المؤلفون: Hendrikse, Liam D, Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H, Erickson, Anders W, Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L, Shokouhian, Mohammad, Suárez, Raúl A, Ly, Michelle, Borlase, Stephanie, Scott, David S, Vladoiu, Maria C, Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y, Kumar, Sachin A, Balin, Polina, Visvanathan, Abhirami, Lee, John JY, Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L, Luu, Betty, Bérubé, Pierre, Wang, Yu C, Pfister, Stefan M, Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A, Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim J, Kros, Johan M, Zitterbart, Karel, Bailey, Swneke D, Eberhart, Charles G, Rao, Amulya AN, Giannini, Caterina, Olson, James M, Garami, Miklós, Hauser, Peter, Phillips, Joanna J, Ra, Young S, de Torres, Carmen, Mora, Jaume, Li, Kay KW, Ng, Ho-Keung, Poon, Wai S, Pollack, Ian F, López-Aguilar, Enrique, Gillespie, G Yancey, Van Meter, Timothy E, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C, Cooper, Michael K, Rubin, Joshua B, Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S, Van Meir, Erwin G, Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G, Faria, Claudia C, Roussel, Martine F, Boop, Frederick, Chan, Jennifer A, Aldinger, Kimberly A, Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E, Thompson, Eric M

المصدر: Nature. 609(7929)

مصطلحات موضوعية: Stem Cell Research, Brain Disorders, Neurosciences, Rare Diseases, Stem Cell Research - Nonembryonic - Non-Human, Aetiology, 1.1 Normal biological development and functioning, Underpinning research, 2.1 Biological and endogenous factors, Cell Differentiation, Cell Lineage, Cerebellar Neoplasms, Cerebellum, Core Binding Factor alpha Subunits, Hedgehog Proteins, Histone Demethylases, Humans, Ki-67 Antigen, Medulloblastoma, Metencephalon, Muscle Proteins, Mutation, Otx Transcription Factors, Repressor Proteins, T-Box Domain Proteins, Transcription Factors, General Science & Technology

الوصف: Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2 in model systems relieves this differentiation blockade, which allows MB cells to spontaneously proceed along normal developmental differentiation trajectories. The specific nature of the split human RL, which is destined to generate most of the neurons in the human brain, and its high level of susceptible EOMES+KI67+ unipolar brush cell progenitor cells probably predisposes our species to the development of G4 MB.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7c06j01kTest

المؤلفون: Scott, David S.¹ (AUTHOR) d.scott@abertay.ac.uk, Fletcher, Thomas² (AUTHOR)

المصدر: Leisure Studies. Jun2024, Vol. 43 Issue 3, p355-362. 8p.

مصطلحات موضوعية: EMOTIONS, LEISURE, YOUNG adults, EMOTION recognition, GRIEF

مستخلص: The document "Emotions and leisure: new insights and perspectives" examines the social nature of emotions in leisure and emphasizes the need for critical research on emotions in contemporary leisure contexts. The authors argue that previous studies on emotions in leisure have been limited by a focus on psychology and quantitative methods, and they advocate for a sociological understanding of emotions as embodied, relational, and culturally specific. The document discusses the work of various scholars who have theorized emotions from a sociological perspective and highlights the importance of broader perspectives and theories in leisure research. The document also presents a collection of 12 original contributions that explore the intersection of emotions and leisure from different disciplinary and methodological perspectives, covering topics such as identity, nature, disability, migration, representations, and the politics of emotions. The collection underscores the significance of emotions in understanding leisure experiences and their impact on individuals and society, while also calling for further interdisciplinary research on the psychological, cultural, anthropological, and educational aspects of emotions in leisure. The authors encourage deeper investigations into topics such as digital technologies, online hate, right-wing nationalist movements, and LGBTQ+ inclusion in physical activities. [Extracted from the article]

: Copyright of Leisure Studies is the property of Routledge and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Hendrikse, Liam, D, Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria, H, Erickson, Anders, W, Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey, L, Shokouhian, Mohammad, Suárez, Raúl, A, Ly, Michelle, Borlase, Stephanie, Scott, David, S, Vladoiu, Maria, C, Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J, Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan, Y, Kumar, Sachin, A, Balin, Polina, Visvanathan, Abhirami, Lee, John, J Y, Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen, L, Luu, Betty, Bérubé, Pierre, Wang, Yu, C, Pfister, Stefan, M, Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa, A, Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne, French, Pim, J, Kros, Johan, M, Zitterbart, Karel, Bailey, Swneke, D, Eberhart, Charles, G, Rao, Amulya, a N, Giannini, Caterina, Olson, James, M, Garami, Miklós, Hauser, Peter, Phillips, Joanna, J, Ra, Young, S, de Torres, Carmen, Mora, Jaume, Li, Kay, K W, Ng, Ho-Keung, Poon, Wai, S, Pollack, Ian, F, López-Aguilar, Enrique, Gillespie, G, Yancey, van Meter, Timothy, E, Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid, C, Cooper, Michael, K, Rubin, Joshua, B, Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Iolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan, S, van Meir, Erwin, G, Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos, G, Faria, Claudia, C, Roussel, Martine, F, Boop, Frederick, Chan, Jennifer, A, Aldinger, Kimberly, A, Razavi, Ferechte, Silvestri, Evelina, Mclendon, Roger, E, Thompson, Eric, M, Ansari, Marc, Garre, Maria, L, Chico, Fernando, Eguía, Pilar, Pérezpeña, Mario, Morrissy, A, Sorana, Cavalli, Florence, M G, Wu, Xiaochong, Daniels, Craig, Rich, Jeremy, N, Jones, Steven, J M, Moore, Richard, A, Marra, Marco, A, Huang, Xi, Reimand, Jüri, Sorensen, Poul, H, Wechsler-Reya, Robert, J, Weiss, William, A, Pugh, Trevor, J, Garzia, Livia, Kleinman, Claudia, L, Stein, Lincoln, D, Jabado, Nada, Malkin, David, Ayrault, Olivier, Golden, Jeffrey, A, Ellison, David, W, Doble, Brad, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra, E, Suzuki, Hiromichi, Millen, Kathleen, J, Taylor, Michael, D

المساهمون: Signalisation, radiobiologie et cancer, Institut Curie Paris -Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay-Centre National de la Recherche Scientifique (CNRS)

المصدر: ISSN: 0028-0836.

مصطلحات موضوعية: Medulloblastoma group 3 group 4 cerebellum rhombic lip CBFA2T2 CBFA2T3 OTX2, Medulloblastoma, group 3, group 4, cerebellum, rhombic lip, CBFA2T2, CBFA2T3, OTX2, [SDV]Life Sciences [q-bio]

الوصف: International audience ; Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong links to early development of the hindbrain 1-4. Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage 5-8. By contrast, mutations that activate WNT signalling lead to WNT MB in the lower RL 9,10. However, little is known about the more commonly occurring group 4 (G4) MB, which is thought to arise in the unipolar brush cell lineage 3,4. Here we demonstrate that somatic mutations that cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells of the cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental

العلاقة: hal-04281032; https://cnrs.hal.science/hal-04281032Test; https://cnrs.hal.science/hal-04281032/documentTest; https://cnrs.hal.science/hal-04281032/file/nihms-1871565.pdfTest

الإتاحة: https://doi.org/10.1038/s41586-022-05215-wTest
https://cnrs.hal.science/hal-04281032Test
https://cnrs.hal.science/hal-04281032/documentTest
https://cnrs.hal.science/hal-04281032/file/nihms-1871565.pdfTest

المؤلفون: Scott, David S., Punch, Samantha

المساهمون: Bridge: A MindSport for All

المصدر: The Sociological Review ; volume 72, issue 1, page 194-212 ; ISSN 0038-0261 1467-954X

مصطلحات موضوعية: Sociology and Political Science

الوصف: The classification of mindsports such as the card game of bridge within sport and society continues to be keenly debated. The concept of ‘physicality’ is often cited as being a prerequisite for an activity to be classed as a ‘sport’, a characteristic typically seen as lacking in mindsports. However, by drawing upon monist conceptualisations of the mind, body and world being intertwined, it is possible to problematise such arguments by highlighting the interconnected sensations experienced when participating in bridge. This article explores such a notion through phenomenologically-inspired analysis of 52 interviews with elite-level bridge players. The findings detail the importance players placed upon aspects of kinaesthesia, physical presence within the competitive environment, and the role of other social actors within their own understandings of their competition experience. These sensorial, emotional and embodied accounts of elite-level bridge shed light on the physical negotiations and socio-cultural influences involved in mindsport, which allude to a greater degree of ‘physicality’ than has previously been discussed.

الإتاحة: https://doi.org/10.1177/00380261231155326Test

المؤلفون: Audet, Daniel J., Scott, David S., Wiemeyer, Stanley N.

المصدر: Journal of Raptor Research

وصف الملف: application/pdf

العلاقة: https://digitalcommons.usf.edu/jrr/vol26/iss4/2Test; https://digitalcommons.usf.edu/context/jrr/article/1972/viewcontent/p00219_p00224.pdfTest

الإتاحة: https://digitalcommons.usf.edu/jrr/vol26/iss4/2Test
https://digitalcommons.usf.edu/context/jrr/article/1972/viewcontent/p00219_p00224.pdfTest

المؤلفون: Hendrikse, Liam D., Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H., Erickson, Anders W., Ong, Winnie, Gordon, Victor, Coudiere-Morrison, Ludivine, Mercier, Audrey L., Shokouhian, Mohammad, Suarez, Raul A., Ly, Michelle, Borlase, Stephanie, Scott, David S., Vladoiu, Maria C., Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J. Javier, Golser, Joseph, Bach, Kathleen, Tram Phuong-Bao, Skowron, Patryk, Wang, Evan Y., Kumar, Sachin A., Balin, Polina, Visvanathan, Abhirami, Lee, John J. Y., Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L., Luu, Betty, Berube, Pierre, Wang, Yu C., Pfister, Stefan M., Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, Francois, Masliah-Planchon, Julien, Grajkowska, Wieslawa A., Loukides, James, Dirks, Peter, Fevre-Montange, Michelle, Jouvet, Anne, French, Pim J., Kros, Johan M., Zitterbart, Karel, Bailey, Swneke D., Eberhart, Charles G., Rao, Amulya A. N., Giannini, Caterina, Olson, James M., Garami, Miklos, Hauser, Peter, Phillips, Joanna J., Ra, Young S., de Torres, Carmen, Mora, Jaume, Li, Kay K. W., Ng, Ho-Keung, Poon, Wai S., Pollack, Ian F., Lopez-Aguilar, Enrique, Gillespie, G. Yancey, Van Meter, Timothy E., Shofuda, Tomoko, Vibhakar, Rajeev, Thompson, Reid C., Cooper, Michael K., Rubin, Joshua B., Kumabe, Toshihiro, Jung, Shin, Lach, Boleslaw, Lolascon, Achille, Ferrucci, Veronica, de Antonellis, Pasqualino, Zollo, Massimo, Cinalli, Giuseppe, Robinson, Shenandoah, Stearns, Duncan S., Van Meir, Erwin G., Porrati, Paola, Finocchiaro, Gaetano, Massimino, Maura, Carlotti, Carlos G., Faria, Claudia C., Roussel, Martine F., Boop, Frederick, Chan, Jennifer A., Aldinger, Kimberly A., Razavi, Ferechte, Silvestri, Evelina, McLendon, Roger E., Thompson, Eric M., Ansari, Marc, Garre, Maria L., Chico, Fernando, Eguia, Pilar, Perezpena, Mario, Morrissy, A. Sorana, Cavalli, Florence M. G., Wu, Xiaochong, Daniels, Craig, Rich, Jeremy N., Jones, Steven J. M., Moore, Richard A., Marra, Marco A., Huang, Xi, Reimand, Juri, Sorensen, Poul H., Wechsler-Reya, Robert J., Weiss, William A., Pugh, Trevor J., Garzia, Livia, Kleinman, Claudia L., Stein, Lincoln D., Jabado, Nada, Malkin, David, Ayrault, Olivier, Golden, Jeffrey A., Ellison, David W., Doble, Brad, Ramaswamy, Vijay, Werbowetski-Ogilvie, Tamra E., Suzuki, Hiromichi, Millen, Kathleen J., Taylor, Michael D.

المساهمون: Kim, Seung-Ki

الوصف: Medulloblastoma (MB) comprises a group of heterogeneous paediatric embryonal neoplasms of the hindbrain with strong linksto early development of the hindbrain(1-4). Mutations that activate Sonic hedgehog signalling lead to Sonic hedgehog MB in the upper rhombic lip (RL) granule cell lineage(5-8). By contrast, mutationsthat activate WNT signalling lead to WNT MB in the lower RL9,10. However, little is known about the more commonly occurringgroup 4 (G4) MB, which isthought to arise in the unipolar brush cell lineage(3,4). Here we demonstrate that somatic mutationsthat cause G4 MB converge on the core binding factor alpha (CBFA) complex and mutually exclusive alterations that affect CBFA2T2, CBFA2T3, PRDM6, UTX and OTX2. CBFA2T2 is expressed early in the progenitor cells ofthe cerebellar RL subventricular zone in Homo sapiens, and G4 MB transcriptionally resembles these progenitors but are stalled in developmental time. Knockdown of OTX2in model systems relieves this differentiation blockade, which allows MB cellsto spontaneously proceed along normal developmental differentiation trajectories. The specific nature ofthe split human RL, which is destined togenerate most ofthe neurons in the human brain, and its high level of susceptible EOMES(+)K167(+) unipolar brush cell progenitor cells probably predisposes our speciesto the development of G4 MB. ; N ; 1

العلاقة: Nature, Vol.609 No.7929, pp.1021-+; https://hdl.handle.net/10371/186175Test; 000857475800001; 173006

الإتاحة: https://doi.org/10.1038/s41586-022-05215-wTest
https://hdl.handle.net/10371/186175Test

المؤلفون: Scott, David S.¹ (AUTHOR) d.scott@abertay.ac.uk, Punch, Samantha² (AUTHOR)

المصدر: Sociological Review. Jan2024, Vol. 72 Issue 1, p194-212. 19p.

مصطلحات موضوعية: *CARD games, *MUSCULAR sense, *CONFIDENCE, *NEGOTIATION, *SENSES

مستخلص: The classification of mindsports such as the card game of bridge within sport and society continues to be keenly debated. The concept of 'physicality' is often cited as being a prerequisite for an activity to be classed as a 'sport', a characteristic typically seen as lacking in mindsports. However, by drawing upon monist conceptualisations of the mind, body and world being intertwined, it is possible to problematise such arguments by highlighting the interconnected sensations experienced when participating in bridge. This article explores such a notion through phenomenologically-inspired analysis of 52 interviews with elite-level bridge players. The findings detail the importance players placed upon aspects of kinaesthesia, physical presence within the competitive environment, and the role of other social actors within their own understandings of their competition experience. These sensorial, emotional and embodied accounts of elite-level bridge shed light on the physical negotiations and socio-cultural influences involved in mindsport, which allude to a greater degree of 'physicality' than has previously been discussed. [ABSTRACT FROM AUTHOR]

المؤلفون: Scott, David S., Fletcher, Thomas

المصدر: Leisure Studies ; page 1-8 ; ISSN 0261-4367 1466-4496

الإتاحة: https://doi.org/10.1080/02614367.2023.2243653Test

المؤلفون: Scott, David S.

المصدر: 1 ; 16

مصطلحات موضوعية: sport-for-development, confidence, emotions, embodiment, phenomenology, ethnography

الوصف: Although sport is widely utilised as a tool for personal development, capacity building, and fostering peace, there are still numerous theoretical gaps in our knowledge about how sport influences individuals’ identities, and how this translates into their everyday lives. Within the academic literature there has been seemingly little focus placed upon participants’ emotional and embodied accounts of their sport-for-development (SfD) experiences. This paper uses phenomenologically-inspired theory to explore individuals’ lived experiences of a SfD course, and their descriptions of the social interactions and feelings of confidence they encountered, in order to address this lack of experiential data. An ethnographic methodology was used to collect data through four sports leadership course observations, and cyclical interviews over 4–10 months with eleven course attendees, plus individual interviews with five tutors. Participants’ understandings of their course experiences and the subsequent influence these understandings had on their lives were described through their use of the term confidence. A further phenomenological and sociological interrogation of this term enabled confidence to be seen as being experienced as a ‘frame’ and ‘through the body’ by participants. This study provides original conceptualisations of confidence in relation to participants’ SfD experiences, as well as important discussions regarding the role of emotions and embodiment in understanding the impact of SfD on participants’ everyday lives.

وصف الملف: application/PDF

العلاقة: Scott, D. S. (2018) ‘The confidence delusion: A sociological exploration of participants’ confidence in sport-for-development’, International Review for the Sociology of Sport. doi:10.1177/1012690218814536; http://hdl.handle.net/2436/621942Test; International Review for the Sociology of Sport

الإتاحة: https://doi.org/10.1177/1012690218814536Test
http://hdl.handle.net/2436/621942Test

المؤلفون: Hendrikse, Liam D., Haldipur, Parthiv, Saulnier, Olivier, Millman, Jake, Sjoboen, Alexandria H., Erickson, Anders W., Ong, Winnie, Gordon, Victor, Coudière-Morrison, Ludivine, Mercier, Audrey L., Shokouhian, Mohammad, Suárez, Raúl A., Ly, Michelle, Borlase, Stephanie, Scott, David S., Vladoiu, Maria C., Farooq, Hamza, Sirbu, Olga, Nakashima, Takuma, Nambu, Shohei, Funakoshi, Yusuke, Bahcheli, Alec, Diaz-Mejia, J. Javier, Golser, Joseph, Bach, Kathleen, Phuong-Bao, Tram, Skowron, Patryk, Wang, Evan Y., Kumar, Sachin A., Balin, Polina, Visvanathan, Abhirami, Lee, John J. Y., Ayoub, Ramy, Chen, Xin, Chen, Xiaodi, Mungall, Karen L., Luu, Betty, Bérubé, Pierre, Wang, Yu C., Pfister, Stefan M., Kim, Seung-Ki, Delattre, Olivier, Bourdeaut, Franck, Doz, François, Masliah-Planchon, Julien, Grajkowska, Wieslawa A., Loukides, James, Dirks, Peter, Fèvre-Montange, Michelle, Jouvet, Anne

المصدر: Nature ; volume 612, issue 7940, page E12-E12 ; ISSN 0028-0836 1476-4687

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41586-022-05578-0Test
https://www.nature.com/articles/s41586-022-05578-0.pdfTest
https://www.nature.com/articles/s41586-022-05578-0Test