المؤلفون: Shuting Xue, Chao Wang, Shibin Zhang, Chuyao Weng, Yuxi Zhang

المصدر: Land, Vol 12, Iss 7, p 1275 (2023)

مصطلحات موضوعية: eco-efficiency, urbanization efficiency, US-SBM, STIRPAT, influencing factors, urban agglomerations, Agriculture

الوصف: Attaining optimal eco-efficiency is of paramount importance in promoting the sustainable and harmonious development of the economy and environment within urban agglomerations. Firstly, this paper utilizes the Super-SBM model with undesirable output to measure the eco-efficiency (EE) of 64 cities in the Beijing–Tianjin–Hebei metropolitan region (BTHMR), the Yangtze River Delta (YRD), the Pearl River Delta (PRD), and the Chengdu–Chongqing Economic Zone (CCEZ) from 2006 to 2019. Secondly, this study puts forth a novel and comprehensive index system aimed at evaluating the urbanization efficiency and sheds light on the spatiotemporal changes in EE and urbanization efficiency. Finally, the STIRPAT model is used to examine the influencing factors of EE and to investigate the correlation between EE and urbanization efficiency. The study found that the overall EE of the four typical urban agglomerations is high, but the trend varies with a decrease of about 12.9% from 2006 to 2019. The mean EE is in the order of CCEZ > PRD > BTHMR > YRD, with mean values of 0.941, 0.909, 0.842, and 0.732, respectively. The level of science and technology and the urbanization efficiency have a significant positive impact on EE, while population, industrial structure, FDI, and greening level have an inhibitory effect on urban eco-efficiency. Based on the results, policy suggestions such as paying attention to regional heterogeneity and giving full play to the government’s macro-regulatory role in shaping the economic and industrial structure are proposed to serve as a guide for the coordinated development of urban agglomerations under the Dual Carbon Target.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2073-445X/12/7/1275Test; https://doaj.org/toc/2073-445XTest

الوصول الحر: https://doaj.org/article/826282cc30db4a3ab0d59f149293fa70Test

المؤلفون: Zhang, Shuting Xue, Chao Wang, Shibin Zhang, Chuyao Weng, Yuxi

المصدر: Land; Volume 12; Issue 7; Pages: 1275

مصطلحات موضوعية: eco-efficiency, urbanization efficiency, US-SBM, STIRPAT, influencing factors, urban agglomerations

الوصف: Attaining optimal eco-efficiency is of paramount importance in promoting the sustainable and harmonious development of the economy and environment within urban agglomerations. Firstly, this paper utilizes the Super-SBM model with undesirable output to measure the eco-efficiency (EE) of 64 cities in the Beijing–Tianjin–Hebei metropolitan region (BTHMR), the Yangtze River Delta (YRD), the Pearl River Delta (PRD), and the Chengdu–Chongqing Economic Zone (CCEZ) from 2006 to 2019. Secondly, this study puts forth a novel and comprehensive index system aimed at evaluating the urbanization efficiency and sheds light on the spatiotemporal changes in EE and urbanization efficiency. Finally, the STIRPAT model is used to examine the influencing factors of EE and to investigate the correlation between EE and urbanization efficiency. The study found that the overall EE of the four typical urban agglomerations is high, but the trend varies with a decrease of about 12.9% from 2006 to 2019. The mean EE is in the order of CCEZ > PRD > BTHMR > YRD, with mean values of 0.941, 0.909, 0.842, and 0.732, respectively. The level of science and technology and the urbanization efficiency have a significant positive impact on EE, while population, industrial structure, FDI, and greening level have an inhibitory effect on urban eco-efficiency. Based on the results, policy suggestions such as paying attention to regional heterogeneity and giving full play to the government’s macro-regulatory role in shaping the economic and industrial structure are proposed to serve as a guide for the coordinated development of urban agglomerations under the Dual Carbon Target.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=multidiscipl::fa7f3a76c7381cc523ccd2f2e82a8335Test

المؤلفون: Shuting Xue, Hong Bian, Haizheng Yu, Shou-Jun Xu, Lina Wei

المصدر: Polycyclic Aromatic Compounds. 42:7091-7099

مصطلحات موضوعية: Forcing (recursion theory), Polymers and Plastics, Hexagonal crystal system, Chemistry, Organic Chemistry, Materials Chemistry, Geometry

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::409c25e63dafa28249be7ee72a62d59dTest
https://doi.org/10.1080/10406638.2021.1996404Test

المؤلفون: Niya Liu, Lei Zhao, Stephanie Roessler, Fubo Ji, Xin Zheng, Zhao Ma, Junfang Ji, Xiyang Wei, Shuting Xue, Jianjuan Zhang, Ruizhe Ren, Jiong Shi, Xing Guo, Zhaogang Liu, Xin Wei Wang, Linda Wong

المصدر: Hepatology

مصطلحات موضوعية: Male, 0301 basic medicine, Cohort Studies, Gene Knockout Techniques, Mice, 0302 clinical medicine, Aged, 80 and over, education.field_of_study, CD24, Liver Neoplasms, Middle Aged, Hepatocellular carcinoma, Neoplastic Stem Cells, Female, 030211 gastroenterology & hepatology, Liver cancer, Signal Transduction, medicine.drug, Adult, Carcinoma, Hepatocellular, Adolescent, Population, Transfection, Article, Young Adult, 03 medical and health sciences, Cancer stem cell, microRNA, Biomarkers, Tumor, medicine, Animals, Humans, Chemoembolization, Therapeutic, education, Aged, Hepatology, business.industry, Hypoxia-Inducible Factor 1, alpha Subunit, medicine.disease, digestive system diseases, MicroRNAs, HEK293 Cells, 030104 developmental biology, HIF1A, A549 Cells, Drug Resistance, Neoplasm, Erythropoietin, Cancer research, Transcriptome, business, Proto-Oncogene Proteins c-akt

الوصف: Background and aims Transarterial chemoembolization (TACE) is a standard locoregional therapy for patients with hepatocellular carcinoma (HCC) patients with a variable overall response in efficacy. We aimed to identify key molecular signatures and related pathways leading to HCC resistance to TACE, with the hope of developing effective approaches in preselecting patients with survival benefit from TACE. Approach and results Four independent HCC cohorts with 680 patients were used. MicroRNA (miRNA) transcriptome analysis in patients with HCC revealed a 41-miRNA signature related to HCC recurrence after adjuvant TACE, and miR-125b was the top reduced miRNA in patients with HCC recurrence. Consistently, patients with HCC with low miR-125b expression in tumor had significantly shorter time to recurrence following adjuvant TACE in two independent cohorts. Loss of miR-125b in HCC noticeably activated the hypoxia inducible factor 1 alpha subunit (HIF1α)/pAKT loop in vitro and in vivo. miR-125b directly attenuated HIF1α translation through binding to HIF1A internal ribosome entry site region and targeting YB-1, and blocked an autocrine HIF1α/platelet-derived growth factor β (PDGFβ)/pAKT/HIF1α loop of HIF1α translation by targeting the PDGFβ receptor. The miR-125b-loss/HIF1α axis induced the expression of CD24 and erythropoietin (EPO) and enriched a TACE-resistant CD24-positive cancer stem cell population. Consistently, patients with high CD24 or EPO in HCC had poor prognosis following adjuvant TACE therapy. Additionally, in patients with HCC having TACE as their first-line therapy, high EPO in blood before TACE was also noticeably related to poor response to TACE. Conclusions MiR-125b loss activated the HIF1α/pAKT loop, contributing to HCC resistance to TACE and the key nodes in this axis hold the potential in assisting patients with HCC to choose TACE therapy.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ce8941f479b6e08e1b61631b60f15ceTest
https://doi.org/10.1002/hep.31448Test

المؤلفون: Shuting Xue (11641130), Hong Bian (1671412), Lina Wei (10836093), Haizheng Yu (11641133), Shou-Jun Xu (11641136)

مصطلحات موضوعية: Biophysics, Medicine, Microbiology, Cell Biology, Physiology, Developmental Biology, Cancer, Plasma Physics, Computational Biology, Physical Sciences not elsewhere classified, Forcing set, complete forcing set, perfect matching, random multiple hexagonal chains

الوصف: Let G be a simple connected graph with vertex set V ( G ) and edge set E ( G ) that admits a perfect matching M . A forcing set of M is a subset of M contained in no other perfect matchings of G . The minimum cardinality of forcing sets is the forcing number of M . A complete forcing set of G , recently introduced by Xu et al. [Complete forcing numbers of catacondensed hexagonal systems, J . Combin . Optim . 29(4) (2015) 803-814], is a subset S of E ( G ) on which the restriction of any perfect matching M of G is a forcing set of M . A complete forcing set of the smallest cardinality is called a minimum complete forcing set, and its cardinality is the complete forcing number of G , denoted by cf ( G ). In this paper, we present the complete forcing sets and complete forcing number of random multiple hexagonal chains.

العلاقة: https://figshare.com/articles/dataset/Complete_Forcing_Numbers_of_Random_Multiple_Hexagonal_Chains/16923131Test

الإتاحة: https://doi.org/10.6084/m9.figshare.16923131.v1Test