المؤلفون: Saisai Ji, Yingli Qu, Qi Sun, Feng Zhao, Yidan Qiu, Zheng Li, Yawei Li, Haocan Song, Miao Zhang, Wenli Zhang, Hui Fu, Jiayi Cai, Zhuona Zhang, Ying Zhu, Zhaojin Cao, Yuebin Lv, Xiaoming Shi

مصطلحات موضوعية: Biochemistry, Genetics, Molecular Biology, Science Policy, Environmental Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, mediation analyses showed, 90 ), respectively, serum alanine aminotransferase, alt mediated 4, 33 ), 45 ), serum alt, aspartate aminotransferase, urinary total, study suggested, sectional study, reported regarding, positively associated, past year, moderate arsenic, mediating role, mediating analysis, lowest quartile, liver dysfunction, liver disease, fourth quartiles

الوقت: 1

الوصف: Inconsistent results have been reported regarding the association between low-to-moderate arsenic (As) exposure and diabetes. The effect of liver dysfunction on As-induced diabetes remains unclear. The cross-sectional study included 10,574 adults from 2017–2018 China National Human Biomonitoring. Urinary total As (TAs) levels were analyzed as markers of As exposure. Generalized linear mixed models and restricted cubic splines models were used to examine the relationships among TAs levels, serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) concentrations, and diabetes prevalence. Mediating analysis was performed to assess whether liver dysfunction mediated the association between TAs and diabetes. Overall, the OR (95% CI) of diabetes in participants in the second, third, and fourth quartiles of TAs were 1.08 (0.88, 1.33), 1.17 (0.94, 1.45), and 1.52 (1.22, 1.90), respectively, in the fully adjusted models compared with those in the lowest quartile. Serum ALT was positively associated with TAs and diabetes. Additionally, mediation analyses showed that ALT mediated 4.32% of the association between TAs and diabetes in the overall population and 8.86% in the population without alcohol consumption in the past year. This study suggested that alleviating the hepatotoxicity of As could have implications for both diabetes and liver disease.

العلاقة: https://figshare.com/articles/journal_contribution/Mediating_Role_of_Liver_Dysfunction_in_the_Association_between_Arsenic_Exposure_and_Diabetes_in_Chinese_Adults_A_Nationwide_Cross-Sectional_Study_of_China_National_Human_Biomonitoring_CNHBM_2017_2018/25104178Test

الإتاحة: https://doi.org/10.1021/acs.est.3c08718.s001Test
https://figshare.com/articles/journal_contribution/Mediating_Role_of_Liver_Dysfunction_in_the_Association_between_Arsenic_Exposure_and_Diabetes_in_Chinese_Adults_A_Nationwide_Cross-Sectional_Study_of_China_National_Human_Biomonitoring_CNHBM_2017_2018/25104178Test

المؤلفون: Chenglong Fei, Lei Liu, Hedong Qi, Yuyang Peng, Jingfen Han, Chunru Wang, Xue Li

مصطلحات موضوعية: Biochemistry, Medicine, Microbiology, Cell Biology, Molecular Biology, Physiology, Immunology, Space Science, Chemical Sciences not elsewhere classified, nuclear factor kappa, mediated hepatic injury, inevitable undesired outcomes, induced hepatocyte apoptosis, hepatic inflammation contributes, findings may open, serum alanine aminotransferase, decorated fullerene nanoparticle, thus ameliorating immune, inhibiting inflammatory cytokines, f primarily distributes, aggravate liver damage, inflammatory cytokines, fullerene materials, aspartate aminotransferase, severe immune, immune homeostasis, alleviate immune, subsequently suppresses, signal pathway, novel avenues

الوصف: Autoimmune hepatitis (AIH) is a severe immune-mediated inflammatory liver disease whose standard of care is immunosuppressive treatment with inevitable undesired outcomes. Macrophage is acknowledged to aggravate liver damage, providing a promising AIH therapeutic target. Accordingly, in this study, a kind of curdlan-decorated fullerene nanoparticle (Cur-F) is fabricated to alleviate immune-mediated hepatic injury for treating AIH via reducing macrophage infiltration in a concanavalin A (Con A)-induced AIH mouse model. After intravenous administration, Cur-F primarily distributes in liver tissues, efficiently eliminates the excessive reactive oxygen species, significantly attenuates oxidative stress, and subsequently suppresses the nuclear factor kappa-B-gene binding (NF-κB) signal pathway, resulting in the lowered production of pro-inflammatory cytokines and the balancing of the immune homeostasis with the prevention of macrophage infiltration in the liver. The regulation of hepatic inflammation contributes to inhibiting inflammatory cytokines-induced hepatocyte apoptosis, decreasing the serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) contents and thus ameliorating immune-mediated hepatic injury. Notably, there is no detectable toxicity to the body. Our findings may open up novel avenues for AIH based on curdlan and fullerene materials.

العلاقة: https://figshare.com/articles/journal_contribution/Curdlan-Decorated_Fullerenes_Mitigate_Immune-Mediated_Hepatic_Injury_for_Autoimmune_Hepatitis_Therapeutics_via_Reducing_Macrophage_Infiltration/25058842Test

الإتاحة: https://doi.org/10.1021/acsami.3c16168.s001Test
https://figshare.com/articles/journal_contribution/Curdlan-Decorated_Fullerenes_Mitigate_Immune-Mediated_Hepatic_Injury_for_Autoimmune_Hepatitis_Therapeutics_via_Reducing_Macrophage_Infiltration/25058842Test

المؤلفون: Roy, Shapna Rani, Sarkar, Chandra Rani, Zahid, ATM Zoadur Rahim, Ahmed, Neaz

المصدر: Journal of Rangpur Medical College; Vol. 8 No. 1 (2023); 65-68 ; 2618-0413

مصطلحات موضوعية: Tobacco smoker, Serum alanine aminotransferase and alkaline phosphatase

الوقت: Bangladesh

الوصف: Background: The use of tobacco has been significantly increased globally in recent decades. Easy availability and the low price gives rise to high consumption of tobacco smoking. Tobacco use is a leading preventable cause of premature mortality and morbidity. Previous studies described the detrimental effects of tobacco smoking on liver function. Objectives: To observe the effects of tobacco consumption on the levels of serum alanine aminotransferase and alkaline phosphatase levels in smokers. Methods: The cross-sectional analytical study was conducted from January 2017 to January 2018 in the department of physiology, Rangpur Medical College, Rangpur. A total number of 60 subjects were selected, among them 30 were apparently healthy non-tobacco chewer non-smoker subjects as control group ( group A) and 30 were apparently healthy smoker non-tobacco chewer subjects ( group B). The subjects were selected from different area of Rangpur city. The effects of cigarette smoking on liver function were studied by measuring the levels of serum alanine aminotransferase and alkaline phosphatase levels. For statistical analysis independent sample “t” test was performed by computer based software SPSS-17.0 version for windows. Results: Serum alanine aminotransferase and alkaline phosphatase levels were significantly higher (p<0.001) in smoker non-tobacco chewer subjects as compared with the healthy control subjects. Conclusion: The increased serum alanine aminotransferase and alkaline phosphatase levels in smoker non-tobacco chewer subjects were evidence of development of liver function impairment due to tobacco smoking and this might offer a new preventive approach to liver function impairment in population with tobacco smoking. J Rang Med Col. March 2023; Vol. 8, No. 1:65-68

وصف الملف: application/pdf

العلاقة: https://www.banglajol.info/index.php/JRPMC/article/view/65063/44182Test; https://www.banglajol.info/index.php/JRPMC/article/view/65063Test

الإتاحة: https://www.banglajol.info/index.php/JRPMC/article/view/65063Test

المؤلفون: Bollerup, Signe, Engsig, Frederik, Hallager, Sofie, Mocroft, Amanda, Roege, Birgit T., Christensen, Peer B., Laursen, Alex L., Krarup, Henrik, Clausen, Mette R., Thielsen, Peter, Madsen, Lone G., Noerregaard, Lars, Barfod, Toke S., Balslev, Ulla, Tarp, Britta, Hansen, Jesper B., Mygind, Lone H., Gerstoft, Jan, Weis, Nina

المصدر: Bollerup , S , Engsig , F , Hallager , S , Mocroft , A , Roege , B T , Christensen , P B , Laursen , A L , Krarup , H , Clausen , M R , Thielsen , P , Madsen , L G , Noerregaard , L , Barfod , T S , Balslev , U , Tarp , B , Hansen , J B , Mygind , L H , Gerstoft , J & Weis , N 2022 , ' Incidence of Hepatocellular Carcinoma and Decompensated Liver Cirrhosis and Prognostic Accuracy of the ....

مصطلحات موضوعية: hepatitis B virus, viral hepatitis, Scandinavia, morbidity, nationwide, SERUM ALANINE AMINOTRANSFERASE, ANTIVIRAL TREATMENT, UPPER LIMITS, PROGRESSION, CAUCASIANS, MANAGEMENT, PREDICTS, OUTCOMES, DISEASE, HBEAG

الوصف: Purpose: We aimed to determine incidence of hepatocellular carcinoma (HCC) and decompensated liver cirrhosis in persons with chronic hepatitis B virus (HBV) infection in Denmark stratified by disease phase, liver cirrhosis, and treatment status at baseline. Additionally, we aimed to assess the prognostic value of the PAGE-B HCC risk score in a mainly non-cirrhotic population. Patients and Methods: In this register-based cohort study, we included all individuals over the age of 18, with chronic HBV infection first registered between 2002 and 2016 in at least one of three nationwide registers. The study population was followed until HCC, decompensated liver cirrhosis, death, emigration, or December 31, 2017, which ever came first. Results: Among 6016 individuals included in the study, 10 individuals with and 23 without baseline liver cirrhosis developed HCC during a median follow up of 7.3 years (range 0.0-15.5). This corresponded to five-year cumulative incidences of 7.1% (95% confidence interval (CI) 2.0-12.3) and 0.2% (95% CI 0.1-0.4) in persons with and without baseline liver cirrhosis. The five-year cumulative incidence of decompensated liver cirrhosis was 0.7% (95% CI 0.5-1.0). Among 2038 evaluated for liver events stratified by disease phase, incidence of HCC was low in all who were non-cirrhotic and untreated for HBV at baseline. PAGE-B score was evaluated in 1529 persons. The 5-year cumulative incidence of HCC was 0, 0.8 (95% CI 0.5-1.8), and 8.7 (95% CI 1.0-16.4) in persons scoring 17, respectively (c-statistic 0.91 (95% CI 0.84-0.98)). Conclusion: We found low incidence of HCC and decompensated liver cirrhosis in persons with chronic HBV infection in Denmark. Moreover, the PAGE-B score showed good accuracy for five-year risk of developing HCC in the population with chronic HBV infection in Denmark.

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.2147/JHC.S372571Test
https://curis.ku.dk/portal/da/publications/incidence-of-hepatocellular-carcinoma-and-decompensated-liver-cirrhosis-and-prognostic-accuracy-of-the-pageb-hcc-risk-score-in-a-low-endemic-hepatitis-b-virus-infected-populationTest(68eb61ba-40a7-421f-a53d-91d09c0e8809).html
https://curis.ku.dk/ws/files/344910437/JHC_372571_incidence_of_hepatocellular_carcinoma_and_decompensated_live.pdfTest

المؤلفون: Yang Li, Qiu Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Science Policy, Virology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wide association study, sup >&# 8722, single nucleotide polymorphisms, potential biological mechanisms, pleiotropy residual sum, multivariable mendelian randomization, 5 × 10, serum aspartate aminotransferase, serum alanine aminotransferase, wide significance (<, independent causal effect, diabetic microvascular complications, alp ), gamma, 206 – 1, 115 – 1, univariable mendelian randomization, three mvmr approaches, previous observational investigations, five uvmr approaches, diabetes risk factors, independent causal effects

الوصف: (A) Forest plot showed the UVMR estimations of DR on ALT and AST. (B) Forest plot showed the UVMR estimations of T2DM with DR on ALT and AST. (TIF)

العلاقة: https://figshare.com/articles/figure/Bidirectional_MR_analysis_revealed_no_reversal_causal_effects_of_DR_on_ALT_and_AST_/25015105Test

الإتاحة: https://doi.org/10.1371/journal.pone.0296894.s006Test
https://figshare.com/articles/figure/Bidirectional_MR_analysis_revealed_no_reversal_causal_effects_of_DR_on_ALT_and_AST_/25015105Test

المؤلفون: Yang Li, Qiu Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Science Policy, Virology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wide association study, sup >&# 8722, single nucleotide polymorphisms, potential biological mechanisms, pleiotropy residual sum, multivariable mendelian randomization, 5 × 10, serum aspartate aminotransferase, serum alanine aminotransferase, wide significance (<, independent causal effect, diabetic microvascular complications, alp ), gamma, 206 – 1, 115 – 1, univariable mendelian randomization, three mvmr approaches, previous observational investigations, five uvmr approaches, diabetes risk factors, independent causal effects

الوصف: (A) is for ALT on DR overall. (B) is for ALT on T2DM with DR. (C) is for AST on DR overall. (D) is for AST on T2DM with DR. (TIF)

العلاقة: https://figshare.com/articles/figure/Scatter_plots_displayed_the_casual_effects_of_serum_ALT_and_AST_levels_on_the_risk_of_DR_overall_and_T2DM_with_DR_/25015093Test

الإتاحة: https://doi.org/10.1371/journal.pone.0296894.s002Test
https://figshare.com/articles/figure/Scatter_plots_displayed_the_casual_effects_of_serum_ALT_and_AST_levels_on_the_risk_of_DR_overall_and_T2DM_with_DR_/25015093Test

المؤلفون: Yang Li, Qiu Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Science Policy, Virology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wide association study, sup >&# 8722, single nucleotide polymorphisms, potential biological mechanisms, pleiotropy residual sum, multivariable mendelian randomization, 5 × 10, serum aspartate aminotransferase, serum alanine aminotransferase, wide significance (<, independent causal effect, diabetic microvascular complications, alp ), gamma, 206 – 1, 115 – 1, univariable mendelian randomization, three mvmr approaches, previous observational investigations, five uvmr approaches, diabetes risk factors, independent causal effects

الوصف: (A) is for ALT on DR overall. (B) is for ALT on T2DM with DR. (C) is for AST on DR overall. (D) is for AST on T2DM with DR. (TIF)

العلاقة: https://figshare.com/articles/figure/The_symmetry_of_funnel_plots_indicated_a_balanced_pleiotropy_/25015096Test

الإتاحة: https://doi.org/10.1371/journal.pone.0296894.s003Test
https://figshare.com/articles/figure/The_symmetry_of_funnel_plots_indicated_a_balanced_pleiotropy_/25015096Test

المؤلفون: Yang Li, Qiu Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Science Policy, Virology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wide association study, sup >&# 8722, single nucleotide polymorphisms, potential biological mechanisms, pleiotropy residual sum, multivariable mendelian randomization, 5 × 10, serum aspartate aminotransferase, serum alanine aminotransferase, wide significance (<, independent causal effect, diabetic microvascular complications, alp ), gamma, 206 – 1, 115 – 1, univariable mendelian randomization, three mvmr approaches, previous observational investigations, five uvmr approaches, diabetes risk factors, independent causal effects

الوصف: (A) is for AST on DR overall. (B) is for AST on T2DM with DR. (TIF)

العلاقة: https://figshare.com/articles/figure/Leave-one-out_results_demonstrated_no_individual_SNPs_that_could_significantly_affect_the_causal_effects_of_AST_on_DR_/25015102Test

الإتاحة: https://doi.org/10.1371/journal.pone.0296894.s005Test
https://figshare.com/articles/figure/Leave-one-out_results_demonstrated_no_individual_SNPs_that_could_significantly_affect_the_causal_effects_of_AST_on_DR_/25015102Test

المؤلفون: Yang Li, Qiu Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Science Policy, Virology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wide association study, sup >&# 8722, single nucleotide polymorphisms, potential biological mechanisms, pleiotropy residual sum, multivariable mendelian randomization, 5 × 10, serum aspartate aminotransferase, serum alanine aminotransferase, wide significance (<, independent causal effect, diabetic microvascular complications, alp ), gamma, 206 – 1, 115 – 1, univariable mendelian randomization, three mvmr approaches, previous observational investigations, five uvmr approaches, diabetes risk factors, independent causal effects

الوصف: Detailed information for the datasets of the exposures and outcomes.

العلاقة: https://figshare.com/articles/dataset/Detailed_information_for_the_datasets_of_the_exposures_and_outcomes_/25015108Test

الإتاحة: https://doi.org/10.1371/journal.pone.0296894.s007Test
https://figshare.com/articles/dataset/Detailed_information_for_the_datasets_of_the_exposures_and_outcomes_/25015108Test

المؤلفون: Yang Li, Qiu Zhang

مصطلحات موضوعية: Biochemistry, Cell Biology, Biotechnology, Science Policy, Virology, Biological Sciences not elsewhere classified, Mathematical Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, wide association study, sup >&# 8722, single nucleotide polymorphisms, potential biological mechanisms, pleiotropy residual sum, multivariable mendelian randomization, 5 × 10, serum aspartate aminotransferase, serum alanine aminotransferase, wide significance (<, independent causal effect, diabetic microvascular complications, alp ), gamma, 206 – 1, 115 – 1, univariable mendelian randomization, three mvmr approaches, previous observational investigations, five uvmr approaches, diabetes risk factors, independent causal effects

الوصف: Background Observational studies show that liver enzymes are diabetes risk factors. However, previous observational investigations on the relationship between liver enzymes and diabetic microvascular complications produced contradictory results. The purpose of this research is to examine the independent causal effects of liver enzymes on diabetic microvascular complications. Methods Univariable Mendelian randomization (UVMR) and multivariable Mendelian randomization (MVMR) were utilized to disentangle the causal effects. The genome-wide association study (GWAS) summary-level statistics were collected from the UK biobank and the FinnGen consortium. Single nucleotide polymorphisms (SNPs) were selected as genetic instruments with genome-wide significance ( p < 5 ×10 −8 ). Five UVMR approaches, including inverse variance weighted (IVW), Bayesian weighted Mendelian randomization, MR-Pleiotropy Residual Sum and Outlier (MR-PRESSO), weighted median, and MR-Egger, and three MVMR approaches, including the extended versions of IVW, MR-Egger, and the Q-minimization methods, were performed to evaluate the causal effects. The robustness of the MR results was further confirmed using several sensitivity analyses. Results UVMR revealed that a genetically predisposed per standard deviation increase in serum alanine aminotransferase (ALT) level increased the risk of diabetic retinopathy (DR) in type 2 diabetes mellitus (T2DM) (IVW OR = 1.489, 95% CI = 1.206–1.772, p = 0.006). Likewise, serum aspartate aminotransferase (AST) levels showed similar results (IVW OR = 1.376, 95% CI = 1.115–1.638, p = 0.017). Furthermore, these effects were consistent after controlling for glycemia and blood pressure using MVMR analysis. Additionally, sensitivity analyses further strengthened the causality. However, no significant associations were found between alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), and diabetic microvascular complications. Conclusions Robust evidence was demonstrated for an independent causal effect of serum ...

العلاقة: https://figshare.com/articles/dataset/The_SNPs_that_were_palindromic_or_incompatible_/25015132Test

الإتاحة: https://doi.org/10.1371/journal.pone.0296894.s013Test
https://figshare.com/articles/dataset/The_SNPs_that_were_palindromic_or_incompatible_/25015132Test