المؤلفون: Falagario, Ugo G, Lantz, Anna, Jambor, Ivan, Busetto, Gian Maria, Bettocchi, Carlo, Finati, Marco, Ricapito, Anna, Luzzago, Stefano, Ferro, Matteo, Musi, Gennaro, Totaro, Angelo, Racioppi, Marco, Carbonara, Umberto, Checcucci, Enrico, Manfredi, Matteo, D'Aietti, Damiano, Porcaro, Antonio Benito, Nordström, Tobias, Björnebo, Lars, Oderda, Marco, Soria, Francesco, Taimen, Pekka, Aronen, Hannu J, Perez, Ileana Montoya, Ettala, Otto, Marchioni, Michele, Simone, Giuseppe, Ferriero, Mariaconsiglia, Brassetti, Aldo, Napolitano, Luigi, Carmignani, Luca, Signorini, Claudia, Conti, Andrea, Ludovico, Giuseppe, Scarcia, Marcello, Trombetta, Carlo, Claps, Francesco, Traunero, Fabio, Montanari, Emanuele, Boeri, Luca, Maggi, Martina, Del Giudice, Francesco, Bove, Pierluigi, Forte, Valerio, Ficarra, Vincenzo, Rossanese, Marta, Mucciardi, Giuseppe, Pagliarulo, Vincenzo, Tafuri, Alessandro, Mirone, Vincenzo, Schips, Luigi, Antonelli, Alessandro, Gontero, Paolo, Cormio, Luigi, Sciarra, Alessandro, Porpiglia, Francesco, Bassi, PierFrancesco, Ditonno, Pasquale, Boström, Peter J, Messina, Emanuele, Panebianco, Valeria, De Cobelli, Ottavio, Carrieri, Giuseppe, PROMOD Study Group

المساهمون: Falagario, Ugo G, Lantz, Anna, Jambor, Ivan, Busetto, Gian Maria, Bettocchi, Carlo, Finati, Marco, Ricapito, Anna, Luzzago, Stefano, Ferro, Matteo, Musi, Gennaro, Totaro, Angelo, Racioppi, Marco, Carbonara, Umberto, Checcucci, Enrico, Manfredi, Matteo, D'Aietti, Damiano, Porcaro, Antonio Benito, Nordström, Tobia, Björnebo, Lar, Oderda, Marco, Soria, Francesco, Taimen, Pekka, Aronen, Hannu J, Perez, Ileana Montoya, Ettala, Otto, Marchioni, Michele, Simone, Giuseppe, Ferriero, Mariaconsiglia, Brassetti, Aldo, Napolitano, Luigi, Carmignani, Luca, Signorini, Claudia, Conti, Andrea, Ludovico, Giuseppe, Scarcia, Marcello, Trombetta, Carlo, Claps, Francesco, Traunero, Fabio, Montanari, Emanuele, Boeri, Luca, Maggi, Martina, Del Giudice, Francesco, Bove, Pierluigi, Forte, Valerio, Ficarra, Vincenzo, Rossanese, Marta, Mucciardi, Giuseppe, Pagliarulo, Vincenzo, Tafuri, Alessandro, Mirone, Vincenzo, Schips, Luigi, Antonelli, Alessandro, Gontero, Paolo, Cormio, Luigi, Sciarra, Alessandro, Porpiglia, Francesco, Bassi, Pierfrancesco, Ditonno, Pasquale, Boström, Peter J, Messina, Emanuele, Panebianco, Valeria, De Cobelli, Ottavio, Carrieri, Giuseppe, PROMOD Study, Group

مصطلحات موضوعية: 5-Alpha-reductase inhibitor, Magnetic resonance imaging, Prostate cancer

الوصف: Purpose: The primary aim of this study was to evaluate if exposure to 5-alpha-reductase inhibitors (5-ARIs) modifies the effect of MRI for the diagnosis of clinically significant Prostate Cancer (csPCa) (ISUP Gleason grade ≥ 2). Methods: This study is a multicenter cohort study including patients undergoing prostate biopsy and MRI at 24 institutions between 2013 and 2022. Multivariable analysis predicting csPCa with an interaction term between 5-ARIs and PIRADS score was performed. Sensitivity, specificity, and negative (NPV) and positive (PPV) predictive values of MRI were compared in treated and untreated patients. Results: 705 patients (9%) were treated with 5-ARIs [median age 69 years, Interquartile range (IQR): 65, 73; median PSA 6.3 ng/ml, IQR 4.0, 9.0; median prostate volume 53 ml, IQR 40, 72] and 6913 were 5-ARIs naïve (age 66 years, IQR 60, 71; PSA 6.5 ng/ml, IQR 4.8, 9.0; prostate volume 50 ml, IQR 37, 65). MRI showed PIRADS 1-2, 3, 4, and 5 lesions in 141 (20%), 158 (22%), 258 (37%), and 148 (21%) patients treated with 5-ARIs, and 878 (13%), 1764 (25%), 2948 (43%), and 1323 (19%) of untreated patients (p < 0.0001). No difference was found in csPCa detection rates, but diagnosis of high-grade PCa (ISUP GG ≥ 3) was higher in treated patients (23% vs 19%, p = 0.013). We did not find any evidence of interaction between PIRADS score and 5-ARIs exposure in predicting csPCa. Sensitivity, specificity, PPV, and NPV of PIRADS ≥ 3 were 94%, 29%, 46%, and 88% in treated patients and 96%, 18%, 43%, and 88% in untreated patients, respectively. Conclusions: Exposure to 5-ARIs does not affect the association of PIRADS score with csPCa. Higher rates of high-grade PCa were detected in treated patients, but most were clearly visible on MRI as PIRADS 4 and 5 lesions. Trial registration: The present study was registered at ClinicalTrials.gov number: NCT05078359.

وصف الملف: ELETTRONICO

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37787941; info:eu-repo/semantics/altIdentifier/wos/WOS:001079688300002; volume:41; issue:11; firstpage:2967; lastpage:2974; numberofpages:8; journal:WORLD JOURNAL OF UROLOGY; https://hdl.handle.net/11368/3060879Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85173915657; https://link.springer.com/article/10.1007/s00345-023-04634-2Test

الإتاحة: https://doi.org/10.1007/s00345-023-04634-2Test
https://hdl.handle.net/11368/3060879Test

المؤلفون: Rubino, Matteo, Ricapito, Anna, Finati, Marco, Falagario, Ugo G, Annese, Pasquale, Mancini, Vito, Busetto, Gian Maria, Cormio, Luigi, Carrieri, Giuseppe, Bettocchi, Carlo

المصدر: Asian Journal of Andrology; Jul/Aug2024, Vol. 26 Issue 4, p344-348, 5p

مستخلص: Previous published studies have shown an improvement of penile hemodynamic parameters after low-intensity extracorporeal shockwave therapy (Li-ESWT). However, the clinical significance of these findings remains unclear, and definitive selection criteria for Li-ESWT based on preexisting comorbidities have yet to be established. This was an observational study of 113 patients with ED, evaluated between January 2019 and December 2021 in Andrology Unit at the Department of Urology and Renal Transplantation, University of Foggia (Foggia, Italy). Penile dynamic Doppler was performed to evaluate vascular parameters and 5-item version of the International Index of Erectile Dysfunction (IIEF-5) questionnaire was administered to assess the severity of ED. This was repeated 1 month after treatment. Patients with a peak systolic velocity (PSV) <30 cm s⁻¹ were considered eligible for Li-ESWT. Our protocol consisted of 8 weekly sessions with 1500 strokes distributed in 5 different locations along the penis. After treatment, a significant mean (±standard deviation [s.d.]) PSV increase of 5.0 (±3.4) cm s⁻¹ was recorded and 52/113 (46.0%) patients reached a PSV >30 cm s⁻¹ at posttherapeutic penile dynamic Doppler. A clinically significant IIEF-5 score improvement was observed in 7 patients, 21 patients, and 2 patients with mild-to-moderate, moderate, and severe pretreatment ED, respectively. No different outcomes were assessed based on smoking habits, previous pelvic surgery, or use of oral phosphodiesterase-5 inhibitor (PDE5i). On the other side, only 1 (6.7%) in 15 patients with diabetes mellitus showed an IIEF-5 score improvement after Li-ESWT. Shockwave treatment determined a significant increase in PSV and correlated IIEF-5 improvement in ED patients. This advantage seemed particularly evident for moderate ED and was not affected by smoking habits, previous pelvic surgery, and use of PDE5i. Conversely, diabetic patients did not benefit from the treatment. [ABSTRACT FROM AUTHOR]

: Copyright of Asian Journal of Andrology is the property of Wolters Kluwer India Pvt Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Cosentino, Marco, Di Nauta, Michele, Boeri, Luca, Ferraioli, Giordana, Lucignani, Gianpaolo, Ricapito, Anna, Gadda, Franco, Iafrate, Massimo, Mancini, Mariangela, Dal Moro, Fabrizio, Ruiz-Castañe, Eduard, Bettocchi, Carlo, Montanari, Emanuele, Sofikitis, Nikolaos

المصدر: World Journal of Urology; 5/13/2024, Vol. 42 Issue 1, p1-9, 9p

مصطلحات موضوعية: PENILE induration, EXTRACORPOREAL shock wave therapy, CONSERVATIVE treatment, COLLAGENASES, LITERATURE reviews

مستخلص: Purpose: To review the literature on the topic, to suggest a common line of treatment applicable across a wide community of specialists, and to contribute in maintaining the high level of interest in this disease. Methods: A comprehensive and exhaustive review of the literature was performed, identifying hundreds of articles on the topic. Results: Peyronie's disease is a condition that has been recognized, studied, and treated for centuries; despite this, if one excludes surgery in cases in which the deformity is stable, no clear treatment (or line of treatment) is available for complete relief of signs and symptoms. Treatment options were divided into local, oral, and injection therapy, and a wide variety of drugs, remedies, and options were identified. Conclusions: Low-intensity extracorporeal shock wave therapy, vacuum therapy, penile traction therapy, phosphodiesterase type 5 inhibitors, hyaluronic acid, and collagenase of Clostridium histolyticum may be recommended only in specific contexts. Further studies on individual options or potential combinations are required. [ABSTRACT FROM AUTHOR]

: Copyright of World Journal of Urology is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Falagario, Ugo Giovanni, Piramide, Federico, Pang, Karl H., Durukan, Emil, Tzelves, Lazaros, Ricapito, Anna, Baekelandt, Loic, Checcucci, Enrico, Carrion, Diego M., Bettocchi, Carlo, Esperto, Francesco

المصدر: Medicina (1010660X); May2024, Vol. 60 Issue 5, p758, 21p

مصطلحات موضوعية: QUALITY of life, PENILE transplantation, DERMAL fillers, SURGICAL complications, VETERINARY surgery, SURGERY

مستخلص: The increase in practices related to enhancing penile size can be attributed to the belief that an improved genital appearance contributes to a man's virility, coupled with an altered self-perception of his body. It is crucial to tailor interventions to meet the genuine needs of patients by thoroughly assessing their history, psychological state, and potential surgical benefits, all while considering the associated risks of complications. This systematic review aims to summarize the available evidence on outcomes, complications, and quality of life after penile augmentation surgery, examining both minimally invasive and more radical techniques. A search of the PubMed and Scopus databases, focusing on English-language papers published in the last 15 years, was performed in December 2023. Papers discussing surgery in animal models and case reports were excluded from the present study unless further evaluated in a follow-up case series. The primary outcomes were changes in penile dimensions, specifically in terms of length and girth, as well as the incidence of surgical complications and the impact on quality of life. A total of 1670 articles were retrieved from the search and 46 were included for analysis. Procedures for penile length perceived enhancements include lipoplasty, skin reconstruction plasty, V-Y and Z plasty, flap reconstruction, scrotoplasty, ventral phalloplasty, and suspensory ligament release; techniques for increasing corporal penile length include penile disassembly, total phalloplasty, and sliding elongation. Finally, penile girth enhancement may be performed using soft tissue fillers, grafting procedures, biodegradable scaffolds, and Penuma^®. In conclusion, while penile augmentation surgeries offer potential solutions for individuals concerned about genital size, the risks and complexities need to be accounted for. [ABSTRACT FROM AUTHOR]

: Copyright of Medicina (1010660X) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Bettocchi, Carlo, Castiglione, Fabio, Cakir, Omer Onur, Falagario, Ugo, Ricapito, Anna

المصدر: Practical Clinical Andrology ; page 47-60 ; ISBN 9783031117008 9783031117015

الوصف: Erectile dysfunction (ED) is defined as the failure to achieve and/or maintain a penile erection that is satisfactory for sexual intercourse. The implantation of a penile prosthesis may be considered in patients who are not suitable for different pharmacotherapies and do not respond to the first and the second line of medical treatment. Intraoperative complications include hematoma formation, floppy glans, perforation of the corpora cavernosa, and urethral injury. Bladder, vascular, and bowel injury are the most dangerous events and should be prevented. Postoperative complications are represented by infections, erosions, and glandular ischemia. There is an increasing interest in the hypothesis of “regenerative” cures for ED aimed at decreasing fibrosis of the corpora cavernosa and rebuilding their normal biological architecture. These new regenerative treatments include stem cell injections, platelet-rich plasma, and low-intensity shock wave therapy.

الإتاحة: https://doi.org/10.1007/978-3-031-11701-5_5Test

المؤلفون: Palumbo, Fabrizio, Sebastiani, Francesco, Procacci, Alessandro, D’Altilia, Nicola, Ricapito, Anna, Cormio, Luigi

المساهمون: DBI S.r.l.

المصدر: Practical Clinical Andrology ; page 61-73 ; ISBN 9783031117008 9783031117015

الوصف: Peyronie’s disease (PD), also known as induration penis plastica (IPP), is a clinical condition characterized by the formation of fibrotic plaques onto the tunica albuginea of the penis, which may result into abnormal penile curvature and deformity, erectile dysfunction (ED), and loss of penile length. The combination of these events may result in the impossibility of performing penetrative intercourse [1].

الإتاحة: https://doi.org/10.1007/978-3-031-11701-5_6Test

المؤلفون: Reisman, Yacov, van Renterghem, Koen, Meijer, Boaz, Ricapito, Anna, Fode, Mikkel, Bettocchi, Carlo

المساهمون: Zorgniotti, International Society forSexual Medicine

المصدر: The Journal of Sexual Medicine ; volume 21, issue 5, page 494-499 ; ISSN 1743-6095 1743-6109

الوصف: Background The acquisition of skills in penile prosthesis surgery has many limitations mainly due to the absence of simulators and models for training. Three-dimensional (3D) printed models can be utilized for surgical simulations, as they provide an opportunity to practice before entering the operating room and provide better understanding of the surgical approach. Aim This study aimed to evaluate and validate a 3D model of human male genitalia for penile prosthesis surgery. Methods This study included 3 evaluation and validation stages. The first stage involved verification of the 3D prototype model for anatomic landmarks compared with a cadaveric pelvis. The second stage involved validation of the improved model for anatomic accuracy and teaching purposes with the Rochester evaluation score. The third stage comprised validation of the suitability of the 3D prototype model as a surgical simulator and for skill acquisition. The third stage was performed at 3 centers using a modified version of a pre-existing, validated questionnaire and correlated with the Rochester evaluation score. Outcome We sought to determine the suitability of 3D model for training in penile prosthesis surgery in comparison with the available cadaveric model. Results The evaluation revealed a high Pearson correlation coefficient (0.86) between questions of the Rochester evaluation score and modified validated questionnaire. The 3D model scored 4.33 ± 0.57 (on a Likert scale from 1 to 5) regarding replication of the relevant human anatomy for the penile prosthesis surgery procedure. The 3D model scored 4.33 ± 0.57 (on a Likert scale from 1 to 5) regarding its ability to improve technical skills, teach and practice the procedure, and assess a surgeon’s ability. Furthermore, the experts stated that compared with the cadaver, the 3D model presented greater ethical suitability, reduced costs, and easier accessibility. Clinical implications A validated 3D model is a suitable alternative for penile prosthesis surgery training. Strengths ...

الإتاحة: https://doi.org/10.1093/jsxmed/qdae020Test
https://academic.oup.com/jsm/article-pdf/21/5/494/57359441/qdae020.pdfTest

المؤلفون: Ricapito, Anna, Rubino, Matteo, Falagario, Ugo G., Mancini, Vito, Busetto, GianMaria, Cormio, Luigi, Carrieri, Giuseppe, Bettocchi, Carlo

المصدر: Journal of Urology ; volume 211, issue 5S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1097/01.ju.0001008900.49567.2e.05Test

المؤلفون: Ninivaggi, Antonella, Falagario, Ugo Giovanni, Cormio, Angelo, Galosi, Andrea Benedetto, Carmignani, Luca, Montanari, Emanuele, Bove, Pierluigi, Gontero, Paolo, Porpiglia, Francesco, Sciarra, Alessandro, Trombetta, Carlo, Bassi, Pierfrancesco, Simone, Giuseppe, Ludovico, Giuseppe, Mirone, Vincenzo, Antonelli, Alessandro, Schips, Luigi, Ricapito, Anna, Busetto, Gian Maria, Ficarra, Vincenzo, Boström, Peter J., De Cobelli, Ottavio, Cormio, Luigi, Carrieri, Giuseppe

المصدر: Journal of Urology ; volume 211, issue 5S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1097/01.ju.0001009448.41537.64.08Test

المؤلفون: Ricapito, Anna, Gupta, Kavita, Connors, Chris, Khargi, Raymond, Yaghoubian, Alan, Gallante, Blair, Atallah, William, Gupta, Mantu

المصدر: Journal of Urology ; volume 211, issue 5S ; ISSN 0022-5347 1527-3792

الإتاحة: https://doi.org/10.1097/01.ju.0001008856.05210.73.13Test