المؤلفون: Tetsuro Yokokawa, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Akiomi Yoshihisa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu-ichi Saitoh, Takafumi Ishida, Akito Shimouchi, Yasuchika Takeishi

المصدر: BMC Cardiovascular Disorders, Vol 17, Iss 1, Pp 1-6 (2017)

مصطلحات موضوعية: Acetone, Breath analysis, Heart failure, Diabetes mellitus, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Abstract Background Breath acetone is a noninvasive biomarker of heart failure; however, its significance in heart failure patients with diabetes mellitus has yet to be clarified. The objective of this study is to investigate whether exhaled acetone concentration is a noninvasive biomarker in heart failure patients with diabetes mellitus. Methods This study prospectively included 35 diabetic patients with stage C heart failure and 20 diabetic patients with or at risk of heart failure (stage A or B). Exhaled breath was collected after an overnight fast. Results The stage C group had significantly higher brain natriuretic peptide levels, larger left ventricular diameter, lower left ventricular ejection fraction, and more frequent use of β-blocker, compared with the stage A or B group. The stage C group had higher exhaled acetone concentrations than the stage A or B group (p = 0.013). Exhaled acetone concentration was correlated with total ketone bodies (r = 0.588, p

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12872-017-0713-0Test; https://doaj.org/toc/1471-2261Test

الوصول الحر: https://doaj.org/article/0311e53845624ac09b8bb06a82373725Test

المؤلفون: Shu-ichi Saitoh, Shunsuke Miura, Takafumi Ishida, Tomoki Kokubun, Yasuchika Takeishi

المصدر: International Heart Journal. 2019, 60(3):736

المؤلفون: Shinya Yamada, MD, Hitoshi Suzuki, MD, Takashi Kaneshiro, MD, Yoshiyuki Kamiyama, MD, Shu-ichi Saitoh, MD, Yasuchika Takeishi, MD

المصدر: Journal of Arrhythmia, Vol 30, Iss 6, Pp 485-490 (2014)

مصطلحات موضوعية: T-wave alternans, Recurrent ventricular tachyarrhythmias, Implantable cardioverter-defibrillator shock therapy, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: Background: T-wave alternans is useful for predicting the occurrence of ventricular tachyarrhythmias and sudden cardiac death in various heart diseases. However, little is known about the clinical significance of T-wave alternans measurement in survivors of ventricular fibrillation (VF) or hemodynamically unstable ventricular tachycardia (VT). Methods: We studied 28 patients with organic heart disease who survived VF or hemodynamically unstable VT (20 males, mean age 63 years). Echocardiography, electrocardiogram (QRS duration and QTc intervals), and Holter monitoring (heart rate variability, heart rate turbulence and T-wave alternans) were performed before implantable cardioverter-defibrillator (ICD) implantation. Positive T-wave alternans was defined as >65 μV. During the follow-up period (10.2±6.2 months), ventricular tachyarrhythmias requiring appropriate shock therapy occurred in eight patients (29%). The subjects were divided into two groups, based on whether appropriate shock therapy was required (n=8, Group A) or not (n=20, Group B). Parameters from echocardiography, electrocardiogram, and Holter monitoring were compared between the two groups in order to investigate their relationship with the incidence of shock therapy after ICD implantation. Results: The prevalence of positive T-wave alternans was significantly higher in Group A than in Group B (88% vs. 15%, P=0.004). Univariate Cox proportional hazard analysis showed that, among the variables measured, only T-wave alternans had predictive power for recurrent ventricular tachyarrhythmias (hazard ratio, 13.17; 95% confidence interval: 1.606–108.1, P=0.016). Conclusions: These results suggest that T-wave alternans by Holter monitoring is useful for predicting recurrent ventricular tachyarrhythmias in survivors of VF or hemodynamically unstable VT.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S188042761400043XTest; https://doaj.org/toc/1880-4276Test

الوصول الحر: https://doaj.org/article/652686af624c4dd3837da35dba4a7708Test

المؤلفون: Akiomi Yoshihisa, Mai Takiguchi, Yuki Kanno, Akihiko Sato, Tetsuro Yokokawa, Shunsuke Miura, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Satoshi Suzuki, Masayoshi Oikawa, Atsushi Kobayashi, Takayoshi Yamaki, Hiroyuki Kunii, Kazuhiko Nakazato, Hitoshi Suzuki, Shu‐ichi Saitoh, Yasuchika Takeishi

المصدر: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 6, Iss 5 (2017)

مصطلحات موضوعية: acid suppressive therapy, heart failure, histamine H2 receptor antagonists, prognosis, proton pump inhibitors, Diseases of the circulatory (Cardiovascular) system, RC666-701

الوصف: BackgroundIt has been recently reported that histamine H2 receptor antagonists (H2RAs) are associated with impairment of ventricular remodeling and incident heart failure. In addition, favorable pleiotropic effects and adverse effects of proton pump inhibitors (PPIs) on cardiovascular disease have also been reported. We examined the associations of acid suppressive therapy using H2RAs or PPIs with cardiac mortality in patients with heart failure. Methods and ResultsIn total, 1191 consecutive heart failure patients were divided into 3 groups: a non–acid suppressive therapy group (n=363), an H2RA group (n=164), and a PPI group (n=664). In the follow‐up period (mean 995 days), 169 cardiac deaths occurred. In the Kaplan–Meier analysis, cardiac mortality was significantly lower in the PPI group than in the H2RA and non–acid suppressive therapy groups (11.0% versus 21.3% and 16.8%, respectively; log‐rank P=0.004). In the multivariable Cox proportional hazards analysis, use of PPIs, but not H2RAs, was found to be an independent predictor of cardiac mortality (PPIs: hazard ratio 0.488, P=0.002; H2RAs: hazard ratio 0.855, P=0.579). The propensity‐matched 1:1 cohort was assessed based on propensity score (H2RAs, n=164; PPIs, n=164). Cardiac mortality was significantly lower in the PPI group than in the H2RA group in the postmatched cohort (log‐rank P=0.025). In the Cox proportional hazards analysis, the use of PPIs was a predictor of cardiac mortality in the postmatched cohort (hazard ratio 0.528, P=0.028). ConclusionsPPIs may be associated with better outcome in patients with heart failure.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2047-9980Test

الوصول الحر: https://doaj.org/article/9ccd7b8f9e424230ae611019ab59ae4eTest

المؤلفون: Koichi Sugimoto, Kazuhiko Nakazato, Akihiko Sato, Satoshi Suzuki, Akiomi Yoshihisa, Takeshi Machida, Shu-Ichi Saitoh, Hideharu Sekine, Yasuchika Takeishi

المصدر: PLoS ONE, Vol 12, Iss 9, p e0184990 (2017)

مصطلحات موضوعية: Medicine, Science

الوصف: Pulmonary arterial hypertension is often associated with connective tissue disease. Although there are some animal models of pulmonary hypertension, an autoimmune disease-based model has not yet been reported. MRL/lpr mice, which have hypergammaglobulinemia, produce various autoimmune antibodies, and develop vasculitis and nephritis spontaneously. However, little is known about pulmonary circulation in these mice. In the present study, we examined the pulmonary arterial pressure in MRL/lpr mice.We used female MRL/lpr mice aged between 12 and 14 weeks. Fluorescent immunostaining showed that there was no deposition of immunoglobulin or C3 in the lung tissue of the MRL/lpr mice. Elevation of interferon-γ and interleukin-6 was recognized in the lung tissue of the MRL/lpr mice. Right ventricular systolic pressure, Fulton index and the ratio of right ventricular weight to body weight in the MRL/lpr mice were significantly higher than those in wild type mice with same background (C57BL/6). The medial smooth muscle area and the proportion of muscularized vessels in the lung tissue of the MRL/lpr mice were larger than those of the C57BL/6 mice. Western blot analysis demonstrated markedly elevated levels of prepro-endothelin-1 and survivin as well as decreased endothelial nitric oxide synthase phosphorylation in the lung tissue of the MRL/lpr mice. Terminal deoxynucleotidyl-transferase-mediated dUTP nick end-labeling assay showed the resistance against apoptosis of pulmonary arterial smooth muscle cells in the MRL/lpr mice.We showed that MRL/lpr mice were complicated with pulmonary hypertension. MRL/lpr mice appeared to be a useful model for studying the mechanism of pulmonary hypertension associated with connective tissue diseases.

وصف الملف: electronic resource

العلاقة: http://europepmc.org/articles/PMC5605000?pdf=renderTest; https://doaj.org/toc/1932-6203Test

الوصول الحر: https://doaj.org/article/b4699cc942304e6e94937c993827f43fTest

المؤلفون: Akiomi Yoshihisa, Akito Shimouchi, Atsushi Kobayashi, Hiroyuki Kunii, Hitoshi Suzuki, Kazuhiko Nakazato, Masayoshi Oikawa, Satoshi Suzuki, Shu-ichi Saitoh, Takafumi Ishida, Takamasa Sato, Takayoshi Yamaki, Tetsuro Yokokawa, Yasuchika Takeishi

المصدر: International Heart Journal. 2018, 59(4):808

المؤلفون: Akiomi Yoshihisa, Akito Shimouchi, Hitoshi Suzuki, Kazuhiko Nakazato, Koichi Sugimoto, Masayoshi Oikawa, Shu-ichi Saitoh, Tetsuro Yokokawa, Yasuchika Takeishi, Yasuhiro Ichijo, Yoshiyuki Matsumoto, Yu Houtsuki

المصدر: International Heart Journal. 2017, 58(5):828

المؤلفون: Akihiko Sato, Isao Kubota, Satoshi Suzuki, Shu-ichi Saitoh, Shunsuke Watanabe, Takafumi Ishida, Takeshi Shimizu, Tetsuro Shishido, Tetsuro Yokokawa, Tomofumi Misaka, Yasuchika Takeishi, Yuichi Nakamura

المصدر: International Heart Journal. 2017, 58(5):778

المؤلفون: Hiroharu Shinjo, Hitoshi Suzuki, Hitoshi Yokoyama, Kazuhiko Nakazato, Masayoshi Oikawa, Shinya Takase, Shu-ichi Saitoh, Tetsuro Yokokawa, Tomoki Kokubun, Yasuchika Takeishi, Yasuhiro Ichijo, Yoshiyuki Matsumoto, Yoshiyuki Sato

المصدر: Internal Medicine. 2018, 57(11):1597

المؤلفون: Hiroyuki Mizukami, Shu-ichi Saitoh, Hirofumi Machii, Shinya Yamada, Yasuto Hoshino, Tomofumi Misaka, Akihito Ishigami, Yasuchika Takeishi

المصدر: International Journal of Molecular Sciences, Vol 14, Iss 5, Pp 9408-9423 (2013)

مصطلحات موضوعية: coronary circulation, oxidant stress, SMP30, cardiac myocyte, coronary arterioles, vasomotor tone, Biology (General), QH301-705.5, Chemistry, QD1-999

الوصف: Senescence marker protein-30 (SMP30) decreases with aging. Mice with SMP30 deficiency, a model of aging, have a short lifespan with increased oxidant stress. To elucidate SMP30’s effect on coronary circulation derived from myocytes, we measured the changes in the diameter of isolated coronary arterioles in wild-type (WT) mice exposed to supernatant collected from isolated paced cardiac myocytes from SMP30 KO or WT mice. Pacing increased hydrogen peroxide in myocytes, and hydrogen peroxide was greater in SMP30 KO myocytes compared to WT myocytes. Antimycin enhanced and FCCP (oxidative phosphorylation uncoupler in mitochondria) decreased superoxide production in both groups. Addition of supernatant from stimulated myocytes, either SMP30 KO or WT, caused vasodilation. The degree of the vasodilation response to supernatant was smaller in SMP30 KO mice compared to WT mice. Administration of catalase to arterioles eliminated vasodilation in myocyte supernatant of WT mice and converted vasodilation to vasoconstriction in myocyte supernatant of SMP30 KO mice. This vasoconstriction was eliminated by olmesartan, an angiotensin II receptor antagonist. Thus, SMP30 deficiency combined with oxidant stress increases angiotensin and hydrogen peroxide release from cardiac myocytes. SMP30 plays an important role in the regulation of coronary vascular tone by myocardium.

وصف الملف: electronic resource

العلاقة: http://www.mdpi.com/1422-0067/14/5/9408Test; https://doaj.org/toc/1422-0067Test

الوصول الحر: https://doaj.org/article/b93596fdff4b41b09191826508d002e5Test