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1دورية أكاديمية
المؤلفون: Shuancheng Ren, Cai Zhang, Faguo Yue, Jinxiang Tang, Wei Zhang, Yue Zheng, Yuanyuan Fang, Na Wang, Zhenbo Song, Zehui Zhang, Xiaolong Zhang, Han Qin, Yaling Wang, Jianxia Xia, Chenggang Jiang, Chao He, Fenlan Luo, Zhian Hu
المصدر: Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
مصطلحات موضوعية: Science
الوصف: Abstract Enhancement of wakefulness is a prerequisite for adaptive behaviors to cope with acute stress, but hyperarousal is associated with impaired behavioral performance. Although the neural circuitries promoting wakefulness in acute stress conditions have been extensively identified, less is known about the circuit mechanisms constraining wakefulness to prevent hyperarousal. Here, we found that chemogenetic or optogenetic activation of GAD2-positive GABAergic neurons in the midbrain dorsal raphe nucleus (DRNGAD2) decreased wakefulness, while inhibition or ablation of these neurons produced an increase in wakefulness along with hyperactivity. Surprisingly, DRNGAD2 neurons were paradoxically wakefulness-active and were further activated by acute stress. Bidirectional manipulations revealed that DRNGAD2 neurons constrained the increase of wakefulness and arousal level in a mouse model of stress. Circuit-specific investigations demonstrated that DRNGAD2 neurons constrained wakefulness via inhibition of the wakefulness-promoting paraventricular thalamus. Therefore, the present study identified a wakefulness-constraining role DRNGAD2 neurons in acute stress conditions.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2041-1723Test
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2دورية أكاديمية
المؤلفون: Tingting Yi, Na Wang, Jing Huang, Yaling Wang, Shuancheng Ren, Yiwen Hu, Jianxia Xia, Yixiang Liao, Xin Li, Fenlan Luo, Qin Ouyang, Yu Li, Ziyi Zheng, Qin Xiao, Rong Ren, Zhongxiang Yao, Xiangdong Tang, Yanjiang Wang, Xiaowei Chen, Chao He, Hong Li, Zhian Hu
المصدر: Advanced Science, Vol 10, Iss 15, Pp n/a-n/a (2023)
مصطلحات موضوعية: Edinger‐Westphal nucleus, general anesthesia, growth hormone secretagogue receptor, sevoflurane, sleep, Science
الوصف: Abstract Sevoflurane has been the most widely used inhaled anesthetics with a favorable recovery profile; however, the precise mechanisms underlying its anesthetic action are still not completely understood. Here the authors show that sevoflurane activates a cluster of urocortin 1 (UCN1+)/cocaine‐ and amphetamine‐regulated transcript (CART+) neurons in the midbrain involved in its anesthesia. Furthermore, growth hormone secretagogue receptor (GHSR) is highly enriched in sevoflurane‐activated UCN1+/CART+ cells and is necessary for sleep induction. Blockade of GHSR abolishes the excitatory effect of sevoflurane on UCN1+/CART+ neurons and attenuates its anesthetic effect. Collectively, their data suggest that anesthetic action of sevoflurane necessitates the GHSR activation in midbrain UCN1+/CART+ neurons, which provides a novel target including the nucleus and receptor in the field of anesthesia.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2198-3844Test
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3
المؤلفون: Junhong, Zhang, Fenlan, Luo, Shuancheng, Ren, Yaling, Wang, Wu, Li, Kan, Xu, Ziyi, Zheng, Chao, He, Jianxia, Xia, Wei, Xiong, Zhi-An, Hu
المصدر: Neuroscience Bulletin. 38:1588-1592
مصطلحات موضوعية: Motor Neurons, Mice, Spinal Cord, Physiology, General Neuroscience, Animals, General Medicine
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70d1e42a2c6ecdf6b69ec5bb463acefaTest
https://doi.org/10.1007/s12264-022-00883-0Test -
4
المؤلفون: Yixiang Liao, Ruyi Wen, Shengwei Fu, Xiaofang Cheng, Shuancheng Ren, Minmin Lu, Ling Qian, Fenlan Luo, Yaling Wang, Qin Xiao, Xiao Wang, Hengying Ye, Xiaolong Zhang, Chenggang Jiang, Xin Li, Shiyin Li, Ruozhi Dang, Yingying Liu, Junjun Kang, Zhongxiang Yao, Jie Yan, Jiaxiang Xiong, Yanjiang Wang, Shengxi Wu, Xiaowei Chen, Yulong Li, Jianxia Xia, Zhian Hu, Chao He
الوصف: Codes used in my Neuron manuscript
العلاقة: https://zenodo.org/record/8415784Test; https://doi.org/10.5281/zenodo.8415784Test; oai:zenodo.org:8415784
الإتاحة: https://doi.org/10.5281/zenodo.8415784Test
https://doi.org/10.5281/zenodo.8415691Test
https://zenodo.org/record/8415784Test -
5
المؤلفون: Juanjuan Zhao, Chengyu Liu, Fenyan Zhang, Ziyi Zheng, Fenlan Luo, Jianxia Xia, Yaling Wang, Zehui Zhang, Jinxiang Tang, Zhenbo Song, Siyu Li, Kan Xu, Mengting Chen, Chenggang Jiang, Chao He, Ling Tang, Zhian Hu, Dong Gao, Shuancheng Ren
المصدر: Cell Reports. 41:111824
مصطلحات موضوعية: Optogenetics, Neurons, Thalamus, Central Amygdaloid Nucleus, Neural Pathways, Wakefulness, General Biochemistry, Genetics and Molecular Biology
الوصف: Heightened wakefulness in response to stressors is essential for survival but can also lead to sleep disorders like insomnia. The paraventricular thalamus (PVT) is both a critical thalamic area for wakefulness and a stress-sensitive brain region. However, whether the PVT and its neural circuitries are involved in controlling wakefulness in stress conditions remains unknown. Here, we find that PVT neurons projecting to the central amygdala (CeA) are activated by different stressors. These neurons are wakefulness-active and increase their activities upon sleep to wakefulness transitions. Optogenetic activation of the PVT-CeA circuit evokes transitions from sleep to wakefulness, whereas selectively silencing the activity of this circuit decreases time spent in wakefulness. Specifically, chemogenetic inhibition of CeA-projecting PVT neurons not only alleviates stress responses but also attenuates the acute stress-induced increase of wakefulness. Thus, our results demonstrate that the PVT-CeA circuit controls physiological wakefulness and modulates acute stress-induced heightened wakefulness.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a3b5f3bd3d7a4c01569a894de08c827Test
https://doi.org/10.1016/j.celrep.2022.111824Test -
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المؤلفون: Han Qin, Ling Fu, Tingliang Jian, Wenjun Jin, Mengru Liang, Jin Li, Qianwei Chen, Xinyu Yang, Haoran Du, Xiang Liao, Kuan Zhang, Rui Wang, Shanshan Liang, Jiwei Yao, Bo Hu, Shuancheng Ren, Chunqing Zhang, Yanjiang Wang, Zhian Hu, Hongbo Jia, Arthur Konnerth, Xiaowei Chen
المصدر: Neuron. 110:4000-4014.e6
مصطلحات موضوعية: Mice, General Neuroscience, Animals, Social Group, Sleep, Memory Consolidation
الوصف: The hippocampal CA2 region plays a key role in social memory. The encoding of such memory involves afferent activity from the hypothalamic supramammillary nucleus (SuM) to CA2. However, the neuronal circuits required for consolidation of freshly encoded social memory remain unknown. Here, we used circuit-specific optical and single-cell electrophysiological recordings in mice to explore the role of sleep in social memory consolidation and its underlying circuit mechanism. We found that SuM neurons projecting to CA2 were highly active during rapid-eye-movement (REM) sleep but not during non-REM sleep or quiet wakefulness. REM-sleep-selective optogenetic silencing of these neurons impaired social memory. By contrast, the silencing of another group of REM sleep-active SuM neurons that projects to the dentate gyrus had no effect on social memory. Therefore, we provide causal evidence that the REM sleep-active hypothalamic neurons that project to CA2 are specifically required for the consolidation of social memory.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::979524c06a8e33bca54fe5264bf4feedTest
https://doi.org/10.1016/j.neuron.2022.09.004Test -
7دورية أكاديمية
المؤلفون: Chao He, Fenlan Luo, Xingshu Chen, Fang Chen, Chao Li, Shuancheng Ren, Qicheng Qiao, Jun Zhang, de Lecea, Luis, Dong Gao, Zhian Hu
المصدر: Cerebral Cortex; Apr2016, Vol. 26 Issue 4, p1590-1608, 19p