المؤلفون: Eri Hagiwara, Ryo Nagasawa, Ryo Okuda, Shigeru Komatsu, Sho Yamada, Takashi Niwa, Takashi Ogura, Takeshi Kaneko, Tomohisa Baba, Tsuneyuki Oda

المصدر: Internal Medicine. 2023, 62(21):3125

المؤلفون: Erina Tabata, Koji Okudela, Midori Sato, Ryo Okuda, Shigeru Komatsu, Tae Iwasawa, Takashi Ogura, Tamiko Takemura

المصدر: Internal Medicine. 2023, 62(12):1723

المؤلفون: Akimasa Sekine, Goushi Matama, Eri Hagiwara, Erina Tabata, Satoshi Ikeda, Tsuneyuki Oda, Ryo Okuda, Hideya Kitamura, Tomohisa Baba, Hiroaki Satoh, Toshihiro Misumi, Shigeru Komatsu, Tae Iwasawa, Takashi Ogura

المصدر: Thoracic Cancer, Vol 13, Iss 17, Pp 2443-2449 (2022)

مصطلحات موضوعية: acute exacerbation, disease activity, interstitial lung disease, lung cancer, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Background The prognosis of lung cancer patients with interstitial lung disease (ILD) is poor, and acute exacerbation (AE) of ILD can occur during chemotherapy as a fatal adverse event. Although AE‐ILD development is correlated with various factors, no reports are investigating the disease activity of lung cancer at the time of AE‐ILD development. Methods All consecutive lung cancer patients with ILD who developed chemotherapy‐related AE‐ILD within 28 days after the last administration of cytotoxic chemotherapy between 2011 and 2020 were retrospectively reviewed. Results Among 206 lung cancer patients with ILD who were treated with cytotoxic chemotherapy, 30 patients were included. The median age was 72 years and all patients were men with smoking history. Usual interstitial pneumonia (UIP) and non‐UIP patterns of ILD was observed in 17 and 13 patients. Most of AE‐ILD occurred during second‐ or later‐line (22/30, 73.3%) and developed within first or second courses during chemotherapy (19/30, 63.3%). Regarding tumor response to chemotherapy at AE‐ILD development, majority of patients (18 patients, 60.0%) experienced progressive disease and only one patient (3.3%) experienced a partial response. Notably, 27 patients (90.0%) did not exhibit any tumor shrinkage of the thoracic lesions. Conclusion Lung cancer was uncontrolled with cytotoxic chemotherapy at the time of AE‐ILD development. Although AE‐ILD during chemotherapy has been generally discussed in terms of drug‐specific adverse effects, uncontrolled lung cancer may be also correlated with AE‐ILD development.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1759-7706Test; https://doaj.org/toc/1759-7714Test

الوصول الحر: https://doaj.org/article/06ba050e03dc4d4ca39c548821bcc906Test

المؤلفون: Yozo Sato, Tomohisa Baba, Hideya Kitamura, Takashi Niwa, Shigeru Komatsu, Eri Hagiwara, Tae Iwasawa, Koji Okudela, Tamiko Takemura, Takashi Ogura

المصدر: BMC Pulmonary Medicine, Vol 22, Iss 1, Pp 1-8 (2022)

مصطلحات موضوعية: Transbronchial lung cryobiopsy, Diffuse parenchymal lung disease, Progressive fibrosing interstitial lung diseases, Reassessment, Diseases of the respiratory system, RC705-779

الوصف: Abstract Background The usefulness and safety of transbronchial lung cryobiopsy (TBLC) for reassessment of diffuse parenchymal lung disease (DPLD) with progression is still unknown. Our purpose was to clarify the usefulness and safety of TBLC for reassessment of DPLD with progression. Methods This retrospective study included 31 patients with DPLD diagnosed by surgical lung biopsy who progressed in the clinical course and underwent TBLC for reassessment between January 2017 and September 2019 at Kanagawa Cardiovascular & Respiratory Center. Two pulmonologists independently selected the clinical diagnosis, treatment strategy, and confidence level of the treatment strategy based on clinical and radiological information with and without pathological information from TBLC. A consensus was reached among the pulmonologists regarding the clinical diagnosis, treatment strategy, and confidence level of the treatment strategy. Complications of TBLC were also examined. Results Seven (22.6%), 5 (16.1%), and 6 (19.4%) of clinical diagnosis was changed after TBLC for Pulmonologist A, for Pulmonologist B, and for consensus, respectively. The treatment strategy was changed in 7 (22.6%), 8 (25.9%), and 6 (19.4%) cases after TBLC for Pulmonologist A, for Pulmonologist B and for consensus, respectively. The definite or high confidence level of the consensus treatment strategy was 54.8% (17/31) without TBLC and 83.9% (26/31) with TBLC. There were 6 cases of moderate bleeding, but no other complications were noted. Conclusions Pathological information from TBLC may contribute to decision-making in treatment strategies for the progression of DPLD, and it may be safely performed.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2466Test

الوصول الحر: https://doaj.org/article/5dab754beaef49e2a5c1b2b032d24261Test

المؤلفون: Ayako Mikami, Haruhito Sugiyama, Hideki Inoue, Jin Takasaki, Junko Terada-Hirashima, Kenji Tsushima, Kyoji Moriya, Manabu Suzuki, Masahide Tanaka, Masaki Okamoto, Masayuki Hojo, Norio Ohmagari, Ryuta Tsuzuki, Sadako Yoshizawa, Shigeru Komatsu, Shinyu Izumi, Toshitaka Muto, Wataru Sugiura, Yasuo To, Yoichiro Hamamoto, Yoshie Tsujimoto, Yukari Uemura, Zenya Saito

المصدر: Drug Discoveries & Therapeutics. 2022, 16(5):225

المؤلفون: Akimasa Sekine, Eri Hagiwara, Erina Tabata, Koichi Sayama, Koji Okudela, Masashi Sakayori, Shigeru Komatsu, Takashi Ogura, Tomohisa Baba, Yozo Sato, Yutaka Muto

المصدر: Internal Medicine. 2022, 61(20):3095

المؤلفون: Akimasa Sekine, Kota Murohashi, Ryota Otoshi, Ryota Shintani, Shigeru Komatsu, Takashi Ogura, Takeo Kasuya, Tomohisa Baba, Tsuneyuki Oda, Yoshikazu Inoue

المصدر: Internal Medicine. 2022, 61(13):2039

المؤلفون: Hiroko Okabayashi, Tomohisa Baba, Ryota Ootoshi, Ryota Shintani, Erina Tabata, Satoshi Ikeda, Takashi Niwa, Tsuneyuki Oda, Ryo Okuda, Akimasa Sekine, Hideya Kitamura, Shigeru Komatsu, Eri Hagiwara, Tamiko Takemura, Takuro Sakagami, Takashi Ogura

المصدر: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-7 (2020)

مصطلحات موضوعية: Sjögren’s syndrome, Bronchial gland, Lymphocytic infiltration, Transbronchial lung cryobiopsy, Diseases of the respiratory system, RC705-779

الوصف: Abstract Background Sjögren’s syndrome (SS) is a systemic autoimmune disease characterized by deteriorated exocrine gland function with associated lymphocytic infiltration. However, there are few pathological studies on bronchial glands in SS. In this study, we aimed to clarify pathological features of bronchial glands in SS. Methods We retrospectively evaluated infiltration of lymphocytes in the bronchial glands incidentally collected by transbronchial lung cryobiopsy (TBLC), which were performed for the diagnosis of diffuse lung diseases. The degrees of lymphocyte infiltration in the bronchial glands were classified into four grades (grade 0–3). We compared the degrees of infiltration of SS with those of other diffuse lung diseases. Results TBLC for diagnosis of diffuse lung diseases were performed on 432 cases during the study period. The samples of 50 cases included bronchial glands. Of those, 20 cases were excluded due to insufficient size or influence of therapy. The remaining 30 cases included 17 of idiopathic interstitial pneumonias, 5 of chronic hypersensitivity pneumonia, 6 of connective tissue disease (SS; n = 4, systemic sclerosis; n = 1, dermatomyositis; n = 1) and 2 of other diseases. In SS, infiltration of lymphocytes was observed in all cases; grade 1 in one, grade 2 in one, and grade 3 in two cases. In contrast, 11 of 26 in other diseases showed no lymphocytes infiltration, with the remaining 15 of grade 1 infiltration. Grade 2 or more infiltration were found only in SS but not in other diseases. Conclusion Our results suggested that high-grade lymphocytic infiltration of bronchial glands is a distinct characteristics in SS.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12890-020-01318-0Test; https://doaj.org/toc/1471-2466Test

الوصول الحر: https://doaj.org/article/df97cf0ef37643309c4d9808551cc493Test

المؤلفون: Hiroaki Nakagawa, Ryota Otoshi, Kohsuke Isomoto, Takuma Katano, Tomohisa Baba, Shigeru Komatsu, Eri Hagiwara, Yasutaka Nakano, Ichiro Kuwahira, Takashi Ogura

المصدر: BMC Pulmonary Medicine, Vol 20, Iss 1, Pp 1-10 (2020)

مصطلحات موضوعية: Concave, Convex, Flow-volume curve, Honeycombing area, Idiopathic pulmonary fibrosis, Diseases of the respiratory system, RC705-779

الوصف: Abstract Background The flow-volume (FV) curve pattern in the pulmonary function test (PFT) for obstructive lung diseases is widely recognized. However, there are few reports on FV curve pattern in idiopathic pulmonary fibrosis (IPF). In this study, we investigated the relationship between FV curve pattern and clinical or radiological features in IPF. Methods The FV curves on PFTs and chest high-resolution computed tomography (HRCT) images of 130 patients with IPF were retrospectively evaluated. The FV curves were divided into four groups based on the presence or absence of the convex and concave patterns: convex/concave, non-convex/concave, convex/non-concave, and non-convex/non-concave. Using a computer-aided system, CT honeycombing area (%HA) and subtracted low attenuation area (%sLAA) were quantitatively measured. To assess the distribution of CT findings, the lung area was divided into upper, lower, central, and peripheral areas. The relationships of FV curve patterns with patient characteristics, spirometry results, and quantitative CT findings were evaluated. Results The patients with convex pattern was identified in 93 (71.5%) and concave pattern in 72 (55.4%). Among the four groups, patients with the convex/non-concave pattern had significantly lower forced vital capacity (FVC) and higher %HA of the upper/peripheral lung area (p = 0.018, and p = 0.005, respectively). The convex/non-concave pattern was a significant predictor of mortality for IPF (hazard ratio, 2.19; p = 0.032). Conclusions Patients with convex/non-concave pattern in FV curve have lower FVC and poorer prognosis with distinct distribution of fibrosis. Hence, FV curve pattern might be a useful predictor of mortality in IPF.

وصف الملف: electronic resource

العلاقة: http://link.springer.com/article/10.1186/s12890-020-01254-zTest; https://doaj.org/toc/1471-2466Test

الوصول الحر: https://doaj.org/article/fafc61ee59824ddfa4e1b9e9db55d7fdTest

المؤلفون: Akimasa Sekine, Eri Hagiwara, Hideya Kitamura, Katsuyuki Higa, Masato Asaoka, Satoshi Etori, Satoshi Ikeda, Shigeru Komatsu, Takashi Ogura, Tomohisa Baba

المصدر: Internal Medicine. 2021, 60(20):3213