المؤلفون: Rukhlenko, Oleksii S., Khorsand, Fahimeh, Krstic, Aleksandar, Rozanc, Jan, Alexopoulos, Leonidas G., Rauch, Nora, Erickson, Keesha E., Hlavacek, William S., Posner, Richard G., Gómez-Coca, Silvia, Rosta, Edina, Fitzgibbon, Cheree, Matallanas, David, Rauch, Jens, Kolch, Walter, Kholodenko, Boris N.

المصدر: Rukhlenko , O S , Khorsand , F , Krstic , A , Rozanc , J , Alexopoulos , L G , Rauch , N , Erickson , K E , Hlavacek , W S , Posner , R G , Gómez-Coca , S , Rosta , E , Fitzgibbon , C , Matallanas , D , Rauch , J , Kolch , W & Kholodenko , B N 2018 , ' Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling ' , Cell Systems . https://doi.org/10.1016/j.cels.2018.06.002Test

مصطلحات موضوعية: RAF inhibitors, drug resistance, mathematical modeling, MAPK pathway, oncogenic RAS, drug synergy, RAF dimerization, conformational transitions of the DFG motif and αC helix

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1016/j.cels.2018.06.002Test
https://kclpure.kcl.ac.uk/portal/en/publications/d98610c5-93c1-4665-bb82-ec0c15fb5cc6Test
https://kclpure.kcl.ac.uk/ws/files/100137399/CELL_SYSTEMS_D_17_00367_R1.pdfTest

المؤلفون: Rodriguez, Javier, Herrero, Ana, Li, Shuijie, Rauch, Nora, Quintanilla, Andrea, Wynne, Kieran, Krstic, Aleksandar, Acosta, Juan Carlos, Taylor, Cormac, Schlisio, Susanne, von Kriegsheim, Alex

المساهمون: Science Foundation Ireland, Cancer Research UK, Wellcome Trust, Carnegie Trust

المصدر: Cell Reports ; volume 24, issue 5, page 1316-1329 ; ISSN 2211-1247

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology

الإتاحة: https://doi.org/10.1016/j.celrep.2018.06.108Test
https://api.elsevier.com/content/article/PII:S2211124718310507?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2211124718310507?httpAccept=text/plainTest

المؤلفون: Fasterius, Erik, Raso, Cinzia, Kennedy, Susan, Rauch, Nora, Lundin, Pär, Kolch, Walter, Uhlen, Mathias, Al-Khalili Szigyarto, Cristina

المصدر: PLOS ONE. 12(2)

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:su:diva-141421Test
https://doi.org/10.1371/journal.pone.0171435Test

المؤلفون: Verlande, Amandine, Krafčíková, Michaela, Potěšil, David, Trantírek, Lukáš, Zdráhal, Zbyněk, Elkalaf, Moustafa, Trnka, Jan, Souček, Karel, Rauch, Nora, Rauch, Jens, Kolch, Walter, Uldrijan, Stjepan

المساهمون: Ministerstvo Školství, Mládeže a Tělovýchovy, Grantová Agentura České Republiky, Seventh Framework Programme, Science Foundation Ireland

المصدر: EMBO reports ; volume 19, issue 2, page 320-336 ; ISSN 1469-221X 1469-3178

مصطلحات موضوعية: Genetics, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.15252/embr.201744524Test

المؤلفون: Rukhlenko, Oleksii S., Halasz, Melinda, Rauch, Nora, Zhernovkov, Vadim, Prince, Thomas, Wynne, Kieran, Maher, Stephanie, Kashdan, Eugene, MacLeod, Kenneth, Carragher, Neil O., Kolch, Walter, Kholodenko, Boris N.

المصدر: Nature ; volume 609, issue 7929, page 975-985 ; ISSN 0028-0836 1476-4687

مصطلحات موضوعية: Multidisciplinary

الإتاحة: https://doi.org/10.1038/s41586-022-05194-yTest
https://www.nature.com/articles/s41586-022-05194-y.pdfTest
https://www.nature.com/articles/s41586-022-05194-yTest

المؤلفون: Jambrina, Pablo G., Rauch, Nora, Pilkington, Ruth, Rybakova, Katja, Nguyen, Lan K., Kholodenko, Boris N., Buchete, Nicolae-Viorel, Kolch, Walter, Rosta, Edina

المصدر: Jambrina , P G , Rauch , N , Pilkington , R , Rybakova , K , Nguyen , L K , Kholodenko , B N , Buchete , N-V , Kolch , W & Rosta , E 2016 , ' Phosphorylation of RAF kinase dimers drives conformational changes that facilitate transactivation ' , Angewandte Chemie - International Edition , vol. 55 , no. 3 , pp. 983-986 . https://doi.org/10.1002/anie.201509272Test

مصطلحات موضوعية: kinases, molecular dynamics, oncogenic signaling, phosphorylation, RAF kinase

وصف الملف: application/pdf

الإتاحة: https://doi.org/10.1002/anie.201509272Test
https://research.monash.edu/en/publications/e9bcc64c-e765-4fe2-92b1-b7eb5dcca4c6Test
https://researchmgt.monash.edu/ws/files/210535396/3573257_oa.pdfTest
http://www.ncbi.nlm.nih.gov/pubmed/26644280Test

المؤلفون: Rauch, Nora, Rukhlenko, Oleksii S, Kolch, Walter, Kholodenko, Boris N

المساهمون: FP7

المصدر: Current Opinion in Structural Biology ; volume 41, page 151-158 ; ISSN 0959-440X

مصطلحات موضوعية: Molecular Biology, Structural Biology

الإتاحة: https://doi.org/10.1016/j.sbi.2016.07.019Test
https://api.elsevier.com/content/article/PII:S0959440X16301002?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S0959440X16301002?httpAccept=text/xmlTest

المؤلفون: Rodriguez, Javier, Pilkington, Ruth, Garcia Munoz, Amaya, Nguyen, Lan K., Rauch, Nora, Kennedy, Susan, Monsefi, Naser, Herrero, Ana, Taylor, Cormac T., von Kriegsheim, Alex

المصدر: Cell Reports ; volume 14, issue 11, page 2745-2760 ; ISSN 2211-1247

الإتاحة: https://doi.org/10.1016/j.celrep.2016.02.043Test
https://api.elsevier.com/content/article/PII:S2211124716301462?httpAccept=text/plainTest
https://api.elsevier.com/content/article/PII:S2211124716301462?httpAccept=text/xmlTest

المؤلفون: Kennedy, Susan A, Jarboui, Mohamed-Ali, Srihari, Sriganesh, Raso, Cinzia, Bryan, Kenneth, Dernayka, Layal, Charitou, Theodosia, Bernal-Llinares, Manuel, Herrera-Montavez, Carlos, Krstic, Aleksandar, Matallanas, David, Kotlyar, Max, Jurisica, Igor, Curak, Jasna, Wong, Victoria, Stagljar, Igor, LeBihan, Thierry, Imrie, Lisa, Pillai, Priyanka, Lynn, Miriam A, Fasterius, Erik, Al-Khalili Szigyarto, Cristina, Breen, James, Kiel, Christina, Serrano, Luis, Rauch, Nora, Rukhlenko, Oleksii, Kholodenko, Boris N, Iglesias-Martinez, Luis F, Ryan, Colm J, Pilkington, Ruth, Cammareri, Patrizia, Sansom, Owen, Shave, Steven, Auer, Manfred, Horn, Nicola, Klose, Franziska, Ueffing, Marius, Boldt, Karsten, Lynn, David J, Kolch, Walter

المساهمون: Kennedy, Susan A, Jarboui, Mohamed-Ali, Srihari, Sriganesh, Raso, Cinzia, Bryan, Kenneth, Dernayka, Layal, Charitou, Theodosia, Bernal-Llinares, Manuel, Herrera-Montavez, Carlo, Krstic, Aleksandar, Matallanas, David, Kotlyar, Max, Jurisica, Igor, Curak, Jasna, Wong, Victoria, Stagljar, Igor, Lebihan, Thierry, Imrie, Lisa, Pillai, Priyanka, Lynn, Miriam A, Fasterius, Erik, Al-Khalili Szigyarto, Cristina, Breen, Jame, Kiel, Christina, Serrano, Lui, Rauch, Nora, Rukhlenko, Oleksii, Kholodenko, Boris N, Iglesias-Martinez, Luis F, Ryan, Colm J, Pilkington, Ruth, Cammareri, Patrizia, Sansom, Owen, Shave, Steven, Auer, Manfred, Horn, Nicola, Klose, Franziska, Ueffing, Mariu, Boldt, Karsten, Lynn, David J, Kolch, Walter

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31980649; info:eu-repo/semantics/altIdentifier/wos/WOS:000543967700005; volume:11; issue:1; firstpage:499; journal:NATURE COMMUNICATIONS; https://hdl.handle.net/11571/1469215Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85078225586

الإتاحة: https://doi.org/10.1038/s41467-019-14224-9Test
https://hdl.handle.net/11571/1469215Test

المؤلفون: Jambrina, Pablo G., Rauch, Nora, Pilkington, Ruth, Rybakova, Katja, Nguyen, Lan K., Kholodenko, Boris N., Buchete, Nicolae‐Viorel, Kolch, Walter, Rosta, Edina

المساهمون: EPSRC, Science Foundation Ireland, European Union, FP7 PRIMES, SynSignal, BBSRC

المصدر: Angewandte Chemie International Edition ; volume 55, issue 3, page 983-986 ; ISSN 1433-7851 1521-3773

الإتاحة: https://doi.org/10.1002/anie.201509272Test