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1دورية
المؤلفون: McGlone, Matt, Bellingham, Peter (Peter J.), Richardson, Sarah J.
المصدر: New Zealand journal of forestry science, 2022; v.52 n.8:25p
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2دورية
المؤلفون: Richardson, Sarah J.
المصدر: New Zealand journal of ecology, 2018; v.42 n.2:p.222-228
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3دورية
المؤلفون: Hoare, Robert J. B., Millar, I R, Richardson, Sarah J.
المصدر: New Zealand entomologist, Mar 2016; v.39 n.1:p.1-14
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4دورية أكاديمية
المؤلفون: Forbes, Adam S., Richardson, Sarah J., Carswell, Fiona E., Mason, Norman W. H., Burrows, Larry E.
المصدر: New Zealand Journal of Ecology, 2023 Jan 01. 47(1), 1-12.
الوصول الحر: https://www.jstor.org/stable/48740241Test
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5دورية أكاديمية
المؤلفون: Palmer, Jonathan G., Turney, Chris S. M., Thomas, Zoë A., Fenwick, Pavla, Richardson, Sarah J., Wilmshurst, Janet M., McGlone, Matt S.
المصدر: New Zealand Journal of Ecology, 2023 Jan 01. 47(1), 1-8.
الوصول الحر: https://www.jstor.org/stable/48740227Test
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6دورية
المصدر: New Zealand journal of ecology, 2014; v.38 n.2:p.221-228
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7دورية
المؤلفون: Smale, M. C., Richardson, Sarah J., Hurst, Jennifer M.
المصدر: New Zealand journal of forestry science, 2014; v.44 n.20:6p
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8دورية أكاديمية
المؤلفون: Gerakios, Florence, Yarnall, Alison J, Bate, Gemma, Wright, Laura, Davis, Daniel, Stephan, Blossom CM, Robinson, Louise, Brayne, Carol, Stebbins, Glenn, Taylor, John-Paul, Burn, David J, Allan, Louise M, Richardson, Sarah J, Lawson, Rachael A
مصطلحات موضوعية: Delirium, Institutionalisation, Mortality, Older people, Outcomes, Parkinson's disease, Humans, Aged, Prospective Studies, Parkinson Disease, Longitudinal Studies, Aftercare, Patient Discharge, Dementia
الوصف: BACKGROUND: Inpatient prevalence of Parkinson's disease (PD) delirium varies widely across the literature. Delirium in general older populations is associated with adverse outcomes, such as increased mortality, dementia, and institutionalisation. However, to date there are no comprehensive prospective studies in PD delirium. This study aimed to determine delirium prevalence in hospitalised PD participants and the association with adverse outcomes, compared to a control group of older adults without PD. METHODS: Participants were hospitalised inpatients from the 'Defining Delirium and its Impact in Parkinson's Disease' and the 'Delirium and Cognitive Impact in Dementia' studies comprising 121 PD participants and 199 older adult controls. Delirium was diagnosed prospectively using the Diagnostic and Statistical Manual of Mental Disorders 5th Edition criteria. Outcomes were determined by medical note reviews and/or home visits 12 months post hospital discharge. RESULTS: Delirium was identified in 66.9% of PD participants compared to 38.7% of controls (p < 0.001). In PD participants only, delirium was associated with a significantly higher risk of mortality (HR = 3.3 (95% confidence interval [CI] = 1.3-8.6), p = 0.014) and institutionalisation (OR = 10.7 (95% CI = 2.1-54.6), p = 0.004) 12 months post-discharge, compared to older adult controls. However, delirium was associated with an increased risk of developing dementia 12 months post-discharge in both PD participants (OR = 6.1 (95% CI = 1.3-29.5), p = 0.024) and in controls (OR = 13.4 (95% CI = 2.5-72.6), p = 0.003). CONCLUSION: Delirium is common in hospitalised PD patients, affecting two thirds of patients, and is associated with increased mortality, institutionalisation, and dementia. Further research is essential to understand how to accurately identify, prevent and manage delirium in people with PD who are in hospital.
وصف الملف: application/pdf
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9دورية أكاديمية
المؤلفون: the nPOD-Virus Working Group, Vecchio, Federica, Carré, Alexia, Korenkov, Daniil, Zhou, Zhicheng, Apaolaza, Paola, Tuomela, Soile, Burgos-Morales, Orlando, Snowhite, Isaac, Perez-Hernandez, Javier, Brandao, Barbara, Afonso, Georgia, Halliez, Clémentine, Kaddis, John, Kent, Sally C., Nakayama, Maki, Richardson, Sarah J., Vinh, Joelle, Verdier, Yann, Laiho, Jutta, Scharfmann, Raphael, Solimena, Michele, Marinicova, Zuzana, Bismuth, Elise, Lucidarme, Nadine, Sanchez, Janine, Bustamante, Carmen, Gomez, Patricia, Buus, Soren, You, Sylvaine, Pugliese, Alberto, Hyoty, Heikki, Rodriguez-Calvo, Teresa, Flodstrom-Tullberg, Malin, Mallone, Roberto
المساهمون: Tampere University, Biosciences, Fimlab Laboratories PLC, LAST, Paediatrics
مصطلحات موضوعية: 3111 Biomedicine, 3123 Gynaecology and paediatrics, 3121 Internal medicine
الوصف: Coxsackievirus B (CVB) infection of pancreatic β cells is associated with β cell autoimmunity and type 1 diabetes. We investigated how CVB affects human β cells and anti-CVB T cell responses. β cells were efficiently infected by CVB in vitro, down-regulated human leukocyte antigen (HLA) class I, and presented few, selected HLA-bound viral peptides. Circulating CD8+ T cells from CVB–seropositive individuals recognized a fraction of these peptides; only another subfraction was targeted by effector/memory T cells that expressed exhaustion marker PD-1. T cells recognizing a CVB epitope cross-reacted with β cell antigen GAD. Infected β cells, which formed filopodia to propagate infection, were more efficiently killed by CVB than by CVB-reactive T cells. Our in vitro and ex vivo data highlight limited CD8+ T cell responses to CVB, supporting the rationale for CVB vaccination trials for type 1 diabetes prevention. CD8+ T cells recognizing structural and nonstructural CVB epitopes provide biomarkers to differentially follow response to infection and vaccination. ; Peer reviewed
وصف الملف: fulltext
العلاقة: eadl1122; 10; https://trepo.tuni.fi/handle/10024/156329Test; URN:NBN:fi:tuni-202404173650
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10دورية أكاديمية
المؤلفون: Vanderhoorn, Jacqui M. M., Wilmshurst, Janet M., Richardson, Sarah J., Etherington, Thomas R., Perry, George L. W.
المصدر: Journal of Biogeography ; ISSN 0305-0270 1365-2699
الوصف: Aim Species severely under‐represented in fossil pollen records leave gaps in interpretations and reconstructions of past vegetation. These ‘silent taxa’ leave little or no trace due to low pollen production, dispersal, preservation and taxonomic resolution. An approach for including them is through associating them with other species with reliable pollen representation. Here, we demonstrate a method for selecting such a proxy species for the Holocene using modern vegetation data. Location New Zealand. Taxon Beilschmiedia tawa (A.Cunn.) Benth. & Hook. F. ex Kirk (Lauraceae). Methods We used vegetation plot data to perform a pairwise co‐occurrence analysis of the New Zealand indigenous forest metacommunity to identify species with a strong positive association with Beilschmiedia tawa (tawa), a common tree severely under‐recorded in the pollen record. For those species, we then modelled their realised climatic niches to identify species with high niche overlap. We discuss how well those species could be interpreted from the Holocene fossil pollen record based on the representation of their pollen taxa. Results Knightia excelsa (rewarewa; Proteaceae) is a potential proxy for B. tawa in Holocene fossil pollen records, and other, range‐limited species may provide community‐specific proxies. We show combining resampling with sub‐sampling is a robust method for reducing the high false positive rate associated with large co‐occurrence analyses (1000+ sites) by limiting the sample size to 100 sites. Main Conclusions We show that the palaeoecology of silent taxa can be studied via proxy species, allowing their past distributions to be better understood. We highlight the importance of modelling many aspects of the realised niche to understand the usefulness and limitations of the silent–proxy association. Future research should focus on testing the underlying assumptions of the silent–proxy relationship so that models built on modern data can confidently be applied to palaeoecological data.
النص الكامل