المؤلفون: Prasad Krishnan, Rajesh Bhosle, Shamshuddin Patel, Dimble Raju, Rafael Cincu, Luis Rafael Moscote-Salazar, Amit Gupta, Amit Agrawal

المصدر: World Neurosurgery: X, Vol 23, Iss , Pp 100297- (2024)

مصطلحات موضوعية: Calvarial haemangioma, Intra diploic, En bloc resection, Cranioplasty, Skull tumours, Surgery, RD1-811, Neurology. Diseases of the nervous system, RC346-429

الوصف: Calvarial haemangiomas are benign, vascular tumours of the skull involving parietal and frontal bones. Mostly these lesions remain asymptomatic, and present with cosmetic deformity, headache, uncommon neurological symptoms and reported as case reports and case series. The radiological appearance can range from sessile growing intradiploically to globular and the lesions may extend outwards or inwards after eroding the outer and inner tables of the skull. “Sunburst appearance” and “Wagon-wheel sign” are classical radiological findings but the lesions may present simply as a lytic expansile or even sclerotic calvarial mass. Because of varied clinical presentation and atypical radiological characteristics, the final diagnosis can be clinched by histology only. In selected cases where these lesions are not cosmetically acceptable, en bloc resection with tumour free margins followed by cranioplasty is the treatment of choice. Most reports of calvarial haemangiomas in literature are in the form of case reports.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2590139724000280Test; https://doaj.org/toc/2590-1397Test

الوصول الحر: https://doaj.org/article/bf7d796a99384fc8839132fa999e451cTest

المؤلفون: Ved Prakash Maurya, Rakesh Kumar Mishra, Pramod Kumar Sharma, Rafael Cincu, Luis Rafael Moscote-Salazar, Amit Agrawal

المصدر: Journal of Medical Evidence, Vol 4, Iss 3, Pp 241-246 (2023)

مصطلحات موضوعية: complications, hydrocephalus, lumbo-peritoneal shunt, outcome, ventriculoperitoneal shunt, Medicine

الوصف: Cerebrospinal fluid (CSF) diversion procedure in the form of ventriculoperitoneal shunt (VPS) has been performed for over a century and is a well-established method for treating hydrocephalus. With the passage of time and the availability of better technology, several other CSF diversion modalities developed with variable risks and benefits. Lumboperitoneal shunt (LPS) is a close and safe contestant for the VP shunt procedure and is regarded as an alternative treatment modality for hydrocephalus. The present scoping review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses guidelines. A literature search for the study was performed on PubMed, COCHRANE, SCOPUS and ScienceDirect (from inception to 7 July 2022). Those studies that were published in the English language with a report on comparison between VPS and LPS for the management of hydrocephalus were included in the review process. Those studies that do not have comparative outcomes, case reports, letters, reviews, preclinical studies, conference reports and non-human studies were excluded from the study. Search results showed 134 records; after removing the duplicates and excluding 12 studies with reasons, five studies were included in the present review. Several complications were described in patients who underwent either VP Shunt or LP Shunt surgery. Although communicating hydrocephalus forms one of the most significant subgroups of patients in neurosurgical practice and VP and LP shunt procedures are also widely performed, the literature review shows limited comparative efficacy. In addition, the reported studies have a broad spectrum of indications, disease conditions and complications with a heterogeneous patient population. To further develop the high level of evidence, there is a need for well-designed prospective protocols to help us develop uniform and practical guidelines. In the present review, we looked into the common complications, including shunt malfunction, shunt infection, subdural haematoma, shunt obstruction and shunt migration between two groups.

وصف الملف: electronic resource

العلاقة: http://www.journaljme.org/article.asp?issn=2667-0720;year=2023;volume=4;issue=3;spage=241;epage=246;aulast=MauryaTest; https://doaj.org/toc/2667-0720Test; https://doaj.org/toc/2667-0739Test

الوصول الحر: https://doaj.org/article/c0041dd660c345f384e988bacc63d8e9Test

المؤلفون: Ebtesam Abdulla, Amit Agrawal, Rafael Cincu, Tariq Janjua, Luis Moscote-Salazar

المصدر: Romanian Neurosurgery, Vol 36, Iss 4 (2022)

مصطلحات موضوعية: contusion index, traumatic brain injury, neurointensive care, Neurology. Diseases of the nervous system, RC346-429

الوصف: Letter to Editor Contusion index - a diagnostic and treatment algorithm for neurointensive care

وصف الملف: electronic resource

العلاقة: http://journals.lapub.co.uk/index.php/roneurosurgery/article/view/2304Test; https://doaj.org/toc/1220-8841Test; https://doaj.org/toc/2344-4959Test

الوصول الحر: https://doaj.org/article/1b08560ce95a42b5af7fb9653d22283dTest

المؤلفون: Amrita Ghosh, Ranabir Pal, Ray Elizabeth Dominic, Mugdha Mittal, Luis Rafael Moscote-Salazar, Bukkambudhi V Murlimanju, Rafael Cincu, Amit Agrawal

المصدر: Indian Journal of Health Sciences and Biomedical Research KLEU, Vol 15, Iss 3, Pp 204-210 (2022)

مصطلحات موضوعية: covid-19, immunology, phytochemicals, plant-based immunotherapy, Medicine

الوصف: CoVID-19 is the most formidable unequaled global challenge invading 220 countries and territories in this millennium to uncountable saga of mortality, disability as humanity is witnessing devastation of socio-economy with more than 4 million deaths till date. The natural history of CoVID-19 from transmission through varied clinical features to overt complications is still under global research and research groups are on the run to trace its ramifications. This ranges from primary involvement of the pulmonary system to multisystem involvement through web of immunological pathways associated with susceptibility, clinical presentations, and severity of COVID-19. It has been hypothesized that the safe and effective mass vaccination program across the globe can ensure flattening of the pandemic curve to prepandemic normal life. This research group explored the basic and applied researches on molecular and immune mechanisms of SARS COV-2 virus. A sincere attempt has been made in futuristic research vision to find potential strengths, shortfalls, and efficacy of the plant-based immunotherapy, antibodies, and vaccine. Different research groups have hypothesized for the best possible use of these indigenous, stable, secure, efficacious natural products by searching their potential to accomplish emergency demands in this trying time. There is an urgent need to understand the inherent immunological predictors of the natural history of the disease spread over the spectrum from mild to severe forms of the disease and harp on these issues. In the wake of multiple waves with worse situations of evolving clinical features with the “variants of concern” and “variants of interest” and innovative interventions, this research group believes in optimum mix of microbial-derived biologicals with immune modifying drugs will broaden the preventive and curative spectrum.

وصف الملف: electronic resource

العلاقة: http://www.ijournalhs.org/article.asp?issn=2542-6214;year=2022;volume=15;issue=3;spage=204;epage=210;aulast=GhoshTest; https://doaj.org/toc/2542-6214Test; https://doaj.org/toc/2542-6222Test

الوصول الحر: https://doaj.org/article/da5cfd39a0a8407aabd1fd5559b46076Test

المؤلفون: Amrita Ghosh, Ranabir Pal, Rakesh Mishra, Rafael Cincu, Luis Rafael Moscote-Salazar, Amit Agrawal

المصدر: Romanian Journal of Neurology, Vol 20, Iss 3, Pp 296-299 (2021)

مصطلحات موضوعية: mirror therapy (mt), motor imagery training, lower extremity (le), randomized controlled trial (rct), rehabilitation, motor recovery, spasticity, functional ability, balance, Medicine, Neurology. Diseases of the nervous system, RC346-429

الوصف: Circulating inflammatory markers may predict the broad clinical spectrum of traumatic brain injury (TBI). The present study aimed to illustrate the role of leukocytes, precisely neutrophil and lymphocytes, in neuroinflammation as a new vista in neuro-critical care. Search terms were: elevations in peripheral blood leukocytes counts, neutrophil, lymphocyte with precisely neutrophil to lymphocyte ratios, associated with adverse outcomes of traumatic brain injury, pre and post-operative conditions of intracerebral haemorrhage, seizures, delirium, non-convulsive status epilepticus, confusion, aphasia, agitation, coma, disability and death. As a result, we identified 16 publications describing leukocyte biomarkers associated with neuroinflammation following TBI from PubMed, Cochrane Registry of Controlled Trials, Medline and Embase (Ovid) on randomised controlled trials (RCTs), non-RCTs and cohort studies published in the last decade. This study concluded that elevations in peripheral blood leukocyte and neutrophil to lymphocyte ratios could predict adverse outcomes of a cerebral haemorrhage.

وصف الملف: electronic resource

العلاقة: https://rjn.com.ro/articles/2021.3/RJN_2021_3_Art-05.pdfTest; https://doaj.org/toc/1843-8148Test; https://doaj.org/toc/2069-6094Test

الوصول الحر: https://doaj.org/article/47d74da91f7f49c5bc0f4e983c0d505cTest

المؤلفون: Abdulla , Ebtesam, Agrawal, Amit, Rafael Cincu, Janjua, Tariq, Moscote-Salazar, Luis

المصدر: Romanian Neurosurgery; Vol. XXXVI, No. 4 (December 2022); 492-493 ; 2344-4959 ; 1220-8841

مصطلحات موضوعية: contusion index, traumatic brain injury, neurointensive care

الوصف: Letter to Editor Contusion index - a diagnostic and treatment algorithm for neurointensive care

وصف الملف: application/pdf

العلاقة: https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/2304/1676Test; https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/2304Test

الإتاحة: https://doi.org/10.33962/roneuro-2022-089Test
https://journals.lapub.co.uk/index.php/roneurosurgery/article/view/2304Test

المؤلفون: Daulat Singh, Jitender Chaturvedi, Rakesh Mishra, Ved Prakash Maurya, Rafael Cincu, Md Yunus, Luis Rafael Moscote-Salazar, Amit Agrawal

المصدر: Journal of Neurointensive Care. 6:9-14

مصطلحات موضوعية: General Medicine

الوصف: There is increasing role of routine laboratory parameters in identifying neuroinflammation in various neurological disorders. This has led to the need to identify reliable, accessible, and cost-effective biomarkers that can help predict the outcome following injury to the brain. The parameters of interest include a neutrophil-to-lymphocyte ratio (NLR), red cell width distribution (RDW), red cell width (RDW)-to-platelet ratio (RPR), and NLR times RPR (NLTRP). The aim of the present systematic review and meta-analysis is to evaluate the prognostic value of Red Cell Distribution Width to Platelet Count Ratio (RPR) in various neuropsychiatric disorders. The studies that reported "Red Cell Distribution Width to Platelet Count Ratio" and "Outcome" in neurological conditions and the full text was published in English were included in the systematic review and if the studies two or more than two a further metanalysis was performed. Two investigators performed the literature search that included PubMed, COCHRANE, SCOPUS, and ScienceDirect (from inception to June 8th 2022). The full text of the shortlisted articles was reviewed, and the articles were included based on our inclusion and exclusion criteria. Search resulted in 293 records, and after removing the duplicates, total five studies were found to be eligible to be included in the systematic review. After analysing the full text, five studies were excluded; out of these four studies described only red cell width distribution but did not mention the details of red cell width distribution-to-platelet distribution ratio and one study had methodology like described in another article (with smaller sample size and the same source of data) by same authors. Haematological parameters are promising predictor of mortality for acute TBI, overall survival (OS) in Glioma, affective disorders, predicting outcome in deep seated ICH.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::6e4a57c0650fe358571912ac089a6289Test
https://doi.org/10.32587/jnic.2022.00563Test

المؤلفون: Rakesh Kumar Mishra, Sagar Galwankar, Joel Gerber, Anuj Jain, Md. Yunus, Rafael Cincu, Luis Rafael Moscote-Salazar, Gabriel Alexander Quiñones-Ossa, Amit Agrawal

المصدر: Journal of Neurosciences in Rural Practice. 13:618-635

مصطلحات موضوعية: General Neuroscience, Neurology (clinical)

الوصف: Objectives: The neutrophil-to-lymphocyte ratio (NLR) is a simple and routinely performed hematological parameter; however, studies on NLR as a prognostic tool in traumatic brain injury (TBI) have yielded contradictory results. Materials and Methods: This systematic review and meta-analysis was conducted according to the Preferred Reporting Items in the Systematic Review and Meta-Analysis guidelines 2020. Electronic databases of PubMed, Cochrane Library, Web of Science, and Scopus were searched. The population consisted of TBI patients in the absence of moderate and severe extracranial injury. Day 1 NLR was taken for the analysis. The outcomes evaluated were mortality and the Glasgow Outcome Scale (GOS). No restrictions were placed on the language, year and country of publication, and duration of follow-up. Animal studies were excluded from the study. Studies, where inadequate data were reported for the outcomes, were included in the qualitative synthesis but excluded from the quantitative synthesis. Study quality was evaluated using the Newcastle-Ottawa scale (NOS). The risk of bias was estimated using the Cochrane RoBANS risk of bias tool. Results: We retrieved 7213 citations using the search strategy and 2097 citations were excluded based on the screening of the title and abstract. Full text was retrieved for 40 articles and subjected to the eligibility criteria, of which 28 were excluded from the study. Twelve studies were eligible for the synthesis of the systematic review while seven studies qualified for the meta-analysis. The median score of the articles was 8/9 as per NOS. The risk of selection bias was low in all the studies while the risk of detection bias was high in all except one study. Ten studies were conducted on adult patients, while two studies reported pediatric TBI. A meta-analysis for GOS showed that high NLR predicted unfavorable outcomes at ≥6 months with a mean difference of −5.18 (95% confidence interval: −10.04, −0.32); P = 0.04; heterogeneity (I2), being 98%. The effect estimates for NLR and mortality were a mean difference of −3.22 (95% confidence interval: −7.12, 0.68), P = 0.11, and an I2 of 85%. Meta-analysis for Area under the curve (AUC) receiver operating characteristic of the included studies showed good predictive power of NLR in predicting outcomes following TBI with AUC 0.706 (95% CI: 0.582–0.829). Conclusion: A higher admission NLR predicts an increased mortality risk and unfavorable outcomes following TBI. However, future research will likely address the existing gaps.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::989ab1d334d3458822feb5f32b201749Test
https://doi.org/10.25259/jnrp-2022-4-21Test

المؤلفون: Ved Prakash Maurya, Rakesh Mishra, Luis Rafael Moscote-Salazar, Tariq Janjua, Rafael Cincu, Amit Agrawal

المصدر: Journal of Neurointensive Care. 5:44-47

الوصف: The golden hour is the time following an injury during which appropriate medical attention carries the highest likelihood of a better outcome. The concept of a golden hour was probably derived from the French Military’s World war I data for the care of trauma victims, but it is suitable for all types of acute emergencies. During these golden sixty minutes, the health care providers must focus on eliminating or mitigating the effect of critical events. If not timely addressed, these essential steps carry a maximum threat to the victim’s life by causing irreversible damage to vital organs. The major challenge in applying intervention during the golden hour is correctly identifying the correctable step in the victim at the earliest. Training individuals about basic life support is the first challenge to delivering care at the scene of an accident/ or event or during transport. The advances in the diagnostic modality and the faster means of transportation have been a major driving force in decreasing mortality during the early hours following the incident. In the present review, we attempt to draw attention to the importance of golden hour and emphasize that team-building and quality improvement are crucial to providing better outcomes.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9b4069cabed10b89b7b6dd1c8b6733a1Test
https://doi.org/10.32587/jnic.2022.00542Test

المؤلفون: Ebtesam Abdulla, Amit Agrawal, Rafael Cincu, Tariq Janjua, Luis Rafael Moscote-Salazar

المصدر: Nepal Journal of Neuroscience. 20:84-85

مصطلحات موضوعية: General Medicine

الوصف: There are dozens of cases of harassment and bullying in academic medicine that are hidden in the most hidden drawers. Harassment in academic medicine is an accepted and widely recognized problem. As a common pattern, the protagonists are always someone with power against people with a lower hierarchy. Abuse in any of its forms, be it physical, moral, or academic, ends up affecting the student's performance and behavior. It should be considered an unacceptable and punishable pattern in any academic setting.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::a49fafe314db8183d3a52eabe3ae25fbTest
https://doi.org/10.3126/njn.v20i1.51025Test