المؤلفون: Hernández Fernández, Carlos Pelayo, Borrego Hernando, Leopoldo, Giménez Arnau, Ana María, Zaragoza Ninet, Violeta, Sanz Sánchez, Tatiana, Miquel Miquel, Francisco Javier, González Pérez, Ricardo, Silvestre Salvador, Juan Francisco, Córdoba Guijarro, Susana, Carrascosa Carrillo, José Manuel, Gatica Ortega, María Elena, Ruiz González, Inmaculada, Mercader García, Pedro, Tous Romero, Fátima, Serra Baldrich, Esther, Pastor-Nieto, María Antonia, Rodríguez Serna, Mercedes, Sánchez Pérez, Javier, Sánchez Gilo, Araceli, Melé Ninot, Gemma, Sánchez-Pedreño Guillén, Paloma, de Vega Martínez, Marina, Gallego Descalzo, Miguel Ángel, García Doval, Ignacio

المساهمون: orcid:0000-0002-4832-5483, orcid:0000-0002-0199-2756, orcid:0000-0001-5434-7753, NO DATA, orcid:0000-0002-5796-7680, orcid:0000-0002-1780-4481, orcid:0000-0001-5238-215X, orcid:0000-0002-8532-6338, orcid:0000-0002-1809-4821, orcid:0000-0003-4266-0771, orcid:0000-0002-8203-5834, orcid:0000-0002-5101-466X, orcid:0000-0002-8309-9725, orcid:0000-0002-3904-3396, orcid:0000-0001-7603-0300, orcid:0000-0001-8382-5419, orcid:0000-0002-2690-3668, orcid:0000-0003-1240-1015, orcid:0000-0003-4941-6405, orcid:0000-0003-0365-0634, orcid:0000-0002-2262-7547, orcid:0000-0002-6881-5260, 57214544289, 7004025265, 24068420100, 24337144700, 6506960206, 6506759329, 55909809000, 57193874699, 35569505100, 26422804500, 57194638206, 6603455998, 57216168318, 57188587516, 6701845879, 15128697400, 7004163814, 7006076733, 35782206200, 55991704800, 6602337891, 57217093612, 12808006600, 6507745043, BU-MED

المصدر: Contact Dermatitis[ISSN 0105-1873], p. 1-9 (Febrero 2024)

مصطلحات موضوعية: 32 Ciencias médicas, 320106 Dermatología, Contact Dermatitis, Disperse Dyes, Patch Tests, Spain, Standard Series, Textile Dye Mix, Textile Dye Series

الوصف: Background: Current frequency and features for positivity to textile dye mix (TDM) in Spain are unknown. Objectives: To study the frequency, clinical features and simultaneous positivity between TDM, para-phenylenediamine (PPD) and specific disperse dyes. Materials and Methods: We analysed all consecutive patients patch-tested with TDM from the Spanish Contact Dermatitis Registry (REIDAC), from 1 January 2019 to 31 December 2022. Within this group, we studied all selected patients patch-tested with a textile dye series. Results: Out of 6128 patients analysed, 3.3% were positive to the TDM and in 34% of them, the sensitisation was considered currently relevant. TDM positivity was associated with working as a hairdresser/beautician and scalp, neck/trunk and arm/forearm dermatitis. From TDM-positive patients, 57% were positive to PPD. One hundred and sixty-four patients were patch-tested with the textile dye series. Disperse Orange 3 was the most frequent positive dye (16%). One of every six cases positive to any dye from the textile dye series would have been missed if patch-tested with the TDM alone. Conclusions: Positivity to TDM is common in Spain and often associated with PPD sensitisation. TDM is a valuable marker of disperse dyes allergy that should be part of the Spanish and European standard series. ; 9 ; 1 ; 10 ; 0,72 ; 5,5 ; Q1 ; Q1 ; SCIE ; 11,0

العلاقة: Contact Dermatitis; Scopus; http://hdl.handle.net/10553/129184Test; 85185485832; Sí

الإتاحة: https://doi.org/10.1111/cod.14513Test
http://hdl.handle.net/10553/129184Test

المؤلفون: Navarro-Triviño, Francisco José, Borrego, Leopoldo, Silvestre-Salvador, Juan Francisco, Mercader-García, Pedro, Giménez-Arnau, Ana M, de Frutos, Francisco Javier Ortiz, Sanz-Sánchez, Tatiana, Melé-Ninot, Gemma, Sánchez-Gilo, Araceli, Zaragoza-Ninet, Violeta, Serra-Baldrich, Esther, Miquel-Miquel, Javier, Córdoba-Guijarro, Susana, Rodríguez-Serna, Mercedes, Ruíz-González, Inmaculada, Manuel Carrascosa-Carrillo, José, de la Fuente, Enrique Gómez, Pastor-Nieto, María Antonia, Heras-Mendaza, Felipe, González-Pérez, Ricardo, Guillén, Paloma Sánchez-Pedreño, Sánchez-Pérez, Javier, Gatica-Ortega, María Elena, Fernández-Redondo, Virginia, Hervella-Garcés, Marcos, Manrique-Martínez, Pilar, Guimaraens-Juanena, Dolores, García-Gavín, Juan, Giménez-Arnau, Elena, Figueras-Nart, Ignaci, Curto-Barredo, Laia, Carlos Armario-Hita, José

المساهمون: AEMPS

المصدر: Actas Dermo-Sifiliográficas ; ISSN 0001-7310

مصطلحات موضوعية: Dermatology, Histology, Pathology and Forensic Medicine

الإتاحة: https://doi.org/10.1016/j.ad.2024.03.024Test
https://api.elsevier.com/content/article/PII:S0001731024002710?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0001731024002710?httpAccept=text/plainTest

المؤلفون: Hernández Fernández, Carlos Pelayo, Borrego Hernando, Leopoldo, Mercader García, Pedro, Giménez Arnau, Anna María, Sánchez Pérez, Javier, Silvestre Salvador, Juan Francisco, González Pérez, Ricardo, Sanz Sánchez, Tatiana, Sánchez Gilo, Araceli, Melé Ninot, Gemma, Zaragoza Ninet, Violeta, Miquel Miquel, Francisco Javier, Carrascosa Carrillo, José Manuel, Córdoba Guijarro, Susana, Gatica Ortega, María Elena, Ruiz González, Inmaculada, Serra Baldrich, Esther, Tous Romero, Fátima, Rodríguez Serna, Mercedes, Pastor Nieto, María Antonia, Pérez Feal, Patricia, Hervella Garcés, Marcos, De Vega Martínez, Marina, García Doval, Ignacio

مصطلحات موضوعية: benzisothiazolinone, contact dermatitis, methylchloroisothiazolinone/methylisothiazolinone, methylisothiazolinone, octylisothiazolinone, patch tests, Spain, standard series

الوصف: Background: Current frequency and risk factors for sensitization to methylisothiazolinone (MI), methylchloroisothiazolinone/methylisothiazolinone (MCI/MI), benzisothiazolinone (BIT) and octylisothiazolinone (OIT) in Spain are not well known. Objectives: To study the frequency of sensitization, risk factors and simultaneous sensitization between the four isothiazolinones. Materials and Methods: We analysed all 2019-2021 consecutive patients patch-tested with MI (0.2% aq.), MCI/MI (0.02% aq.), BIT (0.1% pet.) and OIT (0.1% pet) within the Spanish Contact Dermatitis Registry (REIDAC). Results: A total of 2511 patients were analysed. Frequencies of sensitization were: any isothiazolinone 15.7%, MI 6.8%, MCI/MI 4.8%, BIT 3.5% and OIT 0.5%. MI and MCI/MI sensitization was associated with being occupationally active, hand dermatitis, detergents and age over 40. BIT sensitization was associated with leg dermatitis and age over 40. About one in nine MI-positive patients were positive to BIT, whereas one in five BIT-positive patients were positive to MI. Conclusions: Sensitization to MI, MCI/MI and BIT is still common in Spain, while sensitization to OIT is rare. Currently, sensitization to MI and MCI/MI seems to be occupationally related. Although its origin is unknown, sensitization to BIT is more frequent in patients aged over 40 years. Simultaneous sensitization between MI and BIT is uncommon. ; The Spanish Registry of Contact Dermatitis (REIDAC) is promoted by the Fundación Piel Sana (Academia Española de Dermatología y Venereología), which has received financial support from the Spanish Medicines and Health Products Agency (Agencia Española de Medicamentos y Productos Sanitarios. https://www.boe.es/boe/dias/2022/04/11/pdfs/BOE-A-2022-5975.pdfTest) and Sanofi. The funders were not involved in the design and conduct of the study, collection, management, analysis and interpretation of data, preparation, review, approval of the manuscript, or decision to submit the manuscript for publication.

وصف الملف: application/pdf

العلاقة: Contact Dermatitis 88(3) : 212-219 (2023); http://hdl.handle.net/10810/61037Test

الإتاحة: https://doi.org/10.1111/cod.14251Test
http://hdl.handle.net/10810/61037Test

المؤلفون: Pesqué, David, Borrego Hernando, Leopoldo, Zaragoza-Ninet, Violeta, Sanz-Sánchez, Tatiana, Miquel-Miquel, Francisco Javier, González-Pérez, Ricardo, Silvestre, Juan Francisco, Córdoba-Guijarro, Susana, Carrascosa, José Manuel, Gatica-Ortega, María Elena, Ruiz-González, Inmaculada, Mercader-García, Pedro, Tous-Romero, Fátima, Ortiz de Frutos, Francisco Javier, Serra-Baldrich, Esther, Pastor-Nieto, María Antonia, Rodríguez-Serna, Mercedes, Sánchez Pérez, Javier, Sánchez-Gilo, Araceli, Melé-Ninot, Gemma, Sánchez-Pedreño Guillén, Paloma, Pujol, Ramon Maria, Giménez-Arnau, Ana María

المساهمون: orcid:0000-0002-5821-9780, orcid:0000-0002-0199-2756, NO DATA, orcid:0000-0003-4266-0771, orcid:0000-0002-8203-5834, orcid:0000-0002-3904-3396, orcid:0000-0001-8382-5419, orcid:0000-0003-4941-6405, orcid:0000-0003-0365-0634, orcid:0000-0001-5434-7753, 57220890156, 7004025265, 24337144700, 6506960206, 6506759329, 55909809000, 58850883800, 35569505100, 35548523800, 57194638206, 6603455998, 57216168318, 57188587516, 6602083415, 6701845879, 15128697400, 7004163814, 7006076733, 35782206200, 55991704800, 6602337891, 57188660875, 24068420100, BU-MED

المصدر: Journal of the European Academy of Dermatology and Venereology[ISSN 0926-9959], (Febrero 2024)

مصطلحات موضوعية: 32 Ciencias médicas, 320106 Dermatología

الوصف: Background: There is still limited clinical-practice data on specific clinical and patch test features, as well as on allergen clusters in polysensitization (PS). Objectives: To determine the frequency, relevance, symptoms duration and risk factors in polysensitized patients and to assess possible allergen aggregation. Methods: Prospective multicentric study (January 2019–December 2022) conducted in setting of the Spanish Contact Dermatitis Register (REIDAC). Clinical and patch test data of polysensitized and oligosensitized patients were compared, and risk factors of PS were investigated with logistic multivariate regression. Unsupervised hierarchical clustering and network analysis were used to study allergen aggregation in PS. Results: A total of 10,176 patients were analysed. PS was found in 844 (8.3%). Current relevance was significantly higher in polysensitized patients (p < 0.01). Risk factors for PS were atopic dermatitis (OR: 1.58, 95% CI: 1.24–2.02), age (≥60 years vs. ≤24 years, OR: 1.75, 95% CI: 1.25–2.44) and some special locations (legs vs. face OR: 1.54, 95% CI: 1.05–2.25, hands vs. face OR: 1.46, 95% CI:1.15–1.85, arms vs. face OR: 1.49, 95% CI:1.01–2.20, trunk vs. face OR: 1.40, 95% CI:1.06–1.85). Cluster and network analyses revealed specific-allergen clusters and significant associations, including allergens belonging to metals group, fragrances and botanicals group, topical drugs group, rubber allergens and biocides. Conclusions: This study confirms that PS is structured by discernible patterns of specific-allergen clusters and reinforces significant allergen associations in PS. Cross-reactivity and/or concomitant sensitization could explain the formation of allergen clusters in PS. ; 10 ; 1,51 ; 9,2 ; Q1 ; Q1 ; SCIE ; 11,0

العلاقة: Journal of the European Academy of Dermatology and Venereology; Scopus; http://hdl.handle.net/10553/129530Test; 85186563596; Sí

الإتاحة: https://doi.org/10.1111/jdv.19934Test
http://hdl.handle.net/10553/129530Test

المؤلفون: Gatica‐Ortega, Maria Elena, Pastor‐Nieto, Maria Antonia, Giménez‐Arnau, Ana María, Mercader‐García, Pedro, Sanz‐Sánchez, Tatiana, Carrascosa‐Carrillo, José Manuel, Córdoba‐Guijarro, Susana, Sánchez‐Pérez, Javier, Silvestre, Juan Francisco, Frutos, Francisco Javier Ortiz‐de, Tous‐Romero, Fátima, Fernández‐Redondo, Virginia, Serra‐Baldrich, Esther, Ruíz‐González, Inmaculada, González Pérez, Ricardo, Miquel‐Miquel, Javier, Guillén, Paloma Sánchez‐Pedreño, Hervella‐García, Marcos, Heras‐Mendaza, Felipe, Gómez‐de‐la‐Fuente, Enrique, Zaragoza‐Ninet, Violeta, Gilo, Araceli Sánchez, Rodríguez‐Serna, Mercedes, Melé‐Ninot, Gemma, Descalzo, Miguel Ángel, de‐Vega, Marina, García‐Doval, Ignacio, Borrego, Leopoldo

المصدر: Contact Dermatitis ; volume 90, issue 5, page 507-513 ; ISSN 0105-1873 1600-0536

الوصف: Background A global epidemic of allergic contact dermatitis to (meth)acrylates has been described in relation to the widespread use of manicure products. Objectives To evaluate the frequency of sensitization to 2‐hydroxyethyl methacrylate (2‐HEMA) among consecutively patch tested patients with eczema in Spain; the percentage of current relevance; the MOAHLFA index; and, the potential sources of exposure to (meth)acrylates. Methods From January 2019 to December 2022, 2‐HEMA 2% pet. was prospectively patch tested in 24 REIDAC (Spanish Allergic Contact Dermatitis Registry) centres. Results Six thousand one hundred thirty‐four patients were consecutively patch tested with 2‐HEMA 2% pet. 265/6134 (4.3%) were positive. Positive reactions of current relevance were identified to involve 184/265 (69%). The efficiency (number of patch tests needed to detect relevant positive patch test reactions) was 34 (6134/184). The variable ‘occupational’ was found to be significantly associated with a higher risk for relevant positive reactions to 2‐HEMA (OR: 10.9; 95% CI: 8.1–14.9). Conclusion (Meth)acrylate sensitization is a prevalent health issue in Spain. 2‐HEMA 2% pet. has been identified to be a highly effective (meth)acrylate allergy marker in the GEIDAC baseline series. The responsible authorities should implement policies guaranteeing accurate labelling of industrial, medical, and consumer materials while ensuring the enforcement of said labelling through appropriate legal means.

الإتاحة: https://doi.org/10.1111/cod.14520Test

المؤلفون: Lasheras‐Pérez, Miguel A., Palacios‐Diaz, Rodolfo D., González‐Delgado, Víctor A., Cobreros, Lorena V., Pereira‐Resquin Galván, Gabriel O., Miquel‐Miquel, Javier, Labrandero Hoyos, Carolina, Zaragoza Ninet, Violeta, Melgosa Ramos, Francisco J., Sánchez‐Motilla, José M., Navarro‐Blanco, Fernando, Martín‐Torregrosa, Daniel, Botella‐Estrada, Rafael, Rodríguez‐Serna, Mercedes

المصدر: International Journal of Dermatology ; ISSN 0011-9059 1365-4632

الإتاحة: https://doi.org/10.1111/ijd.17030Test

المؤلفون: Lasheras-Pérez, Miguel Antonio, Palacios-Diaz, Rodolfo David, Martínez-Jarreta, Begoña, Rodríguez-Serna, Mercedes

المصدر: Revista Española de Medicina Legal ; ISSN 0377-4732

مصطلحات موضوعية: Pathology and Forensic Medicine

الإتاحة: https://doi.org/10.1016/j.reml.2024.02.001Test
https://api.elsevier.com/content/article/PII:S0377473224000087?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0377473224000087?httpAccept=text/plainTest

المؤلفون: Palacios-Diaz, Rodolfo David, Lasheras-Pérez, Miguel Antonio, Rodríguez-Serna, Mercedes

المصدر: Enfermedades Infecciosas y Microbiología Clínica ; ISSN 0213-005X

مصطلحات موضوعية: Microbiology (medical), Microbiology, Infectious Diseases

الإتاحة: https://doi.org/10.1016/j.eimc.2023.12.010Test
https://api.elsevier.com/content/article/PII:S0213005X2400185X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0213005X2400185X?httpAccept=text/plainTest

المؤلفون: Mercader‐García, Pedro, Gatica‐Ortega, Maria Elena, González‐Pérez, Ricardo, Pastor‐Nieto, María Antonia, Carrillo, Andrés, Borrego, Leopoldo, Silvestre, Juan Fco., Ortíz‐Frutos, Javier, Tous, Fátima, de la Fuente, Enrique Gómez, Rodríguez‐Serna, Mercedes, Arnau, Ana Giménez, Munera, Mónica, Carrascosa, Jose Manuel, Zaragoza, Violeta, Miquel, Javier, Córdoba, Susana, Serra‐Baldrich, Ester, Sanchez‐Gilo, Araceli, Sánchez‐Pérez, Javier

المصدر: Contact Dermatitis (01051873); Mar2024, Vol. 90 Issue 3, p245-252, 8p

مستخلص: Background: Monitoring of adverse events induced by cosmetics performed by health authorities, known as cosmetovigilance, has been relied on the collection of case notifications. Objectives: We aimed to show how a contact dermatitis registry can contribute to the cosmetovigilance of emerging allergens. We used the example of phenylethyl resorcinol, an infrequent allergen with only 6 previous cases reported in Europe and Japan since 2013. Methods: A systematic search in the Spanish Registry of Contact Dermatitis and Cutaneous Allergy (REIDAC) database was performed to identify patients with positive patch test to phenylethyl resorcinol or cosmetics that contains it between June 2018 and January 2023. We collected the main clinical features of these patients and compared them with those of patients recorded in the registry with similar epidemiological features. Results: Thirteen patients with positive patch test to phenylethyl resorcinol were identified. All the patients were women with a mean age of 42 years (range 32–59) and their lesions were mainly in the face. Conclusion: Assessing the importance of infrequent allergens based solely on a case series is difficult. Multicentre registries facilitate the collection of cases and provide appropriate background information for new allergens. [ABSTRACT FROM AUTHOR]

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المؤلفون: Asensi Cantó, Pedro, Rodríguez Serna, Mercedes, Lloret Madrid, Pilar, Solís Ruiz, Jürgen, Cid Haro, Ana Rosa, Bonanad Boix, Santiago, Haya Guaita, Saturnino

المصدر: TH Open ; volume 06, issue 03, page e154-e155 ; ISSN 2512-9465

الوصف: Emicizumab constitutes a novel and effective prophylaxis for hemophilia A patients with and without inhibitors. In this case report, we describe an emicizumab-induced photosensitivity that forced permanent sun-exposure suppression. To the best of our knowledge, this side effect had not been communicated until present.

الإتاحة: https://doi.org/10.1055/s-0042-1749092Test