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المؤلفون: Matthias Kuhn, Karen Cerosaletti, Anna Lissina, Georgia Afonso, Raphael Scharfmann, Jean-Paul Beressi, Etienne Larger, Francesco Dotta, Bruno Kyewski, Laura Nigi, Howard W. Davidson, Guido Sebastiani, David Price, Manuela Battaglia, Roberto Mallone, Søren Buus, Klaudia Kuranda, Sheena Pinto, Slobodan Culina, Ezio Bonifacio, James E. McLaren, Victor Appay, Ana Inés Lalanne, Thomas Osterbye, Kristin Ladell, Sophie Caillat-Zucman, Anne Eugster, Alicia Maugein
المساهمون: Mallone, Roberto, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Sorbonne Paris Cité (USPC), Université Paris Descartes - Paris 5 (UPD5), Translational Research Program [Seattle, WA, USA], Benaroya Research Institute [Seattle, WA, USA], Division of Developmental Immunology [Heidelberg, Germany], German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Department of Medicine, Surgery and Neuroscience [Siena, Italy] (Diabetes Unit), University Hospital of Siena [Italy]-Fondazione Umberto di Mario ONLUS [Siena, Italy]-Toscana Life Sciences [Siena, Italy], CRTD-DFG Research Center for Regenerative Therapies Dresden [Dresden, Germany] (Medical Faculty), Technische Universität Dresden = Dresden University of Technology (TU Dresden), Department of Immunology and Microbiology [Copenhagen], Faculty of Health and Medical Sciences, University of Copenhagen = Københavns Universitet (UCPH)-University of Copenhagen = Københavns Universitet (UCPH), Division of Infection and Immunity [Cardiff, UK] (School of Medicine), Cardiff University, Service de diabétologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Diabétologie [CH Versailles André Mignot, Le Chesnay], Centre Hospitalier de Versailles André Mignot (CHV), Centre d'Immunologie et des Maladies Infectieuses (CIMI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Departement Hospitalo- Universitaire - Fight Ageing and STress [Paris] (DHU - FAST), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Barbara Davis Center for Childhood Diabetes (BDC), University of Colorado Anschutz [Aurora], Vaccine Research Center [Bethesda, MD, USA], National Institutes of Health [Bethesda] (NIH), Institut für Medizinische Informatik und Biometrie [Dresden, Germany] (Medical Faculty), Diabetes Research Institute [Milan, Italy], IRCCS Ospedale San Raffaele [Milan, Italy], Immunologie, génétique et traitement des maladies métaboliques et du diabète (UMR_S 561), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire Jean Dausset d'Immunologie et d'Histocompatibilité [AP-HP Hôpital Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], This work was performed within the Département Hospitalo-Universitaire AutHorS, supported by the Programme Hospitalier de Recherche Clinique ImMaDiab, Lilly France, the INSERM-Transfert Proof-of-Concept program acDC, the Ile-de-France CORDDIM, and grants from the JDRF (1-PNF-2014-155-A-V and 2-SRA-2016-164- Q-R), the Aviesan/Astra Zeneca 'Diabetes and the Vessel Wall Injury' program, the Société Francophone du Diabète, the Agence Nationale de la Recherche (ANR-2015-CE17-0018-01), the Fondation pour la Recherche Médicale (Equipe FRM DEQ20140329520), and the Helmsley Charitable Trust George S. Eisenbarth nPOD Award for Team Science (2015PG-T1D052) (to R.M.), a JDRF Biomarkers grant (17-2012-598) (to K.C.), an NIH R01 grant (DK052068) (to H.W.D.), Lilly and Fondation Bettencourt-Schueller funds (to R.S.), a European Research Council grant (ERC-2012-AdG) (to B.K.), and funds from JDRF, the Wellcome Trust, and the National Institute for Health Research Cambridge Biomedical Research Centre [to the JDRF/Wellcome Trust Diabetes and Inflammation Laboratory (Cambridge Institute for Medical Research, University of Cambridge), which provided PBMC samples from the JDRF D-GAP study]. Samples from at-risk patients were obtained through a TrialNet ancillary study to the TN-01 Pathway to Prevention study funded by NIH grants U01 DK061010, U01 DK061034, U01 DK061042, U01 DK061058, U01 DK085465, U01 DK085453, U01 DK085461, U01 DK085463, U01 DK085466, U01 DK085499, U01 DK085504, U01 DK085505, U01 DK085509, U01 DK103180, U01- DK103153, U01-DK085476, and U01-DK103266 and by JDRF. D.A.P. is a Wellcome Trust Senior Investigator (100326Z/12/Z). This research was performed with the support of the nPOD, a collaborative T1D research project funded by JDRF. Organ procurement organizations partnering with nPOD to provide research resources are listed at www.jdrfnpod.org/ for-partners/npod-partners/. This project has received funding from the Innovative Medicines Initiative 2 Joint Undertaking (INNODIA, no. 115797). This Joint Undertaking receives support from the Union’s Horizon 2020 research and innovation program and the European Federation of Pharmaceutical Industries and Associations, JDRF, and the Leona M. and Harry B. Helmsley Charitable Trust., Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), University of Copenhagen = Københavns Universitet (KU)-University of Copenhagen = Københavns Universitet (KU), Centre d'Immunologie et de Maladies Infectieuses (CIMI), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), National Institutes of Health [Bethesda] (NIH)-National Institutes of Health, Bethesda
المصدر: Science Immunology
Science Immunology, 2018, 3 (20), ⟨10.1126/sciimmunol.aao4013⟩
Science Immunology, American Association for the Advancement of Science, 2018, 3 (20), ⟨10.1126/sciimmunol.aao4013⟩مصطلحات موضوعية: 0301 basic medicine, geography, endocrine system, geography.geographical_feature_category, endocrine system diseases, [SDV.IMM] Life Sciences [q-bio]/Immunology, T cell, Immunology, General Medicine, Biology, Islet, Epitope, 3. Good health, 03 medical and health sciences, 030104 developmental biology, medicine.anatomical_structure, Antigen, Cell culture, Interferon, medicine, Cytotoxic T cell, [SDV.IMM]Life Sciences [q-bio]/Immunology, CD8, medicine.drug
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::787a7fec2e9c93b9cae858cfe4689cdaTest
https://www.hal.inserm.fr/inserm-01918833/documentTest -
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المؤلفون: Bruno Kyewski, Sheena Pinto, Iris Martin, Chloé Michel, Rita Küchler
المصدر: Journal of immunological methods. 457
مصطلحات موضوعية: 0301 basic medicine, Immunology, Population, Cell Count, Thymus Gland, 03 medical and health sciences, Mice, In vivo, medicine, Immunology and Allergy, Animals, education, Lymph node, Cell Proliferation, education.field_of_study, DNA synthesis, Staining and Labeling, Chemistry, Cell growth, Cell Differentiation, Epithelial Cells, Flow Cytometry, Deoxyuridine, Small intestine, Epithelium, Cell biology, Mice, Inbred C57BL, 030104 developmental biology, medicine.anatomical_structure, Administration, Intravenous, Ex vivo
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::634e4971f547692a8c9a8b9769d7dceeTest
https://pubmed.ncbi.nlm.nih.gov/29605230Test -
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المؤلفون: Meinrad Busslinger, Esther Lutgens, Norbert Gerdes, Tomoyoshi Yamano, Jelena Nedjic, Benedikt Brors, Madlen Steinert, Maria Hinterberger, Sheena Pinto, Naozumi Ishimaru, Sandra D Koser, Bruno Kyewski, Ludger Klein
المساهمون: Medical Biochemistry, ACS - Amsterdam Cardiovascular Sciences, AII - Amsterdam institute for Infection and Immunity
المصدر: Immunity, 42(6), 1048-1061. Cell Press
مصطلحات موضوعية: CD4-Positive T-Lymphocytes, Immunology, Context (language use), Thymus Gland, Biology, Autoantigens, Mice, Negative selection, Downregulation and upregulation, Animals, Humans, Immunology and Allergy, CD40 Antigens, Clonal Selection, Antigen-Mediated, Antigen-presenting cell, Cells, Cultured, Mice, Knockout, Antigen Presentation, B-Lymphocytes, Mice, Inbred BALB C, Repertoire, Histocompatibility Antigens Class II, Cell Differentiation, Central T-cell tolerance induction, Immunoglobulin Class Switching, Cell biology, Infectious Diseases, Central Tolerance, B7-1 Antigen, Central tolerance, CD80, Signal Transduction, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a56a3afa14eff3431ef68e94209df0Test
https://doi.org/10.1016/j.immuni.2015.05.013Test -
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المؤلفون: Thomas Blankenstein, Bruno Kyewski, Sheena Pinto, Dolores J. Schendel, Wolfgang Uckert, Susanne Wilde, Daniel Sommermeyer, Chloé Michel
المصدر: European Journal of Immunology. 44:2811-2821
مصطلحات موضوعية: integumentary system, Immunology, T-cell receptor, Biology, Molecular biology, Epitope, Interleukin 21, Antigen, Transcription (biology), Immunology and Allergy, Cytotoxic T cell, Central tolerance, neoplasms, CD8
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3a44a0ba76d9fb411e37f23443bd8ff6Test
https://doi.org/10.1002/eji.201444499Test -
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المؤلفون: Slobodan, Culina, Ana Ines, Lalanne, Georgia, Afonso, Karen, Cerosaletti, Sheena, Pinto, Guido, Sebastiani, Klaudia, Kuranda, Laura, Nigi, Anne, Eugster, Thomas, Østerbye, Alicia, Maugein, James E, McLaren, Kristin, Ladell, Etienne, Larger, Jean-Paul, Beressi, Anna, Lissina, Victor, Appay, Howard W, Davidson, Søren, Buus, David A, Price, Matthias, Kuhn, Ezio, Bonifacio, Manuela, Battaglia, Sophie, Caillat-Zucman, Francesco, Dotta, Raphael, Scharfmann, Bruno, Kyewski, Roberto, Mallone, Anna, Jones
المصدر: Science immunology. 3(20)
مصطلحات موضوعية: Adult, Male, endocrine system, endocrine system diseases, CD8-Positive T-Lymphocytes, Healthy Volunteers, Article, Cell Line, Islets of Langerhans, Diabetes Mellitus, Type 1, HLA-A2 Antigen, Humans, Female, Child, Pancreas
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::5216bc6ad4f32fe649a7678f097c1828Test
https://pubmed.ncbi.nlm.nih.gov/29429978Test -
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المؤلفون: Tim Holland-Letz, Bruno Kyewski, Fabian Brunk, Alla Slynko, Sheena Pinto, Chloé Michel, Annette Kopp-Schneider
المصدر: European journal of immunology. 47(7)
مصطلحات موضوعية: 0301 basic medicine, Stromal cell, TEC, Cellular differentiation, education, Immunology, Genes, MHC Class II, Gene Expression, chemical and pharmacologic phenomena, Thymus Gland, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Organ Culture Techniques, Immunology and Allergy, Animals, Cell Lineage, Progenitor cell, Cells, Cultured, MHC class II, Thymocytes, biology, hemic and immune systems, Epithelial cell adhesion molecule, Cell Differentiation, Epithelial Cells, Models, Theoretical, Epithelial Cell Adhesion Molecule, Embryonic stem cell, Cell biology, 030104 developmental biology, chemistry, biology.protein, B7-1 Antigen, Leukocyte Common Antigens, Stem cell, tissues, 030215 immunology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b44088e36672097a7582b0b9f3fb2c7Test
https://pubmed.ncbi.nlm.nih.gov/28439878Test -
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المؤلفون: Sheena Pinto, Gisela Eisenhardt, Thomas J. Hoffmann, Larisa Buselic-Wölfel, Christoph Steeneck, Ulrich Deuschle, Claus Kremoser, Manfred Birkel, Michael Albers, Simon Anderhub
المصدر: Cancer Research. 79:1210-1210
مصطلحات موضوعية: Cancer Research, biology, Chemistry, T cell, medicine.medical_treatment, respiratory system, Aryl hydrocarbon receptor, Interleukin 22, Immune system, medicine.anatomical_structure, Oncology, Cancer immunotherapy, Cancer cell, Cancer research, biology.protein, medicine, Cytotoxic T cell, CD8
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::49b671b22ab8f90e48cb999731a57b9fTest
https://doi.org/10.1158/1538-7445.am2019-1210Test -
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المؤلفون: Bruno Kyewski, Hans Jürgen Stark, Sheena Pinto, Stefanie Egle, Petra Boukamp, Katrin Schmidt
المصدر: The Journal of Immunology. 190:1085-1093
مصطلحات موضوعية: Fibroblast Growth Factor 7, Cell division, T-Lymphocytes, Immunology, Cell Culture Techniques, Thymus Gland, Mice, Organ Culture Techniques, Pregnancy, Animals, Humans, Immunology and Allergy, Cell Lineage, Cells, Cultured, Regulation of gene expression, Thymocytes, biology, Lymphopoiesis, RANK Ligand, FOXN1, Epithelial Cells, Forkhead Transcription Factors, Dermis, Fibroblasts, Coculture Techniques, In vitro, Cell biology, Mice, Inbred C57BL, Gene Expression Regulation, Microscopy, Fluorescence, Organ Specificity, RANKL, T cell differentiation, B7-1 Antigen, biology.protein, Female, Developmental biology, Cell Division, CD80, Transcription Factors
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94e879e602ec8c9a28afc689f6b9bce7Test
https://doi.org/10.4049/jimmunol.1201843Test -
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المؤلفون: Evis Havari, HuiJuan Lv, Roderick T. Bronson, Kai W. Wucherpfennig, Bruno Kyewski, Myra A. Lipes, Shannon J. Turley, Raju V. S. R. K. Gottumukkala, Anne L. Fletcher, Ross O. Smith, Sheena Pinto, Khadir Raddassi, Anthony Rosenzweig, Lizbeth Cornivelli, Takashi Matsui
المصدر: Journal of Clinical Investigation. 121:1561-1573
مصطلحات موضوعية: Stromal cell, Myocarditis, HLA-DQ Antigen, T cell, macromolecular substances, General Medicine, Biology, musculoskeletal system, medicine.disease_cause, medicine.disease, Autoimmunity, Immune tolerance, medicine.anatomical_structure, Immunology, Myosin, medicine, MYH6, tissues
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::20199e382883a91197bd1bc761dfed2aTest
https://doi.org/10.1172/jci44583Test -
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المؤلفون: Stefanie Rösch, Bruno Kyewski, Klaus Hexel, Sheena Pinto, Jens Derbinski
المصدر: Proceedings of the National Academy of Sciences. 105:657-662
مصطلحات موضوعية: T cell, Locus (genetics), Thymus Gland, Autoimmune Diseases, Mice, Gene expression, medicine, Animals, Lactation, Gene, Mice, Knockout, Regulation of gene expression, Mice, Inbred C3H, Stochastic Processes, Multidisciplinary, biology, Caseins, Epithelial Cells, Biological Sciences, Milk Proteins, Autoimmune regulator, Molecular biology, medicine.anatomical_structure, Gene Expression Regulation, B7-1 Antigen, Lactalbumin, biology.protein, Female, Whey Acidic Protein, Central tolerance
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4054052ee86818f40e8a10740f41a8aaTest
https://doi.org/10.1073/pnas.0707486105Test