المؤلفون: Riera, Pau

مصطلحات موضوعية: Gross-Pitaevskii equation, Computational Mathematics, Beräkningsmatematik

الوصف: In this thesis, we investigate the numerical solution of time-dependent nonlinear Schrödinger equations (more specifically, the Gross-Pitaevskii equation) that appear in the modeling of Bose-Einstein condensates. Since the model is known to conserve important physical invariants, such as mass and energy of the condensate, our goal is to study the importance of reproducing the conservation on the discrete level. The reliability of conservative, compared to non-conservative, methods shall be studied through high order collocation methods for the time discretization and finite element-based space discretizations. In particular, this includes symplectic discontinuous Galerkin time-stepping methods, as well as Continuous Petrov-Galerkin methods. The methods shall be tested for a problem with a known analytical solution, namely two interacting solitons in 1D. This problem is a suitable choice due to its high sensitivity to oscillations of the energy and difficulty to approximate for large time scales.

وصف الملف: application/pdf

الإتاحة: http://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-194703Test

المؤلفون: Miarons, Marta, Manzaneque, Alba, Riera, Pau, Gutiérrez Nicolás, Fernando

المساهمون: Institut Català de la Salut, Miarons M Servei de Farmàcia, Vall d’Hebron Hospital Universitari, Barcelona, Spain. ReDPyD group from the Spanish Society of Hospital Pharmacy (SEFH), Tenerife, Canarias, Spain. Manzaneque Gordón A Pharmacy Department, Hospital Mutua de Terrassa, Terrassa, Barcelona, Spain. ReDPyD group from the Spanish Society of Hospital Pharmacy (SEFH), Tenerife, Canarias, Spain. Riera P Pharmacy Department, IIB-Sant Pau, Hospital de la Santa Creu i Sant Pau, Carrer Sant Quintí, Barcelona, Spain. U705, Centro de Investigación Biomédica en Red de Enfermedades Raras (CIBERER), Instituto de Salud Carlos III, Barcelona, Spain. ReDPyD group from the Spanish Society of Hospital Pharmacy (SEFH), Tenerife, Canarias, Spain. Gutiérrez Nicolás F Pharmacy Department, Research Unit Hospital Universitario de Canarias (CHUC), Tenerife, Canarias, Spain. ReDPyD group from the Spanish Society of Hospital Pharmacy (SEFH), Tenerife, Canarias, Spain, Vall d'Hebron Barcelona Hospital Campus

المصدر: Scientia

مصطلحات موضوعية: Càncer - Aspectes genètics, Polimorfisme genètic, DISEASES::Neoplasms, Other subheadings::Other subheadings::Other subheadings::/genetics, PHENOMENA AND PROCESSES::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic, ENFERMEDADES::neoplasias, Otros calificadores::Otros calificadores::Otros calificadores::/genética, FENÓMENOS Y PROCESOS::fenómenos genéticos::variación genética::polimorfismo genético

الوصف: Genetic variants; Cancer; Spain ; Variants genètiques; Càncer; Espanya ; Variantes genéticas; Cáncer; España ; Introduction Identifying polymorphisms in the dihydropyrimidine dehydrogenase (DPYD) gene is gaining importance to be able to predict fluoropyrimidine-associated toxicity. The aim of this project was to describe the frequency of the DPYD variants DPYD*2A (rs3918290); c.1679T>G (rs55886062); c.2846A>T (rs67376798) and c.1129-5923C>G (rs75017182; HapB3) in the Spanish oncological patients. Material and Methods Cross-sectional and multicentric study (PhotoDPYD study) conducted in hospitals located in Spain designed to register the frequency of the most relevant DPYD genetic variants in oncological patients. All oncological patients with DPYD genotype were recruited in the participant hospitals. The measures determined where the presence or not of the 4 DPYD previously described variants. Results Blood samples from 8054 patients with cancer from 40 different hospitals were used to determine the prevalence of the 4 variants located in the DPYD gene. The frequency of carriers of one defective DPYD variant was 4.9%. The most frequently identified variant was c.1129-5923C>G (rs75017182) (HapB3), in 2.9%, followed by c.2846A>T (rs67376798) in 1.4%, c.1905 + 1G>A (rs3918290, DPYD*2A) in 0.7% and c.1679T>G (rs55886062) in 0.2% of the patients. Only 7 patients (0.08%) were carrying the c.1129-5923C>G (rs75017182) (HapB3) variant, 3 (0.04%) the c.1905 + 1G>A (rs3918290, DPYD*2A) and one (0.01%) the DPYD c.2846A>T (rs67376798, p.D949V) variant in homozygosis. Moreover, 0.07% were compound heterozygous patients, 3 carrying the DPYD variants DPYD*2A + c.2846A>T, 2 the DPYD c.1129-5923C>G + c.2846A>T and one the DPYD*2A + c.1129-5923C>G variants. Conclusions Our results demonstrate the relatively high frequency of DPYD genetic variants in the Spanish patient with cancer population, which highlights the relevance of their determination before initiating a ...

وصف الملف: application/pdf

العلاقة: The Oncologist;28(5); https://doi.org/10.1093/oncolo/oyad077Test; Miarons M, Manzaneque Gordón A, Riera P, Gutiérrez Nicolás F; RedDPYD Research Group with the Spanish Society of Hospital Pharmacy (SEFH). Allelic Frequency of DPYD Genetic Variants in Patients With Cancer in Spain: The PhotoDPYD Study. Oncologist. 2023 May;28(5):e304-e308.; https://hdl.handle.net/11351/9923Test; 000962843300001

الإتاحة: https://doi.org/10.1093/oncolo/oyad077Test
https://hdl.handle.net/11351/9923Test

المؤلفون: Sainz, Luis, Riera, Pau, Moya, Patricia, Bernal, Sara, Casademont, Jordi, Díaz-Torné, Cesar, Millán, Ana Milena, Park, Hye Sang, Lasa, Adriana, Corominas, Hector

المساهمون: Societat Catalana de Reumatologia, Instituto de Salud Carlos III

المصدر: Arthritis Research & Therapy ; volume 25, issue 1 ; ISSN 1478-6362

الوصف: Background Sarilumab, an IL-6 receptor antagonist, is a first-line biologic disease-modifying anti-rheumatic drug for rheumatoid arthritis. The identification of genetic biomarkers as predictors of response to sarilumab could allow for a personalized treatment strategy to improve clinical outcomes. Methods We conducted a retrospective cohort study of 62 patients treated with sarilumab to determine whether single-nucleotide polymorphisms (SNP) in the IL6R gene could predict efficacy and toxicity responses. Six SNPs previously described in the IL6R gene (rs12083537, rs11265618, rs4329505, rs2228145, rs4537545, and rs4845625) were genotyped in DNA samples obtained from these patients. Using parametric tests, we evaluated the association between these polymorphisms and clinicopathological features. Treatment response was assessed six months after treatment initiation. Satisfactory response was based on EULAR criteria. Low disease activity was determined according to DAS28 and CDAI and quantitative improvements in DAS28 and CDAI scores. Results Three SNPs (rs4845625, rs4329505 and rs11265618) were significantly associated with response outcomes. All of the SNPs, except for rs12083537, had at least one significant association with dyslipidemia or hepatotoxicity. Conclusions These findings support the potential clinical value of SNPs, particularly rs4845625, as potentially useful biomarkers to predict response to sarilumab in patients with RA.

الإتاحة: https://doi.org/10.1186/s13075-023-03209-1Test

المؤلفون: Ligero, Carmen¹ (AUTHOR) mariacarmen.ligero@salutsantjoan.cat, Riera, Pau² (AUTHOR) priera@santpau.cat, El-Amrani, Amine¹ (AUTHOR) amin.elamrany@gmail.com, Bazan, Victor³ (AUTHOR) victorbazang@yahoo.com, Guerra, José M.⁴ (AUTHOR) jguerra@santpau.cat, Herraez, Silvia⁴ (AUTHOR) sherraez@santpau.cat, Viñolas, Xavier⁴ (AUTHOR), Alegret, Josep M.¹ (AUTHOR) josepmaria.alegret@urv.cat

المصدر: Pharmaceuticals (14248247). Jun2024, Vol. 17 Issue 6, p693. 9p.

مصطلحات موضوعية: *AMIODARONE, *BODY mass index, *ATRIAL fibrillation, *BODY composition, *ADIPOSE tissues, *FAT, *ARRHYTHMIA, *WEIGHT gain

مستخلص: Background: Amiodarone is an anti-arrhythmic drug that has extensive tissue distribution and substantial storage in the fat tissue. Different studies have described some implications of body fat composition in its pharmacokinetics and pharmacodynamics. However, no clinical studies have described its implications for clinical efficacy. Methods: We studied 878 patients with persistent atrial fibrillation (AF) treated with a regimen of amiodarone and referred to electrical cardioversion (ECV), included prospectively in two Spanish registries. We analyzed the influence of body mass index (BMI), as well as overweight and obesity, in the efficacy of amiodarone for achieving pharmacologic cardioversion to sinus rhythm (SR) before ECV. Results: A total of 185 patients (21.1%) reverted to SR before ECV. Patients who reverted to SR had a lower BMI than those who did not revert (27.45 ± 4.36 kg/m2 vs. 29.11 ± 4.09 kg/m2; p < 0.001). We observed a progressively lower probability of reverting to SR in overweight and obese patients (normal weight 28.3%, overweight 21.3%, obesity 13.1%; p < 0.001). In the logistic regression, BMI (kg/m2) adjusted for other related variables remained as the main factor inversely related to reversion to SR (OR = 0.904 × kg/m2); CI 75% 0.864–0.946). Conclusions: We observed a negative relationship between an increased BMI and the efficacy of amiodarone for reversion to SR, suggesting a negative clinical impact of excess body fat in its efficacy. [ABSTRACT FROM AUTHOR]

المؤلفون: Martín-Cullell, Berta, Virgili, Anna C, Riera, Pau, Fumagalli, Caterina, Mirallas, Oriol, Pelegrín, Francisco J, Sánchez-Cabús, Santiago, Molina, Víctor, Szafranska, Justyna, Páez, David

المساهمون: Instituto de Salud Carlos III

المصدر: British Journal of Surgery ; volume 111, issue 3 ; ISSN 0007-1323 1365-2168

مصطلحات موضوعية: Surgery

الوصف: Background Histopathological and molecular features have been proposed to hold prognostic information, but few have been validated. The aim of this retrospective study was to validate the Genetic And Morphological Evaluation (‘GAME’) score and assess the impact of histological characteristics on the prognosis in patients with colorectal liver metastases. Methods Data were collected from 176 patients with metastatic colorectal cancer undergoing liver resection at Hospital de la Santa Creu i Sant Pau. Patients were classified into Genetic And Morphological Evaluation score groups and relapse-free survival and overall survival were calculated. Histopathological changes in colorectal liver metastases were documented and prognostic variables were selected to create a post-surgery score, called the Histopathological, Clinical, And Molecular (‘HICAM’) score. Results Regarding the Genetic And Morphological Evaluation score, the high-risk group had a median relapse-free survival of 8.8 months, compared with 20.5 months for the low-risk group (P = 0.005), and the high-risk group had a median overall survival of 37.8 months, compared with 67.0 months for the low-risk group (P = 0.005). Histological examination of 144 liver samples showed that the desertic immune phenotype was associated with worse overall survival in the multivariable analysis (P = 0.020). The Histopathological, Clinical, And Molecular score variables were age at diagnosis, tumour burden score, carcinoembryonic antigen levels greater than or equal to 20 ng/ml, primary tumour resection, TNM stage at diagnosis, molecular status, histopathological growth patterns, and immune phenotypes of the liver. The high-risk group had a median relapse-free survival of 8.4 months, compared with 20.4 months for the low-risk group (P < 0.001), and a median overall survival of 30.4 months, compared with 105.0 months for the low-risk group (P < 0.001). Conclusion The Genetic And Morphological Evaluation score was validated as a preoperative prognostic ...

الإتاحة: https://doi.org/10.1093/bjs/znae016Test
https://academic.oup.com/bjs/article-pdf/111/3/znae016/57117913/znae016.pdfTest

المؤلفون: Sainz, Luis, Riera, Pau, Moya, Patricia, Bernal, Sara, Casademont i Pou, Jordi, Díaz Torne, César, Millán, Ana Milena, Park, Hye Sang, Lasa, Adriana, Corominas, Hèctor, Universitat Autònoma de Barcelona

مصطلحات موضوعية: IL6R, Genetic variants, Tocilizumab, Toxicity, Rheumatoid arthritis, Predictive biomarkers

الوصف: Altres ajuts: Societat Catalana de Reumatologia, Beca STADA 2020-2021 ; Tocilizumab is a first-line biologic disease-modifying anti-rheumatic drug (bDMARD) that inhibits the interleukin-6 (IL-6) pathway by antagonizing the IL-6 receptor (IL-6R). Tocilizumab is widely used to treat rheumatoid arthritis (RA), a prevalent autoimmune disease that can cause irreversible joint damage and disability. Although many bDMARDs have been developed for RA, there is a lack of validated biomarkers which could guide personalized medicine strategies. To evaluate whether single-nucleotide polymorphisms (SNPs) in the IL6R gene could predict tocilizumab toxicity in patients with RA, we conducted a retrospective cohort study of 88 patients treated with tocilizumab. Six SNPs previously described in the IL6R gene were genotyped (rs12083537, rs11265618, rs4329505, rs2228145, rs4537545, and rs4845625). Using parametric tests, we studied the association between the SNPs and hepatotoxicity, infection, hypersensitivity, gastrointestinal, hematological, and dyslipidemia adverse events (AEs). We found associations between dyslipidemia and rs4845625 and between hematological AEs and rs11265618 and rs4329505. No further associations were found for the remaining SNPs and other AEs. Our findings support the potential clinical value of SNPs in the IL6R gene as predictive biomarkers for toxicity to tocilizumab in patients with RA. ; IIB

وصف الملف: application/pdf

العلاقة: Journal of Personalized Medicine; Vol. 13 (december 2022); https://ddd.uab.cat/record/270867Test; urn:10.3390/jpm13010061; urn:oai:ddd.uab.cat:270867; urn:pmcid:PMC9865948; urn:pmc-uid:9865948; urn:pmid:36675722; urn:oai:pubmedcentral.nih.gov:9865948; urn:oai:egreta.uab.cat:publications/88e086ae-fa90-4b08-942c-2cda46346e74

الإتاحة: https://ddd.uab.cat/record/270867Test

المؤلفون: Sainz, Luis, Riera, Pau, Moya, Patricia, Bernal, Sara, Casademont i Pou, Jordi, Díaz Torne, César, Millán, Ana Milena, Park, Hye S, Lasa, Adriana, Corominas, Hèctor, Universitat Autònoma de Barcelona

مصطلحات موضوعية: Genetic variants, IL6R, Predictive factors, Rheumatoid arthritis, Tocilizumab

الوصف: Rheumatoid arthritis (RA) is a prevalent autoimmune disease characterized by chronic arthritis that may lead to irreversible joint damage and significant disability. Patients with RA are commonly treated with Tocilizumab (TCZ), an IL-6 receptor (IL-6R) antagonist, but many patients refractorily respond to this therapy. Identifying genetic biomarkers as predictors of TCZ response could be a key to providing a personalized medicine strategy. We aimed to evaluate whether functional single nucleotide polymorphisms (SNPs) in the IL6R gene could predict TCZ response in patients with RA. We retrospectively included 88 RA patients treated with TCZ. Six SNPs previously described in the IL6R gene (rs12083537, rs11265618, rs4329505, rs2228145, rs4537545, and rs4845625) were genotyped in DNA samples from these patients. Using parametric tests, we evaluated the association between these polymorphisms and clinicopathological features. Responses to treatments were assessed at six months using three variables: a quantitative improvement in Disease activity score including 28 joints (DAS28), a satisfactory European League Against Rheumatism (EULAR) response, and low disease activity (LDA) achievement. The three response variables studied were associated with genetic variant rs4845625, and no association was found with the other five SNPs. Our findings support the potential clinical value of SNPs in the IL6R gene as predictive biomarkers for TCZ response.

وصف الملف: application/pdf

العلاقة: Pharmaceutics; Vol. 14 (september 2022); https://ddd.uab.cat/record/282418Test; urn:10.3390/pharmaceutics14091942; urn:oai:ddd.uab.cat:282418; urn:pmcid:PMC9501307; urn:pmc-uid:9501307; urn:pmid:36145690; urn:oai:pubmedcentral.nih.gov:9501307; urn:oai:egreta.uab.cat:publications/1db5e4e7-a235-45ad-9743-eafc068d87eb

الإتاحة: https://ddd.uab.cat/record/282418Test

المؤلفون: Engel, Janina, Riera, Pau Gayà, Grilli, Joseph, Sola, Pierre

مصطلحات موضوعية: ddc:330, C46, D31, E27, G51, N34, Wealth inequality, HFCS, National Accounts, Pareto distribution

الوصف: Distributional accounts for households enable measurement, study developments and identify drivers of inequality. Distributional information on households' wealth is available from the Household Finance and Consumption Survey only for three points in time (2009 - 2018), while aggregates are available quarterly. This paper presents a novel methodology for deriving quarterly distributional national wealth by (i) improving the alignment of survey fieldwork periods with the national accounts' dates; (ii) correcting for differences in several concepts; (iii) estimating missing wealthy households; (iv) developing time series; and (v) computing euro area aggregates. This paper finds an increase in the net wealth Gini of most euro area countries since 2009; that the richest 1% holds 28% of total net wealth, while the bottom 50% holds 4%; and that the net wealth of the top 1% has grown by almost 50%, compared to 28% for the remaining 99%, with a decrease in the bottom 20%.

العلاقة: Series: ECB Working Paper; No. 2687; urn:isbn:978-92-899-5271-2; gbv-ppn:1811722016; http://hdl.handle.net/10419/269094Test; RePEc:ecb:ecbwps:20222687

الإتاحة: https://doi.org/10.2866/412495Test
http://hdl.handle.net/10419/269094Test

المؤلفون: Vara, Mª Dolores, Mira, Adriana, Miragall, Marta, García-Palacios, Azucena, Botella, Cristina, Gili, Margalida, RIERA, PAU, García-Campayo, Javier, Mayoral-Cleries, Fermin, Baños, Rosa

مصطلحات موضوعية: depression, primary care, internet-based intervention, positive affect

الوصف: Background: A large number of low-intensity Internet-based interventions (IBIs) for the treatment of depression have emerged in Primary Care; most of them focused on decreasing negative emotions. However, recent studies have highlighted the importance of addressing positive affect (PA) as well. This study is a secondary analysis of a randomized control trial. We examine the role of an IBI focused on promoting PA in patients with depression in Primary Care (PC). The specific objectives were to explore the profile of the patients who benefit the most and to analyze the change mechanisms that predict a significantly greater improvement in positive functioning measures. Methods: 56 patients were included. Measures of depression, affect, well-being, health-related quality of life, and health status were administered. Results: Participants who benefited the most were those who had lower incomes and education levels and worse mental health scores and well-being at baseline (7.9%–39.5% of explained variance). Improvements in depression severity and PA were significant predictors of long-term change in well-being, F (3,55) = 17.78, p < 0.001, R2 = 47.8%. Conclusions: This study highlights the importance of implementing IBIs in PC and the relevance of PA as a key target in Major Depressive Disorder treatment.

وصف الملف: application/pdf

العلاقة: Int. J. Environ. Res. Public Health 2020, 17, 8094; PI16/01017; https://www.mdpi.com/journal/ijerphTest; Vara, Mª D.; Mira, Adriana; Miragall, Marta; García-Palacios, Azucena; Botella, Cristina; Gili, Margalida; Riera-Serra, Pau; García-Campayo, Javier; Mayoral-Cleries, Fermín; Baños, Rosa M. 2020. "A Low-Intensity Internet-Based Intervention Focused on the Promotion of Positive Affect for the Treatment of Depression in Spanish Primary Care: Secondary Analysis of a Randomized Controlled Trial" Int. J. Environ. Res. Public Health 17, no. 21: 8094.; http://hdl.handle.net/10234/191241Test; https://doi.org/10.3390/ijerph17218094Test

الإتاحة: https://doi.org/10.3390/ijerph17218094Test
http://hdl.handle.net/10234/191241Test

المؤلفون: Gili, Margalida, Castro, Adoración, García-Palacios, Azucena, Mayoral-Cleries, Fermin, Botella, Cristina, Roca, Miquel, Barceló-Soler, Alberto, Hurtado, María M., Navarro, MªTeresa, Villena, Amelia, Pérez-Ara, M. Ángeles, RIERA, PAU, Baños, Rosa Maria

مصطلحات موضوعية: depression, primary care, internet-based interventions, randomized controlled trial

الوصف: Background: Primary care is a major access point for the initial treatment of depression, but the management of these patients is far from optimal. The lack of time in primary care is one of the major difficulties for the delivery of evidence-based psychotherapy. During the last decade, research has focused on the development of brief psychotherapy and cost-effective internet-based interventions mostly based on cognitive behavioral therapy (CBT). Very little research has focused on alternative methods of treatment for depression using CBT. Thus, there is a need for research into other therapeutic approaches. Objective: This study aimed to assess the effectiveness of 3 low-intensity, internet-based psychological interventions (healthy lifestyle psychoeducational program [HLP], focused program on positive affect promotion [PAPP], and brief intervention based on mindfulness [MP]) compared with a control condition (improved treatment as usual [iTAU]). Methods: A multicenter, 4-arm, parallel randomized controlled trial was conducted between March 2015 and March 2016, with a follow-up of 12 months. In total, 221 adults with mild or moderate major depression were recruited in primary care settings from 3 Spanish regions. Patients were randomly distributed to iTAU (n=57), HLP (n=54), PAPP (n=56), and MP (n=54). All patients received iTAU from their general practitioners. The main outcome was the Spanish version of the Patient Health Questionnaire-9 (PHQ-9) from pretreatment (time 1) to posttreatment (time 2) and up to 6 (time 3) and 12 (time 4) months’ follow-up. Secondary outcomes included the visual analog scale of the EuroQol, the Short-Form Health Survey (SF-12), the Positive and Negative Affect Schedule (PANAS), and the Pemberton Happiness Index (PHI). We conducted regression models to estimate outcome differences along study stages. Results: A moderate decrease was detected in PHQ-9 scores from HLP (β=–3.05; P=.01) and MP (β=–3.00; P=.01) compared with iTAU at posttreatment. There were significant differences ...

وصف الملف: application/pdf

العلاقة: Instituto de Salud Carlos III of the Spanish Ministry of Economy and Competitiveness with the PI13/01171 grant (Efficacy and cost-effectiveness of the low-intensity psychological interventions applied by ICTs for the treatment of depression in primary care: a controlled trial); https://www.jmir.org/2020/6/e15845Test/; Gili M, Castro A, García-Palacios A, Garcia-Campayo J, Mayoral-Cleries F, Botella C, Roca M, Barceló-Soler A, Hurtado MM, Navarro M, Villena A, Pérez-Ara M, Riera-Serra P, Baños RM Efficacy of Three Low-Intensity, Internet-Based Psychological Interventions for the Treatment of Depression in Primary Care: Randomized Controlled Trial J Med Internet Res 2020;22(6):e15845; http://hdl.handle.net/10234/189070Test; https://doi.org/10.2196/15845Test

الإتاحة: https://doi.org/10.2196/15845Test
http://hdl.handle.net/10234/189070Test