المؤلفون: Sales Luis, M, Alcafache, M, Ferreira, S, Fitas, AL, Simões Pereira, J, Caramalho, I, Lopes, L, Limbert, C

مصطلحات موضوعية: Adolescent, Age of Onset, Autoantibodies, Autoimmune Diseases, Biomarkers, Blood Glucose, C-Peptide, Child, Preschool, Diabetes Mellitus, Type 1, Diabetic Ketoacidosis, Female, Follow-Up Studies, Glycated Hemoglobin A, Humans, Hypoglycemic Agents, Infant, Newborn, Insulin, Male, Phenotype, Prognosis, Retrospective Studies, HDE END PED

الوصف: Objectives We aimed to evaluate children with type 1 diabetes (T1D) with early age at onset (EAO) for clinical, immune and metabolic features in order to identify age-related disease phenotypes. Methods Comparative study of two groups of T1D children: EAO (≤5 years) and later age at onset (LAO; >5 years), regarding the presence of other autoimmune (AI) diseases, diabetes ketoacidosis and immunologic profile at onset and metabolic data 1 year after diagnosis. Statistical analysis was performed with significance set for p < 0.05. Results The study included 137 children (EAO = 52, mean age 3.6 ± 1.5 [mean ± standard deviation (SD)] and LAO = 85, mean age 10.4 ± 2.9). EAO was more associated with concomitant AI diseases (p = 0.032). Despite no differences in disease onset, EAO presented with lower C-peptide levels (p = 0.01) and higher absolute lymphocyte number (p < 0.0001), with an inverse correlation between these two variables (p = 0.028). Additionally, the EAO group had a higher frequency of serum detection of three antibodies (Abs) (p = 0.0008), specifically insulin Abs (p = 0.0001). One year after diagnosis, EAO had higher total daily insulin (TDI) dose (p = 0.008), despite similar hemoglobin A1c (HbA1c). Conclusions Our data show an association of EAO T1D with more AI diseases, higher number of Abs, lower initial insulin reservoir and higher insulin requirements 1 year after diagnosis. In this group, immune imbalance seems more evident and disease progression faster, probably reflecting distinct "immune environment" with different ages at disease onset. Further studies in the field of immunogenetics and immune tolerance are required, to improve patient stratification and find novel targets for therapeutic intervention. ; info:eu-repo/semantics/publishedVersion

العلاقة: J Pediatr Endocrinol Metab.2019;32(9):935-941; http://hdl.handle.net/10400.17/3747Test

الإتاحة: https://doi.org/10.1515/jpem-2019-0103Test
http://hdl.handle.net/10400.17/3747Test

المؤلفون: Sampaio, C, Castro-Caldas, A, Sales-Luis, M I, Alves, M, Pinto, L, Apolinario, P

مصطلحات موضوعية: Research Article

وصف الملف: text/html

العلاقة: http://jnnp.bmj.com/cgi/content/short/56/2/220Test; http://dx.doi.org/10.1136/jnnp.56.2.220Test

الإتاحة: https://doi.org/10.1136/jnnp.56.2.220Test
http://jnnp.bmj.com/cgi/content/short/56/2/220Test

المؤلفون: de Carvalho, Mamede, Conceiçato, Isabel, Bentes, Carla, Sales Luis, M. L.

المصدر: Amyloid ; volume 9, issue 2, page 126-133 ; ISSN 1350-6129 1744-2818

الإتاحة: https://doi.org/10.3109/13506120208995245Test

المؤلفون: de Carvalho, M., Miranda, P. C., de Lourdes Sales Luís, M., Ducla-Soares, E.

المصدر: Journal of Neurology ; volume 247, issue 3, page 189-194 ; ISSN 0340-5354 1432-1459

مصطلحات موضوعية: Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1007/s004150050561Test

المؤلفون: Schulte-Mattler, Wilhelm J., Zierz, Stephan, Lensch, Eckart, Faust, Justus, Nix, Wilfred A., Wandel, Eveline, Hanajima, Ritsuko, Kawai, Mitsuru, Yamamoto, Masahiko, Hamada, Kyoko, Shimokawa, Masatake, Kobayashi, Takayoshi, de Carvalho, Mamede, Ferro, Jos�, Sales Luis, M. L., Vita, Giuseppe, Monici, Maria C., Toscano, Antonio, Messina, Corrado

المصدر: Muscle & Nerve ; volume 19, issue 7, page 926-931 ; ISSN 0148-639X 1097-4598

الإتاحة: https://doi.org/10.1002/mus.880190703Test

المؤلفون: Mendonça, Erica, Albuquerque, Luisa, Jácome, Luís, Lurdes Sales Luís, M., Coelho Rosa, F.

المصدر: Nephron ; volume 72, issue 1, page 98-99 ; ISSN 1660-8151 2235-3186

الإتاحة: https://doi.org/10.1159/000188814Test
https://www.karger.com/Article/Pdf/188814Test

المؤلفون: Bensimon, G., Borasio, G., Bossuyt, P. M.M., Brooks, B. R., Camu, W., Chio, A., Conradi, S., Dengler, R., Doble, A., Emery, A. E.H., Hardiman, O., Illa, I., De Jong, J. M.B.V., Kievid, A., Ludolph, A., Markland, C., Meininger, V., Mellinik, M. P., Miller, R. G., Mora, J., Ochs, G., Pouget, J., Robberecht, W., De Sales Luis, M., Shaw, P., Silani, V., Swash, M., Wokke, J. H.J.

المساهمون: Epidemiology and Data Science, APH - Methodology, APH - Personalized Medicine

المصدر: Neuromuscular disorders, 7(6-7), 404-406. Elsevier Limited

مصطلحات موضوعية: medicine.medical_specialty, Veterinary medicine, Clinical research, Drug trial, Neurology, business.industry, Family medicine, Pediatrics, Perinatology and Child Health, Alternative medicine, medicine, Neurology (clinical), business, Genetics (clinical)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c1dbe4f26895cc037ae2e3fa674f2caTest
https://pure.amc.nl/en/publications/48th-enmc-international-workshopTest(dadd36ad-d90e-403d-8ccb-9696e8d0393d).html

المؤلفون: Oey, P. L., Franssen, H., Bernsen, R. A. J. A. M., Wokke, J. H. J., Sales‐Luís, M. L., Galvão, M., Carvalho, M., Sousa, G., Alves, M. M., Serrão, R., Preston, David C., Logigian, Eric L., Yarnitsky, David, Ochoa, Jose L., Van, J. Gert, Rivner, Michael H., Swift, Thomas R., Crout, Barbara O., Rhodes, Karen P.

المصدر: Muscle & Nerve ; volume 14, issue 4, page 375-382 ; ISSN 0148-639X 1097-4598

الإتاحة: https://doi.org/10.1002/mus.880140413Test

المؤلفون: Carvalho, M, Alves, M, Sales-Luís, M L

المصدر: oai:ojs.www.actamedicaportuguesa.com:article/3378

الوصف: Phrenic nerve conduction was studied in 19 volunteers using two different percutaneous methods of stimulation, mono and bipolar. A response was obtained in all nerves studied. The results are comparable using mono or bipolar stimulation method. No significant difference in latency, amplitude, or intensity stimulation applied was found between left and right sides. There was no correlation of age or height with the latency. Latencies above 10 ms or differences between right and left above 1.6 ms are abnormal values. We studied two patients with neurological disorders, one of them with Guillain-Barré syndrome and the other with a bulbar form of Amyotrophic Lateral Sclerosis and respiratory failure. Both of them had prolonged conduction time. This method permits reliable analysis of localized phrenic lesions and abnormalities induced in either the phrenic nerveor diaphragm by generalized disease processes.

الوصف (مترجم): Phrenic nerve conduction was studied in 19 volunteers using two different percutaneous methods of stimulation, mono and bipolar. A response was obtained in all nerves studied. The results are comparable using mono or bipolar stimulation method. No significant difference in latency, amplitude, or intensity stimulation applied was found between left and right sides. There was no correlation of age or height with the latency. Latencies above 10 ms or differences between right and left above 1.6 ms are abnormal values. We studied two patients with neurological disorders, one of them with Guillain-Barré syndrome and the other with a bulbar form of Amyotrophic Lateral Sclerosis and respiratory failure. Both of them had prolonged conduction time. This method permits reliable analysis of localized phrenic lesions and abnormalities induced in either the phrenic nerveor diaphragm by generalized disease processes.

وصف الملف: application/pdf

العلاقة: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3378Test; https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3378/2704Test

الإتاحة: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3378Test

المؤلفون: Sales Luís, M L, Pinto, F

المصدر: oai:ojs.www.actamedicaportuguesa.com:article/3091

وصف الملف: application/pdf

العلاقة: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3091Test; https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3091/2433Test

الإتاحة: https://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/3091Test