يعرض 1 - 10 نتائج من 25 نتيجة بحث عن '"Rossato Viana, Altevir"', وقت الاستعلام: 1.31s تنقيح النتائج
  1. 1
    دورية أكاديمية

    المؤلفون: Rossato Viana, Altevir1 (AUTHOR) rossato.viana@hotmail.com, Eduardo Lago Londero, James1 (AUTHOR), Pinheiro, Pricila Nass2 (AUTHOR), Acosta, Patricia2 (AUTHOR), Duailibe Silva, Larissa1 (AUTHOR), Jacob-Lopes, Eduardo2 (AUTHOR), Ferreira Ourique, Aline3 (AUTHOR), Zepka, Leila Queiroz2 (AUTHOR), Bohn Rhoden, Cristiano Rodrigo3,4 (AUTHOR), Passaglia Schuch, André1 (AUTHOR), Franco, Camila5 (AUTHOR)

    المصدر: Journal of Toxicology & Environmental Health: Part A. 2024, Vol. 87 Issue 5, p199-214. 16p.

    مستخلص: Several medicinal plants have been administered to cancer patients attributed to their anticarcinogenic and chemoprotective properties, in addition to lower toxicity compared to traditional therapies. The aim was to investigate the antioxidant properties and carotenoid composition of aqueous extracts of Mentha piperita or Artemisia vulgaris which were previously found to exert beneficial effects on human health through diet. aqueous extracts exhibited potent antioxidant activity. A diversity of carotenoids was identified in these extracts using HPLC-PDA-MS/MS. Both extracts contained predominantly all-trans-lutein as the main component within this class. In order to investigate antioxidant properties, the 2,2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2′-azino-bis (3-ethylbenzthiazoline-6-sulfonic acid) (ABTS) techniques were used. The (3–4,5 dimethylthiazol-2, 5 diphenyl tetrazolium bromide) (MTT) and Crystal Violet assays assessed cellular cytotoxicity. Assessments of presence of reactive species were carried out following exposure of oral squamous cell carcinoma cell line (SCC-4) to various aqueous extracts of M piperita or A vulgaris utilizing dichlorofluorescein diacetate (DCFH-DA) and nitric oxide (NO) assays. Exposure to these extracts induced severe cytotoxic effects, which led to investigation of the biochemical and molecular mechanisms underlying this observed effect. Data demonstrated that both solutions induced oxidative stress and DNA damage, especially at higher concentrations using agarose gel subjected to electrophoresis. It is known that exposure to excess amounts of antioxidants results in a prooxidant effect which is beneficial in cancer therapy. Further, the extracts were found to reduce viability of SCC-4 in culture, indicating that this antitumoral activity may be of therapeutic importance and requires further study. [ABSTRACT FROM AUTHOR]

  2. 2
    دورية أكاديمية

    المصدر: Journal of Toxicology & Environmental Health: Part A; Jan2024, Vol. 87 Issue 2, p47-56, 10p

    مصطلحات موضوعية: GERMINATION, GRAPHENE oxide, CLOVER, PHYTOGEOGRAPHY, SALTS, ABIOTIC stress

    مستخلص: Among biotic and abiotic stresses, the most restrictive for plant distribution is salt stress, where different concentrations might exert harmful effects on seed germination. Recently, nanomaterials were used successfully to mitigate these stresses, indicating that plants may be able to develop normally in adverse conditions. The aim of this study was to examine the effects of graphene oxide (GO) on the germination of Persian clover seedlings under salt stress conditions. Following sown on substrate paper, seeds were tested after exposure to different concentrations of graphene oxide (0, 125, 250, or 500 mg L-1 GO), sodium chloride (0; -0.1; -0.2; -0.3, or -0.4 MPa NaCl) and/or GO + salt concomitantly, and then stored for 7 days in a germination chamber at 20°C in the presence of light. Seed germination and growth parameters of seedlings were determined. Graphene oxide demonstrated protective effect against salt stress as evident by no marked adverse effects on seed germination where GO blocked the salt-induced reduction in germination. The results obtained provide references for the safe application of nanomaterials and emphasize the significance of GO as a promising material for reducing the toxicity of salts in agriculture. [ABSTRACT FROM AUTHOR]

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  3. 3
    دورية أكاديمية

    المؤلفون: Rossato Viana, Altevir1 (AUTHOR) rossato.viana@hotmail.com, Nicola, Isadora2 (AUTHOR), Franco, Camila2 (AUTHOR), Caetano, Patrícia Acosta3 (AUTHOR), Jacob-Lopes, Eduardo3 (AUTHOR), Zepka, Leila Queiroz3 (AUTHOR), Santos, Daniel4 (AUTHOR), Moraes Flores, Erico Marlon4 (AUTHOR), Stefanello Vizzotto, Bruno2 (AUTHOR), Wolf, Katianne5 (AUTHOR), Ferreira Ourique, Aline5 (AUTHOR), Mortari, Sergio Roberto5 (AUTHOR), Bohn Rhoden, Cristiano Rodrigo5,6 (AUTHOR), Fontanari Krause, Luciana Maria7 (AUTHOR)

    المصدر: Journal of Toxicology & Environmental Health: Part A. 2023, Vol. 86 Issue 21, p816-832. 17p.

    مصطلحات جغرافية: BRAZIL

    مستخلص: The particular plant species found in southern Brazil, Vassobia breviflora (Solanaceae) has only a few apparent studies examining its biological effect. Thus, the aim of the present study was to determine the activity of the acetone extract fraction derived from V. breviflora. Four compounds were identified by ESI-qTOF-MS: eucalrobusone R, aplanoic acid B, pheophorbide A, and pheophytin A. In addition, 5 compounds were identified by HPLC-PDA-MS/MS: all-trans-lutein, 15-cis-lutein, all-trans-β-carotene, 5,8-epoxy-β-carotene, and cis-β-carotene. Cell lines A549 (lung cancer), A375 (melanoma cancer) and HeLa (cervical cancer) were incubated with different concentrations of each studied extract using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT), lactate dehydrogenase (LDH), and 2'−7'dichlorofluorescin diacetate (DCFH-DA) assays. The acetonic extract exhibited cytotoxic activity at a concentration of 0.03 mg/ml in the HeLa strain and 0.1 mg/ml in the others. In addition to increased production of reactive oxygen species (ROS). Antibacterial activity was assessed utilizing minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) in 9 ATCCs strains and 7 clinical isolates, as well as determination of biofilm production. Data demonstrated that MIC and MBC were approximately 256 mg/ml in most of the strains tested and antibiofilm effect at S. aureus, S. epidermidis, A. baumannii, and E. faecalis, concentrations below the MIC. Genotoxic activity on plasmid DNA did not produce significant elevated levels in breaks in the isolated genetic material. [ABSTRACT FROM AUTHOR]

  4. 4
    دورية أكاديمية

    الوصف: In this study, furosemide (FUR) adsorption was performed employing magnetic carbon nanotubes (CNT‧Fe3O4) with different amounts of incorporated magnetite. The CNT and magnetic CNTs were synthesized by chemical vapor deposition (CVD) and co-precipitation methods, respectively. The nanoadsorbents were characterized by FTIR, XRD, Raman, SEM, and VSM techniques. The adsorption experiments revealed that the best performance was obtained by CNT‧Fe3O4 1:10, showing values of 82.39% and 83.5 mg g−1 of removal percentage and maximum adsorption capacity at pH 2.0, due to the improvement in π-π interactions, and the presence of iron nanoparticles enhanced the adsorption, suggesting that cation-π interactions control the process. The sorption process exhibited high dependence on pH, adsorbent dosage, and initial concentration of adsorbate. Sips and Elovich models showed the best adjustment for experimental data, suggesting that the process occurs on a heterogeneous surface and with different energy adsorption sites, respectively. The thermodynamic parameters indicated a spontaneous and exothermic process. The outcome of in vitro cytotoxicity assays revealed that the adsorbent/drug complex, after adsorption, exhibited lower toxic effects than the free drug. On the other hand, the genotoxicity assay showed that only the Fe3O4 caused damage at the DNA level. Magnetic carbon nanotubes prove to be efficient in the removal of furosemide from the aqueous solution. Also, the complex after adsorption showed good biocompatibility, allowing a promising application in the biological area and stimulating future studies in drug repositioning.

    وصف الملف: 12 páginas; application/pdf

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    المساهمون: no funding

    المصدر: Journal of Toxicology and Environmental Health, Part A ; volume 87, issue 2, page 47-56 ; ISSN 1528-7394 1087-2620

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    المؤلفون: Rossato Viana, Altevir1 (AUTHOR) rossato.viana@hotmail.com, Godoy Noro, Bruna2 (AUTHOR), Santos, Daniel3 (AUTHOR), Wolf, Katianne4 (AUTHOR), Sudatti Das Neves, Yasmin5 (AUTHOR), Moresco, Rafael Noal5 (AUTHOR), Ourique, Aline Ferreira4 (AUTHOR), Moraes Flores, Erico Marlon3 (AUTHOR), Rhoden, Cristiano Rodrigo Bohn4,6 (AUTHOR), Maria Fontanari Krause, Luciana7 (AUTHOR), Stefanello Vizzotto, Bruno8 (AUTHOR)

    المصدر: Journal of Toxicology & Environmental Health: Part A. 2023, Vol. 86 Issue 2/3, p51-68. 18p.

    مصطلحات جغرافية: SOUTH America

    مستخلص: Vassobia breviflora (Sendtn.) Hunz is a plant of the Solanaceae family from South America and there are no apparent studies reported on the biological activity of the hexane extract. The aim of this investigation was to conduct phytochemical analyses using ESI-TOF-MS, while antioxidant activities were evaluated by the following methods 1,1-diphenyl-2-picrylhydrazyl (DPPH) 2,2"-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) radical capture (ABTS), ferric reducing antioxidant power (FRAP), total antioxidant capacity (TAC), and total oxidant status (TOS). Antimicrobial activities were performed by determining the minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and antibiofilm formed. Cytotoxicity was measured by MTT and dsDNA PicoGreen tests, beyond the production of reactive oxygen species (ROS) determined by Dichlorodihydrofluorescein diacetate (DCFH-DA). The hexane extract showed the presence of 5 (choline, pantothenic acid, calystegine B, lanciphodylactone I, and 15"-cis-zeaxanthin) compounds detected. V. breviflora extract demonstrated reliable results utilizing different antioxidant methods. In antibacterial activity, V. breviflora extract exhibited inhibitory, bactericidal, and antibiofilm action in biofilm-forming bacteria. The hexane extract exhibited cytotoxicity against melanoma, lung cancer, glioblastoma, leukemia, uterine colon, and hepatocarcinoma tumor cells. In addition, all tested strains resulted in increased production of ROS. This plant extract may be considered in future as an alternative for development of new therapeutic options aimed at the treatment of diverse pathologies. [ABSTRACT FROM AUTHOR]

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    المساهمون: no funding associated with the work

    المصدر: Journal of Toxicology and Environmental Health, Part A ; volume 85, issue 16, page 685-698 ; ISSN 1528-7394 1087-2620