concept can also hinder more detailed memory judgments, which may involve differentiating between closely related items. The current study shows that increased overlap in cortical representations for conceptually-related pictures is associated with increased recognition of repeated concept pictures. Whether similar lure items were falsely remembered as old further depended on the hippocampus, where the presence of more distinct representations protected against later false memory. This work suggests that the differentiability of brain patterns during perception is related to the differentiability of items in memory, but that fine-grain discrimination depends on the interaction between cortex and hippocampus.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9887af99a98306bbae63da594b9035bTest
https://doi.org/10.1523/jneurosci.1766-19.2020Test -
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المؤلفون: Sarah H. Lisanby, Courtney A. Crowell, Bruce Luber, Susan A. Hilbig, Nicolas A. Chrapliwy, Roberto Cabeza, Zhi-De Deng, Duy Nguyen, Simon W. Davis, Lawrence G. Appelbaum, Wesley Lim, Lysianne Beynel
المصدر: Neurosci Biobehav Rev
مصطلحات موضوعية: medicine.medical_specialty, Future studies, Cognitive Neuroscience, medicine.medical_treatment, media_common.quotation_subject, Stimulation, Neuropsychological Tests, Audiology, Article, Task (project management), Behavioral Neuroscience, Cognition, Perception, Reaction Time, medicine, Humans, Attention, media_common, Brain, Transcranial Magnetic Stimulation, Transcranial magnetic stimulation, Neuropsychology and Physiological Psychology, Research Design, Total effects, Meta-analysis, Psychology
الوصف: Online repetitive transcranial magnetic stimulation (rTMS), applied while subjects are performing a task, is widely used to disrupt brain regions underlying cognition. However, online rTMS has also induced “paradoxical enhancement”. Given the rapid proliferation of this approach, it is crucial to develop a better understanding of how online stimulation influences cognition, and the optimal parameters to achieve desired effects. To accomplish this goal, a quantitative meta-analysis was performed with random-effects models fitted to reaction time (RT) and accuracy data. The final dataset included 126 studies published between 1998 and 2016, with 244 total effects for reaction times, and 202 for accuracy. Meta-analytically, rTMS at 10 Hz and 20 Hz disrupted accuracy for attention, executive, language, memory, motor, and perception domains, while no effects were found with 1 Hz or 5 Hz. Stimulation applied at and 10 and 20 Hz slowed down RTs in attention and perception tasks. No performance enhancement was found. Our meta-regression analysis showed that fMRI-guided targeting and short inter-trial interval durations are associated with increased degree of disruption with rTMS.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c79599f510ae3a127196417116dc3670Test
https://doi.org/10.1016/j.neubiorev.2019.08.018Test -
16
المؤلفون: Moritz Dannhauer, Courtney A. Crowell, Hannah Palmer, Lawrence G. Appelbaum, Sarah H. Lisanby, Bruce Luber, Andrew M. Michael, Roberto Cabeza, Angel V. Peterchev, Simon W. Davis, Joyce E‐H. Wang, Eleanor Wood, Susan A. Hilbig, Lysianne Beynel
مصطلحات موضوعية: Working memory, Psychological intervention, Psychology, Cognitive psychology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3c9d0634f40f344fa0de6343567cb6b0Test
https://doi.org/10.1002/brb3.2361/v2/response1Test -
17
المؤلفون: Zachary A. Monge, Mariam Hovhannisyan, Benjamin R. Geib, Tory Worth, Simon W. Davis, Alex Clarke, Amanda Szymanski, Rosalie Cicchinelli, Roberto Cabeza
المساهمون: Apollo - University of Cambridge Repository
المصدر: Memory & Cognition
مصطلحات موضوعية: Visual perception, Semantic feature, 05 social sciences, Cognitive neuroscience of visual object recognition, Representation (systemics), Experimental and Cognitive Psychology, False memory, Object recognition, Object (computer science), 050105 experimental psychology, Article, 03 medical and health sciences, 0302 clinical medicine, Neuropsychology and Physiological Psychology, Arts and Humanities (miscellaneous), Memory, Encoding (memory), Semantic memory, 0501 psychology and cognitive sciences, Psychology, 030217 neurology & neurosurgery, Cognitive psychology, Concepts
الوصف: Humans have a remarkable fidelity for visual long-term memory, and yet the composition of these memories is a longstanding debate in cognitive psychology. While much of the work on long-term memory has focused on processes associated with successful encoding and retrieval, more recent work on visual object recognition has developed a focus on the memorability of specific visual stimuli. Such work is engendering a view of object representation as a hierarchical movement from low-level visual representations to higher level categorical organization of conceptual representations. However, studies on object recognition often fail to account for how these high- and low-level features interact to promote distinct forms of memory. Here, we use both visual and semantic factors to investigate their relative contributions to two different forms of memory of everyday objects. We first collected normative visual and semantic feature information on 1,000 object images. We then conducted a memory study where we presented these same images during encoding (picture target) on Day 1, and then either a Lexical (lexical cue) or Visual (picture cue) memory test on Day 2. Our findings indicate that: (1) higher level visual factors (via DNNs) and semantic factors (via feature-based statistics) make independent contributions to object memory, (2) semantic information contributes to both true and false memory performance, and (3) factors that predict object memory depend on the type of memory being tested. These findings help to provide a more complete picture of what factors influence object memorability. These data are available online upon publication as a public resource.
وصف الملف: application/pdf; text/xml
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ca094429c8d0910173306439b2b7b1eaTest
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المؤلفون: Simon W. Davis, Maureen Ritchey, Rose A. Cooper, Kyle A. Kurkela
المصدر: NeuroImage
NeuroImage, Vol 236, Iss, Pp 118075-(2021)مصطلحات موضوعية: Adult, Male, Default network, Cognitive Neuroscience, Memory, Episodic, Motion Pictures, Precuneus, Hippocampus, Neurosciences. Biological psychiatry. Neuropsychiatry, Biology, 050105 experimental psychology, Article, Angular gyrus, 03 medical and health sciences, Functional connectivity, 0302 clinical medicine, Retrosplenial cortex, Cortex (anatomy), medicine, Connectome, Humans, 0501 psychology and cognitive sciences, Prefrontal cortex, Default mode network, Cerebral Cortex, Episodic memory, 05 social sciences, Default Mode Network, Event cognition, Magnetic Resonance Imaging, medicine.anatomical_structure, Neurology, Posterior cingulate, Visual Perception, Female, Nerve Net, Neuroscience, 030217 neurology & neurosurgery, RC321-571
الوصف: Brain regions within a posterior medial network (PMN) are characterized by sensitivity to episodic tasks, and they also demonstrate strong functional connectivity as part of the default network. Despite its cohesive structure, delineating the intranetwork organization and functional diversity of the PMN is crucial for understanding its contributions to multidimensional event cognition. Here, we probed functional connectivity of the PMN during movie watching to identify its pattern of connections and subnetwork functions in a split-sample replication of 136 participants. Consistent with prior findings of default network fractionation, we identified distinct PMN subsystems: a Ventral PM subsystem (retrosplenial cortex, parahippocampal cortex, posterior angular gyrus) and a Dorsal PM subsystem (medial prefrontal cortex, hippocampus, precuneus, posterior cingulate cortex, anterior angular gyrus). These subsystems were anchored by two complementary regions: Retrosplenial cortex mediated communication between parahippocampal cortex and the Dorsal PM system, and posterior cingulate cortex mediated communication among Dorsal PM regions. Finally, the distinction between PMN subsystems is functionally relevant: whereas both Dorsal and Ventral PM connectivity tracked the movie content, only Ventral PM connections increased in strength at event transitions and appeared sensitive to episodic memory. Overall, these findings provide a model of PMN pathways and reveal distinct functional roles of intranetwork subsystems associated with event cognition.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa996aec04ff1c6a5e96b75b7495f594Test
https://pubmed.ncbi.nlm.nih.gov/33910099Test -
20دورية أكاديمية
المؤلفون: Simon W. Davis N, Jie Zhuang, Paul Wright, Lorraine K. Tyler
المساهمون: The Pennsylvania State University CiteSeerX Archives
الوصف: Age-related sensitivity to task-related modulation
وصف الملف: application/pdf
