المؤلفون: Hitti, Frederick L, Widge, Alik S, Riva-Posse, Patricio, Malone, Donald A, Okun, Michael S, Shanechi, Maryam M, Foote, Kelly D, Lisanby, Sarah H, Ankudowich, Elizabeth, Chivukula, Srinivas, Chang, Edward F, Gunduz, Aysegul, Hamani, Clement, Feinsinger, Ashley, Kubu, Cynthia S, Chiong, Winston, Chandler, Jennifer A, Carbunaru, Rafael, Cheeran, Binith, Raike, Robert S, Davis, Rachel A, Halpern, Casey H, Vanegas-Arroyave, Nora, Markovic, Dejan, Bick, Sarah K, McIntyre, Cameron C, Richardson, R Mark, Dougherty, Darin D, Kopell, Brian H, Sweet, Jennifer A, Goodman, Wayne K, Sheth, Sameer A, Pouratian, Nader

المصدر: Brain Stimulation. 16(3)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Rehabilitation, Neurosciences, Brain Disorders, Good Health and Well Being, Humans, United States, Neurosurgery, Deep Brain Stimulation, Neurosurgical Procedures, Mental Disorders, Psychosurgery, Deep brain stimulation, Treatment resistant depression, Obsessive compulsive disorder, Tourette syndrome, Neuromodulation, Medical and Health Sciences, Neurology & Neurosurgery, Biomedical and clinical sciences, Health sciences

الوصف: ObjectiveDespite advances in the treatment of psychiatric diseases, currently available therapies do not provide sufficient and durable relief for as many as 30-40% of patients. Neuromodulation, including deep brain stimulation (DBS), has emerged as a potential therapy for persistent disabling disease, however it has not yet gained widespread adoption. In 2016, the American Society for Stereotactic and Functional Neurosurgery (ASSFN) convened a meeting with leaders in the field to discuss a roadmap for the path forward. A follow-up meeting in 2022 aimed to review the current state of the field and to identify critical barriers and milestones for progress.DesignThe ASSFN convened a meeting on June 3, 2022 in Atlanta, Georgia and included leaders from the fields of neurology, neurosurgery, and psychiatry along with colleagues from industry, government, ethics, and law. The goal was to review the current state of the field, assess for advances or setbacks in the interim six years, and suggest a future path forward. The participants focused on five areas of interest: interdisciplinary engagement, regulatory pathways and trial design, disease biomarkers, ethics of psychiatric surgery, and resource allocation/prioritization. The proceedings are summarized here.ConclusionThe field of surgical psychiatry has made significant progress since our last expert meeting. Although weakness and threats to the development of novel surgical therapies exist, the identified strengths and opportunities promise to move the field through methodically rigorous and biologically-based approaches. The experts agree that ethics, law, patient engagement, and multidisciplinary teams will be critical to any potential growth in this area.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/49j7w2n0Test
https://escholarship.org/content/qt49j7w2n0/qt49j7w2n0.pdfTest

المؤلفون: Wong, Joshua K, Lopes, Janine Melo Lobo Jofili, Hu, Wei, Wang, Anson, Au, Ka Loong Kelvin, Stiep, Tamara, Frey, Jessica, Toledo, Jon B, Raike, Robert S, Okun, Michael S, Almeida, Leonardo

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Brain Disorders, Rare Diseases, Neurodegenerative, Assistive Technology, Bioengineering, Neurosciences, Clinical Trials and Supportive Activities, Dystonia, Clinical Research, Rehabilitation, Humans, Cross-Over Studies, Deep Brain Stimulation, Dystonic Disorders, Globus Pallidus, Pilot Projects, Treatment Outcome, Deep brain stimulation, Active recharge, Globus pallidus, Cognitive Sciences, Neurology & Neurosurgery, Clinical sciences, Biological psychology

الوصف: BackgroundDeep brain stimulation (DBS) of the globus pallidus interna (GPi) is an effective therapy for select patients with primary dystonia. DBS programming for dystonia is often challenging due to variable time to symptomatic improvement or stimulation induced side effects (SISE) such as capsular or optic tract activation which can prolong device optimization.ObjectiveTo characterize the safety and tolerability of active recharge biphasic DBS (bDBS) in primary dystonia and to compare it to conventional clinical DBS (clinDBS).MethodsTen subjects with primary dystonia and GPi DBS underwent a single center, double blind, nonrandomized crossover study comparing clinDBS versus bDBS. The testing occurred over two-days. bDBS and clinDBS were administered on separate days and each was activated for 6 h. Rating scales were collected by video recording and scored by four blinded movement disorders trained neurologists.ResultsThe bDBS paradigm was safe and well-tolerated in all ten subjects. There were no persistent SISE reported. The mean change in the Unified Dystonia Rating Scale after 4 h of stimulation was greater in bDBS when compared to clinDBS (-6.5 vs 0.3, p

الوصول الحر: https://escholarship.org/uc/item/19j4n9xgTest

المؤلفون: Wong, Joshua K, Mayberg, Helen S, Wang, Doris D, Richardson, R Mark, Halpern, Casey H, Krinke, Lothar, Arlotti, Mattia, Rossi, Lorenzo, Priori, Alberto, Marceglia, Sara, Gilron, Ro’ee, Cavanagh, James F, Judy, Jack W, Miocinovic, Svjetlana, Devergnas, Annaelle D, Sillitoe, Roy V, Cernera, Stephanie, Oehrn, Carina R, Gunduz, Aysegul, Goodman, Wayne K, Petersen, Erika A, Bronte-Stewart, Helen, Raike, Robert S, Malekmohammadi, Mahsa, Greene, David, Heiden, Petra, Tan, Huiling, Volkmann, Jens, Voon, Valerie, Li, Luming, Sah, Pankaj, Coyne, Terry, Silburn, Peter A, Kubu, Cynthia S, Wexler, Anna, Chandler, Jennifer, Provenza, Nicole R, Heilbronner, Sarah R, San Luciano, Marta, Rozell, Christopher J, Fox, Michael D, de Hemptinne, Coralie, Henderson, Jaimie M, Sheth, Sameer A, Okun, Michael S

مصطلحات موضوعية: Biological Psychology, Biomedical and Clinical Sciences, Psychology, Bioengineering, Neurosciences, Assistive Technology, Depression, Rehabilitation, Mental Health, Mental health, deep brain stimulation, artificial intelligence, neuroethics, Parkinson's disease, dystonia, interventional psychiatry, adaptive DBS, epilepsy, Parkinson’s disease, Cognitive Sciences, Experimental Psychology, Biological psychology, Cognitive and computational psychology

الوصف: The deep brain stimulation (DBS) Think Tank X was held on August 17-19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme women in neuromodulation. Dr. Helen Mayberg from Mt. Sinai, NY was the keynote speaker. She discussed milestones and her experiences in developing depression DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging DBS technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank X speakers was that DBS has continued to expand in scope however several indications have reached the "trough of disillusionment." DBS for depression was considered as "re-emerging" and approaching a slope of enlightenment. DBS for depression will soon re-enter clinical trials. The group estimated that globally more than 244,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. This year's meeting was focused on advances in the following areas: neuromodulation in Europe, Asia, and Australia; cutting-edge technologies, closed loop DBS, DBS tele-health, neuroethics, lesion therapy, interventional psychiatry, and adaptive DBS.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/6jh798dxTest

المؤلفون: Johnson, Kara A., Dosenbach, Nico U. F., Gordon, Evan M., Welle, Cristin G., Wilkins, Kevin B., Bronte-Stewart, Helen M., Voon, Valerie, Morishita, Takashi, Sakai, Yuki, Merner, Amanda R., Lázaro-Muñoz, Gabriel, Williamson, Theresa, Horn, Andreas, Gilron, Ro'ee, O'Keeffe, Jonathan, Gittis, Aryn H., Neumann, Wolf-Julian, Little, Simon, Provenza, Nicole R., Sheth, Sameer A., Fasano, Alfonso, Holt-Becker, Abbey B., Raike, Robert S., Moore, Lisa, Pathak, Yagna J., Greene, David, Marceglia, Sara, Krinke, Lothar, Tan, Huiling, Bergman, Hagai, Pötter-Nerger, Monika, Sun, Bomin, Cabrera, Laura Y., McIntyre, Cameron C., Harel, Noam, Mayberg, Helen S., Krystal, Andrew D., Pouratian, Nader, Starr, Philip A., Foote, Kelly D., Okun, Michael S., Wong, Joshua K.

المصدر: Frontiers in Human Neuroscience ; volume 18 ; ISSN 1662-5161

مصطلحات موضوعية: Behavioral Neuroscience, Biological Psychiatry, Psychiatry and Mental health, Neurology, Neuropsychology and Physiological Psychology

الوصف: The Deep Brain Stimulation (DBS) Think Tank XI was held on August 9–11, 2023 in Gainesville, Florida with the theme of “Pushing the Forefront of Neuromodulation”. The keynote speaker was Dr. Nico Dosenbach from Washington University in St. Louis, Missouri. He presented his research recently published in Nature inn a collaboration with Dr. Evan Gordon to identify and characterize the somato-cognitive action network (SCAN), which has redefined the motor homunculus and has led to new hypotheses about the integrative networks underpinning therapeutic DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers, and researchers (from industry and academia) can freely discuss current and emerging DBS technologies, as well as logistical and ethical issues facing the field. The group estimated that globally more than 263,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. This year's meeting was focused on advances in the following areas: cutting-edge translational neuromodulation, cutting-edge physiology, advances in neuromodulation from Europe and Asia, neuroethical dilemmas, artificial intelligence and computational modeling, time scales in DBS for mood disorders, and advances in future neuromodulation devices.

الإتاحة: https://doi.org/10.3389/fnhum.2024.1320806Test

المؤلفون: Wong, Joshua K, Deuschl, Günther, Wolke, Robin, Bergman, Hagai, Muthuraman, Muthuraman, Groppa, Sergiu, Sheth, Sameer A, Bronte-Stewart, Helen M, Wilkins, Kevin B, Petrucci, Matthew N, Lambert, Emilia, Kehnemouyi, Yasmine, Starr, Philip A, Little, Simon, Anso, Juan, Gilron, Ro'ee, Poree, Lawrence, Kalamangalam, Giridhar P, Worrell, Gregory A, Miller, Kai J, Schiff, Nicholas D, Butson, Christopher R, Henderson, Jaimie M, Judy, Jack W, Ramirez-Zamora, Adolfo, Foote, Kelly D, Silburn, Peter A, Li, Luming, Oyama, Genko, Kamo, Hikaru, Sekimoto, Satoko, Hattori, Nobutaka, Giordano, James J, DiEuliis, Diane, Shook, John R, Doughtery, Darin D, Widge, Alik S, Mayberg, Helen S, Cha, Jungho, Choi, Kisueng, Heisig, Stephen, Obatusin, Mosadolu, Opri, Enrico, Kaufman, Scott B, Shirvalkar, Prasad, Rozell, Christopher J, Alagapan, Sankaraleengam, Raike, Robert S, Bokil, Hemant, Green, David, Okun, Michael S

مصطلحات موضوعية: adaptive DBS, artificial intelligence, deep brain stimulation, epilepsy, interventional psychiatry, neuroethics, pain, traumatic brain injury, Rehabilitation, Epilepsy, Neurodegenerative, Assistive Technology, Bioengineering, Brain Disorders, Neurosciences, Neurological, Psychology, Cognitive Sciences, Experimental Psychology

الوصف: DBS Think Tank IX was held on August 25-27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging deep brain stimulation (DBS) technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year's meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/86m904vdTest

المؤلفون: Wong, Joshua K., Mayberg, Helen S., Wang, Doris D., Richardson, R. Mark, Halpern, Casey H., Krinke, Lothar, Arlotti, Mattia, Rossi, Lorenzo, Priori, Alberto, Marceglia, Sara, Gilron, Ro’ee, Cavanagh, James F., Judy, Jack W., Miocinovic, Svjetlana, Devergnas, Annaelle D., Sillitoe, Roy V., Cernera, Stephanie, Oehrn, Carina R., Gunduz, Aysegul, Goodman, Wayne K., Petersen, Erika A., Bronte-Stewart, Helen, Raike, Robert S., Malekmohammadi, Mahsa, Greene, David, Heiden, Petra, Tan, Huiling, Volkmann, Jens, Voon, Valerie, Li, Luming, Sah, Pankaj, Coyne, Terry, Silburn, Peter A., Kubu, Cynthia S., Wexler, Anna, Chandler, Jennifer, Provenza, Nicole R., Heilbronner, Sarah R., Luciano, Marta San, Rozell, Christopher J., Fox, Michael D., de Hemptinne, Coralie, Henderson, Jaimie M., Sheth, Sameer A., Okun, Michael S.

المصدر: Frontiers in Human Neuroscience ; volume 16 ; ISSN 1662-5161

الوصف: The deep brain stimulation (DBS) Think Tank X was held on August 17–19, 2022 in Orlando FL. The session organizers and moderators were all women with the theme women in neuromodulation . Dr. Helen Mayberg from Mt. Sinai, NY was the keynote speaker. She discussed milestones and her experiences in developing depression DBS. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging DBS technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank X speakers was that DBS has continued to expand in scope however several indications have reached the “trough of disillusionment.” DBS for depression was considered as “re-emerging” and approaching a slope of enlightenment. DBS for depression will soon re-enter clinical trials. The group estimated that globally more than 244,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. This year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia, and Australia; cutting-edge technologies, closed loop DBS, DBS tele-health, neuroethics, lesion therapy, interventional psychiatry, and adaptive DBS.

الإتاحة: https://doi.org/10.3389/fnhum.2022.1084782Test

المؤلفون: Wong, Joshua K., Lopes, Janine Melo Lobo Jofili, Hu, Wei, Wang, Anson, Au, Ka Loong Kelvin, Stiep, Tamara, Frey, Jessica, Toledo, Jon B., Raike, Robert S., Okun, Michael S., Almeida, Leonardo

المساهمون: National Institutes of Health, National Institute of Neurological Disorders and Stroke

المصدر: Parkinsonism & Related Disorders ; volume 109, page 105328 ; ISSN 1353-8020

مصطلحات موضوعية: Neurology (clinical), Geriatrics and Gerontology, Neurology

الإتاحة: https://doi.org/10.1016/j.parkreldis.2023.105328Test
https://api.elsevier.com/content/article/PII:S1353802023000512?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S1353802023000512?httpAccept=text/plainTest

المؤلفون: Wong, Joshua K., Deuschl, Günther, Wolke, Robin, Bergman, Hagai, Muthuraman, Muthuraman, Groppa, Sergiu, Sheth, Sameer A., Bronte-Stewart, Helen M., Wilkins, Kevin B., Petrucci, Matthew N., Lambert, Emilia, Kehnemouyi, Yasmine, Starr, Philip A., Little, Simon, Anso, Juan, Gilron, Ro’ee, Poree, Lawrence, Kalamangalam, Giridhar P., Worrell, Gregory A., Miller, Kai J., Schiff, Nicholas D., Butson, Christopher R., Henderson, Jaimie M., Judy, Jack W., Ramirez-Zamora, Adolfo, Foote, Kelly D., Silburn, Peter A., Li, Luming, Oyama, Genko, Kamo, Hikaru, Sekimoto, Satoko, Hattori, Nobutaka, Giordano, James J., DiEuliis, Diane, Shook, John R., Doughtery, Darin D., Widge, Alik S., Mayberg, Helen S., Cha, Jungho, Choi, Kisueng, Heisig, Stephen, Obatusin, Mosadolu, Opri, Enrico, Kaufman, Scott B., Shirvalkar, Prasad, Rozell, Christopher J., Alagapan, Sankaraleengam, Raike, Robert S., Bokil, Hemant, Green, David, Okun, Michael S.

مصطلحات موضوعية: ddc:004

الوصف: DBS Think Tank IX was held on August 25–27, 2021 in Orlando FL with US based participants largely in person and overseas participants joining by video conferencing technology. The DBS Think Tank was founded in 2012 and provides an open platform where clinicians, engineers and researchers (from industry and academia) can freely discuss current and emerging deep brain stimulation (DBS) technologies as well as the logistical and ethical issues facing the field. The consensus among the DBS Think Tank IX speakers was that DBS expanded in its scope and has been applied to multiple brain disorders in an effort to modulate neural circuitry. After collectively sharing our experiences, it was estimated that globally more than 230,000 DBS devices have been implanted for neurological and neuropsychiatric disorders. As such, this year’s meeting was focused on advances in the following areas: neuromodulation in Europe, Asia and Australia; cutting-edge technologies, neuroethics, interventional psychiatry, adaptive DBS, neuromodulation for pain, network neuromodulation for epilepsy and neuromodulation for traumatic brain injury.

وصف الملف: application/pdf

العلاقة: https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/109706Test; urn:nbn:de:bvb:384-opus4-1097062; https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1097062Test; https://doi.org/10.3389/fnhum.2022.813387Test; https://opus.bibliothek.uni-augsburg.de/opus4/files/109706/109706.pdfTest

الإتاحة: https://doi.org/10.3389/fnhum.2022.813387Test
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/109706Test
https://nbn-resolving.org/urn:nbn:de:bvb:384-opus4-1097062Test
https://opus.bibliothek.uni-augsburg.de/opus4/files/109706/109706.pdfTest

المؤلفون: Stanslaski, Scott R., Case, Michelle A., Giftakis, Jonathon E., Raike, Robert S., Stypulkowski, Paul H.

المصدر: Frontiers in Human Neuroscience ; volume 16 ; ISSN 1662-5161

مصطلحات موضوعية: Behavioral Neuroscience, Biological Psychiatry, Psychiatry and Mental health, Neurology, Neuropsychology and Physiological Psychology

الوصف: Background: In prior reports, we described the design and initial performance of a fully implantable, bi-directional neural interface system for use in deep brain and other neurostimulation applications. Here we provide an update on the chronic, long-term neural sensing performance of the system using traditional 4-contact leads and extend those results to include directional 8-contact leads. Methods: Seven ovine subjects were implanted with deep brain stimulation (DBS) leads at different nodes within the Circuit of Papez: four with unilateral leads in the anterior nucleus of the thalamus and hippocampus; two with bilateral fornix leads, and one with bilateral hippocampal leads. The leads were connected to either an Activa PC+S ® (Medtronic) or Percept PC °ledR (Medtronic) deep brain stimulation and recording device. Spontaneous local field potentials (LFPs), evoked potentials (EPs), LFP response to stimulation, and electrode impedances were monitored chronically for periods of up to five years in these subjects. Results: The morphology, amplitude, and latencies of chronic hippocampal EPs evoked by thalamic stimulation remained stable over the duration of the study. Similarly, LFPs showed consistent spectral peaks with expected variation in absolute magnitude dependent upon behavioral state and other factors, but no systematic degradation of signal quality over time. Electrode impedances remained within expected ranges with little variation following an initial stabilization period. Coupled neural activity between the two nodes within the Papez circuit could be observed in synchronized recordings up to 5 years post-implant. The magnitude of passive LFP power recorded from directional electrode segments was indicative of the contacts that produced the greatest stimulation-induced changes in LFP power within the Papez network. Conclusion: The implanted device performed as designed, providing the ability to chronically stimulate and record neural activity within this network for up to 5 years of follow-up.

الإتاحة: https://doi.org/10.3389/fnhum.2022.916627Test

المؤلفون: Wong, Joshua K., Hu, Wei, Barmore, Ryan, Lopes, Janine, Moore, Kathryn, Legacy, Joseph, Tahafchi, Parisa, Jackson, Zachary, Judy, Jack W., Raike, Robert S., Wang, Anson, Tsuboi, Takashi, Okun, Michael S., Almeida, Leonardo

المصدر: Frontiers in Human Neuroscience ; volume 15 ; ISSN 1662-5161

الوصف: Background : Freezing of gait (FOG) is a common symptom in Parkinson’s disease (PD) and can be difficult to treat with dopaminergic medications or with deep brain stimulation (DBS). Novel stimulation paradigms have been proposed to address suboptimal responses to conventional DBS programming methods. Burst-cycling deep brain stimulation (BCDBS) delivers current in various frequencies of bursts (e.g., 4, 10, or 15 Hz), while maintaining an intra-burst frequency identical to conventional DBS. Objective : To evaluate the safety and tolerability of BCDBS in PD patients with FOG. Methods : Ten PD subjects with STN or GPi DBS and complaints of FOG were recruited for this single center, single blinded within-subject crossover study. For each subject, we compared 4, 10, and 15 Hz BCDBS to conventional DBS during the PD medication-OFF state. Results : There were no serious adverse events with BCDBS. It was feasible and straightforward to program BCDBS in the clinic setting. The benefit was comparable to conventional DBS in measures of FOG, functional mobility and in PD motor symptoms. BCDBS had lower battery consumption when compared to conventional DBS. Conclusions : BCDBS was feasible, safe and well tolerated and it has potential to be a viable future DBS programming strategy.

الإتاحة: https://doi.org/10.3389/fnhum.2021.651168Test