المؤلفون: Roemer, Frank W., Guermazi, Ali, Collins, Jamie E., Losina, Elena, Nevitt, Michael C., Lynch, John A., Katz, Jeffrey N., Kwoh, C. Kent, Kraus, Virginia B., Hunter, David J.

مرشدي الرسالة: Univ Arizona, Coll Med, Arthrit Ctr, Univ Arizona, Coll Med, Div Rheumatol

مصطلحات موضوعية: Osteoarthritis, MRI, Progression, Scoring, Biomarkers

الوصف: Background: To describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study. Methods: We conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time. Results: Seventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p < 0.001). Seventy-three percent of cases and 53 % of controls had at least one area with worsening in cartilage surface area (p < 0.001). More cases experienced worsening in Hoffa- and effusion synovitis than controls (17 % vs. 6 % (p < 0.001); 41 % vs. 18 % (p < 0.001), respectively). Conclusions: A wide range of MRI-detected structural pathologies was present in the FNIH cohort. More severe changes, especially for BMLs, cartilage and meniscal damage, were detected primarily among the case group suggesting that early changes in multiple structural domains are associated with radiographic worsening and symptomatic progression.

العلاقة: http://bmcmusculoskeletdisord.biomedcentral.com/articles/10.1186/s12891-016-1310-6Test

الإتاحة: http://hdl.handle.net/10150/623126Test
http://arizona.openrepository.com/arizona/handle/10150/623126Test

المؤلفون: Kim, Jason S, Borges, Silvana, Clauw, Daniel J, Conaghan, Philip G, Felson, David T, Fleming, Thomas R, Glaser, Rachel, Hart, Elizabeth, Hochberg, Marc, Kim, Yura, Kraus, Virginia B, Lapteva, Larissa, Li, Xiaojuan, Majumdar, Sharmila, McAlindon, Timothy E, Mobasheri, Ali, Neogi, Tuhina, Roemer, Frank W, Rothwell, Rebecca, Shibuya, Robert, Siegel, Jeffrey, Simon, Lee S, Spindler, Kurt P, Nikolov, Nikolay P

مصطلحات موضوعية: Medical Biotechnology, Biomedical and Clinical Sciences, Osteoarthritis, Aging, Arthritis, Clinical Research, Clinical Trials and Supportive Activities, Musculoskeletal, Good Health and Well Being, Biomarkers, Disease Progression, Drug Development, Humans, Structure-modifying therapy, Regulatory approval, Drug development, Disease-modifying therapy, Clinical benefit, Long-term benefit, Clinical Sciences, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences

الوصف: ObjectiveTo summarize proceedings of a workshop convened to discuss the current state of science in the disease of osteoarthritis (OA), identify the knowledge gaps, and examine the developmental and regulatory challenges in bringing these products to market.DesignSummary of the one-day workshop held virtually on June 22nd, 2021.ResultsSpeakers selected by the Planning Committee presented data on the current approach to assessment of OA therapies, biomarkers in OA drug development, and the assessment of disease progression and long-term benefit.ConclusionsDemonstrated by numerous failed clinical trials, OA is a challenging disease for which to develop therapeutics. The challenge is magnified by the slow time of onset of disease and the need for clinical trials of long duration and/or large sample size to demonstrate the effect of an intervention. The OA science community, including academia, pharmaceutical companies, regulatory agencies, and patient communities, must continue to develop and test better clinical endpoints that meaningfully reflect disease modification related to long-term patient benefit.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/2cf6v3kpTest

المؤلفون: Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Katz, Jeffrey N, Nevitt, Michael C, Lynch, John A, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Kwoh, C Kent, Hoffmann, Steve, Kraus, Virginia B

المصدر: Arthritis Care & Research. 74(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biomedical Imaging, Pain Research, Arthritis, Aging, Chronic Pain, Clinical Research, Musculoskeletal, Biomarkers, Cartilage, Articular, Disease Progression, Humans, Knee Joint, Magnetic Resonance Imaging, National Institutes of Health (U.S.), Osteoarthritis, Knee, Synovitis, United States, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science

الوصف: ObjectiveTo determine the optimal combination of imaging and biochemical biomarkers for use in the prediction of knee osteoarthritis (OA) progression.MethodsThe present study was a nested case-control trial from the Foundation of the National Institutes of Health OA Biomarkers Consortium that assessed study participants with a Kellgren/Lawrence grade of 1-3 who had complete biomarker data available (n = 539 to 550). Cases were participants' knees that had radiographic and pain progression between 24 and 48 months compared to baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) that had a P value of

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/64n63926Test

المؤلفون: Moradi, Kamyar, Mohajer, Bahram, Guermazi, Ali, Kwoh, C. Kent, Bingham, Clifton O., Mohammadi, Soheil, Cao, Xu, Wan, Mei, Roemer, Frank W., Demehri, Shadpour

المساهمون: National Institutes of Health, National Institute on Aging, National Institute of Arthritis and Musculoskeletal and Skin Diseases

المصدر: Journal of Cachexia, Sarcopenia and Muscle ; ISSN 2190-5991 2190-6009

الوصف: Background Preclinical rheumatoid arthritis (Pre‐RA) is defined as the early stage before the development of clinical RA. While cachexia is a well‐known and potentially modifiable complication of RA, it is not known if such an association exists also in the Pre‐RA stage. To investigate such issue, we aimed to compare the longitudinal alterations in the muscle composition and adiposity of participants with Pre‐RA with the matched controls. Methods In this observational cohort study, the Osteoarthritis Initiative (OAI) participants were categorized into Pre‐RA and propensity score (PS)‐matched control groups. Pre‐RA was retrospectively defined as the absence of RA from baseline to year‐2, with progression to physician‐diagnosed clinical RA between years 3–8 of the follow‐up period. Using a validated deep learning algorithm, we measured MRI biomarkers of thigh muscles and adiposity at baseline and year‐2 follow‐ups of the cohort. The outcomes were the differences between Pre‐RA and control groups in the 2‐year rate of change for thigh muscle composition [cross‐sectional area (CSA) and intramuscular adipose tissue (Intra‐MAT)] and adiposity [intermuscular adipose tissue (Inter‐MAT) and subcutaneous adipose tissue (SAT)]. Linear mixed‐effect regression models were used for comparison. Results After 1:3 PS‐matching of the groups for confounding variables (demographics, risk factors, co‐morbidities, and knee osteoarthritis status), 408 thighs (102 Pre‐RA and 306 control) of 322 participants were included (age mean ± SD: 61.7 ± 8.9 years; female/male: 1.8). Over a 2‐year period, Pre‐RA was associated with a larger decrease in total thigh muscle CSA [estimate, 95% confidence interval (CI): −180.13 mm 2 /2‐year, −252.80 to −107.47, P ‐value < 0.001]. Further examination of thigh muscle composition showed that the association of the presence of Pre‐RA with a larger decrease in muscle CSA over 2 years was noticeable in the quadriceps, flexors, and sartorius muscle groups ( P ‐values < 0.05). Comparison of ...

الإتاحة: https://doi.org/10.1002/jcsm.13533Test

المؤلفون: Moradi, Kamyar, Kwee, Robert M, Mohajer, Bahram, Guermazi, Ali, Roemer, Frank W, Ibad, Hamza Ahmed, Haugen, Ida K, Berenbaum, Francis, Demehri, Shadpour

مصطلحات موضوعية: Osteoarthritis

الوصف: Objectives There is no evidence linking specific osteoarthritis (OA) types, such as erosive hand OA (EHOA), with distant generalised changes in muscle composition (sarcopenia), which can potentially be modified. This study pioneers the exploration of the association between EHOA and sarcopenia, both of which are predominantly observed in the older adults. Methods Using the Osteoarthritis Initiative cohort, we selected hand OA (modified Kellgren and Lawrence (grade ≥2 in ≥1 hand joint) participants with radiographic central erosions in ≥1 joints (EHOA group) and propensity score-matched hand OA participants with no erosion (non-EHOA group). MRI biomarkers of thigh muscles were measured at baseline, year 2 and year 4 using a validated deep-learning algorithm. To adjust for ‘local’ effects of coexisting knee OA (KOA), participants were further stratified according to presence of radiographic KOA. The outcomes were the differences between EHOA and non-EHOA groups in the 4-year rate of change for both intramuscular adipose tissue (intra-MAT) deposition and contractile (non-fat) area of thigh muscles. Results After adjusting for potential confounders, 844 thighs were included (211 EHOA:633 non-EHOA; 67.1±7.5 years, female/male:2.9). Multilevel mixed-effect regression models showed that EHOA is associated a different 4-year rate of change in intra-MAT deposition (estimate, 95% CI: 71.5 mm2/4 years, 27.9 to 115.1) and contractile area (estimate, 95% CI: −1.8%/4 years, −2.6 to −1.0) of the Quadriceps. Stratified analyses showed that EHOA presence is associated with adverse changes in thigh muscle quality only in participants without KOA. Conclusions EHOA is associated with longitudinal worsening of thigh muscle composition only in participants without concomitant KOA. Further research is needed to understand the systemic factors linking EHOA and sarcopenia, which unlike EHOA is modifiable through specific interventions.

وصف الملف: text/html

العلاقة: http://ard.bmj.com/cgi/content/short/83/6/799Test; http://dx.doi.org/10.1136/ard-2023-224997Test

الإتاحة: https://doi.org/10.1136/ard-2023-224997Test
http://ard.bmj.com/cgi/content/short/83/6/799Test

المؤلفون: Jansen, Mylène P., Hodgins, Diana, Mastbergen, Simon C., Kloppenburg, Margreet, Blanco García, Francisco J, Haugen, Ida K., Berenbaum, Francis, Eckstein, Felix, Roemer, Frank W., Wirt, Wolfgang

مصطلحات موضوعية: Gait, Osteoarthritis, Pathology, ROM, Structure

الوصف: [Abstract] Objective: To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods: IMI-APPROACH recruited 297 clinical knee OA patients. Gait data was collected (GaitSmart®) and OA-related joint measures determined from knee radiographs (KIDA) and MRIs (qMRI/MOAKS). Patients were divided into those with/without radiographic OA (ROA). Principal component analyses (PCA) were performed on gait parameters; linear regression models were used to evaluate whether image-based structural and demographic parameters were associated with gait principal components. Results: Two hundred seventy-one patients (age median 68.0, BMI 27.0, 77% female) could be analyzed; 149 (55%) had ROA. PCA identified two components: upper leg (primarily walking speed, stride duration, hip range of motion [ROM], thigh ROM) and lower leg (calf ROM, knee ROM in swing and stance phases). Increased age, BMI, and radiographic subchondral bone density (sclerosis), decreased radiographic varus angle deviation, and female sex were statistically significantly associated with worse lower leg gait (i.e. reduced ROM) in patients without ROA (R2 = 0.24); in ROA patients, increased BMI, radiographic osteophytes, MRI meniscal extrusion and female sex showed significantly worse lower leg gait (R2 = 0.18). Higher BMI was significantly associated with reduced upper leg function for non-ROA patients (R2 = 0.05); ROA patients with male sex, higher BMI and less MRI synovitis showed significantly worse upper leg gait (R2 = 0.12). Conclusion: Structural OA pathology was significantly associated with gait in patients with clinical knee OA, though BMI may be more important. While associations were not strong, these results provide a significant association between OA symptoms (gait) and joint structure.

العلاقة: https://doi.org/10.1007/s00256-024-04666-8Test; Jansen MP, Hodgins D, Mastbergen SC, Kloppenburg M, Blanco FJ, Haugen IK, Berenbaum F, Eckstein F, Roemer FW, Wirth W. Can gait patterns be explained by joint structure in people with and without radiographic knee osteoarthritis?: data from the IMI-APPROACH cohort. Skeletal Radiol. 2024 Mar 27. Epub ahead of print.; http://hdl.handle.net/2183/36070Test

الإتاحة: https://doi.org/10.1007/s00256-024-04666-8Test
http://hdl.handle.net/2183/36070Test

المؤلفون: Yu, Shirley P., Deveza, Leticia A., Kraus, Virginia B., Karsdal, Morten, Bay-Jensen, Anne-Christine, Collins, Jamie E., Guermazi, Ali, Roemer, Frank W., Ladel, Christoph, Bhagavath, Venkatesha, Hunter, David J.

المساهمون: University of Sydney, Foundation for the National Institutes of Health, National Institutes of Health, Else Kröner-Fresenius-Stiftung, Nordic Bioscience, National Health and Medical Research Council

المصدر: Arthritis Research & Therapy ; volume 26, issue 1 ; ISSN 1478-6362

الوصف: Background To assess the prognostic value of short-term change in biochemical markers as it relates to bone marrow lesions (BMLs) on MRI in knee osteoarthritis (OA) over 24 months and, furthermore, to assess the relationship between biochemical markers involved with tissue turnover and inflammation and BMLs on MRI. Methods Data from the Foundation for the National Institutes of Health OA Biomarkers Consortium within the Osteoarthritis Initiative ( n = 600) was analyzed. BMLs were measured according to the MRI Osteoarthritis Knee Score (MOAKS) system (0–3), in 15 knee subregions. Serum and urinary biochemical markers assessed were as follows: serum C-terminal crosslinked telopeptide of type I collagen (CTX-I), serum crosslinked N-telopeptide of type I collagen (NTX-I), urinary CTX-Iα and CTX-Iβ, urinary NTX-I, urinary C-terminal cross-linked telopeptide of type II collagen (CTX-II), serum matrix metalloproteinase (MMP)-degraded type I, II, and III collagen (C1M, C2M, C3M), serum high sensitivity propeptide of type IIb collagen (hsPRO-C2), and matrix metalloproteinase-generated neoepitope of C-reactive protein (CRPM). The association between change in biochemical markers over 12 months and BMLs over 24 months was examined using regression models adjusted for covariates. The relationship between C1M, C2M, C3M, hsPRO-C2, and CRPM and BMLs at baseline and over 24 months was examined. Results Increases in serum CTX-I and urinary CTX-Iβ over 12 months were associated with increased odds of changes in the number of subregions affected by any BML at 24 months. Increase in hsPRO-C2 was associated with decreased odds of worsening in the number of subregions affected by any BML over 24 months. C1M and C3M were associated with BMLs affected at baseline. Conclusions Short-term changes in serum CTX-I, hsPRO-C2, and urinary CTX-Iβ hold the potential to be prognostic of BML progression on MRI. The association of C1M and C3M with baseline BMLs on MRI warrants further investigation.

الإتاحة: https://doi.org/10.1186/s13075-023-03253-xTest

المؤلفون: Kopp, Markus, Wiesmueller, Marco, Buchbender, Mayte, Kesting, Marco, Nagel, Armin M., May, Matthias S., Uder, Michael, Roemer, Frank W., Heiss, Rafael

المصدر: Investigative Radiology ; volume 59, issue 3, page 223-229 ; ISSN 1536-0210 0020-9996

الوصف: Objectives Temporomandibular disorders (TMDs) are common and may cause persistent functional limitations and pain. Magnetic resonance imaging (MRI) at 1.5 and 3 T is commonly applied for the evaluation of the temporomandibular joint (TMJ). No evidence is available regarding the feasibility of modern low-field MRI for the assessment of TMDs. The objective of this prospective study was to evaluate the image quality (IQ) of 0.55 T MRI in direct comparison with 1.5 T MRI. Materials and Methods Seventeen patients (34 TMJs) with suspected intraarticular TMDs were enrolled, and both 0.55 and 1.5 T MRI were performed on the same day. Two senior readers independently evaluated the IQ focusing on the conspicuity of disc morphology (DM), disc position (DP), and osseous joint morphology (OJM) for each joint. We analyzed the IQ and degree of artifacts using a 4-point Likert scale (LS) at both field strengths. A fully sufficient IQ was defined as an LS score of ≥3. Nonparametric Wilcoxon test for related samples was used for statistical comparison. Results The median IQ for the DM and OJM at 0.55 T was inferior to that at 1.5 T (DM: 3 [interquartile range {IQR}, 3–4] vs 4 [IQR, 4–4]; OJM: 3 [IQR, 3–4] vs 4 [IQR 4–4]; each P < 0.001). For DP, the IQ was comparable (4 [IQR 3–4] vs 4 [IQR 4–4]; P > 0.05). A sufficient diagnostic IQ was maintained for the DM, DP, and OJM in 92% of the cases at 0.55 T and 100% at 1.5 T. Minor image artifacts (LS score of ≥3) were more prevalent at 0.55 T (29%) than at 1.5 T (12%). Conclusions Magnetic resonance imaging of the TMJ at 0.55 T yields a lower IQ than does MRI at 1.5 T but maintains sufficient diagnostic confidence in the majority of patients. Further improvements are needed for reliable clinical application.

الإتاحة: https://doi.org/10.1097/rli.0000000000001008Test

المؤلفون: Collins, Jamie E., Roemer, Frank W., Guermazi, Ali

المساهمون: NIH

المصدر: Osteoarthritis and Cartilage Open ; volume 6, issue 2, page 100465 ; ISSN 2665-9131

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.ocarto.2024.100465Test
https://api.elsevier.com/content/article/PII:S2665913124000323?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2665913124000323?httpAccept=text/plainTest

المؤلفون: Crema, Michel D, Roemer, Frank W, Nevitt, Michael C, Felson, David T, Marra, Monica D, Lynch, John A, Tolstykh, Irina, Lewis, Cora E, Torner, James, Guermazi, Ali

المصدر: Osteoarthritis and cartilage open. 3(4)

مصطلحات موضوعية: Cross-sectional study, Longitudinal study, Magnetic resonance imaging, Osteoarthritis, Reliability, Arthritis, Chronic Pain, Pain Research, Clinical Research, Musculoskeletal

الوصف: ObjectiveTo determine reliability among four experienced and calibrated readers in cross-sectional and longitudinal semi-quantitative MRI assessments of knee osteoarthritis (OA) in the Multicenter Osteoarthritis (MOST) study.DesignFrom all MOST participants with at least one knee with readable 60-month and 84-month paired knee MRIs (1.0 ​T extremity systems), we selected 10 subjects having a spectrum of baseline disease severity of cartilage, bone marrow lesions, and meniscal damage and a spectrum of longitudinal changes in severity at 24 months follow-up. MRIs were independently assessed using the WORMS grading system by four musculoskeletal radiologists with the chronological sequence known to the readers. Kappa statistics were used to determine agreement between each pair of readers and Kendall's coefficient of concordance to determine average agreement across readers.ResultsFor most features, cross-sectional reliability was substantial to almost perfect. Regarding longitudinal reliability (detection of longitudinal change), inter-reader reliability as weighted kappa values ranged from 0.62 to 0.78 for cartilage damage, 0.75-0.88 for bone marrow lesions, 0.75-0.92 for meniscal tears, 0.67-0.95 for meniscal extrusion, 0.51-0.77 for bone attrition, 0.43-0.76 for osteophytes, 0.31-0.70 for Hoffa-synovitis, and 0.47-0.85 for effusion-synovitis. Kendall's coefficient ranged from 0.65 to 0.98.ConclusionHigh levels of cross-sectional reliability and moderate to high longitudinal reliability was achieved using four experienced readers in semiquantitative MRI-assessment of most knee OA features.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9rp3h28qTest