نتائج البحث - "Reese, Peter P"

1

دورية أكاديمية

Health inequities and the inappropriate use of race in nephrology

المؤلفون: Eneanya, Nwamaka D, Boulware, L Ebony, Tsai, Jennifer, Bruce, Marino A, Ford, Chandra L, Harris, Christina, Morales, Leo S, Ryan, Michael J, Reese, Peter P, Thorpe, Roland J, Morse, Michelle, Walker, Valencia, Arogundade, Fatiu A, Lopes, Antonio A, Norris, Keith C

المصدر: Nature Reviews Nephrology. 18(2)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Generic health relevance, Good Health and Well Being, Health Inequities, Health Status Disparities, Humans, Nephrology, Racism, Social Justice, United States, Urology & Nephrology, Clinical sciences

الوصف: Chronic kidney disease is an important clinical condition beset with racial and ethnic disparities that are associated with social inequities. Many medical schools and health centres across the USA have raised concerns about the use of race - a socio-political construct that mediates the effect of structural racism - as a fixed, measurable biological variable in the assessment of kidney disease. We discuss the role of race and racism in medicine and outline many of the concerns that have been raised by the medical and social justice communities regarding the use of race in estimated glomerular filtration rate equations, including its relationship with structural racism and racial inequities. Although race can be used to identify populations who experience racism and subsequent differential treatment, ignoring the biological and social heterogeneity within any racial group and inferring innate individual-level attributes is methodologically flawed. Therefore, although more accurate measures for estimating kidney function are under investigation, we support the use of biomarkers for determining estimated glomerular filtration rate without adjustments for race. Clinicians have a duty to recognize and elucidate the nuances of racism and its effects on health and disease. Otherwise, we risk perpetuating historical racist concepts in medicine that exacerbate health inequities and impact marginalized patient populations.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9rs4p7mdTest

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2

دورية أكاديمية

A Machine Learning-Driven Virtual Biopsy System For Kidney Transplant Patients

المؤلفون: Yoo, Daniel, Divard, Gillian, Raynaud, Marc, Cohen, Aaron, Mone, Tom D., Rosenthal, John Thomas, Bentall, Andrew J., Stegall, Mark D., Naesens, Maarten, Zhang, Huanxi, Wang, Changxi, Gueguen, Juliette, Kamar, Nassim, Bouquegneau, Antoine, Batal, Ibrahim, Coley, Shana M., Gill, John S., Oppenheimer, Federico, De Sousa-Amorim, Erika, Kuypers, Dirk R. J., Durrbach, Antoine, Seron, Daniel, Rabant, Marion, Van Huyen, Jean-Paul Duong, Campbell, Patricia, Shojai, Soroush, Mengel, Michael, Bestard, Oriol, Basic-Jukic, Nikolina, Jurić, Ivana, Boor, Peter, Cornell, Lynn D., Alexander, Mariam P., Toby Coates, P., Legendre, Christophe, Reese, Peter P., Lefaucheur, Carmen, Aubert, Olivier, Loupy, Alexandre

المصدر: Nature Communications ; volume 15, issue 1 ; ISSN 2041-1723

مصطلحات موضوعية: General Physics and Astronomy, General Biochemistry, Genetics and Molecular Biology, General Chemistry, Multidisciplinary

الوصف: In kidney transplantation, day-zero biopsies are used to assess organ quality and discriminate between donor-inherited lesions and those acquired post-transplantation. However, many centers do not perform such biopsies since they are invasive, costly and may delay the transplant procedure. We aim to generate a non-invasive virtual biopsy system using routinely collected donor parameters. Using 14,032 day-zero kidney biopsies from 17 international centers, we develop a virtual biopsy system. 11 basic donor parameters are used to predict four Banff kidney lesions: arteriosclerosis, arteriolar hyalinosis, interstitial fibrosis and tubular atrophy, and the percentage of renal sclerotic glomeruli. Six machine learning models are aggregated into an ensemble model. The virtual biopsy system shows good performance in the internal and external validation sets. We confirm the generalizability of the system in various scenarios. This system could assist physicians in assessing organ quality, optimizing allograft allocation together with discriminating between donor derived and acquired lesions post-transplantation.

الإتاحة: https://doi.org/10.1038/s41467-023-44595-zTest
https://www.nature.com/articles/s41467-023-44595-z.pdfTest
https://www.nature.com/articles/s41467-023-44595-zTest

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3

دورية أكاديمية

The 10-Year Effects of Intensive Lifestyle Intervention on Kidney Outcomes

المؤلفون: Lavenburg, Linda-Marie U., Schaubel, Douglas E., Chao, Ariana M., Reese, Peter P., Cohen, Jordana B.

المساهمون: National Institutes of Health

المصدر: Kidney Medicine ; page 100814 ; ISSN 2590-0595

الإتاحة: https://doi.org/10.1016/j.xkme.2024.100814Test
https://api.elsevier.com/content/article/PII:S2590059524000256?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2590059524000256?httpAccept=text/plainTest

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4

دورية أكاديمية

المصدر: Kidney Medicine. 2(5)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Kidney Disease, Clinical Research, Depression, Transplantation, Mental Health, Organ Transplantation, Behavioral and Social Science, Renal and urogenital, Good Health and Well Being, CRIC Study Investigators, Kidney Transplant, depression, quality-of-life, wait-listing, Clinical sciences

الوصف: Rationale & objectiveAmong individuals with chronic kidney disease (CKD), poor self-reported health is associated with adverse outcomes including hospitalization and death. We sought to examine the association between health-related quality-of-life (HRQoL) and depressive symptoms in advanced CKD and subsequent access to the kidney transplant waiting list.Study designProspective cohort study.Setting & population1,676 Chronic Renal Insufficiency Cohort (CRIC) study participants with estimated glomerular filtration rates ≤ 30 mL/min/1.73 m2 at study entry or during follow-up.ExposuresHRQoL ascertained by 5 scales of the Kidney Disease Quality of Life-36 Survey (Physical Component Summary [PCS], Mental Component Summary, Symptoms, Burdens, and Effects), with higher scores indicating better HRQoL, and depressive symptoms ascertained using the Beck Depression Inventory.OutcomesTime to kidney transplant wait-listing and time to pre-emptive wait-listing.Analytic approachTime-to-event analysis using Cox proportional hazards regression.ResultsDuring a median follow-up of 5.1 years, 652 (39%) participants were wait-listed, of whom 304 were preemptively wait-listed. Adjusted for demographics, comorbid conditions, estimated glomerular filtration rate slope, and cognitive function, participants with the highest scores on the Burden and Effects scales, respectively, had lower rates of wait-listing than those with the lowest scores on the Burden (wait-listing adjusted hazard ratio [aHR], 0.70; 95% CI, 0.57-0.85; P

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/7jj7k6jzTest

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5

دورية أكاديمية

Cognitive Impairment in Non–Dialysis-Dependent CKD and the Transition to Dialysis: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study

المصدر: American Journal of Kidney Diseases. 72(4)

مصطلحات موضوعية: Clinical Research, Kidney Disease, Brain Disorders, Renal and urogenital, Good Health and Well Being, Adult, Age Factors, Aged, Cognitive Behavioral Therapy, Cognitive Dysfunction, Cohort Studies, Disease Progression, Female, Humans, Incidence, Kidney Failure, Chronic, Logistic Models, Male, Middle Aged, Multivariate Analysis, Neuropsychological Tests, Predictive Value of Tests, Prognosis, Renal Dialysis, Renal Insufficiency, Chronic, Retrospective Studies, Risk Assessment, Severity of Illness Index, Sex Factors, Transitional Care, Treatment Outcome, CRIC Study Investigators, CKD to ESRD transition, Chronic kidney diseases, central venous catheter, cognitive impairment, dementia, dialysis access, dialysis modality, end-stage renal disease, executive function, incident ESRD, memory, peritoneal dialysis, transplant waitlisting, Clinical Sciences, Public Health and Health Services, Urology & Nephrology

الوصف: BACKGROUND:Advanced chronic kidney disease is associated with elevated risk for cognitive impairment. However, it is not known whether and how cognitive impairment is associated with planning and preparation for end-stage renal disease. STUDY DESIGN:Retrospective observational study. SETTING & PARTICIPANTS:630 adults participating in the CRIC (Chronic Renal Insufficiency Cohort) Study who had cognitive assessments in late-stage CKD, defined as estimated glome-rular filtration rate ≤ 20mL/min/1.73m2, and subsequently initiated maintenance dialysis therapy. PREDICTOR:Predialysis cognitive impairment, defined as a score on the Modified Mini-Mental State Examination lower than previously derived age-based threshold scores. Covariates included age, race/ethnicity, educational attainment, comorbid conditions, and health literacy. OUTCOMES:Peritoneal dialysis (PD) as first dialysis modality, preemptive permanent access placement, venous catheter avoidance at dialysis therapy initiation, and preemptive wait-listing for a kidney transplant. MEASUREMENTS:Multivariable-adjusted logistic regression. RESULTS:Predialysis cognitive impairment was present in 117 (19%) participants. PD was the first dialysis modality among 16% of participants (n=100), 75% had preemptive access placed (n=473), 45% avoided using a venous catheter at dialysis therapy initiation (n=279), and 20% were preemptively wait-listed (n=126). Predialysis cognitive impairment was independently associated with 78% lower odds of PD as the first dialysis modality (adjusted OR [aOR], 0.22; 95% CI, 0.06-0.74; P=0.02) and 42% lower odds of venous catheter avoidance at dialysis therapy initiation (aOR, 0.58; 95% CI, 0.34-0.98; P=0.04). Predialysis cognitive impairment was not independently associated with preemptive permanent access placement or wait-listing. LIMITATIONS:Potential unmeasured confounders; single measure of cognitive function. CONCLUSIONS:Predialysis cognitive impairment is associated with a lower likelihood of PD as a first dialysis modality and of venous catheter avoidance at dialysis therapy initiation. Future studies may consider addressing cognitive function when testing strategies to improve patient transitions to dialysis therapy.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/9gd7p9k3Test

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6

دورية أكاديمية

Additional file 1 of Using structured problem solving to promote fluid consumption in the prevention of urinary stones with hydration (PUSH) trial ...

المؤلفون: Reese, Peter P., Shah, Salima, Funsten, Emily, Amaral, Sandra, Audrain-McGovern, Janet, Koepsell, Kristen, Wessells, Hunter, Harper, Jonathan D., McCune, Rebecca, Scales, Charles D., Kirkali, Ziya, Maalouf, Naim M., Lai, H. Henry, Desai, Alana C., Al-Khalidi, Hussein R., Tasian, Gregory E.

مصطلحات موضوعية: Medicine, Sociology, FOS Sociology, Biological Sciences not elsewhere classified, Cancer, Science Policy, Infectious Diseases, FOS Health sciences

الوصف: Supplementary Material 1 ...

الإتاحة: https://doi.org/10.6084/m9.figshare.25918899.v110.6084/m9.figshare.2591889910.1097/ju.000000000000233110.1038/ki.2015.32110.1002/jbmr.255310.2215/cjn.0434051410.1007/s00198-014-2998-510.1016/s0272-6386Test(98)70136-210.1093/ndt/16.11.223210.1016/j.juro.2013.09.02110.1016/j.juro.2016.07.09010.1038/ki.1979.17310.1111/j.1464-410x.1984.tb05346.x10.1681/asn.201812124110.1016/s0022-5347(01)66321-310.1080/10503307.2014.89777010.1177/014572170730841210.1001/jamainternmed.2013.215210.1016/s0002-8223(02)90347-010.2105/ajph.91.10.168610.1093/her/14.3.399
https://springernature.figshare.com/articles/journal_contribution/Additional_file_1_of_Using_structured_problem_solving_to_promote_fluid_consumption_in_the_prevention_of_urinary_stones_with_hydration_PUSH_trial/25918899/1Test

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7

دورية أكاديمية

Social network interventions to reduce race disparities in living kidney donation: Design and rationale of the friends and family of kidney transplant patients study (FFKTPS)

المؤلفون: Daw, Jonathan, Verdery, Ashton M., Ortiz, Selena E., Reed, Rhiannon Deierhoi, Locke, Jayme E., Redfield, Robert R., Kloda, David, Liu, Michel, Mentch, Heather, Sawinski, Deirdre, Aguilar, Diego, Porter, Nathaniel D., Roberts, Mary K., McIntyre, Katie, Reese, Peter P.

المساهمون: Social Science Research Institute, Pennsylvania State University, National Institute of Diabetes and Digestive and Kidney Diseases, Comprehensive Transplant Institute, University of Alabama at Birmingham

المصدر: Clinical Transplantation ; volume 37, issue 10 ; ISSN 0902-0063 1399-0012

الوصف: Introduction Racial/ethnic disparities in living donor kidney transplantation (LDKT) are a persistent challenge. Although nearly all directed donations are from members of patients’ social networks, little is known about which social network members take steps toward living kidney donation, which do not, and what mechanisms contribute to racial/ethnic LDKT disparities. Methods We describe the design and rationale of the Friends and Family of Kidney Transplant Patients Study, a factorial experimental fielding two interventions designed to promote LKD discussions. Participants are kidney transplant candidates at two centers who are interviewed and delivered an intervention by trained center research coordinators. The search intervention advises patients on which social network members are most likely to be LKD contraindication‐free; the script intervention advises patients on how to initiate effective LKD discussions. Participants are randomized into four conditions: no intervention, search only, script only, or both search and script. Patients also complete a survey and optionally provide social network member contact information so they can be surveyed directly. This study will seek to enroll 200 transplant candidates. The primary outcome is LDKT receipt. Secondary outcomes include live donor screening and medical evaluations and outcomes. Tertiary outcomes include LDKT self‐efficacy, concerns, knowledge, and willingness, measured before and after the interventions. Conclusion This study will assess the effectiveness of two interventions to promote LKD and ameliorate Black‐White disparities. It will also collect unprecedented information on transplant candidates’ social network members, enabling future work to address network member structural barriers to LKD.

الإتاحة: https://doi.org/10.1111/ctr.15064Test

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8

دورية أكاديمية

Organ Transplantation Outcomes of Deceased Organ Donors in Organ Procurement Organization-Based Recovery Facilities Versus Acute-Care Hospitals

المؤلفون: Vail, Emily A., Schaubel, Douglas E., Abt, Peter L., Martin, Niels D., Reese, Peter P., Neuman, Mark D.

المساهمون: National Institutes of Health, Agency for Healthcare Research and Quality

المصدر: Progress in Transplantation ; volume 33, issue 2, page 110-120 ; ISSN 1526-9248 2164-6708

مصطلحات موضوعية: Transplantation

الوصف: Introduction Recovery of donated organs at organ procurement organization (OPO)-based recovery facilities has been proposed to improve organ donation outcomes, but few data exist to characterize differences between facilities and acute-care hospitals. Research Question To compare donation outcomes between organ donors that underwent recovery procedures in OPO-based recovery facilities and hospitals. Design Retrospective study of Organ Procurement and Transplantation Network data. From a population-based sample of deceased donors after brain death April 2017 to June 2021, donation outcomes were examined in 10 OPO regions with organ recovery facilities. Primary exposure was organ recovery procedure in an OPO-based organ recovery. Primary outcome was the number of organs transplanted per donor. Multivariable regression models were used to adjust for donor characteristics and managing OPO. Results Among 5010 cohort donors, 2590 (51.7%) underwent recovery procedures in an OPO-based facility. Donors in facilities differed from those in hospitals, including recovery year, mechanisms of death, and some comorbid diseases. Donors in OPO-based facilities had higher total numbers of organs transplanted per donor (mean 3.5 [SD1.8] vs 3.3 [SD1.8]; adjusted mean difference 0.27, 95% confidence interval 0.18-0.36). Organ recovery at an OPO-based facility was also associated with more lungs, livers, and pancreases transplanted. Conclusion Organ recovery procedures at OPO-based facilities were associated with more organs transplanted per donor than in hospitals. Increasing access to OPO-based organ recovery facilities may improve rates of organ transplantation from deceased organ donors, although further data are needed on other important donor management quality metrics.

الإتاحة: https://doi.org/10.1177/15269248231164176Test

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9

دورية أكاديمية

Deceased Organ Donor Management and Organ Distribution From Organ Procurement Organization-Based Recovery Facilities Versus Acute-Care Hospitals

المؤلفون: Vail, Emily A., Schaubel, Douglas E., Potluri, Vishnu S., Abt, Peter L., Martin, Niels D., Reese, Peter P., Neuman, Mark D.

المساهمون: National Institute of Diabetes and Digestive and Kidney Diseases, Agency for Healthcare Research and Quality

المصدر: Progress in Transplantation ; ISSN 1526-9248 2164-6708

مصطلحات موضوعية: Transplantation

الوصف: Introduction: Organ recovery facilities address the logistical challenges of hospital-based deceased organ donor management. While more organs are transplanted from donors in facilities, differences in donor management and donation processes are not fully characterized. Research Question: Does deceased donor management and organ transport distance differ between organ procurement organization (OPO)-based recovery facilities versus hospitals? Design: Retrospective analysis of Organ Procurement and Transplant Network data, including adults after brain death in 10 procurement regions (April 2017-June 2021). The primary outcomes were ischemic times of transplanted hearts, kidneys, livers, and lungs. Secondary outcomes included transport distances (between the facility or hospital and the transplant program) for each transplanted organ. Results: Among 5010 deceased donors, 51.7% underwent recovery in an OPO-based recovery facility. After adjustment for recipient and system factors, mean differences in ischemic times of any transplanted organ were not significantly different between donors in facilities and hospitals. Transplanted hearts recovered from donors in facilities were transported further than hearts from hospital donors (median 255 mi [IQR 27, 475] versus 174 [IQR 42, 365], P = .002); transport distances for livers and kidneys were significantly shorter ( P < .001 for both). Conclusion: Organ recovery procedures performed in OPO-based recovery facilities were not associated with differences in ischemic times in transplanted organs from organs recovered in hospitals, but differences in organ transport distances exist. Further work is needed to determine whether other observed differences in donor management and organ distribution meaningfully impact donation and transplantation outcomes.

الإتاحة: https://doi.org/10.1177/15269248231212918Test

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10

دورية أكاديمية

Cognitive function, self-management, and outcomes among liver transplant recipients: LivCog, a multicenter, prospective study

المؤلفون: Serper, Marina, Chafale, Adwait, Burdzy, Alex, Kim, Minjee, Asrani, Sumeet K., Yoshino Benavente, Julia, Gershon, Richard, Reese, Peter P., Schaubel, Douglas E., Boike, Justin R., Blanco, Maria C., Wolf, Michael S.

المصدر: Hepatology Communications ; volume 7, issue 10 ; ISSN 2471-254X

الوصف: Liver transplantation is a life-saving option for decompensated cirrhosis. Liver transplant recipients require advanced self-management skills, intact cognitive skills, and care partner support to improve long-term outcomes. Gaps remain in understanding post-liver transplant cognitive and health trajectories, and patient factors such as self-management skills, care partner support, and sleep. Our aims are to (1) assess pre-liver transplant to post-liver transplant cognitive trajectories and identify risk factors for persistent cognitive impairment; (2) evaluate associations between cognitive function and self-management skills, health behaviors, functional health status, and post-transplant outcomes; and (3) investigate potential mediators and moderators of associations between cognitive function and post-liver transplant outcomes. LivCog is a longitudinal, prospective observational study that will enroll 450 adult liver transplant recipients and their caregivers/care partners. The duration of the study is 5 years with 24 additional months of patient follow-up. Data will be collected from participants at 1, 3, 12, and 24 months post-transplant. Limited pre-liver transplant data will also be collected from waitlisted candidates. Data collection methods include interviews, surveys, cognitive assessments, and actigraphy/sleep diary measures. Patient measurements include sociodemographic characteristics, pretransplant health status, cognitive function, physical function, perioperative measures, medical history, transplant history, self-management skills, patient-reported outcomes, health behaviors, and clinical outcomes. Caregiver measures assess sociodemographic variables, health literacy, health care navigation skills, self-efficacy, care partner preparedness, nature and intensity of care, care partner burden, and community participation. By elucidating various health trajectories from pre-liver transplant to 2 years post-liver transplant, LivCog will be able to better characterize recipients at higher risk of ...

الإتاحة: https://doi.org/10.1097/hc9.0000000000000259Test

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