المؤلفون: Martin Tristani-Firouzi, Gunnar Seemann, Ricardo A. Navarro-Polanco, Frank B. Sachse, Robin Moss, Eloy G. Moreno-Galindo

المصدر: PLoS Computational Biology
PLoS Computational Biology, Vol 14, Iss 10, p e1006438 (2018)

مصطلحات موضوعية: 0301 basic medicine, Physiology, Sensory Physiology, Action Potentials, 030204 cardiovascular system & hematology, Biochemistry, Ion Channels, 0302 clinical medicine, Heart Rate, Muscarinic acetylcholine receptor, Medicine and Health Sciences, Biology (General), Receptor, Sinoatrial Node, Membrane potential, Ecology, Chemistry, Physics, Simulation and Modeling, Models, Cardiovascular, Depolarization, Potassium channel, Markov Chains, Electrophysiology, Computational Theory and Mathematics, Modeling and Simulation, Physical Sciences, Ion Channel Gating, Acetylcholine, medicine.drug, Research Article, Markov Models, QH301-705.5, Cardiology, Biophysics, Neurophysiology, Research and Analysis Methods, Membrane Potential, 03 medical and health sciences, Cellular and Molecular Neuroscience, Heart rate, Genetics, medicine, Humans, Molecular Biology, Ecology, Evolution, Behavior and Systematics, Receptor, Muscarinic M2, Biology and Life Sciences, Proteins, Computational Biology, medicine.disease, Probability Theory, Inappropriate sinus tachycardia, 030104 developmental biology, Mathematics, Neuroscience

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::649423645cec558262d5c1acc86708c6Test
http://europepmc.org/articles/PMC6197694Test

المؤلفون: Maik Kschischo, Janine Holze, Holger Fröhlich, Christina Elliott, George S. Baillie, Benjamin Engelhardt

مصطلحات موضوعية: 0301 basic medicine, CHO Cells, Biology, Muscarinic Agonists, Bioinformatics, Models, Biological, Second Messenger Systems, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Cricetulus, Cyclic AMP, Animals, Cytoskeleton, General Environmental Science, G protein-coupled receptor, Pharmacology, Receptor, Muscarinic M2, General Immunology and Microbiology, Applied Mathematics, General Neuroscience, Chinese hamster ovary cell, General Medicine, Isoxazoles, Mathematical Concepts, Cyclic Nucleotide Phosphodiesterases, Type 4, Quaternary Ammonium Compounds, 030104 developmental biology, RGS14, Signalling, Modeling and Simulation, Second messenger system, Biophysics, Steady state (chemistry), Flux (metabolism), Signal Transduction

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c809da028722f99df24cda60608d157cTest
https://eprints.gla.ac.uk/137881/1/137881.pdfTest

المؤلفون: Jesús Giraldo, Pedro Renault

المصدر: International Journal of Molecular Sciences, Vol 22, Iss 187, p 187 (2021)
International Journal of Molecular Sciences
Volume 22
Issue 1
Dipòsit Digital de Documents de la UAB
Universitat Autònoma de Barcelona

مصطلحات موضوعية: 0301 basic medicine, Protein Conformation, Coupled motions, Allosteric regulation, Druggability, Computational biology, Molecular Dynamics Simulation, Molecular dynamics, 01 natural sciences, Article, Catalysis, Receptors, G-Protein-Coupled, lcsh:Chemistry, Inorganic Chemistry, 03 medical and health sciences, GPCR, Allosteric Regulation, Normal modes, 0103 physical sciences, Physical and Theoretical Chemistry, Collective dynamics, Allosteric sites, Receptor, lcsh:QH301-705.5, Molecular Biology, Spectroscopy, G protein-coupled receptor, Strongly coupled, Receptor, Muscarinic M2, Binding Sites, 010304 chemical physics, Chemistry, Organic Chemistry, normal modes, General Medicine, dynamical correlations, Predictive value, molecular dynamics, Computer Science Applications, coupled motions, 030104 developmental biology, Dynamical correlations, lcsh:Biology (General), lcsh:QD1-999, allosteric sites, Hydrophobic and Hydrophilic Interactions, Allosteric Site

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40ad6d3c0f11c7ca8e6d79ecc61b1e16Test
https://doi.org/10.3390/ijms22010187Test

المؤلفون: Sijia S. Dong, William A. Goddard, Ravinder Abrol

المصدر: Biophysical Journal. 110:2618-2629

مصطلحات موضوعية: Models, Molecular, 0301 basic medicine, Rotation, Protein Conformation, Biophysics, Protein Structure, Secondary, Receptors, G-Protein-Coupled, 03 medical and health sciences, 0302 clinical medicine, Metastability, Humans, Computer Simulation, Receptors, Somatostatin, Adrenergic beta-2 Receptor Agonists, G protein-coupled receptor, Receptor, Muscarinic M2, Protein Stability, Chemistry, Relaxation (NMR), Proteins, Energy landscape, Interaction energy, Crystallography, 030104 developmental biology, Energy profile, Chemical physics, 030220 oncology & carcinogenesis, Helix, Thermodynamics, Receptors, Adrenergic, beta-2, Monte Carlo Method, Energy (signal processing), Protein Binding

وصف الملف: application/pdf; application/zip

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7ae99fa4baa46b8497449cafbf19deTest
https://doi.org/10.1016/j.bpj.2016.04.028Test

المؤلفون: Xiaoming Lu, Ruiyun Wang, Xiaohua Hou, Wei Qian, Jun Song, Tao Bai, Guanghai Yang, Lei Zhang

المصدر: European Journal of Pharmacology. 780:180-187

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Neurogenesis, Ileum, Bethanechol, Muscle Development, Jejunum, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Butylscopolammonium Bromide, Muscarinic acetylcholine receptor, medicine, Humans, Antrum, Receptor, Muscarinic M3, Pharmacology, Receptor, Muscarinic M2, Dose-Response Relationship, Drug, Chemistry, Muscarinic acetylcholine receptor M3, Muscle, Smooth, Visceral pain, Middle Aged, Gastrointestinal Tract, medicine.anatomical_structure, Endocrinology, Organ Specificity, 030220 oncology & carcinogenesis, Female, 030211 gastroenterology & hepatology, Antispasmodic, medicine.symptom, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b649c56efe16edce054a5c9d9533fc7Test
https://doi.org/10.1016/j.ejphar.2016.03.047Test

المؤلفون: Javier Alamilla, Eloy G. Moreno-Galindo, Ricardo A. Navarro-Polanco, Martin Tristani-Firouzi, José A. Sánchez-Chapula

المصدر: Pflügers Archiv - European Journal of Physiology. 468:1207-1214

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, medicine.medical_specialty, Potassium Channels, Physiology, medicine.drug_class, Clinical Biochemistry, Muscarinic Agonists, Muscarinic agonist, Membrane Potentials, Receptors, G-Protein-Coupled, 03 medical and health sciences, 0302 clinical medicine, Physiology (medical), Internal medicine, Muscarinic acetylcholine receptor, medicine, Animals, Humans, Myocytes, Cardiac, Receptor, G protein-coupled receptor, Receptor, Muscarinic M2, Binding Sites, Chemistry, Acetylcholine, Potassium channel, HEK293 Cells, 030104 developmental biology, Endocrinology, G Protein-Coupled Inwardly-Rectifying Potassium Channels, Pilocarpine, Cats, Potassium, Biophysics, Rabbits, Ion Channel Gating, 030217 neurology & neurosurgery, Signal Transduction, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc9c2c327371da575ce7ccc29942defTest
https://doi.org/10.1007/s00424-016-1812-yTest

المؤلفون: Chie Ishii, Toshio Moritani, Mami Fujibayashi, Akira Suda, Norio Ishii, Yohko Shiraishi, Yoshio Hirayasu, Masataka Taguri, Masatoshi Miyauchi, Saki Hattori, Ikuko Kishida

المصدر: Neuropsychobiology. 74:60-67

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Genotype, Population, Autonomic Nervous System, Polymorphism, Single Nucleotide, behavioral disciplines and activities, 03 medical and health sciences, 0302 clinical medicine, Asian People, Japan, Heart Rate, Internal medicine, mental disorders, Muscarinic acetylcholine receptor, medicine, Humans, In patient, Association (psychology), education, Biological Psychiatry, Receptor, Muscarinic M3, Receptor, Muscarinic M2, education.field_of_study, business.industry, Receptor, Muscarinic M1, Muscarinic acetylcholine receptor M2, Middle Aged, medicine.disease, Receptors, Muscarinic, 030227 psychiatry, Psychiatry and Mental health, Autonomic nervous system, Neuropsychology and Physiological Psychology, Endocrinology, Schizophrenia, Cholinergic, Female, business, 030217 neurology & neurosurgery, Antipsychotic Agents

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a314316dd406c27f5ab5e8d696ccae3aTest
https://doi.org/10.1159/000452770Test

المؤلفون: Danielle Graveron-Demilly, Jérémy Pinguet, Abderrahim El Guerrab, Jérémy Ferrier, David Balayssac, Maryse Chalus, Fabien Marchand, Youssef Aissouni, Mathilde Bayet-Robert, Romain Dalmann, Damien Richard, Alain Eschalier, Laurence Daulhac

المصدر: The Journal of Neuroscience. 35:16418-16430

مصطلحات موضوعية: Male, Organoplatinum Compounds, Gene Expression, Muscarinic Antagonists, Insular cortex, Synaptic Transmission, Rats, Sprague-Dawley, Piperidines, Parasympathetic Nervous System, Muscarinic acetylcholine receptor, medicine, Oxotremorine, Animals, Donepezil, Interpersonal Relations, RNA, Messenger, Cerebral Cortex, Analgesics, Receptor, Muscarinic M2, business.industry, General Neuroscience, Membrane Transport Proteins, Muscarinic acetylcholine receptor M2, Articles, Rats, Oxaliplatin, Hyperalgesia, Indans, Neuropathic pain, Neuralgia, Cholinesterase Inhibitors, medicine.symptom, business, Neuroscience, Acetylcholine, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcace37a055cb6fd61ba1362f0c36335Test
https://doi.org/10.1523/jneurosci.1537-15.2015Test

المؤلفون: Sung Jin Kim, Soon Ki Sung, Young Kyu Kwon, Hyun Park, Noo Ri Hong, Byung Joo Kim, Tae Seok Ahn

المصدر: Molecular Medicine Reports. 12:6370-6376

مصطلحات موضوعية: Male, Cancer Research, medicine.medical_specialty, Thapsigargin, Pain, Calcium-Transporting ATPases, Diamines, Pharmacology, Biology, Guanosine Diphosphate, Biochemistry, Mice, symbols.namesake, chemistry.chemical_compound, Piperidines, Internal medicine, Current clamp, Intestine, Small, Muscarinic acetylcholine receptor, Genetics, medicine, Methoctramine, Animals, Molecular Biology, Cells, Cultured, Receptor, Muscarinic M3, Mice, Inbred BALB C, Receptor, Muscarinic M2, Plants, Medicinal, Muscarinic acetylcholine receptor M3, Muscarinic acetylcholine receptor M2, Thionucleotides, Interstitial Cells of Cajal, Interstitial cell of Cajal, Endocrinology, Flufenamic acid, Oncology, chemistry, symbols, Molecular Medicine, Female, Gastrointestinal Motility, Phytotherapy, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cac013c3b99f56875e0365cd612732e4Test
https://doi.org/10.3892/mmr.2015.4203Test

المؤلفون: Brian Ethell, Steve Collingwood, David A. Sykes, Toby C. Kent, Steven J. Charlton, Alexandre Trifilieff, Kenny J. Watson

المصدر: Toxicology and Applied Pharmacology. 287:9-16

مصطلحات موضوعية: Male, medicine.drug_class, Bronchoconstriction, Scopolamine Derivatives, Blood Pressure, Muscarinic Antagonists, Pharmacology, Toxicology, Cardiovascular System, Models, Biological, Risk Assessment, Bronchial Provocation Tests, Radioligand Assay, Heart Rate, Rats, Inbred BN, Bronchodilator, Muscarinic acetylcholine receptor, Bradycardia, medicine, Muscarinic Receptor Binding, Animals, Glycopyrronium bromide, Tiotropium Bromide, Receptor, Muscarinic M2, COPD, business.industry, Airway Resistance, Muscarinic antagonist, Muscarinic acetylcholine receptor M2, medicine.disease, Glycopyrrolate, Bronchodilator Agents, respiratory tract diseases, Methacholine, Hypotension, business, Protein Binding, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f2282ceaaef5eac619d57ddb721c23fTest
https://doi.org/10.1016/j.taap.2015.05.012Test