المؤلفون: Landi, Antonio, Heg, Dik, Frigoli, Enrico, VRANCKX, Pascal, Windecker, Stephan, Siegrist, Patrick, Cayla, Guillaume, Wlodalczak, Adrian, Cook, Stephane, Gomez-Blazquez, Ivan, Feld, Yair, Seung-Jung, Park, Mates, Martin, Lotan, Chaim, Gunasekaran, Sengottuvelu, Nanasato, Mamoru, Das , Rajiv, Kelbaek, Henning, Teiger, Emmanuel, Escaned, Javier, Ishibashi, Yuki, Montalescot, Gilles, Matsuo, Hitoshi, Debeljacki, Dragan, Smits, Pieter C., Valgimigli, Marco

المساهمون: Landi, Antonio, Heg, Dik, Frigoli, Enrico, VRANCKX, Pascal, Windecker, Stephan, Siegrist, Patrick, Cayla, Guillaume, Wlodalczak, Adrian, Cook, Stephane, Gomez-Blazquez, Ivan, Feld, Yair, Seung-Jung, Park, Mates, Martin, Lotan, Chaim, Gunasekaran, Sengottuvelu, Nanasato, Mamoru, Das , Rajiv, Kelbaek, Henning, Teiger, Emmanuel, Escaned, Javier, Ishibashi, Yuki, Montalescot, Gilles, Matsuo, Hitoshi, Debeljacki, Dragan, Smits, Pieter C., Valgimigli, Marco

مصطلحات موضوعية: KEY WORDS antiplatelet therapy, dual antiplatelet therapy, high bleeding risk, percutaneous coronary intervention

الوصف: BACKGROUND Clinical outcomes and treatment selection after completing the randomized phase of modern trials, investigating antiplatelet therapy (APT) after percutaneous coronary intervention (PCI), are unknown. OBJECTIVES The authors sought to investigate cumulative 15-month and 12-to-15-month outcomes after PCI during routine care in the MASTER DAPT trial. METHODS The MASTER DAPT trial randomized 4,579 high bleeding risk patients to abbreviated (n = 2,295) or standard (n = 2,284) APT regimens. Coprimary outcomes were net adverse clinical outcomes (NACE) (all-cause death, myocardial infarction, stroke, and BARC 3 or 5 bleeding); major adverse cardiac and cerebral events (MACCE) (all-cause death, myocardial infarction, and stroke); and BARC type 2, 3, or 5 bleeding. RESULTS At 15 months, prior allocation to a standard APT regimen was associated with greater use of intensified APT; NACE and MACCE did not differ between abbreviated vs standard APT (HR: 0.92 [95% CI: 0.76-1.12]; P = 0.399 and HR: 0.94 [95% CI: 0.76-1.17]; P = 0.579; respectively), as during the routine care period (HR: 0.81 [95% CI: 0.50-1.30]; P = 0.387 and HR: 0.74 [95% CI: 0.43-1.26]; P = 0.268; respectively). BARC 2, 3, or 5 was lower with abbreviated APT at 15 months (HR: 0.68 [95% CI: 0.56-0.83]; P = 0.0001) and did not differ during the routine care period. The treatment effects during routine care were consistent with those observed within 12 months after PCI. CONCLUSIONS At 15 months, NACE and MACCE did not differ in the 2 study groups, whereas the risk of major or clinically relevant nonmajor bleeding remained lower with abbreviated compared with standard APT. (Management of High Bleeding Risk Patients Post Bioresorbable Polymer Coated Stent Implantation With an Abbreviated Versus Prolonged DAPT Regimen [MASTER DAPT]; NCT03023020) (J Am Coll Cardiol Intv 2023;16:798-812) (c) 2023 by the American College of Cardiology Foundation. ; The study was sponsored by the European Cardiovascular Research Institute, a nonprofit organization, and ...

وصف الملف: application/pdf

العلاقة: JACC-Cardiovascular Interventions, 16 (7) , p. 798 -812; http://hdl.handle.net/1942/40569Test; 812; 798; 16; 000996512200001

الإتاحة: https://doi.org/10.1016/j.jcin.2023.01.366Test
http://hdl.handle.net/1942/40569Test

المؤلفون: Abdelwahed, Youssef S., Siegrist, Patrick T., Skurk, Carsten, Landmesser, Ulf

المساهمون: Charité - Universitätsmedizin Berlin

المصدر: The International Journal of Cardiovascular Imaging ; volume 39, issue 5, page 1079-1080 ; ISSN 1875-8312

الإتاحة: https://doi.org/10.1007/s10554-022-02790-xTest

المؤلفون: Panuccio, Giuseppe, Werner, Gerald S, De Rosa, Salvatore, Torella, Daniele, Leistner, David M, Siegrist, Patrick T, Haghikia, Arash, Skurk, Carsten, Mashayekhi, Kambis, Landmesser, Ulf, Abdelwahed, Youssef S

المصدر: Am J Cardiol ; ISSN:1879-1913 ; Volume:222

مصطلحات موضوعية: calcification, chronic total occlusions, computed tomography, coronary imaging, percutaneous coronary intervention, precision medicine

الوصف: "Full moon" is a central calcification that occludes the entire vessel on coronary computed tomography angiography (CCTA). We examined the association of full moon calcification as identified by CCTA, on clinical and procedural outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI). We studied patients who underwent elective CTO-PCI in 2 European centers and had preprocedural CCTA. The primary end point was the inability to cross the lesion and/or the need for extensive debulking techniques. Secondary end points were procedural success, in-hospital cardiac mortality, the need for extensive debulking techniques, myocardial infarction, major adverse cardiac events (defined as in-hospital death, myocardial infarction, and clinically driven target vessel revascularization), and stent thrombosis. Secondary procedural end points included procedural time, fluoroscopy time, number of guidewires and balloons, stent length, number and diameter, and contrast volume. Multivariable logistic regression analysis was performed, identifying potential covariates related to the primary outcome according to knowledge and previous studies. Subsequently, a stepwise selection approach was performed to select factors with the greatest predictive value. Of 140 patients included, 28 (20%) had a full moon calcified CTO plaque. Patients in the full moon group were older and had more cardiovascular risk factors. There was not significant difference in the need for retrograde approach and anterograde dissection and reentry techniques between the full moon group and the other groups (32.1% vs 37.5%, p = 0.59 and 0% vs 1.7%, p = 0.47, respectively). Patients in the full moon group had greater incidence of the primary outcome than did those who did not have full moon morphology (53.5% vs 12.5%, p <0.001). On multivariable analysis that included chronic kidney failure and previous coronary artery bypass surgery, full moon calcification was associated with greater incidence of the primary end point (odds ratio 6.5, 95% confidence interval 2.1 to 20.5, p = 0.001). Moreover, less procedural success (71.4% vs 87.5%, p = 0.03), greater incidence of coronary perforations (14.2% vs 3.5%, p <0.02), and greater procedural (172.5 [118.0 to 237.5] vs 144.0 [108.50 to 174.75], p = 0.02) and fluoroscopic time (62.6 [38.1 to 83.0] vs 42.8 [29.5 to 65.7], p = 0.03) were observed in the full moon group. Overall major adverse cardiac events did not differ between the 2 groups (1 patient in the full moon group vs 1 patient in the non-full moon group; 3.5% vs 0.8%, p = 0.29). In conclusion, full moon calcification on CCTA was independently associated with procedural complexity and adverse outcomes in CTO-PCI.

العلاقة: https://doi.org/10.1016/j.amjcard.2024.05.008Test; https://pubmed.ncbi.nlm.nih.gov/38761964Test

الإتاحة: https://doi.org/10.1016/j.amjcard.2024.05.008Test
https://pubmed.ncbi.nlm.nih.gov/38761964Test

المؤلفون: Abdelwahed, Youssef S., Weber, Alberto C., Siegrist, Patrick T.

المصدر: JACC: Cardiovascular Interventions ; volume 14, issue 4, page 476-480 ; ISSN 1936-8798

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.jcin.2020.11.016Test
https://api.elsevier.com/content/article/PII:S1936879820322834?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1936879820322834?httpAccept=text/plainTest

المؤلفون: Abdelwahed, Youssef, Skurk, Carsten, Siegrist, Patrick, Landmesser, Ulf, Werner, Gerald

المصدر: Cardiovascular Medicine ; ISSN 1664-204X

الإتاحة: https://doi.org/10.4414/cvm.2021.02185Test

المؤلفون: Holy, Erik W, Jakob, Philipp, Manka, Robert, Stähli, Barbara E, Siegrist, Patrick T, Ruschitzka, Frank, Templin, Christian

المصدر: Holy, Erik W; Jakob, Philipp; Manka, Robert; Stähli, Barbara E; Siegrist, Patrick T; Ruschitzka, Frank; Templin, Christian (2020). Impact of a nationwide COVID-19 lockdown on acute coronary syndrome referrals. Cardiology Journal, 27(5):633-635.

مصطلحات موضوعية: Clinic for Cardiology, 610 Medicine & health

وصف الملف: application/pdf

العلاقة: https://www.zora.uzh.ch/id/eprint/198598/1/69670-215473-3-PB.pdfTest; info:pmid/32643140; urn:issn:1898-018X

الإتاحة: https://doi.org/10.5167/uzh-19859810.5603/CJ.a2020.0091Test
https://www.zora.uzh.ch/id/eprint/198598Test/
https://www.zora.uzh.ch/id/eprint/198598/1/69670-215473-3-PB.pdfTest

المؤلفون: Cammann, Victoria L., Szawan, Konrad A., D’Ascenzo, Fabrizio, Gili, Sebastiano, Dreiding, Sara, Würdinger, Michael, Manka, Robert, Stähli, Barbara E., Holy, Erik W., Siegrist, Patrick, Jakob, Philipp, Meyer, Philippe, Iannaccone, Mario, Di Simone, Emanuela, Secco, Gioel Gabrio, Saccocci, Matteo, Bettari, Luca, Ielasi, Alfonso, Tespili, Maurizio, Quadri, Giorgio, Varbella, Ferdinando, Raposeiras-Roubin, Sergio, Abu-Assi, Emad, Mancone, Massimo, Sardella, Gennaro, Infusino, Fabio, Fedele, Francesco, Patti, Giuseppe, Mennuni, Marco, Rognoni, Andrea, Bollati, Mario, Olivotti, Luca, Cordone, Stefano, Carugo, Stefano, Barbieri, Lucia, Gaido, Luca, Giammaria, Massimo, Gambino, Alfonso, D’Amico, Maurizio, Galluzzo, Alessandro, Ugo, Fabrizio, Trabattoni, Daniela, De Filippo, Ovidio, De Ferrari, Gaetano Maria, Vecchione, Carmine, Citro, Rodolfo, Ghadri, Jelena R., Templin, Christian

المصدر: Clinical Research in Cardiology ; volume 109, issue 12, page 1601-1604 ; ISSN 1861-0684 1861-0692

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, General Medicine

الإتاحة: https://doi.org/10.1007/s00392-020-01742-6Test

المؤلفون: Raber, Lorenz, Haener, Jonas, Waksman, Ron, Lüscher, Thomas, Moccetti, Marco, Stortecky, Stefan, Fournier, Stephane, Garcia-Garcia, Hector, Siegrist, Patrick

المصدر: Journal of the American College of Cardiology ; volume 76, issue 17, page B116-B117 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.jacc.2020.09.284Test
https://api.elsevier.com/content/article/PII:S0735109720368947?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0735109720368947?httpAccept=text/plainTest

المؤلفون: Raber, Lorenz, Haener, Jonas, Waksman, Ron, Moccetti, Marco, Roffi, Marco, Stortecky, Stefan, Muller, Olivier, Garcia-Garcia, Hector, Siegrist, Patrick

المصدر: Journal of the American College of Cardiology ; volume 72, issue 13, page B189 ; ISSN 0735-1097

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine

الإتاحة: https://doi.org/10.1016/j.jacc.2018.08.1643Test
https://api.elsevier.com/content/article/PII:S0735109718376502?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0735109718376502?httpAccept=text/plainTest

المؤلفون: Shahin, Mohammady, Gaemperli, Oliver, Siegrist, Patrick, Alibegovic, Jasmina

المصدر: Cardiology Research ; volume 8, issue 6, page 331-335 ; ISSN 1923-2829 1923-2837

الإتاحة: https://doi.org/10.14740/cr598eTest
http://www.cardiologyres.org/index.php/Cardiologyres/article/download/665/708Test