المؤلفون: Motonari Fukui, Satoshi Marumo, Yusuke Hayashi

المصدر: Internal Medicine. 2023, 62(11):1635

المؤلفون: Shinya Tsukamoto, Takamasa Kitajima, Satoshi Marumo, Motonari Fukui

المصدر: Respirology Case Reports, Vol 11, Iss 1, Pp n/a-n/a (2023)

مصطلحات موضوعية: lung neoplasms, proton therapy, pulmonary leiomyosarcoma, transbronchial biopsy, transbronchial cryobiopsy, Diseases of the respiratory system, RC705-779

الوصف: Abstract The diagnosis of pulmonary leiomyosarcoma using bronchoscopy is difficult, and surgical resection is often performed for definitive diagnosis and curative therapy. We report a case of pulmonary leiomyosarcoma, successfully diagnosed using repeated transbronchial cryobiopsy (TBCB). A 69‐year‐old‐woman was found to have an oval mass in the left hilar region extending into the left main bronchus on computed tomography (CT). All transbronchial biopsy specimens were necrotic, but repeated TBCB removed the necrotic tissue from the tumour and finally led to the diagnosis of pulmonary leiomyosarcoma. Proton therapy was administered, which caused shrinkage of the tumour. Thus, TBCB is useful for definitive diagnosis of leiomyosarcoma without surgical biopsy. Repeated TBCB can reduce tumour volume, eliminate atelectasis, and reduce the extent of radiotherapy exposure.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2051-3380Test

الوصول الحر: https://doaj.org/article/987c445d93294a0bac7fe25339c230bfTest

المؤلفون: Takamasa Kitajima, Hirotaka Tamesada, Satoshi Marumo, Motonari Fukui

المصدر: Allergology International, Vol 71, Iss 3, Pp 417-419 (2022)

مصطلحات موضوعية: Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1323893022000168Test; https://doaj.org/toc/1323-8930Test

الوصول الحر: https://doaj.org/article/c6c135c7d7654cdd9fcb7a664728790eTest

المؤلفون: Motonari Fukui, Satoshi Marumo, Takamasa Kitajima, Yusuke Hayashi

المصدر: Internal Medicine. 2022, 61(14):2227

المؤلفون: Yusuke Hayashi, Yuko Katayama, Minoru Sakuragi, Ayano Hayashi, Hiroko Kakita, Michihiro Uyama, Satoshi Marumo, Motonari Fukui

المصدر: Journal of Medical Case Reports, Vol 15, Iss 1, Pp 1-6 (2021)

مصطلحات موضوعية: Anti-glomerular basement membrane disease, Double-positive disease, Microscopic polyangiitis, Small cell lung cancer, Medicine

الوصف: Abstract Background The association between a preceding malignancy and the onset of anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) has been reported in several studies. While the co-existence of ANCA and anti-glomerular basement membrane (GBM) antibodies in an individual patient is not a common occurrence, this double-positive disease currently has no optimal treatment method. Herein, we report a case of a double-positive disease involving the sequential development of acute kidney injury (AKI) and diffuse alveolar hemorrhage (DAH) in a patient with small cell lung cancer (SCLC). Case presentation A 75-year-old Japanese woman was diagnosed with small cell lung cancer (cT3N2M1b cStage IV) and received chemotherapy. After one cycle of chemotherapy, she experienced fever and malaise. Her serum creatinine level rapidly increased, and she tested positive for myeloperoxidase (MPO)-ANCA and anti-GBM antibody. She was diagnosed with AKI due to microscopic polyangiitis (MPA) based on renal biopsy. Corticosteroid therapy was initiated, which improved her renal dysfunction. Eight days after she was discharged from the hospital, she complained of dyspnea and bloody sputum, and her condition rapidly progressed to respiratory failure. Upon chest imaging, ground-glass opacities were seen in her bilateral lower lungs. Laboratory examinations after admission revealed a lower MPO-ANCA titer and an elevated anti-GBM antibody titer compared to her previous admission. We diagnosed her with DAH due to an anti-GBM disease. After corticosteroid pulse therapy, plasma exchange was performed five times; her oxygen saturation and chest radiologic findings improved gradually. Following five cycles of plasma exchange, her oxygen saturation recovered to 95% in room air. Conclusions To our knowledge, this is the first reported case of vasculitis caused by MPA and anti-GBM disease leading to the development of AKI and DAH during treatment of SCLC. SCLC, MPA, and anti-GBM disease may occur sequentially. A double-positive disease might have a worse prognosis; therefore, intensive therapy is more likely to achieve a better outcome.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1752-1947Test

الوصول الحر: https://doaj.org/article/10b2b4f1e6704fd8a42f902a383701ecTest

المؤلفون: Sho Yamada, Takamasa Kitajima, Satoshi Marumo, Motonari Fukui

المصدر: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-5 (2021)

مصطلحات موضوعية: Legionnaire’s disease, Bilateral central scotomata, Ocular involvement, Exudative retinal detachment, Case report, Infectious and parasitic diseases, RC109-216

الوصف: Abstract Background Legionnaire’s disease is one of the major causes of community-acquired pneumonia and is occasionally complicated by neurological symptoms. However, reports of ocular lesions due to Legionnaire’s disease are limited. Case presentation We report the case of a patient with Legionnaire’s disease presenting as bilateral central scotomata due to retinal lesions. The patient consulted due to fever and bilateral central scotomata, as well as other extrapulmonary symptoms. Optical coherence tomography (OCT) showed bilateral accumulations of fluid under the retina, and the patient was diagnosed with bilateral exudative retinal detachment. Later, Legionnaire’s disease was confirmed by pulmonary infiltrates on chest imaging and positive urinary antigen for Legionella pneumophila. After administration of antibiotics, the bilateral central scotomata and bilateral subretinal fluid accumulations completely resolved, as did the other extrapulmonary symptoms and the pulmonary infiltrates. Thus, the bilateral central scotomata due to exudative retinal detachment were thought to be caused by Legionnaire’s disease. Conclusions This case demonstrates that Legionnaire’s disease can present as bilateral central scotomata. We may consider the possibility of extrapulmonary involvement complicating Legionnaire’s disease when we encounter bilateral ocular lesions in patients with fever and pneumonia.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1471-2334Test

الوصول الحر: https://doaj.org/article/5ac3430ae4cd4632995c7bb5eadb04abTest

المؤلفون: Motonari Fukui, Satoshi Marumo, Takafumi Nishimura, Toka Hamaguchi, Tomoki Maetani

المصدر: Internal Medicine. 2022, 61(4):527

المؤلفون: Masahiro Shirata, Yuta Yoshimoto, Satoshi Marumo, Kiyoko Tamai, Motonari Fukui

المصدر: International Journal of Infectious Diseases, Vol 97, Iss , Pp 270-277 (2020)

مصطلحات موضوعية: Mycobacteroides abscessus complex, drug susceptibility testing, checkerboard assay, imipenem, Infectious and parasitic diseases, RC109-216

الوصف: Objectives: A standard treatment regimen against Mycobacteroides abscessus complex (MABC) infections has not yet been established, making MABC difficult to treat successfully. In this study, we sought to develop an active ingredient for the clinical treatment of MABC infections. Methods: We screened 102 MABC strains isolated from clinical specimens using DNA sequence analysis with the housekeeping genes hsp65 and rpoB. Drug susceptibility testing was performed against two subspecies—Mycobacteroides abscessus subsp. abscessus (M. abscessus) and Mycobacteroides abscessus subsp. massiliense (M. massiliense)—using eight antimicrobial agents (clarithromycin, amikacin, doxycycline, imipenem, linezolid, moxifloxacin, faropenem, and rifampicin). The combined efficacy of the antimicrobial agents was investigated using a checkerboard method. Results: We identified 51 isolates as M. abscessus, 46 as M. massiliense, and five as others. Most of the M. abscessus isolates (83.0 %) exhibited inducible resistance to clarithromycin via the expression of the erm(41) gene. Combinations of imipenem with linezolid, moxifloxacin, and rifampicin exhibited additive effects against 81.0 %, 40.7 %, and 26.9 % of M. abscessus, respectively, and against 54.5 %, 69.2 %, and 30.8 % of M. massiliense, respectively. Conclusions: These results demonstrated the potential efficacy of a regimen containing imipenem against M. abscessus and M. massiliense infections.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1201971220304422Test; https://doaj.org/toc/1201-9712Test

الوصول الحر: https://doaj.org/article/ea011a74ee2e46ef84c65b67127028d6Test

المؤلفون: Akihiro Ito, Isao Ito, Daiki Inoue, Satoshi Marumo, Tetsuya Ueda, Hiroaki Nakagawa, Masato Taki, Atsushi Nakagawa, Shuji Tatsumi, Takashi Nishimura, Tetsuhiro Shiota, Tadashi Ishida

المصدر: International Journal of Infectious Diseases, Vol 92, Iss , Pp 228-233 (2020)

مصطلحات موضوعية: Infectious and parasitic diseases, RC109-216

الوصف: Objectives: The usefulness of serial procalcitonin (PCT) measurements for predicting the prognosis and treatment efficacy for hospitalised community-acquired pneumonia (CAP) patients was investigated. Methods: This prospective, multicentre, cohort study enrolled consecutive CAP patients who were hospitalised at 10 hospitals in western Japan from September 2013 to September 2016. PCT and C-reactive protein (CRP) were measured on admission (PCT D1 and CRP D1), within 48–72 h after admission (PCT D3 and CRP D3), and within 144–192 h after admission. CURB-65 and the Pneumonia Severity Index (PSI) were assessed on admission. The primary outcome was 30-day mortality; secondary outcomes were early and late treatment failure rates. Results: A total of 710 patients were included. The 30-day mortality rate was 3.1%. On multivariate analysis, only PCT D3/D1 ratio >1 [odds ratio (95% confidence interval): 4.33 (1.46–12.82),P = 0.008] and PSI [odds ratio (95% confidence interval): 2.32 (1.07–5.03), P = 0.03] were significant prognostic factors. Regarding treatment efficacy, PCT D3/D1 >1 was a significant predictor of early treatment failure on multivariate analysis. PCT D3/D1 with the PSI significantly improved the prognostic accuracy over that of the PSI alone. Conclusions: PCT should be measured consecutively, not only on admission, to predict the prognosis and treatment efficacy in CAP. Keywords: Biomarker, C-reactive protein, Pneumonia, Procalcitonin, Prognosis

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S1201971220300205Test; https://doaj.org/toc/1201-9712Test

الوصول الحر: https://doaj.org/article/109c1aa0f9ca4f39ae310faf6ed944e2Test

المؤلفون: Akihiro Ueda, Daiki Inoue, Sadayuki Matsumoto, Satoshi Marumo, Tomokazu Nakagawa, Yujiro Kikuchi, Yuwa Oka

المصدر: Internal Medicine. 2021, 60(19):3167