يعرض 1 - 10 نتائج من 50 نتيجة بحث عن '"Schir, Edith"', وقت الاستعلام: 1.01s تنقيح النتائج
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    دورية أكاديمية
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    دورية أكاديمية

    المؤلفون: Dupuis, Claire, Le Bihan, Clément, Maubon, Daniele, Calvet, Laure, Ruckly, Stéphane, Schwebel, Carole, Bouadma, Lila, Azoulay, Elie, Cornet, Muriel, Timsit, Jean-Francois, Hamidfar-Roy, Rebecca, Ciroldi, Magalie, Paugam-Burtz, Clichy Catherine, Foucrier, Arnaud, Navellou, Jean Christophe, Wolff, Michel, Mourvillier, Bruno, Sonneville, Romain, Chemam, Sarah, Gruson, Didier, Souweine, Bertrand, Lautrette, Alexandre, Charles, Pierre Emmanuel, Bruyere, Rémi, Hamet, Maël, Allaouchiche, Bernard, Guillaume, Christian, Ber, Charles-Eric, Prothet, Johanne, Rimmele, Thomas, Argaud, Laurent, Simon, Marie, Cour, Martin, Hernu, Romain, Jaber, Samir, Jung, Boris, Conseil, Mathieu, Coisel, Yannael, Belafia, Fouad, Klouche, Kada, Amigues, Laurent, Machado, Sonia, Serveaux, Marianne, Chastre, Jean, Trouillet, Jean-Louis, Cousson, Joël, Raclot, Pascal, Floch, Thierry, Zeni, Fabrice, Darmon, Michael, Pichon, Matthias, Coudrot, Maud, Ninet, Sebastien, Diconne, Eric, Schlemmer, Benoit, Lemiale, Virginie, Maziers, Nicolas, Meziani, Ferhat, Schnell, David, Boisrame-Helms, Julie, Neagu-Anca, Raluca, Delabranche, Xavier, Martinet, Olivier, Garrouste-Orgeas, Maité, Misset, Benoit, Brunee, Fabrice, Laurent, Virginie, Lacave, Guillaume, Bedos, Jean-Pierre, Hammi, Khadija, Styfalova, Lenka, Fritzsch, Joelle, Letrou, Sophie, Estevez, Lucie, Devaux, Therese, Dubien, Celine, Bayarassou, Soumia, Faure, Catherine Jouvene, de La Salle, Sylvie, Prades, Albert, Rodriguez, Annie, Meur, Pierre, Warchol, Magda, El Haouari, Hanane, Theodose, Igor, Fournier, Julien, Cavelot, Sebastien, Kodja, Lilia Bakir, Faure, Marie Joyeux, Tacco, Frédéric, Roos, Sonia, Dupre, Karima, Abazid, Malek, Essert, Michele, Arnaud, Philippe, P., Papy, Emmanuelle, Ghezzoul, Bellabes, Gerbouin, Olivier, Peccoux, Sandrine Corny, Fagnoni, Philippe, Millaret, Anne, Pivot, Christine, Gerard, Cecile, Breuker, Cyril, Castet, Audrey, Charbonnier, Fanny, Legrand, Maryline, Mordini, Julia, Chambrin, Isabelle Madeleine, Clauss, Anne Hutt, Cherifi, Mohamed, Pattyn, Anne, Cornet, Murielle, Benveniste, Eliane, Grenouillet, Frédéric, Chochillon, Christian, Accoberry, Isabelle, Pons, Denis, Mrozek, Natacha, Dalle, Frédéric, Picot, Stephane, Beyerle, Francoise, Bienvenu, Anne-Lise, Bourgeois, Nathalie, Fekkar, Arnaud, Toubas, Dominique, Raberin, Hélène, Candolfi, Ermanno, Bru, Valérie, Kitzis, Marie Dominique, Senghor, Yaye, Palette, Catherine, Vesin, Aurélien, Zahar, Jean-Ralph, Mira, Jean-Paul, Larrey, Dominique, Zarski, Jean-Pierre, Schir, Edith

    المساهمون: CHU Clermont-Ferrand, Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Université de Montpellier (UM), Centre Hospitalier Universitaire CHU Grenoble (CHUGA), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hopital Saint-Louis AP-HP (AP-HP), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM)-Centre National de la Recherche Scientifique (CNRS)

    المصدر: ISSN: 2328-8957.

    الوصف: International audience ; Background. We aimed to assess the prognostic value of repeated measurements of serum (1-3)-β-D-glucan (BDG), mannanantigen (mannan-Ag), and antimannan antibodies (antimannan-Ab) for the occurrence of invasive candidiasis (IC) in a high-risk nonimmunocompromised population. Methods. This was a preplanned ancillary analysis of the EMPIRICUS Randomized Clinical Trial, including nonimmunocompromised critically ill patients with intensive care unit-acquired sepsis, multiple Candida colonization, and multiple organ failure who were exposed to broad-spectrum antibacterial agents. BDG (>80 and >250 pg/mL), mannan-Ag (>125 pg/ mL), and antimannan-Ab (>10 AU) were collected repeatedly. We used cause-specific hazard models. Biomarkers were assessed at baseline in the whole cohort (cohort 1). Baseline covariates and/or repeated measurements and/or increased biomarkers were then studied in the subgroup of patients who were still alive at day 3 and free of IC (cohort 2). Results. Two hundred thirty-four patients were included, and 215 were still alive and free of IC at day 3. IC developed in 27 patients (11.5%), and day 28 mortality was 29.1%. Finally, BDG >80 pg/mL at inclusion was associated with an increased risk of IC (CSHR[IC], 4.67; 95% CI, 1.61-13.5) but not death (CSHR[death], 1.20; 95% CI, 0.71-2.02). Conclusions. Among high-risk patients, a first measurement of BDG >80 pg/mL was strongly associated with the occurrence of IC. Neither a cutoff of 250 pg/mL nor repeated measurements of fungal biomarkers seemed to be useful to predict the occurrence of IC. The cumulative risk of IC in the placebo group if BDG >80 pg/mL was 25.39%, which calls into question the efficacy of empirical therapy in this subgroup.

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    دورية أكاديمية

    المساهمون: UCL - SSS/DDUV/GECE - Génétique cellulaire

    المصدر: Oncoimmunology, Vol. 9, no.1, p. 1738812 (2020)

    الوصف: The efficacy of immune checkpoint inhibitors has been shown to depend on preexisting antitumor immunity; thus, their combination with cancer vaccines is an attractive therapeutic approach. Plasmacytoid dendritic cells (PDC) are strong inducers of antitumor responses and represent promising vaccine candidates. We developed a cancer vaccine approach based on an allogeneic PDC line that functioned as a very potent antigen-presenting cell in pre-clinical studies. In this phase Ib clinical trial, nine patients with metastatic stage IV melanoma received up to 60 million irradiated PDC line cells loaded with 4 melanoma antigens, injected subcutaneously at weekly intervals. The primary endpoints were safety and tolerability. The vaccine was well tolerated and no serious vaccine-induced side effects were recorded. Strikingly, there was no allogeneic response toward the vaccine, but a significant increase in the frequency of circulating anti-tumor specific T lymphocytes was observed in two patients, accompanied by a switch from a naïve to memory phenotype, thus demonstrating priming of antigen-specific T-cells. Signs of clinical activity were observed, including four stable diseases according to IrRC and vitiligoïd lesions. Four patients were still alive at week 48. We also demonstrate the in vitro enhancement of specific T cell expansion induced by the synergistic combination of peptide-loaded PDC line with anti-PD-1, as compared to peptide-loaded PDC line alone. Taken together, these clinical observations demonstrate the ability of the PDC line based-vaccine to prime and expand antitumor CD8+ responses in cancer patients. Further trials should test the combination of this vaccine with immune checkpoint inhibitors.

    العلاقة: boreal:243356; http://hdl.handle.net/2078.1/243356Test; info:pmid/32313721; urn:ISSN:2162-4011

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    دورية أكاديمية

    المصدر: ISSN: 2044-6055 ; BMJ open, vol. 7, no. 2 (2017) e013434.

    الوصف: Islet transplantation may be an appropriate treatment option for patients with severely unstable type 1 diabetes experiencing major glucose variability with severe hypoglycaemia despite intensive insulin therapy. Few data are available on the costs associated with islet transplantation in relation to its benefits. The STABILOT study proposes to assess the economic impact of islet transplantation in comparison with the current best medical treatment defined as sensor-augmented pump (SAP) therapy.

    العلاقة: info:eu-repo/semantics/altIdentifier/pmid/28219959; https://archive-ouverte.unige.ch/unige:93703Test; unige:93703

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    دورية أكاديمية

    المصدر: Pharmactuel; Vol. 45 No. 2 (2012) ; 0834-065X

    الوصف: Résumé Objectif : Nous décrivons ici un cas d’hyperéosinophilie majeure, isolée, découverte fortuitement, apparue après l’administration de ranélate de strontium, puis régressive à l’arrêt du traitement. Résumé du cas : Une patiente de 73 ans, suivie pour une polyarthrite rhumatoïde traitée par biothérapie, s’est vue proposer un traitement par ranélate de strontium pour une ostéoporose fracturaire. Trois mois plus tard, à l’occasion du suivi biologique de sa biothérapie, on a découvert une hyperéosinophilie majeure, atteignant 3,7 X 109/L sans autre anomalie clinique ou biologique associée. Par la suite, une interruption, par la patiente, de la prise médicamenteuse de ranélate de strontium a entraîné la disparition de l’hyperéosinophilie. Cette anomalie de l’hémogramme est enfin réapparue après la reprise du traitement. Devant cette chronologie évocatrice de l’imputabilité du médicament, le traitement a été définitivement suspendu. La normalisation des éosinophiles un mois plus tard a persisté avec un recul de neuf mois. Discussion : Vingt-deux cas de syndrome d’hypersensibilité médicamenteuse (ou Drug Rash with Eosinophilia and Systemic Symptoms) ont été rapportés sous ranélate de strontium. Cependant, aucun cas d’hyperéosinophilie isolée n’a été rapporté à ce jour à notre connaissance et aucune surveillance biologique n’est recommandée au cours de ce traitement. Des complications viscérales graves auraient pu apparaître si l’administration du ranélate de strontium à notre patiente avait été poursuivie. Conclusion : Nous recommandons la surveillance systématique de l’hémogramme sous ranélate de strontium. Abstract Objective: We describe a case of isolated hypereosinophilia that was discovered fortuitously, appearing after the administration of strontium ranelate and regressing following treatment discontinuation. Case summary: A patient age 73 treated with a biologic agent for rheumatoid arthritis was proposed treatment with strontium ranelate for osteoporosis with fragility fracture. During routine follow-up ...

    وصف الملف: application/pdf

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    دورية أكاديمية

    المساهمون: Service de Soins Intensifs Michallon, Université Joseph Fourier - Grenoble 1 (UJF)-Centre Hospitalier Universitaire CHU Grenoble (CHUGA)-Hôpital Michallon, Outcome Réa (Outcomerea), Unité de Soins Intensifs et de Maladies Infectieuses, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Unité de Soins Intensifs Saint-Louis, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal Paris, TheREx, Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique EHESP (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Epilepsies de l'Enfant et Plasticité Cérébrale (U1129), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie pronostique des cancers et affections graves, Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM), Pharmacologie, Université Joseph Fourier - Grenoble 1 (UJF)-Hôpital Michallon, The study is promoted by the university hospital of Grenoble. This project has received funding from a research grant from Astellas received by the university hospital Albert Michallon (university of Grenoble 1).

    المصدر: ISSN: 1745-6215 ; Trials ; https://inserm.hal.science/inserm-00913515Test ; Trials, 2013, 14 (1), pp.399. ⟨10.1186/1745-6215-14-399⟩.

    الوصف: International audience ; BACKGROUND: The potential interest of antifungal treatment of non-immunocompromized patients with sepsis, extra-digestive Candida colonization and multiple organ failure is unknown. It represents three-quarters of antifungals prescribed in Intensive Care Units. It may allow early treatment of invasive fungal infection in the incubation phase but expose patients to unnecessary antifungal treatments with subsequent cost and fungal selection pressure. As early diagnostic tests for invasive candidiasis are still considered to be insufficient, the potential interest in this strategy needs to be demonstrated. METHODS: This prospective multicenter, double blind, randomized-controlled trial is conducted in 23 French Intensive Care Units. All adult patients, mechanically ventilated for more than four days with sepsis of unknown origin and with at least one extradigestive fungal colonization site and multiple organ failure are eligible for randomization. Patients with proven invasive candidiasis are not included. After a complete mycological screening, patients are allocated to receive micafungin 100 mg intravenously once a day or placebo for 14 days. We plan to enroll 260 patients. The main objective is to demonstrate that micafungin increases survival of patients without invasive candidiasis at day 28 as compared to placebo. Other outcomes include day 28 and 90 survival and organ failure evolution. Additionally, pharmacokinetics of micafungin in enrolled patients will be measured and evolution of fungal biomarkers and susceptibility profiles of infecting fungi will also be followed. DISCUSSION: This study will help to provide guidelines for treating non-immunocompromized patients with fungal colonization multiple organ failure and sepsis of unknown origin.Trial registration: Clinicaltrials.gov number NCT01773876.

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    المساهمون: Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire [Grenoble] (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Pharmacologie, Université Joseph Fourier - Grenoble 1 (UJF)-Hôpital Michallon, Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

    المصدر: Thérapie
    Thérapie, EDP Sciences, 2015, 70 (6), pp.493-499

    الوصف: International audience

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    دورية أكاديمية

    المساهمون: Institute for Advanced Biosciences / Institut pour l'Avancée des Biosciences (Grenoble) (IAB), Centre Hospitalier Universitaire Grenoble (CHU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Etablissement français du sang - Auvergne-Rhône-Alpes (EFS)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ), Université Grenoble Alpes - UFR Pharmacie (UGA UFRP), Université Grenoble Alpes 2016-2019 (UGA 2016-2019 ), Université Grenoble Alpes - UFR Médecine (UGA UFRM), Pharmacologie, Université Joseph Fourier - Grenoble 1 (UJF)-Hôpital Michallon, Techniques pour l'Evaluation et la Modélisation des Actions de la Santé (TIMC-IMAG-ThEMAS), Techniques de l'Ingénierie Médicale et de la Complexité - Informatique, Mathématiques et Applications, Grenoble - UMR 5525 (TIMC-IMAG), VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)-VetAgro Sup - Institut national d'enseignement supérieur et de recherche en alimentation, santé animale, sciences agronomiques et de l'environnement (VAS)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP )-Centre National de la Recherche Scientifique (CNRS)-Université Joseph Fourier - Grenoble 1 (UJF)

    المصدر: Hyper Article en Ligne - Sciences de l'Homme et de la Société ; ISSN: 0040-5957 ; EISSN: 1958-5578 ; Thérapie ; Thérapie, EDP Sciences, 2015, 70 (6), pp.493-499

    مصطلحات موضوعية: hist, genre

    الوصف: International audience

    العلاقة: hal-02007460; 10670/1.d82k51; https://hal.univ-grenoble-alpes.fr/hal-02007460Test

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    دورية أكاديمية
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    دورية أكاديمية