المؤلفون: Sakurai, Fumie, Yukawa, Takafumi, Kina, Asato, Murakami, Masataka, Takami, Kazuaki, Morimoto, Sachie, Seto, Masaki, Kamata, Makoto, Yamashita, Tohru, Nakashima, Kosuke, Narita, Naohiro, Bettini, Ezio, Ugolini, Annarosa, Corsi, Mauro, Hasui, Tomoaki

المصدر: Bioorganic & Medicinal Chemistry ; volume 56, page 116576 ; ISSN 0968-0896

مصطلحات موضوعية: Organic Chemistry, Clinical Biochemistry, Drug Discovery, Pharmaceutical Science, Molecular Biology, Molecular Medicine, Biochemistry

الإتاحة: https://doi.org/10.1016/j.bmc.2021.116576Test
https://api.elsevier.com/content/article/PII:S0968089621005848?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0968089621005848?httpAccept=text/plainTest

المؤلفون: Sakurai, Fumie, Khutia, Anupam, Kikuchi, Takashi, Fujita, Makoto

المساهمون: Accelerated Innovation Research Initiative Turning Top Science and Ideas into High-Impact Values

المصدر: Chemistry – A European Journal ; volume 23, issue 60, page 15035-15040 ; ISSN 0947-6539 1521-3765

الوصف: Crystalline sponges (CS) used under a set of standard conditions have often failed to give viable N‐containing nucleophilic compounds. Despite the high affinity of these nucleophiles to the binding sites of the CS, N‐containing compounds considerably harm the coordination framework of the CS during the guest‐soaking step. Herein, it is disclosed that these compounds are efficiently absorbed into the CS, without harming the host, under mild conditions (<4 °C, <2 μg) that normally do not work for common organic guests. Moreover, the use of ZnCl 2 as the metal component of CS significantly improved the tolerance and robustness of the host framework toward N‐containing compounds. Out of 22 drug (or drug‐like) N‐containing compounds chosen from the WHO model list of essential medicines, we succeeded in analyzing 17 analytes with the modified protocols and/or by using the ZnCl 2 ‐noded CS. This demonstrates that the CS method is now a practical tool for drug‐discovery research in pharmaceutical industries.

الإتاحة: https://doi.org/10.1002/chem.201704176Test

المؤلفون: Hamasaka, Go, Sakurai, Fumie, Uozumi, Yasuhiro

المساهمون: JST-CREST, JST-ACCEL

المصدر: Tetrahedron ; volume 71, issue 37, page 6437-6441 ; ISSN 0040-4020

مصطلحات موضوعية: Organic Chemistry, Drug Discovery, Biochemistry

الإتاحة: https://doi.org/10.1016/j.tet.2015.04.108Test
https://api.elsevier.com/content/article/PII:S0040402015006353?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0040402015006353?httpAccept=text/plainTest

المؤلفون: Sakurai, Fumie, Yukawa, Takafumi, Taniguchi, Takahiko

المصدر: Organic Letters ; volume 21, issue 18, page 7254-7257 ; ISSN 1523-7060 1523-7052

مصطلحات موضوعية: Organic Chemistry, Physical and Theoretical Chemistry, Biochemistry

الإتاحة: https://doi.org/10.1021/acs.orglett.9b02482Test

المؤلفون: Wada, Naoki, Kersten, Roland D., Iwai, Takahiro, Lee, Shoukou, Sakurai, Fumie, Kikuchi, Takashi, Fujita, Daishi, Fujita, Makoto, Weng, Jing‐Ke

المساهمون: Life Sciences Research Foundation, Pew Charitable Trusts, Kinship Foundation

المصدر: Angewandte Chemie International Edition ; volume 57, issue 14, page 3671-3675 ; ISSN 1433-7851 1521-3773

الوصف: Characterization of complex natural product mixtures to the absolute structural level of their components often requires significant amounts of starting materials and lengthy purification process, followed by arduous structure elucidation efforts. The crystalline sponge (CS) method has demonstrated utility in the absolute structure elucidation of isolated organic compounds at miniscule quantities compared to conventional methods. In this work, we developed a new CS‐based workflow that greatly expedites the in‐depth structural analysis of crude natural product extracts. Using a crude extract of the red alga Laurencia pacifica , we showed that CS affinity screening prior to compound isolation enables prioritization of analytes present in the extract, and we subsequently resolved the molecular structures of six sesquiterpenes with stereochemical clarity from around 10 mg crude extract. This study demonstrates a new chemotyping workflow that can greatly accelerate natural product discovery from complex samples.

الإتاحة: https://doi.org/10.1002/anie.201713219Test

المؤلفون: Kai, Kenji, Sogame, Mai, Sakurai, Fumie, Nasu, Norihiro, Fujita, Makoto

المساهمون: Ministry of Education, Culture, Sports, Science and Technology

المصدر: Organic Letters ; volume 20, issue 12, page 3536-3540 ; ISSN 1523-7060 1523-7052

الإتاحة: https://doi.org/10.1021/acs.orglett.8b01311Test

المؤلفون: Hamasaka, Go, Sakurai, Fumie, Uozumi, Yasuhiro

المصدر: ChemInform ; volume 46, issue 28 ; ISSN 0931-7597 1522-2667

الإتاحة: https://doi.org/10.1002/chin.201528052Test

المؤلفون: Sakurai, Fumie, Hamasaka, Go, Uozumi, Yasuhiro

المصدر: Dalton Transactions ; volume 44, issue 17, page 7828-7834 ; ISSN 1477-9226 1477-9234

الوصف: Two amphiphilic palladium NNC-pincer complexes bearing hydrophilic tri(ethylene glycol) chains and hydrophobic dodecyl chains were designed and prepared for the development of a new aquacatalytic system.

الإتاحة: https://doi.org/10.1039/c5dt00434aTest
http://pubs.rsc.org/en/content/articlepdf/2015/DT/C5DT00434ATest

المؤلفون: Hamasaka, Go, Sakurai, Fumie, Uozumi, Yasuhiro

المصدر: Chemical Communications ; volume 51, issue 18, page 3886-3888 ; ISSN 1359-7345 1364-548X

الوصف: Allylic arylation of allylic acetates by sodium tetraarylborates in the presence of ppb to ppm (molar) loadings of a palladium NNC-pincer complex catalyst in methanol at 50 °C gave the corresponding arylated products in excellent yields.

الإتاحة: https://doi.org/10.1039/c4cc09726bTest
http://pubs.rsc.org/en/content/articlepdf/2015/CC/C4CC09726BTest

المؤلفون: Uozumi, Yasuhiro, Sakurai, Fumie

المصدر: Synfacts ; volume 8, issue 09, page 1034-1034 ; ISSN 1861-1958 1861-194X

الإتاحة: https://doi.org/10.1055/s-0032-1317051Test