المؤلفون: Hewitt, Ian K., Roebuck, Derek J., Montini, Giovanni

المساهمون: University of Western Australia

المصدر: Pediatric Radiology ; volume 53, issue 13, page 2651-2661 ; ISSN 1432-1998

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Pediatrics, Perinatology and Child Health

الوصف: Background A first febrile urinary tract infection (UTI) is a common condition in children, and pathways of management have evolved over time. Objective To determine the extent to which pediatricians and surgeons differ in their investigation and management of a first febrile UTI, and to evaluate the justifications for any divergence of approach. Materials and methods A literature search was conducted for papers addressing investigation and/or management following a first febrile UTI in children published between 2011 and 2021. Searches were conducted on Medline, Embase, and the Cochrane Controlled Trials Register. To be eligible for inclusion, a paper was required to provide recommendations on one or more of the following: ultrasound (US) and voiding cystourethrogram (VCUG), the need for continuous antibiotic prophylaxis and surgery when vesicoureteral reflux (VUR) was detected. The authorship required at least one pediatrician or surgeon. Authorship was categorized as medical, surgical, or combined. Results Pediatricians advocated less imaging and intervention and were more inclined to adopt a “watchful-waiting” approach, confident that any significant abnormality, grades IV–V VUR in particular, should be detected following a second febrile UTI. In contrast, surgeons were more likely to recommend imaging to detect VUR ( p <0.00001), and antibiotic prophylaxis ( p <0.001) and/or surgical correction ( p =0.004) if it was detected, concerned that any delay in diagnosis and treatment could place the child at risk of kidney damage. Papers with combined authorship displayed intermediate results. Conclusion There are two distinct directions in the literature regarding the investigation of an uncomplicated first febrile UTI in a child. In general, when presented with a first febrile UTI in a child, physicians recommend fewer investigations and less treatment, in contrast to surgeons who advocate extensive investigation and aggressive intervention in the event that imaging detects an abnormality. This ...

الإتاحة: https://doi.org/10.1007/s00247-023-05771-xTest

المؤلفون: Rungsiprakarn, Phassawan, Ryan, Anne L., Wong, Daniel D., Luo, Minjie, Kazahaya, Ken, Arkader, Alexandre, Lau, Loretta M.S., Ajuyah, Pamela, Rudzinski, Erin, Kreiger, Portia A., Roebuck, Derek J., Surrey, Lea F., Foo, Tiffany S.Y.

المصدر: JCO Precision Oncology; 6/27/2024, Vol. 10, p1-9, 9p

مصطلحات موضوعية: SOFT tissue tumors, GIANT cell tumors, BONE cells, TUMORS in children

مستخلص: HMGA2::NCOR2 keratin-positive giant cell tumors in children with response to imatinib in an infant [ABSTRACT FROM AUTHOR]

: Copyright of JCO Precision Oncology is the property of American Society of Clinical Oncology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Banerjee, Debasish B, Parekh, Pooja, Cross, Kate, Blackburn, Simon, Roebuck, Derek J, Curry, Joe, Eaton, Simon, Patel, Premal A, De Coppi, Paolo

المصدر: Pediatric Surgery International , 38 pp. 707-712. (2022)

مصطلحات موضوعية: Gastro-oesophageal reflux disease, Nissen fundoplication, Redo fundoplication, Gastro-jejunal feeding

الوصف: PURPOSE: To determine the management and outcomes of patients with gastro-oesophageal reflux (GOR) that requires further intervention following failure of Nissen fundoplication (NF). METHODS: After institutional audit department approval, a retrospective review of paediatric patients who had further intervention following failure of primary NF between January 2006 and December 2015 for GOR at our centre was performed. Data are presented as median (range). RESULTS: Of 820 patients who underwent NF, 190 (23%) received further procedures for GOR management at a median of 21 months of age (6–186); 90/190 (47%) had gastro-jejunal feeding (GJ). Of these, 67 (74%) remained on GJ feeds up to a median of 48 months and 23/90 (26%) had a second NF after GJ feeding. 97/190 (51%) had a redo fundoplication without having had a GJ; thus, 120/190 (63%) of patients having a further procedure went on to have a second NF after a median period of 15 months (1–70 months). Three patients (2%) had early emergency wrap revision 4 days after first fundoplication (we classed this as an ‘early complication’). Of the seven patients who failed a 3rd NF, 4 continued GJ feeding, 2 of had oesophagogastric dissociation; 2 had 4th NF of which 1 was successful and 1 patient had gastric pacemaker and is successfully feeding orally. Patients who were finally successfully managed with GJ underwent 2 (2–5) tube changes/year. We found patients who had a previous GJ were more likely to have failure of the redo fundoplication than those who had not to have the GJ (16/24 vs. 30/90, p = 0.005). CONCLUSION: The chance of success decreases with every further attempt at fundoplication. The only factor significantly associated with failure of redo fundoplication was whether the patient previously had a GJ tube. In patients with failed fundoplications, when symptom free on jejunal feedings, further anti-reflux surgical intervention should be avoided. A randomized prospective study is needed for patient selection.

وصف الملف: text

العلاقة: https://discovery.ucl.ac.uk/id/eprint/10144340/1/Accepted_version.pdfTest; https://discovery.ucl.ac.uk/id/eprint/10144340Test/

الإتاحة: https://discovery.ucl.ac.uk/id/eprint/10144340/1/Accepted_version.pdfTest
https://discovery.ucl.ac.uk/id/eprint/10144340Test/

المؤلفون: Brennan, Eileen, Davis, Meryl, Forman, Colin, Hamilton, George, KURT ŞÜKÜR, EDA DİDEM, Kessaris, Nicos, Tullus, Kjell, Minhas, Kishore, Stuart, Sam, McLaren, Clare A., Marks, Stephen D., Stojanovic, Jelena, Roebuck, Derek J., Patel, Premal A.

الوصف: Renovascular hypertension in most cases requires endovascular treatment and/or surgery. This is technically much more difficult in small children and there is very limited published knowledge in this age group. We here present treatment and outcome of young children with renovascular hypertension at our institution. Children below 2 years of age, with renovascular hypertension between January 1998 and March 2020 were retrospectively reviewed. Demographics and treatment modalities were noted. Primary outcome was blood pressure within a week after the procedures and at last available visit. Sixty-six angiographies were performed in 34 patients. Median age at time of first angiography was 1.03 (interquartile range (IQR) 0.4-1.4) years and systolic blood pressure at presentation 130 (IQR 130-150) mm Hg. Thirty-eight percent (13/34) of children were incidentally diagnosed and 18% (6/34) presented with heart failure. Twenty-six (76%) children had main renal artery stenosis and 17 (50%) mid-aortic syndrome. Seventeen (50%) children showed intrarenal, six (18%) mesenteric, and three (9%) cerebrovascular involvement. Twenty patients underwent 45 percutaneous transluminal angioplasty procedures and seven children surgeries. In 44% of the 16 patients who underwent only percutaneous transluminal angioplasty blood pressure was normalized, 38% had improvement on same or decreased treatment and 19% showed no improvement. Complications were seen in 7.5% (5/66) of angiographies. In four of the seven (57%) children who underwent surgery blood pressure was normalized, two had improved (29%) and one unchanged (14%) blood pressure.

العلاقة: 558b710a-e753-40f0-9111-4243d6f891f2; https://avesis.hacettepe.edu.tr/publication/details/558b710a-e753-40f0-9111-4243d6f891f2/oaiTest

الإتاحة: https://doi.org/10.1007/s00431-022-04550-4Test
https://avesis.hacettepe.edu.tr/publication/details/558b710a-e753-40f0-9111-4243d6f891f2/oaiTest

المؤلفون: Kurt-Sukur, Eda Didem, Brennan, Eileen, Davis, Meryl, Forman, Colin, Hamilton, George, Kessaris, Nicos, Marks, Stephen D., McLaren, Clare A., Minhas, Kishore, Patel, Premal A., Roebuck, Derek J., Stojanovic, Jelena, Stuart, Sam, Tullus, Kjell

المصدر: European Journal of Pediatrics ; volume 181, issue 9, page 3367-3375 ; ISSN 1432-1076

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الوصف: Renovascular hypertension in most cases requires endovascular treatment and/or surgery. This is technically much more difficult in small children and there is very limited published knowledge in this age group. We here present treatment and outcome of young children with renovascular hypertension at our institution. Children below 2 years of age, with renovascular hypertension between January 1998 and March 2020 were retrospectively reviewed. Demographics and treatment modalities were noted. Primary outcome was blood pressure within a week after the procedures and at last available visit. Sixty-six angiographies were performed in 34 patients. Median age at time of first angiography was 1.03 (interquartile range (IQR) 0.4–1.4) years and systolic blood pressure at presentation 130 (IQR 130–150) mm Hg. Thirty-eight percent (13/34) of children were incidentally diagnosed and 18% (6/34) presented with heart failure. Twenty-six (76%) children had main renal artery stenosis and 17 (50%) mid-aortic syndrome. Seventeen (50%) children showed intrarenal, six (18%) mesenteric, and three (9%) cerebrovascular involvement. Twenty patients underwent 45 percutaneous transluminal angioplasty procedures and seven children surgeries. In 44% of the 16 patients who underwent only percutaneous transluminal angioplasty blood pressure was normalized, 38% had improvement on same or decreased treatment and 19% showed no improvement. Complications were seen in 7.5% (5/66) of angiographies. In four of the seven (57%) children who underwent surgery blood pressure was normalized, two had improved (29%) and one unchanged (14%) blood pressure. Conclusion : In small children with renovascular hypertension below the age of 2 years, percutaneous transluminal angioplasty caused significant improvement in blood pressure with low complication profile. Surgery can be recommended where percutaneous transluminal angioplasty and medical treatments failed. What is Known: • Renovascular hypertension is diagnosed in all age groups from a few weeks ...

الإتاحة: https://doi.org/10.1007/s00431-022-04550-4Test

المؤلفون: Trinder, Sarah M., Ruhayel, Sandra D., Gottardo, Nicholas G., McLaren, Clare A., Ryan, Anne L., Roebuck, Derek J.

المصدر: Journal of Pediatric Hematology/Oncology; Nov2023, Vol. 45 Issue 8, p467-471, 5p

المؤلفون: Roebuck, Derek J., Murray, Conor, McLaren, Clare A.

المصدر: Frontiers in Pediatrics ; volume 8 ; ISSN 2296-2360

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.3389/fped.2020.579032Test

المؤلفون: Minhas, Kishore¹ (AUTHOR), Roebuck, Derek J.^1,2,3 (AUTHOR), Sebire, Neil⁴ (AUTHOR), Cho, Alexander⁵ (AUTHOR), Patel, Premal A.¹ (AUTHOR) premal.patel@gosh.nhs.uk

المصدر: Pediatric Radiology. Aug2023, Vol. 53 Issue 9, p1903-1910. 8p. 2 Color Photographs, 1 Chart.

مصطلحات موضوعية: *CHILDREN'S hospitals, *BIOPSY, *GRANULOSA cell tumors

مستخلص: Background: Traditionally, testicular biopsy is performed using an open surgical approach. Ultrasound-guided percutaneous biopsy is a less invasive alternative and can be performed in children. Objective: The aim of this study is to report our technique and to assess the diagnostic accuracy and safety of ultrasound-guided percutaneous biopsy of testicular masses in children. Materials and methods: This is a 16-year retrospective review of ultrasound-guided percutaneous testicular biopsies at a single pediatric hospital. Results: We performed nine ultrasound-guided testicular biopsies in 9 patients (median age: 3 years, range: 4 months–11 years; median weight: 20.9 kg, range: 8.4–35 kg; median volume of testicular lesion biopsied: 4.4 mL, range: 1.2–17 mL). A percutaneous co-axial technique was used for 5/9 biopsies with absorbable gelatin sponge tract embolization performed in 4 of those biopsies. A non-co-axial technique was used in 4/9 biopsies. A median of three cores, range 2–6, were obtained. The diagnostic yield was 89% with one biopsy yielding material suggestive of, but insufficient for, a definitive diagnosis. The most common histological diagnosis was leukemic infiltration, occurring in 6/9 biopsies. Of the remaining three biopsies, one biopsy was suggestive of, but not confirmatory for, juvenile granulosa cell tumor and two biopsies confirmed normal testicular tissue; the long-term follow-up of which demonstrated normal growth and no lasting damage. There was one (clinically insignificant) complication out of nine biopsies (11%, 95% confidence interval 0–44%): a mild, self-resolving scrotal hematoma. Conclusion: Ultrasound-guided testicular biopsy can be performed safely in children as an alternative to open surgical biopsy, with a high diagnostic yield and low complication rate. [ABSTRACT FROM AUTHOR]

المؤلفون: Minhas, Kishore, Roebuck, Derek J., Sebire, Neil, Cho, Alexander, Patel, Premal A.

المصدر: Pediatric Radiology ; volume 53, issue 9, page 1971-1973 ; ISSN 1432-1998

مصطلحات موضوعية: Radiology, Nuclear Medicine and imaging, Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1007/s00247-023-05690-xTest

المؤلفون: Roebuck, Derek J., Chippington, Samantha, Berry, Bligh D., Gibson, Craig

المصدر: World Journal of Pediatrics ; volume 19, issue 6, page 614-618 ; ISSN 1708-8569 1867-0687

مصطلحات موضوعية: Pediatrics, Perinatology and Child Health

الإتاحة: https://doi.org/10.1007/s12519-023-00692-zTest