المؤلفون: De Angelis, Simona, Medda, Emanuela, Rotondi, Daniela, Masocco, Maria, Minardi, Valentina, Contoli, Benedetta, Possenti, Valentina, Sorbo, Angela, D'Amato, Marilena, Turco, Anna Chiara, Pastorelli, Alberto Augusto, Stacchini, Paolo, Cas, Roberto Da, Bagnasco, Marcello, Bonofiglio, Daniela, Gasperi, Maurizio, Meringolo, Domenico, Mian, Caterina, Moleti, Mariacarla, Vermiglio, Francesco, Puxeddu, Efisio, Taccaliti, Augusto, Tonacchera, Massimo, Ulisse, Salvatore, Dimida, Antonio, Rago, Teresa, Nazzari, Elena, Schiavo, Mara, Bossert, Irene, Sturniolo, Giacomo, Corbetta, Carlo, Cereda, Cristina, Cappelletti, Laura, Camilot, Marta, Teofoli, Francesca, Ciatti, Renzo, Tarsi, Elisabetta, Perrotti, Nicola, Marasco, Onorina, Scozzafava, Giovanna, Righetti, Francesca, Andò, Sebastiano, Catalano, Stefania, Cristofaro, Mariarosaria, Sorrenti, Giovanni, Censi, Simona, Morelli, Silvia, Baldini, Enke, Plutino, Giuseppe, Copparoni, Roberto, Alonzo, Elena, Giacomozzi, Claudia, Silano, Marco, Olivieri, Antonella

المساهمون: De Angelis, Simona, Medda, Emanuela, Rotondi, Daniela, Masocco, Maria, Minardi, Valentina, Contoli, Benedetta, Possenti, Valentina, Sorbo, Angela, D'Amato, Marilena, Turco, Anna Chiara, Pastorelli, Alberto Augusto, Stacchini, Paolo, Cas, Roberto Da, Bagnasco, Marcello, Bonofiglio, Daniela, Gasperi, Maurizio, Meringolo, Domenico, Mian, Caterina, Moleti, Mariacarla, Vermiglio, Francesco, Puxeddu, Efisio, Taccaliti, Augusto, Tonacchera, Massimo, Ulisse, Salvatore, Dimida, Antonio, Rago, Teresa, Nazzari, Elena, Schiavo, Mara, Bossert, Irene, Sturniolo, Giacomo, Corbetta, Carlo, Cereda, Cristina, Cappelletti, Laura, Camilot, Marta, Teofoli, Francesca, Ciatti, Renzo, Tarsi, Elisabetta, Perrotti, Nicola, Marasco, Onorina, Scozzafava, Giovanna, Righetti, Francesca, Andò, Sebastiano, Catalano, Stefania, Cristofaro, Mariarosaria, Sorrenti, Giovanni, Censi, Simona, Morelli, Silvia, Baldini, Enke, Plutino, Giuseppe, Copparoni, Roberto, Alonzo, Elena, Giacomozzi, Claudia, Silano, Marco, Olivieri, Antonella

مصطلحات موضوعية: iodine, iodine prophylaxi, iodized salt, surveillance, thyroid

الوصف: CONTEXT: In 2005, a nationwide program of iodine prophylaxis on a voluntary basis was implemented in Italy by law. However, recent data on iodine status are lacking. OBJECTIVE: The aim of this study was to evaluate efficiency, effectiveness, and possible adverse effects (increased occurrence of thyroid autoimmunity and hyperthyroidism) of the Italian iodine prophylaxis program. METHODS: From 2015 to 2019, a nationwide survey was performed. The use of iodized salt was evaluated in a sample of 164 593 adults and in 998 school canteens. A sample of 4233 schoolchildren (aged 11-13 years) was recruited to assess urinary iodine concentration, prevalence of goiter, and thyroid hypoechogenicity on ultrasound, with the latter being an indirect indicator of thyroid autoimmunity. Neonatal TSH values of 197 677 infants screened in regions representative of Northern, Central, and Southern Italy were analyzed to investigate the percentage of TSH values >5.0 mIU/L. Data on methimazole prescriptions were analyzed as indirect indicators of new cases of hyperthyroidism. RESULTS: The prevalence of the use of iodized salt was 71.5% in adult population and 78% in school canteens. A median urinary iodine concentration of 124 μg/L, a prevalence of goiter of 2.2%, and a prevalence of thyroid hypoechogenicity of 5.7% were observed in schoolchildren. The percentage of neonatal TSH values >5.0 mIU/L resulted still higher (5.1%) than the World Health Organization threshold of 3.0%, whereas the prescriptions of methimazole showed a reduction of 13.5%. CONCLUSION: Fifteen years of iodine prophylaxis have led to iodine sufficiency in Italy, although there still is concern about iodine nutritional status during pregnancy.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37820735; info:eu-repo/semantics/altIdentifier/wos/WOS:001099762900001; volume:109; issue:2; firstpage:e495; lastpage:e507; numberofpages:13; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; https://hdl.handle.net/11577/3508734Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85182955631

الإتاحة: https://doi.org/10.1210/clinem/dgad593Test
https://hdl.handle.net/11577/3508734Test

المؤلفون: De Angelis, Simona, Medda, Emanuela, Rotondi, Daniela, Masocco, Maria, Minardi, Valentina, Contoli, Benedetta, Possenti, Valentina, Sorbo, Angela, D'Amato, Marilena, Turco, Anna Chiara, Pastorelli, Alberto Augusto, Stacchini, Paolo, Da Cas, Roberto, Bagnasco, Marcello, Bonofiglio, Daniela, Gasperi, Maurizio, Meringolo, Domenico, Mian, Caterina, Moleti, Mariacarla, Vermiglio, Francesco, Puxeddu, Efisio, Taccaliti, Augusto, Tonacchera, Massimo, Ulisse, Salvatore, Dimida, Antonio, Rago, Teresa, Nazzari, Elena, Schiavo, Mara, Bossert, Irene, Sturniolo, Giacomo, Corbetta, Carlo, Cereda, Cristina, Cappelletti, Laura, Camilot, Marta, Teofoli, Francesca, Ciatti, Renzo, Tarsi, Elisabetta, Perrotti, Nicola, Marasco, Onorina, Scozzafava, Giovanna, Righetti, Francesca, Andò, Sebastiano, Catalano, Stefania, Cristofaro, Mariarosaria, Sorrenti, Giovanni, Censi, Simona, Morelli, Silvia, Baldini, Enke, Plutino, Giuseppe, Copparoni, Roberto, Alonzo, Elena, Giacomozzi, Claudia, Silano, Marco, Olivieri, Antonella

المساهمون: De Angelis, Simona, Medda, Emanuela, Rotondi, Daniela, Masocco, Maria, Minardi, Valentina, Contoli, Benedetta, Possenti, Valentina, Sorbo, Angela, D'Amato, Marilena, Turco, Anna Chiara, Pastorelli, Alberto Augusto, Stacchini, Paolo, Da Cas, Roberto, Bagnasco, Marcello, Bonofiglio, Daniela, Gasperi, Maurizio, Meringolo, Domenico, Mian, Caterina, Moleti, Mariacarla, Vermiglio, Francesco, Puxeddu, Efisio, Taccaliti, Augusto, Tonacchera, Massimo, Ulisse, Salvatore, Dimida, Antonio, Rago, Teresa, Nazzari, Elena, Schiavo, Mara, Bossert, Irene, Sturniolo, Giacomo, Corbetta, Carlo, Cereda, Cristina, Cappelletti, Laura, Camilot, Marta, Teofoli, Francesca, Ciatti, Renzo, Tarsi, Elisabetta, Perrotti, Nicola, Marasco, Onorina, Scozzafava, Giovanna, Righetti, Francesca, Andò, Sebastiano, Catalano, Stefania, Cristofaro, Mariarosaria, Sorrenti, Giovanni, Censi, Simona, Morelli, Silvia, Baldini, Enke, Plutino, Giuseppe, Copparoni, Roberto, Alonzo, Elena, Giacomozzi, Claudia, Silano, Marco, Olivieri, Antonella

مصطلحات موضوعية: iodine, iodine prophylaxis, iodized salt, surveillance, thyroid

الوصف: Context: In 2005, a nationwide program of iodine prophylaxis on a voluntary basis was implemented in Italy by law. However, recent data on iodine status are lacking.Objective: The aim of this study was to evaluate efficiency, effectiveness, and possible adverse effects (increased occurrence of thyroid autoimmunity and hyperthyroidism) of the Italian iodine prophylaxis program.Methods: From 2015 to 2019, a nationwide survey was performed. The use of iodized salt was evaluated in a sample of 164 593 adults and in 998 school canteens. A sample of 4233 schoolchildren (aged 11-13 years) was recruited to assess urinary iodine concentration, prevalence of goiter, and thyroid hypoechogenicity on ultrasound, with the latter being an indirect indicator of thyroid autoimmunity. Neonatal TSH values of 197 677 infants screened in regions representative of Northern, Central, and Southern Italy were analyzed to investigate the percentage of TSH values >5.0 mIU/L. Data on methimazole prescriptions were analyzed as indirect indicators of new cases of hyperthyroidism.Results: The prevalence of the use of iodized salt was 71.5% in adult population and 78% in school canteens. A median urinary iodine concentration of 124 mu g/L, a prevalence of goiter of 2.2%, and a prevalence of thyroid hypoechogenicity of 5.7% were observed in schoolchildren. The percentage of neonatal TSH values >5.0 mIU/L resulted still higher (5.1%) than the World Health Organization threshold of 3.0%, whereas the prescriptions of methimazole showed a reduction of 13.5%.Conclusion: Fifteen years of iodine prophylaxis have led to iodine sufficiency in Italy, although there still is concern about iodine nutritional status during pregnancy.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37820735; info:eu-repo/semantics/altIdentifier/wos/WOS:001099762900001; journal:THE JOURNAL OF CLINICAL ENDOCRINOLOGY AND METABOLISM; https://hdl.handle.net/11391/1566515Test

الإتاحة: https://doi.org/10.1210/clinem/dgad593Test
https://hdl.handle.net/11391/1566515Test

المؤلفون: De Angelis, Simona, Bagnasco, Marcello, Moleti, Mariacarla, Regalbuto, Concetto, Tonacchera, Massimo, Vermiglio, Francesco, Medda, Emanuela, Rotondi, Daniela, Di Cosmo, Caterina, Dimida, Antonio, Rago, Teresa, Schiavo, Mara, Nazzari, Elena, Bossert, Irene, Sturniolo, Giacomo, Cesaretti, Graziano, Olivieri, Antonella

المساهمون: De Angelis, Simona, Bagnasco, Marcello, Moleti, Mariacarla, Regalbuto, Concetto, Tonacchera, Massimo, Vermiglio, Francesco, Medda, Emanuela, Rotondi, Daniela, Di Cosmo, Caterina, Dimida, Antonio, Rago, Teresa, Schiavo, Mara, Nazzari, Elena, Bossert, Irene, Sturniolo, Giacomo, Cesaretti, Graziano, Olivieri, Antonella

مصطلحات موضوعية: iodine, schoolchildren, body mass index, thyroid, obesity

الوصف: The frequency of overweight and obese children has increased worldwide, particularly in economically developed countries. No studies have been conducted to verify whether the increasing frequency of overweight and obesity in schoolchildren may affect the evaluation of iodine nutritional status in populations. The aim of this study was to verify whether urinary iodine concentration, thyroid volume and thyroid hypoechoic pattern may be affected by body mass index (BMI) in schoolchildren.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/33256547; info:eu-repo/semantics/altIdentifier/wos/WOS:000613485900001; firstpage:1; lastpage:12; numberofpages:12; journal:THYROID; http://hdl.handle.net/11570/3187750Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85104557633

الإتاحة: https://doi.org/10.1089/thy.2020.0189Test
http://hdl.handle.net/11570/3187750Test

المؤلفون: De Angelis, Simona, Bagnasco, Marcello, Moleti, Mariacarla, Regalbuto, Concetto, Tonacchera, Massimo, Vermiglio, Francesco, Medda, Emanuela, Rotondi, Daniela, Di Cosmo, Caterina, Dimida, Antonio, Rago, Teresa, Schiavo, Mara, Nazzari, Elena, Bossert, Irene, Sturniolo, Giacomo, Cesaretti, Graziano, Olivieri, Antonella

المصدر: Thyroid ; volume 31, issue 5, page 829-840 ; ISSN 1050-7256 1557-9077

الإتاحة: https://doi.org/10.1089/thy.2020.0189Test

المؤلفون: Simone, Rita, Brizzolara, Renata, Chiappori, Alessandra, Milintenda-Floriani, Francesca, Natale, Clelia, Greco, Luigi, Schiavo, Mara, Bagnasco, Marcello, Pesce, Giampaola, Saverino, Daniele

مصطلحات موضوعية: Article

الوصف: Celiac disease (CD) is a multifactorial disorder influenced by environmental, genetic and immunological factors. Increasing evidence showed CTLA-4 gene as an important susceptibility locus for autoimmune disorders. A native soluble cytotoxic T-lymphocyte-associated protein-4 (sCTLA-4), lacking of transmembrane sequence, has been described in several autoimmune diseases. We aimed to evaluate the presence of increased sCTLA-4 concentration in the serum of patients with CD and the possible immunoregulatory function. Blood samples were collected from 160 CD patients; sCTLA-4 levels were evaluated by ELISA, western blot and reverse transcription–PCR. The capability of serum sCTLA-4 to modulate T-lymphocyte proliferation in vitro was evaluated by two-way mixed leukocyte reaction assay. We demonstrated high levels of sCTLA-4 in serum of untreated celiac patients. Additionally, we observed that sCTLA-4 concentrations are related to gluten intake and that a correlation between autoantibodies to tissue transglutaminase and sCTLA-4 concentration exists. Moreover, sCTLA-4 levels correlate with the degree of mucosal damage. Conversely, no correlation between sCTLA4 levels and the HLA-related risk was observed. Finally, we show that sCTLA-4 from sera of CD patients displays functional activities. These results strongly suggest a regulation of sCTLA-4 synthesis depending on the presence or absence of dietary gluten and imply a possible immunomodulatory effect on cytotoxic T lymphocyte functions. In gluten-exposed patients, serum sCTLA-4 levels might provide insight about mucosal injury.

وصف الملف: text/html

العلاقة: http://intimm.oxfordjournals.org/cgi/content/short/dxp069v1Test; http://dx.doi.org/10.1093/intimm/dxp069Test

الإتاحة: https://doi.org/10.1093/intimm/dxp069Test
http://intimm.oxfordjournals.org/cgi/content/short/dxp069v1Test

المؤلفون: Giusti Massimo, Caputo Mauro, Calamia Iolanda, Bagnara Mariaclaudia, Ceresola Enrica, Schiavo Mara, Mussap Michele, Ferone Diego, Minuto Francesco, Bagnasco Marcello

المصدر: Thyroid Research, Vol 2, Iss 1, p 6 (2009)

مصطلحات موضوعية: Diseases of the endocrine glands. Clinical endocrinology, RC648-665

الوصف: Background Large multinodular goiter (MNG) in elderly people is a common finding which can require intervention. The long-term effect of radioiodine therapy on thyroid volume (TV) and function after recombinant human (rh) TSH pre-treatment was evaluated. Methods After baseline evaluation, 40 subjects over 60 years old with a large MNG were treated with 131 I up to the activity of 600 MBq. Nineteen patients were pretreated with rhTSH (0.1 mg on 2 consecutive days; group 1) while 21 subjects underwent treatment without rhTSH pretreatment (group 2). TV was monitored every 6–12 months by ultrasonography. The median follow-up period was 36 months. Results At the baseline, the groups matched in terms of TV, 24-h radioiodine uptake (RAIU), urinary iodine and neck complaints. The number of subjects pretreated with anti-thyroid drugs was significantly (P = 0.01) greater in group 2 than in group 1; TSH was more suppressed (P = 0.003) and f-T3 was more elevated (P = 0.005) in group 2 than in group 1 patients. RhTSH increased 24-h RAIU in group 1 up to the baseline level observed in group 2. The 131 I activity administered was similar in both groups. Adverse events were slight and similar in both groups. A permanent post-radioiodine toxic condition was reported only in 2 patients in group 2. After radioiodine therapy, hypothyroidism was observed in significantly more group 1 patients than group 2 patients (P = 0.002). While TV was reduced in both groups, the percentage TV reduction recorded at the last examination was significantly higher (P = 0.03) in group 1 than in group 2. MNG-related complaints were significantly reduced in both group 1 (P = 0.0001 vs baseline) and group 2 (P = 0.001) patients. Conclusion Low radioiodine activities after pretreatment with low-dosage rhTSH are able to reduce TV and improve MNG-related symptoms in elderly subjects.

العلاقة: http://www.thyroidresearchjournal.com/content/2/1/6Test; https://doaj.org/toc/1756-6614Test; https://doaj.org/article/fe0df311ef6447df8089017ce0fe8ed0Test

الإتاحة: https://doi.org/10.1186/1756-6614-2-6Test
https://doaj.org/article/fe0df311ef6447df8089017ce0fe8ed0Test

المؤلفون: SCHIAVO, MARA

المساهمون: Schiavo, Mara, BAGNASCO, MARCELLO

مصطلحات موضوعية: Settore MED/09 - Medicina Interna

الوصف: Indagine epidemiologica sull'apporto iodico e sulla prevalenza del gozzo in Liguria nell¿ambito del monitoraggio della iodoprofilassi in Italia

العلاقة: http://hdl.handle.net/11567/929167Test

الإتاحة: https://doi.org/10.15167Test/schiavo-mara_phd2018-05-17
http://hdl.handle.net/11567/929167Test

المؤلفون: SCHIAVO, MARA, Bagnara MC, Camerieri L, Pomposelli E, GIUSTI, MASSIMO, PESCE, GIAMPAOLA, Reitano C, Caputo M, BAGNASCO, MARCELLO

المساهمون: Schiavo, Mara, Bagnara, Mc, Camerieri, L, Pomposelli, E, Giusti, Massimo, Pesce, Giampaola, Reitano, C, Caputo, M, Bagnasco, Marcello

الوصف: Radioiodine is a common therapeutic option for Multinodular Toxic Goiter (MTG). We evaluated an algorithm for personalized radioiodine activity calculation. Ninety-three (28 male, 65 female; 43-84 years) patients with MTG eligible for radioiodine treatment (131I-iodide) were studied. The quantity of 131I-iodide to be administered was estimated by Thyroid Volume Reduction (TVR) algorithm, developed for Graves' disease. It takes into account 131I uptake, its effective half-life (T1/2eff), thyroid volume, and its expected reduction during treatment. A comparison with the activity calculated by other dosimetric protocols and the "fixed" activity method was performed. 131I uptake was measured by external counting, thyroid volume by ultrasonography (US), thyroid stimulating hormone (TSH), and thyroid hormones by standard immunometric methods. In a follow-up of 6-120 months, remission of hyperthyroidism after a single 131I-iodide treatment was observed in 76 patients (64 euthyroid, 12 hypothyroid). The thyroid volume reduction observed by US after the treatment fairly correlated with what predicted by our model; T1/2eff was highly variable and critically affected dose calculation. The administered activities (median 526 MBq, range 156-625 MBq) were slightly lower than the "fixed" activities (600 MBq) and with respect to the other protocols' prescriptions (-15/38%); the median 131I activity administered to relapsed patients (605 MBq) was significantly greater (P=0.01) with respect to the dose administered to cured patients (471 MBq). Our study shows that an effective cure of MTG can be obtained with relatively low 131I activities and probably with a relatively low incidence of hypothyroidism, using TVR method.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25151403; info:eu-repo/semantics/altIdentifier/wos/WOS:000351661100022; volume:48; firstpage:902; lastpage:908; numberofpages:7; journal:ENDOCRINE; http://hdl.handle.net/11567/778596Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84943015136

الإتاحة: https://doi.org/10.1007/s12020-014-0398-4Test
http://hdl.handle.net/11567/778596Test

المؤلفون: GIUSTI, MASSIMO, Caorsi, V, MORTARA, LORENZO, CAPUTO, ORESTE MARIO, MONTI, ELEONORA, SCHIAVO, MARA, Bagnara, Mc, MINUTO, FRANCESCO, BAGNASCO, MARCELLO

المساهمون: Giusti, Massimo, Caorsi, V, Mortara, Lorenzo, Caputo, ORESTE MARIO, Monti, Eleonora, Schiavo, Mara, Bagnara, Mc, Minuto, Francesco, Bagnasco, Marcello

الوصف: Radioiodine is a common therapeutic option for Multinodular Toxic Goiter (MTG). We evaluated an algorithm for personalized radioiodine In multinodular goitre (MNG), low radioiodine (RAI) activity after recombinant human (rh) TSH is able to reduce thyroid volume (TV) and improve symptoms. Our aim was to evaluate the long-term outcome of RAI after rhTSH treatment in patients who were divided according to their baseline TSH levels. Eighteen patients (69.2 ± 6.1 year) presented non-toxic (TSH >0.3 mIU/l) MNG (TV: 61.0 ± 3.8 ml; group 1), while 13 patients (74.1 ± 7.9 year) had non-autoimmune pre-toxic (TSH <0.3 mIU/l) MNG (TV: 82.6 ± 14.4 ml; group 2). TSH, thyroid hormones, TV (by ultrasonography), body mass index (BMI), symptoms and quality of life (QoL) were evaluated. Treatment induced short-term thyrotoxicosis in both groups, but this was slightly more marked in group 2 than in group 1. The number and severity of adverse events were similar. The follow-up period was 55.3 ± 4.1 months in group 1 and 57.2 ± 5.1 months in group 2. The final TV reduction was similar in groups 1 (63.4 ± 3.6%) and 2 (57.2 ± 4.6%) and TV reduction positively correlated only with initial TV. At the last examination, 14 group-1 subjects were on L-T4 therapy, while 2 group-2 subjects were on methimazole. An increase in BMI was noted only in group 2. MNG-related symptoms were significantly reduced in both groups. Symptoms related to sub-clinical hyperthyroidism improved in group 2, while no significant changes in QoL were noted in either group. This study confirms the effectiveness of rhTSH adjuvant treatment in reducing TV after low RAI activities, irrespective of baseline thyroid status. TSH levels <0.3 mIU/l proved to be predictive of a more severe thyrotoxic phase after rhTSH and RAI, while initial TSH levels >0.3 mIU/l were more frequently followed by a need for L-T4 therapy. Compressive symptoms improved in the majority of subjects.

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/23619962; info:eu-repo/semantics/altIdentifier/wos/WOS:000331639000009; ispartofbook:Endocrine; volume:45; firstpage:221; lastpage:229; numberofpages:9; journal:ENDOCRINE; http://hdl.handle.net/11567/780211Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84894569588

الإتاحة: https://doi.org/10.1007/s12020-013-9959-1Test
http://hdl.handle.net/11567/780211Test

المؤلفون: SCHIAVO, MARA, SAVERINO, DANIELE

المساهمون: Schiavo, Mara, Saverino, Daniele

الوصف: Gene association studies are very appealing in autoimmune diseases. In recent years, access to other human gene sequences prompted investigators to focus on genes encoding the immune regulatory proteins such as the costimulatory, adhesion molecules, cytokines and chemokines and their receptors. Among them, cytotoxic T-lymphocyte antigen-4 (CTLA-4) has been extensively studied for its pivotal role in autoimmunity. As a central regulatory element of the immune responses magnitude, CTLA-4 could act as a double-edged sword and only the optimal expression ensures an effective, but at the same time, safe immune response. Thus, we can argue that CTLA-4 alleles associated with abnormal membrane expression could make a person more susceptible to tumor growth and/or manifestation of autoimmune diseases. Unfortunately, the relationship between the presence of SNP conferring susceptibility/protection to autoimmune disease and the genetic regulation/modification of CTLA-4 is the not yet fully clarified, and in some aspects conflicting.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/10.2174/1871522211313020002; volume:13; firstpage:89; lastpage:96; numberofpages:8; journal:IMMUNOLOGY, ENDOCRINE & METABOLIC AGENTS IN MEDICINAL CHEMISTRY; http://hdl.handle.net/11567/565119Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84878655891

الإتاحة: http://hdl.handle.net/11567/565119Test