المؤلفون: Ketcham, John M., Harwood, Stephen J., Aranda, Ruth, Aloiau, Athenea N., Bobek, Briana M., Briere, David M., Burns, Aaron C., Caddell Haatveit, Kersti, Calinisan, Andrew, Clarine, Jeffery, Elliott, Adam, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jones, Benjamin, Kuehler, Jon, Lawson, J. David, Nguyen, Natalie, Parker, Cody, Pearson, Kelly E., Rahbaek, Lisa, Saechao, Barbara, Wang, Xiaolun, Waters, Anna, Waters, Laura, Watkins, Ashlee H., Olson, Peter, Smith, Christopher R., Christensen, James G., Marx, Matthew A.

المساهمون: Mirati Therapeutics

المصدر: Journal of Medicinal Chemistry ; volume 67, issue 6, page 4936-4949 ; ISSN 0022-2623 1520-4804

مصطلحات موضوعية: Drug Discovery, Molecular Medicine

الإتاحة: https://doi.org/10.1021/acs.jmedchem.4c00078Test

المؤلفون: Ketcham, John M., Haling, Jacob, Khare, Shilpi, Bowcut, Vickie, Briere, David M., Burns, Aaron C., Gunn, Robin J., Ivetac, Anthony, Kuehler, Jon, Kulyk, Svitlana, Laguer, Jade, Lawson, J. David, Moya, Krystal, Nguyen, Natalie, Rahbaek, Lisa, Saechao, Barbara, Smith, Christopher R., Sudhakar, Niranjan, Thomas, Nicole C., Vegar, Laura, Vanderpool, Darin, Wang, Xiaolun, Yan, Larry, Olson, Peter, Christensen, James G., Marx, Matthew A.

المساهمون: Mirati Therapeutics

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 14, page 9678-9690 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.2c00741Test

المؤلفون: Smith, Christopher R., Aranda, Ruth, Bobinski, Thomas P., Briere, David M., Burns, Aaron C., Christensen, James G., Clarine, Jeffery, Engstrom, Lars D., Gunn, Robin J., Ivetac, Anthony, Jean-Baptiste, Ronald, Ketcham, John M., Kobayashi, Masakazu, Kuehler, Jon, Kulyk, Svitlana, Lawson, J. David, Moya, Krystal, Olson, Peter, Rahbaek, Lisa, Thomas, Nicole C., Wang, Xiaolun, Waters, Laura M., Marx, Matthew A.

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 3, page 1749-1766 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01900Test

المؤلفون: Wang, Xiaolun, Allen, Shelley, Blake, James F., Bowcut, Vickie, Briere, David M., Calinisan, Andrew, Dahlke, Joshua R., Fell, Jay B., Fischer, John P., Gunn, Robin J., Hallin, Jill, Laguer, Jade, Lawson, J. David, Medwid, James, Newhouse, Brad, Nguyen, Phong, O’Leary, Jacob M., Olson, Peter, Pajk, Spencer, Rahbaek, Lisa, Rodriguez, Mareli, Smith, Christopher R., Tang, Tony P., Thomas, Nicole C., Vanderpool, Darin, Vigers, Guy P., Christensen, James G., Marx, Matthew A.

المصدر: Journal of Medicinal Chemistry ; volume 65, issue 4, page 3123-3133 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c01688Test

المؤلفون: Hallin, Jill, Bowcut, Vickie, Calinisan, Andrew, Briere, David M., Hargis, Lauren, Engstrom, Lars D., Laguer, Jade, Medwid, James, Vanderpool, Darin, Lifset, Ella, Trinh, David, Hoffman, Natalie, Wang, Xiaolun, David Lawson, J., Gunn, Robin J., Smith, Christopher R., Thomas, Nicole C., Martinson, Matthew, Bergstrom, Alex, Sullivan, Francis, Bouhana, Karyn, Winski, Shannon, He, Leo, Fernandez-Banet, Julio, Pavlicek, Adam, Haling, Jacob R., Rahbaek, Lisa, Marx, Matthew A., Olson, Peter, Christensen, James G.

المصدر: Nature Medicine ; volume 28, issue 10, page 2171-2182 ; ISSN 1078-8956 1546-170X

مصطلحات موضوعية: General Biochemistry, Genetics and Molecular Biology, General Medicine

الإتاحة: https://doi.org/10.1038/s41591-022-02007-7Test
https://www.nature.com/articles/s41591-022-02007-7.pdfTest
https://www.nature.com/articles/s41591-022-02007-7Test

المؤلفون: Reichard, Holly A., Schiffer, Hans H., Monenschein, Holger, Atienza, Josephine M., Corbett, Gerard, Skaggs, Alton W., Collia, Deanna R., Ray, William J., Serrats, Jordi, Bliesath, Joshua, Kaushal, Nidhi, Lam, Betty P., Amador-Arjona, Alejandro, Rahbaek, Lisa, McConn, Donavon J., Mulligan, Victoria J., Brice, Nicola, Gaskin, Philip L. R., Cilia, Jackie, Hitchcock, Stephen

المصدر: Journal of Medicinal Chemistry ; volume 64, issue 15, page 11527-11542 ; ISSN 0022-2623 1520-4804

الإتاحة: https://doi.org/10.1021/acs.jmedchem.1c00820Test

المؤلفون: Xiaolun Wang, Allen, Shelley, Blake, James F., Bowcut, Vickie, Briere, David M., Calinisan, Andrew, Dahlke, Joshua R., Fell, Jay B., Fischer, John P., Gunn, Robin J., Hallin, Jill, Laguer, Jade, Lawson, J. David, Medwid, James, Newhouse, Brad, Phong Nguyen, O'Leary, Jacob M., Olson, Peter, Pajk, Spencer, Rahbaek, Lisa

المصدر: Journal of Medicinal Chemistry; 2/24/2022, Vol. 65 Issue 4, p3123-3133, 11p

المؤلفون: Wang, Xiaolun, Allen, Shelley, Blake, James F., Bowcut, Vickie, Briere, David M., Calinisan, Andrew, Dahlke, Joshua R., Fell, Jay B., Fischer, John P., Gunn, Robin J., Hallin, Jill, Laguer, Jade, Lawson, J. David, Medwid, James, Newhouse, Brad, Nguyen, Phong, O’Leary, Jacob M., Olson, Peter, Pajk, Spencer, Rahbaek, Lisa, Rodriguez, Mareli, Smith, Christopher R., Tang, Tony P., Thomas, Nicole C., Vanderpool, Darin, Vigers, Guy P., Christensen, James G., Marx, Matthew A.

المصدر: Journal of Medicinal Chemistry; February 2022, Vol. 65 Issue: 4 p3123-3133, 11p

مستخلص: KRASG12D, the most common oncogenic KRAS mutation, is a promising target for the treatment of solid tumors. However, when compared to KRASG12C, selective inhibition of KRASG12Dpresents a significant challenge due to the requirement of inhibitors to bind KRASG12Dwith high enough affinity to obviate the need for covalent interactions with the mutant KRAS protein. Here, we report the discovery and characterization of the first noncovalent, potent, and selective KRASG12Dinhibitor, MRTX1133, which was discovered through an extensive structure-based activity improvement and shown to be efficacious in a KRASG12Dmutant xenograft mouse tumor model.

المؤلفون: Rahbæk, Lisa, Christophersen, Carsten

المصدر: Rahbæk , L & Christophersen , C 2001 , The Isoxazole Alkaloids . in The Alkaloids . Academic Press , pp. 185-233 .

الوصف: kemi

الإتاحة: https://curis.ku.dk/portal/da/publications/the-isoxazole-alkaloidsTest(013d41e0-74c6-11db-bee9-02004c4f4f50).html

المؤلفون: Rahbæk, Lisa, Frisvad, J. C., Christophersen, Sven Carsten

المصدر: Rahbæk , L , Frisvad , J C & Christophersen , S C 2000 , ' An amendment of Aspergillus section Candidi based on chemotaxonomical evidence ' , Phytochemistry , no. 53 , pp. 581-586 .

الوصف: Kemi

الإتاحة: https://curis.ku.dk/portal/da/publications/an-amendment-of-aspergillus-section-candidi-based-on-chemotaxonomical-evidenceTest(6a46c0d0-74c6-11db-bee9-02004c4f4f50).html