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1دورية أكاديمية
المصدر: International Journal of Yoga, Vol 10, Iss 2, Pp 103-106 (2017)
مصطلحات موضوعية: Body mass index, hypertension, pranayama, systolic and diastolic blood pressure, yoga practice, Miscellaneous systems and treatments, RZ409.7-999
الوصف: Background: Yoga, an ancient Indian system of exercise and therapy is an art of good living or an integrated system for the benefit of the body, mind, and inner spirit. Regular practice of yoga can help to increase blood flow to the brain, reduce stress, have a calming effect on the nervous system, and greatly help in reducing hypertension. Aim: Aim of the present study is to evaluate the effect of 1-month yoga practice on body mass index (BMI), and blood pressure (BP). Materials and Methods: The present study was conducted to determine the effect of yoga practice on 64 participants (age 53.6 ± 13.1 years) (experimental group) whereas the results were compared with 26 healthy volunteers (control group). We examined the effects of yoga on physiological parameters in a 1-month pilot study. Most of the participants were learner and practiced yoga for 1 h daily in the morning for 1 month. BMI and BP (systolic and diastolic) were studied before and after 1 month of yoga practice. Results: Yoga practice causes decreased BMI (26.4 ± 2.5–25.22 ± 2.4), systolic BP (136.9 ± 22.18 mmHg to 133 ± 21.38 mmHg), and diastolic BP (84.7 ± 6.5 mmHg to 82.34 ± 7.6 mmHg). On the other hand, no significant changes were observed in BMI and BP of control group. Conclusion: This study concludes that yoga practice has potential to control BMI and BP without taking any medication.
وصف الملف: electronic resource
العلاقة: http://www.ijoy.org.in/article.asp?issn=0973-6131;year=2017;volume=10;issue=2;spage=103;epage=106;aulast=ChauhanTest; https://doaj.org/toc/0973-6131Test
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2دورية أكاديمية
المؤلفون: Ashutosh Chauhan, Deepak Kumar Semwal, Satyendra Prasad Mishra, Sandeep Goyal, Rajendra Marathe, Ruchi Badoni Semwal
المصدر: Medical Sciences, Vol 4, Iss 4, p 16 (2016)
مصطلحات موضوعية: renal cell carcinoma, mammalian target of rapamycin, mitogen activated protein kinase, target therapy, Medicine
الوصف: Renal cell carcinoma (RCC) is the most common neoplasm that occurs in the kidney and is marked by a unique biology, with a long history of poor response to conventional cancer treatments. In the past few years, there have been significant advancements to understand the biology of RCC. This has led to the introduction of novel targeted therapies in the management of patients with metastatic disease. Patients treated with targeted therapies for RCC had shown positive impact on overall survival, however, no cure is possible and patients need to undergo treatment for long periods of time, which raises challenges to manage the associated adverse events. Moreover, many patients may not respond to it and even response may not last long enough in the responders. Many inhibitors of the Mammalian target of Rapamycin (mTOR) signaling pathway are currently being used in treatment of advanced RCC. Studies showed that inhibitions of mTOR pathways induce Mitogen-Activated Protein Kinase (MAPK) escape cell death and cells become resistant to mTOR inhibitors. Because of this, there is a need to inhibit both pathways with their inhibitors comparatively for a better outcome and treatment of patients with RCC.
وصف الملف: electronic resource
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المؤلفون: Satyendra Prasad Mishra, Shyam Sundar Manna
المصدر: The Journal of Phytopharmacology. 7:199-202
مصطلحات موضوعية: Range (biology), Forestry, Biology
الوصف: Exploration of the traditional knowledge of the indigenous people is very important for revealing the uses of plants and plant parts for medicinal purpose. Once the medicinal use of these plants is known, their active ingredients have to be identified and their efficacy has to be tested scientifically. A good number of modern medicines are now available which has been formulated taking the traditional knowledge into consideration. Besides people all over the world now shift their attention to herbal drugs because they are comparatively safer and cheaper. In these contexts, ethnomedicinal studies are of great significance. In the present paper, attempts have been made enlist the ethnomedicinal plants of Lalgarh forest range of India. The study reveals that 52 different plant species are used by the local people to cure different diseases. Out of the 52 plant species, 17 are herbs, 20 trees, 11 shrubs, and 4 are climbers. The list of plant parts, habit, mode of their use and purpose has been documented in this study.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::3360de4c99665204b4ac5c95847b98dcTest
https://doi.org/10.31254/phyto.2018.7216Test -
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المؤلفون: Pandian Arjun, Deepak Semwal, Ruchi Badoni Semwal, Satyendra Prasad Mishra, Anita Blessy Vijayan, Masilamani Krishnamoorthy
المصدر: Current Nutrition & Food Science. 11:282-291
مصطلحات موضوعية: Nutrition and Dietetics, Public Health, Environmental and Occupational Health, Food Science
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5e57e948cd731dd4bbca17feb87cb5a4Test
https://doi.org/10.2174/1573401311666150603233951Test -
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المؤلفون: Ruchi Badoni Semwal, Satyendra Prasad Mishra, Ashutosh Chauhan, Rani Ojha, Deepak Kumar Semwal
المصدر: Anti-Cancer Agents in Medicinal Chemistry. 17
مصطلحات موضوعية: Cancer Research, Cell Survival, Pyridines, Antineoplastic Agents, Apoptosis, p38 Mitogen-Activated Protein Kinases, Structure-Activity Relationship, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, Tumor Cells, Cultured, Humans, Medicine, MTT assay, Viability assay, Carcinoma, Renal Cell, Protein Kinase Inhibitors, Cell Proliferation, Sirolimus, Pharmacology, Kidney, Dose-Response Relationship, Drug, Molecular Structure, business.industry, Cell growth, TOR Serine-Threonine Kinases, Imidazoles, Cancer, medicine.disease, Kidney Neoplasms, medicine.anatomical_structure, Cell culture, 030220 oncology & carcinogenesis, Cancer research, Molecular Medicine, Drug Screening Assays, Antitumor, Tumor Suppressor Protein p53, business, 030217 neurology & neurosurgery
الوصف: Background Renal cell carcinoma (RCC) is one of the most common neoplasms that occurs in the kidney and is marked by a unique biology, with a long history of poor response to conventional cancer treatments. In recent years, there have been significant advancements implemented to understanding the biology of RCC, which has led to the introduction of novel targeted therapies in the management of patients with metastatic disease. Objective The present study was designed to evaluate the effects of p38 MAPK inhibitor (SB203580), alone and in combination with mTOR inhibitor (CCI779) on apoptosis and cell proliferation. Method Subtoxic concentrations of inhibitors were selected by MTT assay using A-498, ACHN and primary culture of RCC. Results All the three types of RCC cells had almost similar response towards these inhibitors. The results revealed that 25µM of SB203580 and 20µM of CCI779 at 48 hrs decreased cell viability by 20% and 30%, respectively, whereas the combination of both inhibitors showed a maximum of 40% reduction in cell viability. Conclusion The study concludes that the combination of SB203580 and CCI779 inhibitors may induce cellular senescence in A-498 cells with higher potency than that of individual inhibitors.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::777fb392f293c8d84ecaae3cfb5d009aTest
https://doi.org/10.2174/1871520617666170213111002Test -
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المصدر: Journal of Medical Sciences. 15:139-146
مصطلحات موضوعية: Reduction (complexity), medicine.medical_specialty, Traditional medicine, Adverse health effect, business.industry, Alternative medicine, medicine, General Medicine, Intensive care medicine, business
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::c0b95fa06c8abc6c5db3fe9ee5e173d3Test
https://doi.org/10.3923/jms.2015.139.146Test -
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المصدر: Journal of integrative medicine. 15(2)
مصطلحات موضوعية: 0301 basic medicine, Pathology, medicine.medical_specialty, Research areas, business.industry, Aberrant cell, Cancer, Neoplasms therapy, Disease, medicine.disease, Bioinformatics, Medicine, Ayurvedic, Cancer pathogenesis, 03 medical and health sciences, 030104 developmental biology, Complementary and alternative medicine, Neoplasms, medicine, Humans, Neoplasm staging, Traditional knowledge, business, Early Detection of Cancer, Neoplasm Staging
الوصف: The term Kriyakala refers to the recognition of the stage of a disease's progress, which helps to determine appropriate measure to correct the imbalance in Doshas (biological factors). It is a compound expression, comprised of Kriya and Kala, where Kriya means the choice to treatment (medicine, food and daily-routine) used to improve the disturbance in Doshas, and Kala refers to the stage of progress of a disease. Sushruta, an ancient Indian surgeon, has described the concept of Kriyakala in Varnaprashnadhyaya, an ancient Vedic Sanskrit text, which seeks to explain the incidence of Varnas in terms of Doshic disturbances. Varna, in modern parlance, may be described as an inflammatory process that may lead ulceration and chronic inflammation, promoting all stages of carcinogenesis. Abnormal interactions between Prakriti (genotype) and environmental factors vitiate the Doshas and impair immunity, which can lead to aberrant cell growth and cancer. Moreover, the interaction between vitiated Doshas and weak Dhatus (body tissues) manifests as cancers of a specific organ. Shatkriyakala (six stages of progress of a disease), on the other hand, provides a framework to assess the cancer and its pathogenesis in different stages. According to Ayurvedic concepts, all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas, rejuvenating Dhatus and restoring immunity in cancer patients. The present review describes the six stages of Shatkriyakala in detail, with an emphasis on research areas to validate the concept of Shatkriyakala. This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c0390232447f43b1f07fd250dfeee3dTest
https://pubmed.ncbi.nlm.nih.gov/28285613Test -
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المصدر: Ayu
مصطلحات موضوعية: Ayurvedic research and methodology, medicine.medical_specialty, Modern medicine, Traditional medicine, business.industry, media_common.quotation_subject, Research methodology, Alternative medicine, General Medicine, Review Article, personalized medicine, traditional medicine, Promotion (rank), medicine, Engineering ethics, Personalized medicine, Rasayana, business, media_common, Medical systems
الوصف: Ayurveda is a science of life with a holistic approach to health and personalized medicine. It is one of the oldest medical systems, which comprises thousands of medical concepts and hypothesis. Interestingly, Ayurveda has ability to treat many chronic diseases such as cancer, diabetes, arthritis, and asthma, which are untreatable in modern medicine. Unfortunately, due to lack of scientific validation in various concepts, this precious gift from our ancestors is trailing. Hence, evidence-based research is highly needed for global recognition and acceptance of Ayurveda, which needs further advancements in the research methodology. The present review highlights various fields of research including literary, fundamental, drug, pharmaceutical, and clinical research in Ayurveda. The review further focuses to improve the research methodology for Ayurveda with main emphasis on the fundamental research. This attempt will certainly encourage young researchers to work on various areas of research for the development and promotion of Ayurveda.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37a1bbc1e432afb79847e6f7bcd75893Test
https://pubmed.ncbi.nlm.nih.gov/27833362Test -
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المؤلفون: Rajendra Marathe, Ruchi Badoni Semwal, Sandeep Goyal, Deepak Kumar Semwal, Ashutosh Chauhan, Satyendra Prasad Mishra
المصدر: Medical Sciences, Vol 4, Iss 4, p 16 (2016)
Medical Sciencesمصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Programmed cell death, renal cell carcinoma, lcsh:Medicine, Disease, Review, urologic and male genital diseases, 03 medical and health sciences, 0302 clinical medicine, Renal cell carcinoma, medicine, PI3K/AKT/mTOR pathway, mammalian target of rapamycin, Kidney, business.industry, mitogen activated protein kinase, target therapy, lcsh:R, Cancer, medicine.disease, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Immunology, Cancer research, Signal transduction, business
الوصف: Renal cell carcinoma (RCC) is the most common neoplasm that occurs in the kidney and is marked by a unique biology, with a long history of poor response to conventional cancer treatments. In the past few years, there have been significant advancements to understand the biology of RCC. This has led to the introduction of novel targeted therapies in the management of patients with metastatic disease. Patients treated with targeted therapies for RCC had shown positive impact on overall survival, however, no cure is possible and patients need to undergo treatment for long periods of time, which raises challenges to manage the associated adverse events. Moreover, many patients may not respond to it and even response may not last long enough in the responders. Many inhibitors of the Mammalian target of Rapamycin (mTOR) signaling pathway are currently being used in treatment of advanced RCC. Studies showed that inhibitions of mTOR pathways induce Mitogen-Activated Protein Kinase (MAPK) escape cell death and cells become resistant to mTOR inhibitors. Because of this, there is a need to inhibit both pathways with their inhibitors comparatively for a better outcome and treatment of patients with RCC.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ef7bcc3b61257230c507b2d962a942dTest
http://www.mdpi.com/2076-3271/4/4/16Test -
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المؤلفون: Ramya Ranjan Mishra, Sobha Chandra Rath, Jogeswar Panigrahi, Alok Ranjan Sahu, Satyendra Prasad Mishra
المصدر: The Nucleus. 55:27-35
مصطلحات موضوعية: Cajanus scarabaeoides, food and beverages, Introgression, Cell Biology, Biology, biology.organism_classification, medicine.disease_cause, RAPD, Cajanus, chemistry.chemical_compound, Meiosis, chemistry, Pollen, Molecular marker, Botany, Genetics, medicine, Molecular Medicine, Molecular Biology, Hybrid
الوصف: Cajanus scarabaeoides has many desirable agronomic traits that deserve attention for introgression into pigeonpea cultivars. An inter-specific F1 hybrid was raised using C. cajan (ICP-26) as seed parent and C. scarabaeoides (ICPW-94) as pollen parent. Hybridity of the F1 plant was affirmed by analyzing the morphological attributes, such as seed coat color, leaf shape, brown striations in the petal, pod features, and intermediate branching type etc. Most of the pollen mother cells (PMC) in the F1 hybrid have shown regular meiosis, but in some PMCs chromosome heteromorphism was observed for two pairs of bivalents during diakinesis, leading to precocious separation of bivalents (62.81 %) at metaphase-I, and bridge formation (7.44 %) and laggards (2.48 %) at anaphase-I. SDS-PAGE of two major seed protein fractions (albumin and globulin) detected five polypeptide bands (Mol wt. 40.7, 39.8, 32.4, 23.5 and 19.5 KDa) unique to C. scarabaeoides, the male parent, in the F1 hybrids that evidenced the hybridity of F1 plants. Further, RAPD and ISSR marker analysis revealed the hybrid nature of the putative F1 plant. These analyses showed the inheritance of 28 RAPD and 12 ISSR markers, unique to C. scarabaeoides - the pollen parent, to F1 hybrids. This complementary use of cyto-morphological analysis, and molecular marker based genotyping allowed precise evaluation of the C. cajan × C. scarabaeoides inter-specific hybrid.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::30e9607b0e7107febc3c82eee4575e0bTest
https://doi.org/10.1007/s13237-012-0050-8Test
النص الكامل