المؤلفون: Antoine F. VILLA, Didier PAYEN, Dominique ELIAS, François BLOT, Helene HASNI-PICHARD, Herve SAGEOT, Joel POUPON, Marc POCARD, Nathalie JOLY, Radia ABOURA, Robert GARNIER, Souleiman EL BALKHI

المصدر: Industrial Health. 2015, 53(1):28

المؤلفون: Radia Aboura, Naïm Bouazza, Inès Gana, Jean-Marc Tréluyer, Isabelle Desguerre, Camille Chenevier-Gobeaux, Yi Zheng, Rima Nabbout, Déborah Hirt, Manon Tauzin, Sihem Benaboud, Cécile Freihuber, Thierry Billette de Villemeur

المصدر: The Journal of Clinical Pharmacology. 61:677-687

مصطلحات موضوعية: Male, Pediatrics, medicine.medical_specialty, Adolescent, Metabolic Clearance Rate, Population, Lamotrigine, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, 0302 clinical medicine, Pharmacokinetics, medicine, Humans, Pharmacology (medical), Dosing, Child, education, Pharmacology, education.field_of_study, Epilepsy, Dose-Response Relationship, Drug, medicine.diagnostic_test, business.industry, Body Weight, Infant, New population, Therapeutic drug monitoring, Child, Preschool, 030220 oncology & carcinogenesis, Cohort, Anticonvulsants, Female, Drug Monitoring, business, medicine.drug, Pediatric population

الوصف: Lamotrigine is a broad-spectrum antiepileptic drug with high interindividual variability in serum concentrations in children. The aims of this study were to evaluate the predictive performance of pediatric population pharmacokinetic (PPK) models published on lamotrigine, to build a new model with our monitoring data and to evaluate the current recommended doses. A validation cohort included patients treated with lamotrigine who had a serum level assayed during therapeutic drug monitoring (TDM). PPK models published in the literature were first applied to the validation cohort. We assessed their predictive performance using mean prediction errors, root mean squared errors, and visual predictive checks. A new model was then built using the data. Dose simulations were performed to evaluate the doses recommended. We included 270 lamotrigine concentrations ranging from 0.5 to 17.9 mg/L from 175 patients. The median (range) age and weight were 11.8 years (0.8-18 years) and 32.7 kg (8-110 kg). We tested 6 PPK models; most had acceptable bias and precision but underestimated the variability of the cohort. We built a 1-compartment model with first-order absorption and elimination, allometric scaling, and effects of inhibitor and inducer comedications. In our cohort, 22.6% of trough concentrations were below 2.5 mg/L. In conclusion, we proposed a PPK model that can be used for TDM of lamotrigine in children. In our population, a high percentage of children had low trough concentrations of lamotrigine. As the intervals of recommended doses are large, we suggest aiming at the higher range of doses to reach the target concentration.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4accbe9973611d2b0e640ecda786b5f4Test
https://doi.org/10.1002/jcph.1791Test

المؤلفون: Naïm Bouazza, Rima Nabbout, Yi Zheng, Thierry Billette de Villemeur, Sihem Benaboud, Camille Chenevier-Gobeaux, Inès Gana, Manon Tauzin, Cécile Freihuber, Jean-Marc Tréluyer, Déborah Hirt, Radia Aboura, Isabelle Desguerre

المصدر: The Journal of Clinical Pharmacology. 59:406-417

مصطلحات موضوعية: Male, Oncology, medicine.medical_specialty, Population, Models, Biological, 030226 pharmacology & pharmacy, 03 medical and health sciences, Increasing weight, 0302 clinical medicine, Pharmacokinetics, Internal medicine, medicine, Humans, Pharmacology (medical), Trough Concentration, education, Pharmacology, education.field_of_study, medicine.diagnostic_test, business.industry, Valproic Acid, External validation, Bayes Theorem, Therapeutic drug monitoring, 030220 oncology & carcinogenesis, Cohort, Anticonvulsants, Female, Drug Monitoring, business, Pediatric population

الوصف: Valproate is an old-generation antiepileptic drug often used in children. The pharmacokinetics of valproate are noteworthy for a large and difficult to predict interindividual variability in measured serum concentrations and for saturable protein binding. A model-based approach to personalize valproate treatment could be relevant in pediatric patients. The aims of this study were to review all published valproate population pharmacokinetic models in children and assess them by external validation to determine their predictive performance. Through simulations with the best model, we evaluated dosing regimen. A validation data set included valproate serum concentrations assayed during routine therapeutic drug monitoring of epileptic children. We applied to our population 11 published pediatric population pharmacokinetic models. For each model, predictive performance was assessed by external validation, using bias and precision calculations as well as goodness-of-fit plots. Dose simulations were conducted with the best predictive model to evaluate dosing regimen. The validation data set contained 178 valproate concentrations ranging from 13.4 to 128 mg/L from 114 patients. The best model exhibited a mean prediction error of 6.6 mg/L and a root mean squared error of 25.1 mg/L, with no model misspecification evidenced by visual predictive check. In our cohort, half the patients had a trough concentration

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db2c18de635f5c97535d954206566d85Test
https://doi.org/10.1002/jcph.1333Test

المؤلفون: Radia Aboura, Inès Gana, Naïm Bouazza, Jean-Marc Treluyer, Déborah Hirt, Sihem Benaboud, Frantz Foissac, Sana Boujaafar, Gabrielle Lui, Yi Zheng

المصدر: Journal of pharmaceutical and biomedical analysis. 196

مصطلحات موضوعية: Formic acid, Pyridones, Clinical Biochemistry, Pharmaceutical Science, Ultrafiltration, 01 natural sciences, Piperazines, Analytical Chemistry, chemistry.chemical_compound, Pharmacokinetics, Tandem Mass Spectrometry, Raltegravir Potassium, Drug Discovery, Oxazines, medicine, Humans, Spectroscopy, Darunavir, Chromatography, High Pressure Liquid, Chromatography, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, 010401 analytical chemistry, Reproducibility of Results, Raltegravir, Blood proteins, 0104 chemical sciences, Ultrafiltration (renal), Pharmaceutical Preparations, Therapeutic drug monitoring, Dolutegravir, Heterocyclic Compounds, 3-Ring, medicine.drug, Chromatography, Liquid

الوصف: Dolutegravir, raltegravir and darunavir are three antiretroviral drugs widely used in combined antiretroviral therapies. These three drugs are highly bound to plasma proteins. Compared to the total concentration, the concentration of unbound drug which is considered as the only pharmacological active form should be more informative to improve therapeutic drug monitoring in patients to avoid virological failure or toxicity. The aim of the present study was to develop an ultrafiltration protocol and a LC-MS/MS method to simultaneously determine the concentrations of the unbound dolutegravir, raltegravir and darunavir in human plasma. Finally, 150 μL of plasma was ultrafiltrated using Centrifree® ultrafiltration devices with ultracel YM-T membrane (cutoff 30 KDa) during 5 min at 37 °C at 1500 g. Then, 20 μL of the ultrafiltrate were injected into the LC-MS/MS system. The chromatographic separation was carried out on a BEH C18 column using a mobile phase containing deionized water and acetonitrile, both with 0.05 % (v/v) of formic acid, with a gradient elution at a flow rate of 0.5 mL/min. The run time was only 4 min. The calibration curve ranged from 0.5-200 ng/mL for dolutegravir, 1 to 400 ng/mL for raltegravir and 10-4000 ng/mL for darunavir. This method was validated with a good precision (inter- and intra-day CV% lower than 14 %) and a good accuracy (inter- and intra-day bias between -5.6-8.8 %) for all the analytes. This method is simple, reliable and suitable for pharmacokinetic studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c687e1bc3a95fe6d8774e684c92d8cbTest
https://pubmed.ncbi.nlm.nih.gov/33571728Test

المؤلفون: Jean-Marc Tréluyer, Déborah Hirt, Radia Aboura, Gabrielle Lui, Sihem Benaboud, Naïm Bouazza, Frantz Foissac, Sana Boujaafar, Inès Gana, Yi Zheng

المساهمون: Evaluation thérapeutique et pharmacologie périnatale et pédiatrique (EA_7323), Université Paris Descartes - Paris 5 (UPD5), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)

المصدر: Journal of Pharmaceutical and Biomedical Analysis
Journal of Pharmaceutical and Biomedical Analysis, Elsevier, 2020, 182, pp.113119-. ⟨10.1016/j.jpba.2020.113119⟩

مصطلحات موضوعية: Anti-HIV Agents, Clinical Biochemistry, Pharmaceutical Science, Integrase inhibitor, 01 natural sciences, Analytical Chemistry, chemistry.chemical_compound, Tandem Mass Spectrometry, Drug Discovery, medicine, Humans, [CHIM]Chemical Sciences, Chromatography, High Pressure Liquid, Spectroscopy, Darunavir, Randomized Controlled Trials as Topic, Chromatography, medicine.diagnostic_test, 010405 organic chemistry, Chemistry, Elvitegravir, 010401 analytical chemistry, Reproducibility of Results, Raltegravir, 3. Good health, 0104 chemical sciences, Therapeutic drug monitoring, Rilpivirine, Dolutegravir, Ritonavir, Drug Monitoring, medicine.drug

الوصف: Therapeutic drug monitoring (TDM) is essential in the optimization of antiretroviral (ARV) treatments. In this work, we describe a new method for the simultaneous quantification of six molecules: the three novel ARV agents dolutegravir (DTG), elvitegravir (ELV) and rilpivirine (RPV), the first integrase inhibitor raltegravir (RAL) and its major metabolite the raltegravir-β- d -glucuronide (RAL-GLU), an protease inhibitor darunavir (DRV) and its booster ritonavir (RTV) in human plasma. The drugs were extracted from 100 μL of plasma by a simple method of protein precipitation using acetonitrile. The separation was carried out on a Kinetex phehyl-hexyl column using a phase mobile composed of 55 % of water (0.05 % formic acid,v/v) and 45 % of methanol (0.05 % formic acid,v/v). The flow rate was set at 0.5 mL/min. The calibration ranged from 60 to 15000 ng/mL for DRV, from 20 to 5000 ng/mL for DTG and ELV, from 10 to 2500 ng/mL for RAL, RAL-GLU, RTV and RPV. The proposed method was validated with a good precision (inter- and intra-day CV% inferior to 12.3 %) and a good accuracy (inter- and intra-day bias between −9.9 % and 10 %) for all the analytes. The proposed method is simple, reliable and suitable for therapeutic drug monitoring (TDM) and for pharmacokinetics studies.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22c6923c424756daf8f2f0a57b32eeb7Test
https://hal.archives-ouvertes.fr/hal-03489828Test

المؤلفون: Sihem Benaboud, Jean-Marc Tréluyer, Saik Urien, Julie Toubiana, Mathieu Genuini, Claire Heilbronner, Déborah Hirt, Radia Aboura, Sylvain Renolleau, Mehdi Oualha, Agathe Béranger

المصدر: Clinical Pharmacokinetics. 57:867-875

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Cefotaxime, Adolescent, Critical Illness, 030106 microbiology, Population, law.invention, 03 medical and health sciences, Randomized controlled trial, Pharmacokinetics, law, Humans, Medicine, Pharmacology (medical), Prospective Studies, Dosing, Child, education, Pharmacology, Volume of distribution, Pediatric intensive care unit, education.field_of_study, Dose-Response Relationship, Drug, business.industry, Infant, Bacterial Infections, Models, Theoretical, Anti-Bacterial Agents, Surgery, Child, Preschool, Anesthesia, Female, Median body, business, medicine.drug

الوصف: During sepsis, optimal plasma antibiotic concentrations are mandatory. Modifications of pharmacokinetic parameters could lead to low drug concentrations and therefore, insufficient therapeutic levels. The aim of this study was to build a population pharmacokinetic model for cefotaxime and its metabolite desacetylcefotaxime in order to optimize individual dosing regimens for critically ill children. All children aged

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d4bd11ef7623a4bb829fb7e7ceaf2f8Test
https://doi.org/10.1007/s40262-017-0602-9Test

المؤلفون: Sihem Benaboud, Ziqing Wang, Gabrielle Lui, Déborah Hirt, Radia Aboura, Jean-Marc Tréluyer, Inès Gana, Yi Zheng

المصدر: Biomedical Chromatography. 33:e4506

مصطلحات موضوعية: Adult, Adolescent, Clinical Biochemistry, 030226 pharmacology & pharmacy, 01 natural sciences, Biochemistry, High-performance liquid chromatography, Pefloxacin, Analytical Chemistry, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Drug Stability, Pharmacokinetics, Limit of Detection, Levofloxacin, Moxifloxacin, Drug Discovery, medicine, Humans, Child, Molecular Biology, Chromatography, High Pressure Liquid, Aged, Aged, 80 and over, Pharmacology, Chromatography, medicine.diagnostic_test, Chemistry, 010401 analytical chemistry, Infant, Newborn, Infant, Reproducibility of Results, General Medicine, Middle Aged, bacterial infections and mycoses, Gatifloxacin, 0104 chemical sciences, Ciprofloxacin, Therapeutic drug monitoring, Child, Preschool, Linear Models, Spectrophotometry, Ultraviolet, Fluoroquinolones, medicine.drug

الوصف: Levofloxacin, pefloxacin, ciprofloxacin and moxifloxacin are four fluoroquinolones used in the treatment of serious bacterial infections. The antibacterial activity of fluoroquinolones is concentration dependent. Therefore, therapeutic drug monitoring in daily clinical practice is warranted to ensure the therapy's efficacy and prevent bacterial resistance. The purpose of the present study was to develop a method using high-pressure liquid chromatography with an ultraviolet detector for simultaneous quantification of these four fluoroquinolones in human plasma. A 50 μL aliquot of plasma was precipitated by 200 μL of methanol using gatifloxacin as internal standard. The chromatographic separation was performed on a Kinetex XB-C18 column using a mobile phase composed of a mixture of orthophosphoric acid 0.4% (v/v), acetonitrile and methanol at a flow rate of 1.2 mL/min. Dual UV wavelength mode was used, with levofloxacin and moxifloxacin monitored at 293 nm, and pefloxacin and ciprofloxacin monitored at 280 nm. The calibration was linear over the ranges of 0.125-25 mg/L for levofloxacin, 0.1-20mg/L for moxifloxacin and 0.05-10 mg/L for both pefloxacin and ciprofloxacin. Inter- and intra-day trueness and precision were

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68e07bb2cb315cec16f6a576bc179b76Test
https://doi.org/10.1002/bmc.4506Test

المؤلفون: Radia, Aboura, Abdeldjelil, Lansari

المساهمون: Owe, Manfred, D'Urso, Guido, Moreno, Jose F., Calera, Alfonso

المصدر: SPIE Proceedings ; Remote Sensing for Agriculture, Ecosystems, and Hydrology V ; ISSN 0277-786X

الإتاحة: https://doi.org/10.1117/12.512204Test

المؤلفون: Joël Poupon, Radia Aboura, François Blot, Herve Sageot, Dominique Elias, Antoine Villa, Nathalie Joly, Helene Hasni-Pichard, Robert Garnier, Didier Payen, Souleiman El Balkhi, Marc Pocard

المصدر: ResearcherID
Industrial Health

مصطلحات موضوعية: Adult, Male, Operating Rooms, medicine.medical_specialty, Organoplatinum Compounds, Health, Toxicology and Mutagenesis, Operating Tables, Regional perfusion, Antineoplastic Agents, Air Pollutants, Occupational, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Air pollutants, Floors and Floorcoverings, Occupational Exposure, Perioperative chemotherapy, medicine, Humans, Gloves, Surgical, Peritoneal Neoplasms, Surface samples, HIPEC, business.industry, Skin exposure, Public Health, Environmental and Occupational Health, Atmospheric samples, Hyperthermia, Induced, Middle Aged, Contamination, Hand, Shoes, 3. Good health, Oxaliplatin, Surgery, Personnel, Hospital, Chemotherapy, Cancer, Regional Perfusion, 030220 oncology & carcinogenesis, Biomonitoring, Original Article, Female, 030211 gastroenterology & hepatology, Occupational exposure, business, medicine.drug

الوصف: The aim of this study was to evaluate air and surface contaminations, and internal contamination of healthcare workers during open-abdomen HIPEC using oxaliplatin. Platinum (Pt) was measured in urine of exposed workers and in multiple air and surface samples. Three successive HIPEC procedures were investigated in each of the two hospitals participating in the study. Analysis of air samples did not detect any oxaliplatin contamination. Heavy contamination of the operating table, the floor at the surgeon’s feet, and the surgeon’s overshoes were observed. Hand contamination was observed in surgeons using double gloves for intra-abdominal chemotherapy administration, but not in those using three sets of gloves. Pt was not detected in urine samples obtained after HIPEC (

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02a49dd4b57d0672fc6be3fd2486afadTest
http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000349938100004&KeyUID=WOS:000349938100004Test