المؤلفون: Nalini Gupta, Parikshaa Gupta, Manish Rohilla, Radhika Srinivasan, Arvind Rajwanshi, Pranab Dey, Aleena Jain, Shruti Gupta

المصدر: Diagnostic Cytopathology. 49:226-231

مصطلحات موضوعية: Male, medicine.medical_specialty, Histology, Tuberculosis, Cytodiagnosis, Biopsy, Fine-Needle, Population, 030209 endocrinology & metabolism, Pathology and Forensic Medicine, 03 medical and health sciences, 0302 clinical medicine, Lymphadenitis, Cytology, Humans, Medicine, Lymphocytes, education, Histiocyte, Retrospective Studies, education.field_of_study, Granuloma, business.industry, Infant, General Medicine, Adenitis, medicine.disease, Dermatology, Giant cell, 030220 oncology & carcinogenesis, BCG Vaccine, Primary immunodeficiency, Female, Lymph Nodes, business, Complication

الوصف: Background Bacille Calmette-Guerin (BCG) adenitis is a common complication of post-BCG vaccination. Awareness of this lesser known entity in fine-needle aspiration (FNA) is important to prevent misdiagnosis. Aim This study described the clinical presentation, cytomorphological features and disease pattern in patients with BCG adenitis. Materials and methods We analyzed a series of 15 patients with BCG adenitis seen from July 2017 to July 2019. The detailed clinical and cytomorphology of these cases were studied. Results Age of presentation ranged from 3 to 12 months. Male to female ratio was 2.75:1. A total of four children were diagnosed with primary immunodeficiency. Three children had acyanotic heart disease. Most of the children had left axillary lymph node enlargement. Cytomorphology showed the presence of polymorphs (66.7%), histiocytic aggregates (80%) and reactive lymphoid population (60%). Epithelioid granulomas (26.7%) and giant cells (6.7%) were present. The necrotic background was present in all but one case. Ziehl-Neelsen stain for acid-fast bacilli was positive in all but two cases. Conclusion A high index of clinical suspicion for BCG lymphadenitis should be kept in mind for patients who are recently vaccinated. FNA cytology, combined with clinical correlation, is useful for diagnosis and management.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::103c144cc2ba7ad7c05f50b0e5b0cd81Test
https://doi.org/10.1002/dc.24613Test

المؤلفون: Subhash Chandra Saha, Shruti Gupta, Parikshaa Gupta, Seema Chopra, Radhika Srinivasan, Arvind Rajwanshi, Pooja Sikka

المصدر: Journal of Gynecologic Surgery. 36:209-213

مصطلحات موضوعية: medicine.medical_specialty, Pathology, Stromal cell, Endometrial stromal sarcoma, business.industry, Mesenchymal stem cell, Uterus, Endometriosis, Obstetrics and Gynecology, medicine.disease, Malignant transformation, Surgery, Stromal sarcoma, medicine.anatomical_structure, Medicine, business

الوصف: Background: Endometrial stromal sarcomas (ESS) are uncommon mesenchymal neoplasms of the uterus, composed of cells closely resembling normal proliferative endometrial stromal tissue. ESS account fo...

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::372a6df340ca85d112dbb711d8f5e61bTest
https://doi.org/10.1089/gyn.2019.0144Test

المؤلفون: Manish Rohilla, Radhika Srinivasan

المصدر: Breast Cancer ISBN: 9789811645457

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::0e01c3aa7403fb8135e18d50d7c4524cTest
https://doi.org/10.1007/978-981-16-4546-4_7Test

المؤلفون: Radhika Srinivasan, Shyamala Mani, Samayita Ghosh

المصدر: Climate Change and the Health Sector ISBN: 9781003190516
Climate Change and the Health Sector

مصطلحات موضوعية: business.industry, Water stress, Health care, Effective management, Business, Environmental planning

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::9adeed7b0106a46669b1978e6a3cff3fTest
https://doi.org/10.4324/9781003190516-19Test

المؤلفون: Tim M. Strom, Shruti Gupta, Radhika Srinivasan, Bettina Lorenz-Depiereux, Rajesh Kumar, Devi Dayal

المصدر: Intractable & Rare Diseases Research. 10:55-57

مصطلحات موضوعية: 0301 basic medicine, Sanger sequencing, Proband, Pathology, medicine.medical_specialty, business.industry, General Medicine, 030105 genetics & heredity, medicine.disease, Calcinosis cutis, 03 medical and health sciences, symbols.namesake, Exon, Hyperphosphatemia, 0302 clinical medicine, medicine, symbols, Tumoral calcinosis, business, Gene, 030217 neurology & neurosurgery, Calcification

الوصف: Hyperphosphatemic familial tumoral calcinosis (HFTC) is an extremely rare autosomal recessive disorder caused by variants in the GALNT3 (N-acetylgalactosaminyltransferase 3), FGF23 (Fibroblast Growth Factor-23) and αKL (α-Klotho) genes, which results in progressive calcification of soft tissues. We describe the case of a 9-year-old girl who presented with recurrent hard nodular swellings on her feet and knees which intermittently discharged chalky white material. Her younger brother also had a similar condition. Both siblings showed hyperphosphatemia, but the parentsbiochemical parameters were normal. The histological features of the material aspirated from a skin lesion were consistent with tumoral calcinosis. Sanger sequencing identified a novel homozygous non-synonymous sequence variant in exon 10 of the GALNT3 gene (NM_004482.3:c.[1681T>A];[1681T>A], NP_004473.2:p. [Cys561Ser];[Cys561Ser] in the proband and her affected brother. The parents were heterozygous carriers for the same sequence variant. In conclusion, we report a new variant in the GALNT3 gene that caused HFTC in a North Indian family.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::b1455cb76a150a612702c0aae5f087aaTest
https://doi.org/10.5582/irdr.2020.03084Test

المؤلفون: Vinay Munikoti, Deepak Bansal, Usha Singh, Radhika Srinivasan, Amita Trehan, Richa Jain, Zoramathara Zadeng, Nandita Kakkar, Akshay Kumar Saxena, Arvind Rajwanshi

المصدر: Pediatric Hematology Oncology Journal, Vol 1, Iss 2, p S35 (2016)

مصطلحات موضوعية: Pediatrics, RJ1-570

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2468124516301656Test; https://doaj.org/toc/2468-1245Test

الوصول الحر: https://doaj.org/article/c8b85daf5388446ab7ebcf02a60c71b2Test

المؤلفون: Sanjeev Khera, Amita Trehan, K.L.N. Rao, Deepak Bansal, Nandita Kakkar, Radhika Srinivasan

المصدر: Pediatric Hematology Oncology Journal, Vol 1, Iss 2, p S27 (2016)

مصطلحات موضوعية: Pediatrics, RJ1-570

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S246812451630119XTest; https://doaj.org/toc/2468-1245Test

الوصول الحر: https://doaj.org/article/7278f9cd110b4896aef425e7f0651ba5Test

المؤلفون: Rashmi Bagga, Radhika Srinivasan, Shalmoli Bhattacharyya, Shifa Javed

المصدر: Molecular and Cellular Biochemistry. 473:51-62

مصطلحات موضوعية: 0301 basic medicine, Epithelial-Mesenchymal Transition, medicine.medical_treatment, Clinical Biochemistry, Cell, Uterine Cervical Neoplasms, Biology, 03 medical and health sciences, 0302 clinical medicine, Cancer stem cell, Cell Line, Tumor, Gene expression, medicine, Humans, Insulin-Like Growth Factor I, Molecular Biology, Cisplatin, Cervical cancer, Growth factor, Cell Biology, General Medicine, medicine.disease, Neoplasm Proteins, 030104 developmental biology, medicine.anatomical_structure, Apoptosis, Cell culture, 030220 oncology & carcinogenesis, Neoplastic Stem Cells, Cancer research, Female, Signal Transduction, medicine.drug

الوصف: Cancer stem cells (CSC) drive tumour progression and are implicated in relapse and resistance to conventional cancer therapies. Identification of differentially expressed genes by gene expression (GEP) profiling may help identify the differentially activated signalling pathways in cancer stem cells as opposed to bulk tumour cells which will provide new insights into cancer stem cell biology and aid in identification of novel therapeutic targets. Our study focused on the inhibition of CSC from cervical cancer cell lines by targeting insulin-like growth factor (IGF), which was identified by differential GEP. Targeted inhibition of IGF-1 by JB-1 trifluoroacetate (inhibitor of IGF) was carried out in SiHa, RSBS-14 and RSBS-43 cervical cancer derived cell lines. Effect of cisplatin was also evaluated. Inhibition of IGF-1 signalling was confirmed by demonstration of reduction in p-Akt levels. The cell biological effects of IGF-1 inhibition included an increase in G2M/S fraction, increased apoptosis and decreased invasive ability. JB-1 and cisplatin showed synergism. However, transcript levels of stemness and EMT markers showed variable levels following IGF inhibition. Overall, this proof-of-concept study has shown that IGF-1 is an attractive target for inhibition of CSC in invasive cervical cancer.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::619fe4a597bb20186cf48bf314ac728cTest
https://doi.org/10.1007/s11010-020-03807-6Test

المؤلفون: Gaurav Prakash, Upasana Gautam, Ariba Zaidi, Ashwani Sood, Amanjit Bal, Radhika Srinivasan

المصدر: Cytopathology. 31:598-601

مصطلحات موضوعية: Pathology, medicine.medical_specialty, Histology, medicine.diagnostic_test, business.industry, Thyroid, Immunocytochemistry, General Medicine, medicine.disease, Pathology and Forensic Medicine, Thyroid carcinoma, BRAF V600E, medicine.anatomical_structure, Fine-needle aspiration, Langerhans cell histiocytosis, Mutation (genetic algorithm), medicine, business, Cell block

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::fb83881a03e67d2cf877400d6695bc0fTest
https://doi.org/10.1111/cyt.12816Test

المؤلفون: Manish Rohilla, Gargi Kapatia, Parikshaa Gupta, Radhika Srinivasan, Pranab Dey, Arvind Rajwanshi, Ojas Gupta, Uma Nahar Saikia, Nalini Gupta

المصدر: Cytopathology. 31:136-143

مصطلحات موضوعية: Adult, Male, Pathology, medicine.medical_specialty, Histology, Adolescent, Gastrointestinal Stromal Tumors, Cytodiagnosis, Biopsy, Fine-Needle, Immunocytochemistry, Rectum, 030209 endocrinology & metabolism, Pathology and Forensic Medicine, Metastasis, Diagnosis, Differential, Young Adult, 03 medical and health sciences, 0302 clinical medicine, Biomarkers, Tumor, medicine, Humans, Neoplasm Metastasis, neoplasms, Aged, Aged, 80 and over, GiST, business.industry, Stomach, Mediastinum, Neoplasms, Second Primary, General Medicine, Middle Aged, medicine.disease, digestive system diseases, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Duodenum, Female, business, Epithelioid cell

الوصف: Aim To explore the cytological spectrum of the gastrointestinal stromal tumour (GIST) including its metastatic sites. Material and methods A total of 42 patients (45 sites) diagnosed with GIST or its metastases on fine needle aspiration cytology were studied over a period of 5 years. May-Grunwald Giemsa- and haematoxylin and eosin-stained smears were reviewed and analysed for the cytomorphological spectrum of GIST. Results Primary GIST alone was seen in 24 cases, E-GIST in eight cases and metastasis in 11 cases (one patient showing metastasis at two distinct sites), whereas concurrent primary and metastatic lesions were noted in two cases. Amongst primary sites, the most commonly affected location was stomach (n = 22), followed by ileum (n = 2), duodenum (n = 1) and rectum (n = 1). Extra-GIST was seen in retroperitoneum and pelvis (n = 3 each), omentum and mediastinum (n = 1 each). Fine needle aspiration cytology was done from 11 metastatic sites of GIST which included liver, gall bladder fossa, chest wall, and thigh. The classic spindle cell arrangement was the predominant cytological pattern. About 8.8% cases showed predominant epithelioid cell morphology and 15.5% cases had a mixed cytomorphology comprising of both spindle cell and epithelioid cell patterns. Nuclear pseudoinclusions, perinuclear vacuoles and multinucleation were seen in four cases. Immunocytochemistry on cell-block sections for confirmation was performed in 18 cases and all these cases showed strong c-KIT positivity. Conclusion In this largest case series of cytomorphological diagnosis of GIST, we describe the cytomorphology and immunocytochemistry of primary and metastatic GIST. GISTs with predominant epithelioid cell morphology may pose a diagnostic dilemma therefore in all suspected cases of GIST, immunocytochemistry for c-KIT and/or DOG1 should be employed on cell-block preparations to confirm the diagnosis of GIST.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c0311eeef623b2cd8a063ebfa16d53Test
https://doi.org/10.1111/cyt.12785Test