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1دورية أكاديمية
المؤلفون: Yang Li, Shu-ting Yang, Shuying Yang
المصدر: Genes and Diseases, Vol 11, Iss 1, Pp 4-6 (2024)
مصطلحات موضوعية: Medicine (General), R5-920, Genetics, QH426-470
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2352304222003282Test; https://doaj.org/toc/2352-3042Test
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2دورية أكاديمية
المؤلفون: Chi-Mei Kuo, Pin-Chun Su, Shu-Ting Yang, Hao-Wei Chung, Hsiu-Lin Chen
المصدر: Children, Vol 11, Iss 5, p 610 (2024)
مصطلحات موضوعية: furosemide, ductus arteriosus, spontaneous closure, very-low-birth-weight, preterm, infants, Pediatrics, RJ1-570
الوصف: Ductus arteriosus closure may be delayed in preterm infants, and prostaglandin, a vasodilator, can affect ductal patency. Furosemide can increase renal prostaglandin synthesis, so its net effect on patent ductus arteriosus (PDA) is uncertain. Our goal is to explore the relationship between furosemide and spontaneous ductal closure in very-low-birth-weight preterm infants. Our treatment for PDA involves fluid restriction initially and furosemide administration for hemodynamically significant PDA until closure is confirmed by the echocardiogram. We enrolled 105 infants from 1 January 2019 to 30 June 2022 and evaluated the impact of furosemide on ductal closure, including exposure duration and cumulative dose. There is no correlation between furosemide exposure and spontaneous ductal closure (p = 0.384). Furosemide exposure does not delay the postmenstrual age at which spontaneous ductal closure occurs (p = 0.558). The time for spontaneous ductal closure is positively associated with furosemide prescription days (coefficient value = 0.547, p = 0.026) and negatively with gestational age (coefficient value = −0.384, p = 0.062). The prescription of furosemide does not impact the probability or time duration of ductus arteriosus spontaneous closure. The cumulative dose of furosemide has minimal impact on ductal closure. The correlation between furosemide exposure duration and ductal patency duration is likely due to our treatment protocol, with gestational age being a significant factor.
وصف الملف: electronic resource
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3دورية أكاديمية
المؤلفون: Xiangnan Li, Mingyang Wang, Qibin Zhou, Ming Ge, Mengdan Zhang, Wenfeng Liu, Zhenpu Shi, Hongyun Yue, Huishuang Zhang, Yanhong Yin, Shu-Ting Yang
مصطلحات موضوعية: Biochemistry, Pharmacology, Science Policy, Mental Health, Chemical Sciences not elsewhere classified, method dramatically improves, cocoating collaborative strategy, whose electrochemical performance, construct high performance, 4 , 3 , preoxidation fully decomposed, recycled cathode materials, recover spent lifepo, directly regenerated materials, spent lifepo, cocoating layer, recycled urgently, recycled lfp, commercial materials, widely used, severely degraded, regeneration lifepo, regenerated lifepo, recent years, new scheme, massive amount, manufacturing cost, ion batteries, energy storage
الوصف: There have been a massive amount of spent LiFePO 4 batteries produced in recent years because LiFePO 4 is widely used in energy storage and electric vehicles, which need to be recycled urgently. However, considering the manufacturing cost of LiFePO 4 , traditional metallurgical technology is not economical to recover spent LiFePO 4 . Moreover, the performance of directly regenerated materials is inferior to that of commercial materials. It hinders the development of recycled cathode materials for lithium-ion batteries. Herein, spent LiFePO 4 with severely degraded is regenerated by preoxidation and prilling combine cocoating strategy. The preoxidation fully decomposed the binder and residual carbon. The subsequent regeneration process synthesized spherical LiFePO 4 with carbon and Li 3 PO 4 cocoating layer, whose electrochemical performance is comparable to commercial LiFePO 4 . This method dramatically improves the rate and low temperature electrochemical performance of the regenerated LiFePO 4 , which provides a new scheme for the reuse of recycled LFP in lithium-ion batteries.
الإتاحة: https://doi.org/10.1021/acsmaterialslett.3c01161.s001Test
https://figshare.com/articles/journal_contribution/The_Prilling_and_Cocoating_Collaborative_Strategy_to_Construct_High_Performance_of_Regeneration_LiFePO_sub_4_sub_Materials/25041022Test -
4دورية أكاديمية
المؤلفون: Shu-Ting Yang, Tilo H. Yang, Bor-Wei Liang, Han-Chieh Lo, Wen-Hao Chang, Po-Yen Lin, Ching-Yuan Su, Yann-Wen Lan
مصطلحات موضوعية: Biophysics, Biochemistry, Genetics, Molecular Biology, Neuroscience, Physiology, Mental Health, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, switching ratio alongside, switching drain voltages, submicron memtransistors made, oxide traps within, multistate memory effects, monocrystalline monolayer mos, garnered increasing attention, feature defective channels, efficient neuromorphic devices, optimized memtransistor demonstrates, decreasing channel length, channel length diminishes, memtransistor behavior becomes, 2 , memtransistor designed, channel lengths, memtransisor behavior, work highlights, understanding holds, set voltage, intrinsic properties
الوصف: Multiterminal memtransistors made from two-dimensional (2D) materials have garnered increasing attention in the pursuit of low-power heterosynaptic neuromorphic circuits. However, existing 2D memtransistors tend to necessitate high set voltages (>1 V) or feature defective channels, posing concerns regarding material integrity and intrinsic properties. Herein, we present a monocrystalline monolayer MoS 2 memtransistor designed for operation within submicron regimes. Under reverse drain bias sweeps, our experiments reveal memristive behavior within the device, further controllable through modulation of the gate terminal. This controllability facilitates the consistent manifestation of multistate memory effects. Notably, the memtransistor behavior becomes more significant as the channel length diminishes, particularly with channel lengths below 1.6 μm, showcasing an increase in the switching ratio alongside a decrease in the set voltage with the decreasing channel length. Our optimized memtransistor demonstrates the ability to exhibit individual resistance states spanning 5 orders of magnitude, with switching drain voltages of approximately 0.05 V. To elucidate these findings, we investigate hot carrier effects and their interplay with oxide traps within the HfO 2 dielectric. This work highlights the importance of memtransisor behavior in highly scaled 2D transistors, particularly those featuring low contact resistances. This understanding holds the potential to tailor memory characteristics essential for the development of energy-efficient neuromorphic devices.
الإتاحة: https://doi.org/10.1021/acsnano.3c09030.s001Test
https://figshare.com/articles/journal_contribution/Submicron_Memtransistors_Made_from_Monocrystalline_Molybdenum_Disulfide/25065960Test -
5دورية أكاديمية
المؤلفون: Gongsheng Yuan, Shu-ting Yang, Shuying Yang
المصدر: Cell Insight, Vol 2, Iss 6, Pp 100102- (2023)
مصطلحات موضوعية: Biology (General), QH301-705.5, Medicine (General), R5-920
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2772892723000263Test; https://doaj.org/toc/2772-8927Test
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6دورية أكاديمية
المؤلفون: Hao-Wei Chung, Shu-Ting Yang, Fu-Wen Liang, Hsiu-Lin Chen
المصدر: Pediatrics and Neonatology, Vol 64, Iss 4, Pp 411-419 (2023)
مصطلحات موضوعية: bronchopulmonary dysplasia, conservative treatment, necrotizing enterocolitis, patent ductus arteriosus treatment, preterm infant, Pediatrics, RJ1-570
الوصف: Background: The patent ductus arteriosus (PDA) treatment in very preterm infants is controversial. This study focused on preterm infants born at 28–32 weeks of gestation and analyzed the association between various PDA treatments and clinical outcomes. Methods: We conducted a retrospective cohort study of infants born at 28–32 weeks of gestation between 2016 and 2019 at 22 hospitals in the Taiwan Premature Infant Follow-up Network. We categorized the infants into four groups according to treatment strategies: medication, primary surgery, medication plus surgery, or conservative treatment. Results: A total of 1244 infants presented with PDA, and 761 (61.1%) were treated. Medication was the predominant treatment (50.0%), followed by conservative treatment (38.9%), medication plus surgery (7.6%), and primary surgery (3.5%). The risk of mortality was not reduced in the active treatment group compared to the conservative treatment group. There was a higher prevalence of severe intraventricular hemorrhage, necrotizing enterocolitis (NEC), and any degree of bronchopulmonary dysplasia (BPD) in both the primary surgery and medication plus surgery groups than in the conservative treatment group. After adjustment, both the primary surgery and medication plus surgery groups still had higher odds ratios for the occurrence of NEC and any degree of BPD. Conclusions: Compared with active PDA treatment, conservative treatment for PDA did not increase the risk of mortality and morbidity in very preterm infants born at 28–32 weeks of gestation. The risks and benefits of surgery (PDA ligation) in these infants must be considered cautiously.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S1875957222002741Test; https://doaj.org/toc/1875-9572Test
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7دورية أكاديمية
المؤلفون: Tzyy-Rong Huang, Hsiu-Lin Chen, Shu-Ting Yang, Pin-Chun Su, Hao-Wei Chung
المصدر: Biomedicines, Vol 12, Iss 4, p 838 (2024)
مصطلحات موضوعية: non-invasive ventilation, nasal continuous positive airway pressure, nasal intermittent positive pressure ventilation, minimally invasive surfactant therapy, neonatal respiratory distress syndrome, Biology (General), QH301-705.5
الوصف: In recent years, the utilization of minimally invasive surfactant therapy (MIST) and Non-invasive ventilation (NIV) as the primary respiratory assistance has become increasingly prevalent among preterm infants with neonatal respiratory distress syndrome (RDS). This study aims to compare the outcomes between MIST administered with nasal continuous positive airway pressure (NCPAP) versus nasal intermittent positive pressure ventilation (NIPPV), with the objective of exploring the respiratory therapeutic benefits of these two approaches. This retrospective study collected data from the neonatal intensive care unit of Kaohsiung Medical University Hospital spanning from January 2016 to June 2021. Infants were divided into two groups based on the type of NIV utilized. The NCPAP group comprised 32 infants, while the NIPPV group comprised 22 infants. Statistical analysis revealed significant differences: the NIPPV group had a smaller gestational age, lower birth weight, higher proportion of female infants, and earlier initiation of MIST. Additionally, the NIPPV group exhibited higher incidence rates of retinopathy of prematurity, longer respiratory support duration, prolonged hospitalization, and mortality. However, upon adjustment, these differences were not statistically significant. Analysis of venous blood gas and respiratory parameter changes indicated that both the NCPAP and NIPPV groups experienced improvements in oxygenation and ventilation following MIST.
وصف الملف: electronic resource
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8دورية أكاديمية
المؤلفون: Shu-Ting Yang, Hao-Wei Chung, Hsiu-Lin Chen
المصدر: Children, Vol 11, Iss 3, p 351 (2024)
مصطلحات موضوعية: nasal continuous positive airway pressure, high-flow nasal cannula, preterm, Pediatrics, RJ1-570
الوصف: Nasal continuous positive airway pressure (NCPAP) is extensively used for preterm infants experiencing respiratory distress syndrome (RDS). Weaning from NCPAP includes direct weaning or gradually extending room air exposure. However, a high-flow nasal cannula (HFNC) is an alternative weaning method. Therefore, this study evaluated the clinical outcomes of HFNC and progressively increasing room air duration as weaning strategies. This study enrolled 46 preterm infants with RDS receiving NCPAP support who underwent the cyclic use of NCPAP and HFNC weaning protocol as the HFNC group; a retrospective analysis included 87 preterm infants weaned from NCPAP by gradually extending room air duration as the room air group. Differences in clinical conditions, complications, and short-term outcomes between the weaning methods were compared. The mean post-menstrual age at initiating NCPAP weaning was lower in the room air group than in the HFNC group (mean ± SD, 35.2 ± 2.3 weeks vs. 33.2 ± 2.5 weeks, p < 0.001). Hospital stay duration and total respiratory therapy days were longer in the HFNC group (96 ± 38 days and 80 ± 37 days, respectively) than in the room air group (78 ± 28 days and 56 ± 25 days, respectively), with p-values of 0.006 and
وصف الملف: electronic resource
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9دورية أكاديمية
المؤلفون: Gongsheng Yuan, Shu-ting Yang, Shuying Yang
المصدر: Molecular Therapy: Nucleic Acids, Vol 31, Iss , Pp 197-210 (2023)
مصطلحات موضوعية: MT: Oligonucleotides: Therapies and Applications, regulator of G protein signaling 12, inflammatory arthritis, synovial fibroblasts, cilia, MYCBP2, Therapeutics. Pharmacology, RM1-950
الوصف: Synovial fibroblasts are the active and aggressive drivers in the progression of arthritis, but the cellular and molecular mechanisms remain unknown. Here, our results showed that regulator of G protein signaling 12 (RGS12) maintained ciliogenesis in synovial fibroblasts, which is critical for the development of inflammatory arthritis. Deletion of RGS12 led to a significant decrease in ciliogenesis, adhesion, migration, and secretion of synovial fibroblasts. Mechanistically, RGS12 overexpression in synovial fibroblasts increased the length and number of cilia but decreased the protein level of kinesin family member 2A (KIF2A). The results of LC-MS analyses showed that RGS12 interacted with MYC binding protein 2 to enhance its ubiquitination activity, through which the KIF2A protein was degraded in synovial fibroblasts. Moreover, overexpression of KIF2A blocked the increases in cilia length and number. Mice with RGS12 deficiency or treatment of RGS12 shRNA nanoparticles significantly decreased the clinical score, paw swelling, synovitis, and cartilage destruction during inflammatory arthritis by inhibiting the activation of synovial fibroblasts. Therefore, this study provides evidence that RGS12 activates synovial fibroblasts’ pathological function via promoting MCYBP2-mediated degradation of KIF2A and ciliogenesis. Our data suggest that RGS12 may be a potential drug target for the treatment of inflammatory arthritis.
وصف الملف: electronic resource
العلاقة: http://www.sciencedirect.com/science/article/pii/S2162253122003389Test; https://doaj.org/toc/2162-2531Test
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10دورية أكاديمية
المؤلفون: Yenming J. Chen, Lung-Chang Lin, Shu-Ting Yang, Kao-Shing Hwang, Chia-Te Liao, Wen-Hsien Ho
المصدر: IEEE Access, Vol 11, Pp 90801-90810 (2023)
مصطلحات موضوعية: Photoplethysmogram imaging (PPGi), non-contact surveillance, predictive adversarial adaptation, homographic filter, risk-sensitive generation, adaptive thresholding, Electrical engineering. Electronics. Nuclear engineering, TK1-9971
الوصف: Long-term wiring on a newborn patient could be a disguise scene for parents. Unobtrusive and reliable monitoring without wiring can be a euphoric alternative for newborns and parents in obstetrics and gynecology (OB/GYN) incubation rooms. However, reliable and continuous non-contact surveillance in an incubation room is challenging. Therefore, a novel photoplethysmography imaging (PPGi) is developed specifically for baby skins through predictive adversarial adaptation and risk-sensitive generative synchronizer. Our artificial intelligence approach does not take blind guesses from input-output pairs. We apply an intelligent step to decouple the influence of fluctuated illumination through a generative algorithm of artificial intelligence. To boost skin detection performance, we capture those pixels with periodic variations and maximize the coherence of the extraction algorithm by the generative synchronizer. The periodic variations are matched by a synthesized pulse from the output PPGi signals through the control of a risk-sensitive filter to not over-compensate the illuminate variation. Based on the sensed pulsation, we synthesize the corresponding pulsation signals on the flight to identify the living skin in a spatiotemporal image sequence. We find that our skin classifier in risk-sensitive generative synchronizer effectively improves the quality of the resulting non-contact PPGi signal. Our algorithm produces substantial accuracy in the performance of PPGi reconstruction in the critical environment of newborn care. In the limited illustration of the incubation room, our non-contact PPGi can still achieve an average accuracy of 96.62%.
وصف الملف: electronic resource
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