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81
المؤلفون: J F, Valdivia, S, Khattak
المصدر: The Mount Sinai journal of medicine, New York. 67(5-6)
مصطلحات موضوعية: Analgesics, Opioid, Treatment Outcome, Therapeutic Equivalency, Patient Selection, Methadyl Acetate, Humans, Drug Tolerance, Opioid-Related Disorders, Methadone
الوصف: The development and approval of levo-alpha-acetylmethadol (LAAM) as a pharmacotherapeutic agent in opioid agonist therapy provided an alternative to methadone. Clinicians recognized the potential benefits that LAAM, a synthetic mu agonist with pharmacological properties which differ from those of methadone,could have in the treatment management of addicts in opioid agonist therapy. We report our experience utilizing LAAM from 1995 to 1999 at the Hines VA opioid agonist therapy clinic. The addition of LAAM to the clinic's treatment armamentarium has resulted in management options that have improved the areas of patient recruitment, patient retention, patient traffic, take-home medication, detoxification, and treatment outcomes.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::55bebfb4f650b1a354dc47f05ffbd87aTest
https://pubmed.ncbi.nlm.nih.gov/11064490Test -
82
المؤلفون: R, Loebstein, G, Atanackovic, R, Bishai, J, Wolpin, S, Khattak, G, Hashemi, M, Gobrial, S, Baruchel, S, Ito, G, Koren
المصدر: Journal of clinical pharmacology. 39(5)
مصطلحات موضوعية: Adult, Adolescent, Statistics as Topic, Age Factors, Kidney Function Tests, Drug Administration Schedule, Risk Factors, Child, Preschool, Humans, Kidney Diseases, Ifosfamide, Child, Antineoplastic Agents, Alkylating, Retrospective Studies
الوصف: Ifosfamide is widely used in the treatment of pediatric solid tumors. Its main adverse effects are various forms of renal tubular and glomerular damage. The authors sought to determine factors that predict the risk for the development and severity of ifosfamide-induced nephrotoxicity in children and to examine the long-term outcome of this complication. A total of 174 children who had received ifosfamide for various cancers were studied. Nephrotoxicity was assessed by laboratory markers of glomerular and tubular function and a grading score (none, mild, moderate, severe). Patients were assessed 4 to 12 weeks after each ifosfamide course, 3 months after completion of chemotherapy, and 5 years later. Of 174 children, 72 (41.4%) developed tubular dysfunction, whereas only 11 (6.3%) demonstrated glomerular dysfunction; 40 (23.0%) demonstrated mild toxicity, 16 (9.2%) demonstrated moderate toxicity, and 16 (9.2%) developed severe nephrotoxicity. The four severity subgroups (none, mild, moderate, severe) received comparable doses/m2/cycle of ifosfamide and mesna. Children exhibiting severe toxicity were significantly younger compared to those with moderate, mild, or no nephrotoxicity (median age: 2.2, 7.0, 8.2, and 10.5 years, respectively; p0.001) and received significantly higher cumulative doses of ifosfamide (49.6 +/- 12.3, 46.0 +/- 13.1, 36.2 +/- 9.7, and 33.8 +/- 7.6 g/m2, respectively; p0.001). Cumulative doses of cisplatin were higher among children with severe nephrotoxicity compared to those with moderate, mild, or no toxicity, although this difference did not reach statistical significance. Of all risk factors analyzed by multiple regression analysis, age was the most significant predictor for the grade of nephrotoxicity (p0.001), followed by the cumulative dose of ifosfamide (p = 0.005). Seven out of 16 children (44.0%) with severe nephrotoxicity and 4 out of 16 children (25.0%) with moderate nephrotoxicity demonstrated severe chronic tubular toxicity over a follow-up period of 5 years. Since severe ifosfamide-induced renal toxicity tends to be chronic in a substantial number of treated children, it should be balanced carefully against efficacy. Cumulative ifosfamide doses of 45 g/m2 and above should be carefully considered, especially in children younger than age 3.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::d7f4ed2288914b0dc9a962d524eade94Test
https://pubmed.ncbi.nlm.nih.gov/10234592Test -
83
المؤلفون: S S Nishtar, R Rajendran, A Mathur, S Khattak
المصدر: Emergency Medicine Journal. 25:314-315
مصطلحات موضوعية: Adult, medicine.medical_specialty, Pediatrics, Myocarditis, Fulminant, Cardiomyopathy, Disease, Critical Care and Intensive Care Medicine, Inflammatory bowel disease, Gastroenterology, Electrocardiography, Crohn Disease, Internal medicine, medicine, Humans, Crohn's disease, business.industry, Cardiogenic shock, General Medicine, medicine.disease, digestive system diseases, Bowel obstruction, Acute Disease, Emergency Medicine, Female, business, Intestinal Obstruction
الوصف: Myocarditis is an uncommon association of Crohn's disease. It has been reported to occur independently of inflammatory bowel disease activity. The case history is presented of a young woman admitted to hospital with acute small bowel obstruction as a presentation of active Crohn's disease which was further complicated by fulminant myocarditis leading to cardiogenic shock. This could have proved fatal if not recognised and managed appropriately. Myocarditis is rare, but it can be a life-threatening association of inflammatory bowel disease which needs early recognition and prompt treatment.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fe4ac1a55b1f203f4355d3e8033d98aeTest
https://doi.org/10.1136/emj.2007.054643Test -
84دورية أكاديمية
المؤلفون: Razia Haider, Dr. Muhammad, Younus Javed, Naveed S. Khattak
المساهمون: The Pennsylvania State University CiteSeerX Archives
الوصف: Routing in sensor networks is a challenging issue due to inherent constraints such as energy, memory and CPU processing capabilities. The energy efficiency is one of the key concerns in sensor networks for their better performance, as sensor nodes are limited in their battery power. In this research work, different routing algorithms have been studied and the main focus was on geographic routing in sensor networks. A location based protocol EAGR (Energy Aware Greedy Routing) has been presented for sensor networks to extend the lifetime of the network and to get higher data delivery rate and to balance the energy consumption of nodes. In EAGR, each node makes the local decision to choose its next hop. This algorithm works on forwarding rule based on location and energy levels of nodes. Each node knows its own geographic location and its energy levels and the location and energy level of its neighbors. The transmitting node writes the geographic position of destination into the packet header and forwards it to the destination by establishing the sub-destinations. The sub-destination nodes must be alive and geographically near to the destination node to route the packet by choosing the shortest and reliable path. Simulation has been made by using
وصف الملف: application/pdf
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85
المؤلفون: S Khattak, R Rajendran, Salman S Nishtar, A Mathur
المصدر: Case Reports. 2009:bcr1120081204-bcr1120081204
مصطلحات موضوعية: medicine.medical_specialty, Myocarditis, Crohn disease, business.industry, Fulminant, Cardiogenic shock, General Medicine, medicine.disease, Gastroenterology, Inflammatory bowel disease, Article, digestive system diseases, Bowel obstruction, Internal medicine, medicine, business, Rare disease
الوصف: Myocarditis is an uncommon association of Crohn disease. It has been reported to occur independently of inflammatory bowel disease activity. The case history is presented of a young woman admitted to hospital with acute small bowel obstruction as a presentation of active Crohn disease, which was further complicated by fulminant myocarditis leading to cardiogenic shock. This could have proved fatal if not recognised and managed appropriately. Myocarditis is rare, but it can be a life-threatening association of inflammatory bowel disease that needs early recognition and prompt treatment.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7f5cbf4eaffde19c7af84357d8f6e8b2Test
https://doi.org/10.1136/bcr.11.2008.1204Test -
86
المؤلفون: S. Thiele, C. de Rivera, N.W. Milgram, S. Khattak
المصدر: International Journal of Developmental Neuroscience. 24:508-508
مصطلحات موضوعية: medicine.medical_specialty, Developmental Neuroscience, Autistic spectrum disorder, medicine, Test protocol, Audiology, Autistic spectrum, Psychology, Developmental Biology
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::729d582edd4a188c6cf1c80c66ef3628Test
https://doi.org/10.1016/j.ijdevneu.2006.09.093Test -
87
المؤلفون: S Khattak, Bairbre Connolly, D Manson, P Burrows
المصدر: Pediatric Radiology. 24:592-593
مصطلحات موضوعية: Hemoptysis, medicine.medical_specialty, Right middle lobe, Bronchial Arteries, Lesion, Pseudoaneurysm, Aneurysm, medicine.artery, medicine, Humans, Radiology, Nuclear Medicine and imaging, business.industry, Vascular disease, Respiratory disease, medicine.disease, Surgery, Radiography, Child, Preschool, Pediatrics, Perinatology and Child Health, Female, medicine.symptom, Complication, Bronchial artery, business, Job Syndrome
الوصف: A 2-year-old girl presented with a large right middle lobe cavitating lesion, complicated by life-threatening hemoptysis secondary to hyperimmunoglobulinemia E (hyper IgE) syndrome (Job's syndrome). This proved to be a bronchial artery pseudoaneurysm which was successfully embolized.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32fbea497a3da7e6c25d0075f54212eTest
https://doi.org/10.1007/bf02012742Test -
88
المؤلفون: Anwar S. Khattak
المصدر: Optical Engineering. 32:2788
مصطلحات موضوعية: Physics, Synthetic aperture radar, Scanner, Exit pupil, business.industry, General Engineering, Physics::Optics, Laser, Refraction, Atomic and Molecular Physics, and Optics, Collimated light, law.invention, Radius of curvature (optics), Optics, law, Prism, business
الوصف: An economical refracting type laser beam scanning device, exhibiting a minimum across-scan error without corrective measures, is described. The main structural assembly of the device consists of a rotating prism, a fixed spherical lens, and a fixed convex spherical auxiliary reflector (SAR). Trigonometric equations are developed to determine the radius of curvature of the SAR and the size of the exit pupil. Resolution analyses are presented for a specific set of design parameters.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::4710a49853e1f58e7d9d086479f0de36Test
https://doi.org/10.1117/12.148104Test -
89
المؤلفون: James F. Ruff, Steven R. Abt, Mohammad S. Khattak, Rodney J. Wittier
المصدر: Journal of the American Water Resources Association. 24:1193-1200
مصطلحات موضوعية: Energy gradient, Ecology, Turbulence, Flow (psychology), Mechanics, Surface finish, Open-channel flow, Flume, Geotechnical engineering, Geology, Riprap, Earth-Surface Processes, Water Science and Technology, Communication channel
الوصف: A series of flume tests were conducted to determine the flow resistance of angular shaped riprap in steep channels. Flow resistance was expressed in terms of the Darcy-Weisbach friction factor and the Manning's roughness coefficient. Prototype channels of 4 ft. (1.2 m) and 12 ft. (3.7 m) in width were constructed at slopes ranging from 0.01 to 0.20. The channel beds were comprised of angular riprap of median diameters of 1, 2, 4, 5, and 6 inches (2.59, 5.59, 10.41, 12.95, and 15.75 cms). The Darcy-Weisbach and Manning's coefficients were determined for each test condition prior to bed failure. The resulting Darcy-Weisbach coefficients were related to the channel energy gradient and the bed relative submergence for highly turbulent flow. Also, Manning's roughness coefficients were related to the product of the median stone diameter and energy gradient. Because of the angular shape of the riprap and the wedging and/or packing of the bed materials, the resistance to flow was found to exceed the flow resistance values predicted by previous studies. Expressions were presented for estimating the resistance to flow for angular riprap in steep channels.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::1dfb5692605c4f8dce8ed1a027d2214cTest
https://doi.org/10.1111/j.1752-1688.1988.tb03038.xTest -
90
المؤلفون: R M Chaudhri, J Rashid, M S Khattak, M M Chaudhri
المصدر: Journal of Physics D: Applied Physics. 17:769-773
مصطلحات موضوعية: Glow discharge, Acoustics and Ultrasonics, Chemistry, Analytical chemistry, Condensed Matter Physics, Discharge pressure, Cathode, Surfaces, Coatings and Films, Electronic, Optical and Magnetic Materials, law.invention, Anode, Townsend discharge, law, Electrode, Gas-filled tube, Current (fluid), Atomic physics
الوصف: The effect of the interelectrode gap on some characteristics of the glow discharge in electronegative gases (oxygen and air) at low pressures (0.1-1 Torr) has been studied in a specially constructed discharge tube with parallel plate electrode geometry. In this tube the interelectrode gap could be varied without altering the discharge pressure or the planarity of the electrodes. The interelectrode gap has been found to have a profound effect, both on the magnitude of the discharge current and its stability. The current decreased to zero, at a constant pressure and applied voltage, as the anode was gradually moved towards the edge of the cathode dark space or drawn away from the cathode beyond the Faraday dark space. This variation of the current has been discussed. Moreover, when the interelectrode gap was such that the discharge current was less than about 70% of the maximum discharge current, highly regular oscillations of frequency in the range 1-6 Hz developed. This behaviour has been explained by the formation of negative ions of the gas and their subsequent decay. When the applied voltage was so low that only a Townsend discharge formed, regular instabilities of low frequency occurred at all interelectrode gap values studied.
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6c67c516e95c9d59efea1f54819ec534Test
https://doi.org/10.1088/0022-3727/17/4/015Test
