المؤلفون: Salgado Fuentes, Blanca, Viúdez Pareja, Cristina

المصدر: Encuentros en la Biología; Vol. 14 Núm. 177 (2021): Primavera 2021; 16-18 ; 2254-0296 ; 1134-8496

الوصف: Aging is a complex and high-impact process, closely related to oxidative stress and ROS generation. The role of ROS in aging has been controversial; nevertheless, its influence on this phenomenon is clear. Thus, ROS research is expected to bring new perspectives and solutions to a widespread process which is a risk factor for multiple pathologies. ; El envejecimiento es un proceso complejo y de gran impacto, que está estrechamente relacionado con el estrés oxidativo y la generación de especies reactivas de oxígeno (del inglés ROS). El papel de las ROS en el envejecimiento ha sido motivo de controversia; no obstante, su implicación en este fenómeno es clara, de modo que se espera que su estudio proporcione nuevas perspectivas en el abordaje de un proceso que no sólo es un factor de riesgo para múltiples enfermedades, sino que además, nos atañe a todos.

وصف الملف: application/pdf

العلاقة: https://revistas.uma.es/index.php/enbio/article/view/16696/16848Test; https://revistas.uma.es/index.php/enbio/article/view/16696Test

الإتاحة: https://doi.org/10.24310/enbio.v14i177.16696Test
https://revistas.uma.es/index.php/enbio/article/view/16696Test

المؤلفون: Salgado Fuentes, Blanca, Sastre, Isabel, Bullido Gómez-Heras, María Jesús, Aldudo, Jesús

المساهمون: UAM. Departamento de Biología Molecular

مصطلحات موضوعية: Human Alphaherpesvirus 1, Infection, Fungus Antibody, Biología y Biomedicina / Biología

الوصف: An increasing body of evidence strongly suggests that infections or reactivations of herpes simplex virus type 1 (HSV-1) may be closely linked to Alzheimer’s disease (AD). Promising results have been obtained using cell and animal models of HSV-1 infection, contributing to the understanding of the molecular mechanisms linking HSV-1 infection and AD neurodegeneration. ReNcell VM is a human neural stem cell line that has been used as a model system to study the impact of various infectious agents on the central nervous system. In this study, we demonstrate the suitability of the ReNcell VM cell line for developing a new in vitro model of HSV-1 infection. By following standard differentiation protocols, we were able to derive various nervous cell types, including neurons, astrocytes, and oligodendrocytes, from neural precursors. Additionally, we demonstrated the susceptibility of ReNcell VM cells, including precursor and differentiated cells, to HSV-1 infection and subsequent viral-induced AD-like neurodegeneration. Our findings support the use of this cell line to generate a new research platform for investigating AD neuropathology and its most significant risk factors, which may lead to important discoveries in the context of this highly impactful disease ; This work was funded by the Spanish Ministerio de Ciencia e Innovación (PID2020-113921RBI00)

وصف الملف: application/pdf

العلاقة: Microorganisms; https://doi.org/10.3390/microorganisms11051205Test; Gobierno de España. PID2020-113921RB-I00; Microorganisms 11.5 (2023): 1205; 2076-2607 (online); http://hdl.handle.net/10486/707939Test; 1205-1; 1205-18; 11

الإتاحة: https://doi.org/10.3390/microorganisms11051205Test
http://hdl.handle.net/10486/707939Test