المؤلفون: Ledergerber B, Lundgren JD, Walker AS, Sabin C, Justice A, Reiss P, Mussini C, Wit F, d'Arminio Monforte A, Weber R, Fusco G, Staszewski S, Law M, Hogg R, Lampe F, Gill MJ, Phillips AN, Rooney, P. q, Taylor, S. q, Couldwell, D. r, Austin, D. s, Block, M. s, Clemons, J. s, Finlayson, R. s, Petoumenos, K. s, Quan, D. s, Smith, D. s, O'Connor, C. t, Gorton, C. t, Allen, D. u, Mulhall, B. u, Mutimer, K. v, Keeffe, N. v, Cooper, D. w, Carr, A. w, Miller, J. w, Pell, C. w, Ellis, D. x, Baker, D. y, Kidd, J. y, McFarlane, R. y, Liang, M. T. z, Brown, K. aa, Huffam, S. ab, Savage, J. ab, Morgan, Knibbs, P. ab, Sowden, D. ac, Walker, A. ac, Orth, D. ad, Lister, G. ad, Chuah, J. ae, Fankhauser, W. ae, Dickson, B. ae, Bradford, D. af, Wilson, C. af, Ree, H. ag, Magon, Anderson, J. ah, Moore, R. ah, Russell, D. ah, McGovern, G. ah, McNair, Bal, Fairley, K. ah, Roth, N. ai, Eu, B. ai, Strecker, S. ai, D. ai, Wood, H. ai, Mijch, A. aj, Hoy, J. aj, Pierce, McCormack, C. aj, Watson, K. aj, Medland, N. ak, Daye, J. al, Mallal, S. am, French, M. am, Skett, J. am, Maxwel, D. am, Cain, A. am, Montroni, M. an, Scalise, G. an, Costantini, A. an, Giacometti, Tirelli, U. ao, Nasti, G. ao, Pastore, G. ap, Ladisa, N. ap, Perulli, M. L. ap, Suter, F. aq, Arici, C. aq, Maggiolo, Chiodo, F. ar, Gritti, F. M. ar, Colangeli, V. ar, Fiorini, C. ar, Guerra, L. ar, Carosi, G. as, Cadeo, G. P. as, Minardi, C. as, Vangi, D. as, Paraninfo, Casari, S. as, Pan, A. as, Patroni, Torti, Quiros Roldan, E. as, Tomasoni, L. as, Moretti, F. as, Nasta, P. as, Uccelli, M. C. as, Bertelli, Rizzardini, G. at, Migliorino, M. at, Abeli, C. at, Manconi, P. E. au, Piano, P. au, Ferraro, T. av, Scerbo, A. av, Pizzigallo, E. aw, Ricci, F. aw, Santoro, D. ax, Pusterla, L. ax, Carnevale, G. ay, Galloni, D. ay, Viganò, P. az, Mena, M. az, Ghinelli, F. ba, Sighinolfi, L. ba, Leoncini, F. bb, Mazzotta, Pozzi, M. bb, Lo Caputo, S. bb, Angarano, G. bc, Grisorio, B. bc, Ferrara, S. bc, Grima, P. bd, Tundo, Pagano, G. be, Piersantelli, N. be, Alessandrini, A. be, Piscopo, R. be, Toti, M. bf, Chigiotti, S. bf, Soscia, F. bg, Tacconi, L. bg, Orani, A. bh, Perini, P. bh, Nigro, M. bh, Scasso, A. bi, Vincenti, Scalzini, A. bj, Fibbia, G. bj, Moroni, M. bk, Lazzarin, A. bk, Cargnel, Vigevani, G. M. bk, Caggese, L. bk, Tordato, F. bk, Novati, R. bk, Galli, Merli, S. bk, Pastecchia, C. bk, Moioli, Esposito, R. bl, Abrescia, N. bm, Chirianni, A. bm, Izzo, C. bm, Piazza, M. bm, De Marco, Montesarchio, V. bm, Manzillo, E. bm, Nappa, S. bm, Colomba, A. bn, Abbadessa, V. bn, Prestileo, T. bn, Mancuso, S. bn, Ferrari, C. bo, Pzzaferri, P. bo, Filice, G. bp, Minoli, L. bp, Bruno, R. bp, Maserati, S. bp, Tinelli, C. bp, Pauluzzi, S. bq, Baldelli, F. bq, Petrelli, E. br, Cioppi, A. br, Alberici, F. bs, Ruggieri, A. bs, Menichetti, F. bt, Martinelli, C. bt, De Stefano, C. bu, La Gala, A. bu, Zauli, T. bv, Ballardini, G. bv, Magnani, G. bw, Ursitti, M. A. bw, Arlotti, M. bx, Ortolani, P. bx, Ortona, L. by, Dianzani, F. by, Ippolito, G. by, Antinori, A. bz, Antonucci, G. bz, D'Elia, S. bz, Narciso, P. bz, Petrosillo, N. bz, Vullo, V. bz, De Luca, Del Forno, L. bz, Zaccarelli, M. bz, De Longis, Ciardi, D'Offizi, Noto, Lichtner, Capobianchi, M. R. bz, Girardi, E. bz, Pezzotti, Rezza, Mura, M. S. ca, Mannazzu, M. ca, Caramello, P. cb, Sinicco, A. cb, Soranzo, M. L. cb, Gennero, L. cb, Sciandra, M. cb, Salassa, B. cb, Grossi, P. A. cc, Basilico, C. cc, Poggio, A. cd, Bottari, G. cd, Raise, E. ce, Pasquinucci, S. ce, De Lalla, F. cf, Tositti, G. cf, Resta, F. cg, Chimienti, A. cg, Lepri Cozzi, A. ch, Bachmann, S. fb, Battegay, M. fb, Bernasconi, E. fb, Bucher, H. fb, Bürgisser, P. fb, Cattacin, Egger, Erb, Fierz, W. fb, Fischer, Flepp, Fontana, A. fb, Francioli, Furrer, H. J. fb, Gorgievski, Günthard, Hirschel, B. fb, Kaiser, L. fb, Kind, C. fb, Klimkait, T. fb, Lauper, U. fb, Opravil, Paccaud, F. fb, Pantaleo, G. fb, Perrin, Piffaretti, J. C. fb, Rickenbach, Rudin, Schüpbach, J. fb, Speck, R. fb, Tarr, Telenti, Trkola, Vernazza, Yerly, de Wolf, F. ci, van Sighem, A. I. ci, van Valkengoed, I. ci, Gras, L. ci, Bronsveld, W. ci, Veldkamp, A. ci, Prins, J. M. cj, Bos, J. C. cj, Schattenkerk Eeftinck, J. K. M. cj, Godfried, M. H. cj, Lange, J. M. A. cj, Lowe, S. H. cj, van der Meer, J. T. M. cj, Nellen, F. J. B. cj, Pogany, K. cj, van der Poll, T. cj, Ruys, T. A. cj, Sankatsing, S. cj, van der Valk, M. cj, van Vonderen, M. G. A. cj, Wit, F. W. M. N. cj, van Eeden, A. cj, ten Veen, J. H. cj, van Dam, P. S. cj, Hillebrand Haverkort, M. E. cj, Brinkman, Frissen, P. H. J. cj, Weigel, H. M. cj, Mulder, J. W. cj, van Gorp, E. C. M. cj, Meenhorst, P. L. cj, Mairuhu, A. T. A. cj, Veenstra, J. cj, Danner, S. A. cj, Van Agtmael, M. A. cj, Claessen, F. A. P. cj, Geerlings, S. E. cj, Perenboom, R. M. cj, Jurriaans, Back, N. K. T. cj, Cuijpers, Rietra, P. J. G. M. cj, Roozendaal, K. J. cj, Pauw, W. cj, van Zanten, A. P. cj, Smits, P. H. M. cj, von Blomberg, B. M. E. cj, Savelkoul, P. cj, Zaaijer, H. cj, Beijnen, Crommentuyn, K. M. L. cj, Huitema, A. D. R. cj, Kappelhoff, B. cj, de Maat, M. M. R. cj, Richter, C. ck, van der Berg, J. ck, van Leusen, R. ck, Swanink, Vriesendorp, R. cl, Jeurissen, F. J. F. cl, Kauffmann, R. H. cm, Koger, E. L. W. cm, Franck, P. F. H. cm, Lampe, A. S. cm, Jansen, C. L. cm, Bravenboer, B. cn, ten Napel, C. H. H. co, Mudrikova, T. co, Hendriks, R. co, Sprenger, H. G. cp, Miesen, W. M. A. J. cp, Schirm, J. cp, Benne, D. cp, ten Kate, R. W. cq, Veenendaal, D. cq, van Houte, D. P. F. cr, Leemhuis, M. P. cr, Pole, M. cr, Storm, H. cr, van Zeijl, J. H. cr, Kroon, F. P. cs, Schippers, E. F. cs, Kroes, A. C. M. cs, Claas, H. C. J. cs, Schreij, G. ct, van de Geest, S. ct, Verbon, A. ct, Bruggeman, C. A. M. V. A. ct, Goossens, V. J. ct, Koopmans, P. P. cu, Telgt, M. cu, van der Ven, A. J. A. M. cu, Burger, D. M. cu, Hugen, P. W. H. cu, Galama, J. M. D. cu, Poort, Y. A. G. M. cu, van der Ende, M. E. cv, Gyssens, I. C. cv, de Marie, S. cv, Nouwen, J. L. cv, Niesters, M. G. cv, Osterhaus, A. D. M. E. cv, Schutten, M. cv, Juttmann, J. R. cw, Buiting, A. G. M. cw, Swaans, C. A. M. cw, Schneider, M. M. E. cx, Bonten, M. J. M. cx, Borleffs, J. C. C. cx, Hoepelman, I. M. cx, Jaspers, C. A. J. J. cx, Schouten, I. cx, Schurink, C. A. M. cx, Boucher, C. A. B. cx, Schuurman, R. cx, Blok, W. L. cy, Groeneveld, P. H. P. cz, Boel, E. da, Jansz, A. F. da, Dabis, F. db, Thiebaut, R. db, Chêne, G. db, Lawson Ayayi, S. db, Meyer, L. dc, Boufassa, F. dc, Hamouda, O. dd, P. de, G. de, Touloumi, G. df, Hatzakis, A. df, Karafoulidou, Katsarou, O. df, Brettle, R. dg, Del Amo, J. dh, del Romero, van Asten, L. di, van Benthem, B. di, M. di, Coutinho, R. di, Kirk, O. dj, Pedersen, C. dj, Hernández Aguado, I. dk, Pérez Hoyos, S. dk, Eskild, A. dl, Bruun, J. N. dl, Sannes, M. dl, Lee, C. dm, Johnson, A. M. dn, Babiker, A. dn, Darbyshire, J. dn, Gill, N. dn, Porter, K. dn, P. do, Vanhems, M. do, Cooper, D. dp, Kaldor, J. dpdq, Ashton, L. dp, D. dq, L. dq, Vizzard, J. dq, Muga, R. dr, P. ds, J. dt, Cayla, J. du, Garcia de Olalla, P. du, Day, N. E. dv, De Angelis, D. dv, K. fb, A. dw, S. dw, J. dw, Tyrer, F. dw, Beral, V. fb, N. fb, Raffanti, Becker, Scarsella, Braun, Most, Balu, Gilbert, Fleenor, Ising, Dieterich, D. fb, Fusco, Losso, M. dx, Duran, A. dx, Vetter, N. dy, Clumeck, N. dz, De Wit, S. dz, Kabeya, K. dz, Poll, B. dz, Colebunders, R. dz, Machala, L. ea, Rozsypal, H. ea, Nielsen, J. eb, Lundgren, O. eb, Olsen, C. H. eb, Gerstoft, Katzenstein, T. eb, Hansen, A. B. E. eb, Skinhøj, P. eb, C. eb, Zilmer, K. ec, Rauka, M. ec, Katlama, C. ed, De Sa, M. ed, Viard, J. P. ed, Saint Marc, T. ed, P. ed, Pradier, Dietrich, M. ee, Manegold, C. ee, van Lunzen, J. ee, Stellbrink, H. J. ee, Miller, V. ee, Goebel, F. D. ee, Salzberger, B. ee, Rockstroh, Kosmidis, J. ef, Gargalianos, P. ef, Sambatakou, H. ef, Perdios, Panos, G. ef, Filandras, A. ef, Banhegyi, D. eg, Mulcahy, F. eh, Yust, I. ei, Burke, M. ei, Pollack, S. ei, Hassoun, J. ei, Sthoeger, Z. ei, Maayan, Vella, S. ej, Chiesi, A. ej, C. ej, Pristerá, R. ej, F. ej, Gabbuti, Bedini, E. ej, V. ej, Santopadre, P. ej, Franci, M. ej, Castagna, Viksna, L. ek, Rozentale, B. ek, Chaplinskas, S. el, Hemmer, R. em, Staub, T. em, J. en, Maeland, A. en, Ormaasen, V. en, Knysz, B. eo, Gasiorowski, J. eo, Horban, A. eo, Prokopowicz, D. eo, Wiercinska Drapalo, Boron Kaczmarska, Pynka, M. eo, Beniowski, Trocha, H. eo, Smiatacz, T. eo, Antunes, F. ep, Mansinho, K. ep, Maltez, Duiculescu, D. eq, Streinu Cercel, A. eq, Mokrás, M. er, Staneková, D. er, González Lahoz, J. es, Diaz, B. es, García Benayas, T. es, Martin Carbonero, L. es, Soriano, V. es, Clotet, Jou, A. es, Conejero, Tural, C. es, Gatell, J. M. es, Miró, Zamora, Blaxhult, A. et, Karlsson, Pehrson, P. et, P. eu, B. eu, Schiffer, V. eu, H. eu, Chentsova, N. ev, Barton, S. ew, A. M. ew, Mercey, D. ew, Phillips, A. ew, Youle, M. ew, M. A. ew, Mocroft, Murphy, Weber, J. ew, Scullard, G. ew, Fisher, R. ew, Loveday, C. ew, B. ex, Ruiz, L. ex, Helm, E. B. fb, Carlebach, Mösch, Müller, Haberl, Korn, Stephan, Bickel, Gute, Locher, Lutz, Klauke, Doerr, H. W. fb, Stürmer, Dauer, Jennings, Alexander, Braitstein, Chan, Cote, Gataric, Harrigan, P. R. fb, Harris, Bonner, Montaner, O'Shaughnessy, Yip, Chaloner, Gumley, Ransom, Sabin, C. A. fb, Lipman, J. ey, Read, R. ey, F. ez, Riccio, G. fa, Borghi, CASTELLI, Francesco

المساهمون: Ledergerber, B, Lundgren, Jd, Walker, A, Sabin, C, Justice, A, Reiss, P, Mussini, C, Wit, F, d'Arminio Monforte, A, Weber, R, Fusco, G, Staszewski, S, Law, M, Hogg, R, Lampe, F, Gill, Mj, Castelli, Francesco, Phillips, An, Rooney, P. q, Taylor, S. q, Couldwell, D. r, Austin, D., Block, M., Clemons, J., Finlayson, R., Petoumenos, K., Quan, D., Smith, D., O'Connor, C. t, Gorton, C. t, Allen, D. u, Mulhall, B. u, Mutimer, K. v, Keeffe, N. v, Cooper, D. w, Carr, A. w, Miller, J. w, Pell, C. w, Ellis, D. x, Baker, D. y, Kidd, J. y, Mcfarlane, R. y, Liang, M. T. z, Brown, K., Aa, Huffam, S., Ab, Savage, J., Ab, Morgan, Knibbs, P., Ab, Sowden, D., Ac, Walker, A., Ac, Orth, D., Ad, Lister, G., Ad, Chuah, J., Ae, Fankhauser, W., Ae, Dickson, B., Ae, Bradford, D., Af, Wilson, C., Af, Ree, H., Ag, Magon, Anderson, J., Ah, Moore, R., Ah, Russell, D., Ah, Mcgovern, G., Ah, Mcnair, Bal, Fairley, K., Ah, Roth, N., Ai, Eu, B., Ai, Strecker, S., Ai, D., Ai, Wood, H., Ai, Mijch

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000222392900031; volume:364; firstpage:51; lastpage:62; journal:THE LANCET; http://hdl.handle.net/11379/1071Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-3042740596

الإتاحة: http://hdl.handle.net/11379/1071Test

المؤلفون: Ledergerber, B, Lundgren, Jd, Walker, As, Sabin, C, Justice, A, Reiss, P, Mussini, C, Wit, F, d'Arminio Monforte, A, Weber, R, Fusco, G, Staszewski, S, Law, M, Hogg, R, Lampe, F, Gill, Mj, Castelli, Francesco, Phillips, An, Rooney, P. q, Taylor, S. q, Couldwell, D. r, Austin, D. s, Block, M. s, Clemons, J. s, Finlayson, R. s, Petoumenos, K. s, Quan, D. s, Smith, D. s, O'Connor, C. t, Gorton, C. t, Allen, D. u, Mulhall, B. u, Mutimer, K. v, Keeffe, N. v, Cooper, D. w, Carr, A. w, Miller, J. w, Pell, C. w, Ellis, D. x, Baker, D. y, Kidd, J. y, Mcfarlane, R. y, Liang, M. T. z, Brown, Aa, K., Huffam, Ab, S., Savage, Ab, J., Morgan, Knibbs, Ab, P., Sowden, Ac, D., Walker, Ac, A., Orth, Ad, D., Lister, Ad, G., Chuah, Ae, J., Fankhauser, Ae, W., Dickson, Ae, B., Bradford, Af, D., Wilson, Af, C., Ree, Ag, H., Magon, Anderson, Ah, J., Moore, Ah, R., Russell, Ah, D., Mcgovern, Ah, G., Mcnair, Bal, Fairley, Ah, K., Roth, Ai, N., Ai, B., Strecker, Ai, S., Ai, D., Wood, Ai, H., Mijch, Aj, A., Hoy, Aj, J., Pierce, Mccormack, Aj, C., Watson, Aj, K., Medland, Ak, N., Daye, Al, J., Mallal, Am, S., French, Am, M., Skett, Am, J., Maxwel, Am, D., Cain, Am, A., Montroni, An, M., Scalise, An, G., Costantini, An, A., Giacometti, Tirelli, Ao, U., Nasti, Ao, G., Pastore, Ap, G., Ladisa, Ap, N., Perulli, M. L., Ap, Suter, Aq, F., Arici, Aq, C., Maggiolo, Chiodo, Ar, F., Gritti, F. M., Ar, Colangeli, Ar, V., Fiorini, Ar, C., Guerra, Ar, L., Carosi, As, G., Cadeo, G. P., As, Minardi, As, C., Vangi, As, D., Paraninfo, Casari, As, S., Pan, As, A., Patroni, Torti, Quiros, Roldan, As, E., Tomasoni, As, L., Moretti, As, F., Nasta, As, P., Uccelli, M. C., As, Bertelli, Rizzardini, At, G., Migliorino, At, M., Abeli, At, C., Manconi, P. E., Au, Piano, Au, P., Ferraro, Av, T., Scerbo, Av, A., Pizzigallo, Aw, E., Ricci, Aw, F., Santoro, Ax, D., Pusterla, Ax, L., Carnevale, Ay, G., Galloni, Ay, D., Viganò, Az, P., Mena, Az, M., Ghinelli, Ba, F., Sighinolfi, Ba, L., Leoncini, Bb, F., Mazzotta, Pozzi, Bb, M., Caputo, Lo, Bb, S., Angarano, Bc, G., Grisorio, Bc, B., Ferrara, Bc, S., Grima, Bd, P., Tundo, Pagano, Be, G., Piersantelli, Be, N., Alessandrini, Be, A., Piscopo, Be, R., Toti, Bf, M., Chigiotti, Bf, S., Soscia, Bg, F., Tacconi, Bg, L., Orani, Bh, A., Perini, Bh, P., Nigro, Bh, M., Scasso, Bi, A., Vincenti, Scalzini, Bj, A., Fibbia, Bj, G., Moroni, Bk, M., Lazzarin, Bk, A., Cargnel, Vigevani, G. M., Bk, Caggese, Bk, L., Tordato, Bk, F., Novati, Bk, R., Galli, Merli, Bk, S., Pastecchia, Bk, C., Moioli, Esposito, Bl, R., Abrescia, Bm, N., Chirianni, Bm, A., Izzo, Bm, C., Piazza, Bm, M., Marco, De, Montesarchio, Bm, V., Manzillo, Bm, E., Nappa, Bm, S., Colomba, Bn, A., Abbadessa, Bn, V., Prestileo, Bn, T., Mancuso, Bn, S., Ferrari, Bo, C., Pzzaferri, Bo, P., Filice, Bp, G., Minoli, Bp, L., Bruno, Bp, R., Maserati, Bp, S., Tinelli, Bp, C., Pauluzzi, Bq, S., Baldelli, Bq, F., Petrelli, Br, E., Cioppi, Br, A., Alberici, Bs, F., Ruggieri, Bs, A., Menichetti, Bt, F., Martinelli, Bt, C., Stefano, De, Bu, C., Gala, La, Bu, A., Zauli, Bv, T., Ballardini, Bv, G., Magnani, Bw, G., Ursitti, M. A., Bw, Arlotti, Bx, M., Ortolani, Bx, P., Ortona, By, L., Dianzani, By, F., Ippolito, By, G., Antinori, Bz, A., Antonucci, Bz, G., D'Elia, Bz, S., Narciso, Bz, P., Petrosillo, Bz, N., Vullo, Bz, V., Luca, De, Del, Forno, Bz, L., Zaccarelli, Bz, M., Longis, De, Ciardi, D'Offizi, Noto, Lichtner, Capobianchi, M. R., Bz, Girardi, Bz, E., Pezzotti, Rezza, Mura, M. S., Ca, Mannazzu, Ca, M., Caramello, Cb, P., Sinicco, Cb, A., Soranzo, M. L., Cb, Gennero, Cb, L., Sciandra, Cb, M., Salassa, Cb, B., Grossi, P. A., Cc, Basilico, Cc, C., Poggio, Cd, A., Bottari, Cd, G., Raise, Ce, E., Pasquinucci, Ce, S., Lalla, De, Cf, F., Tositti, Cf, G., Resta, Cg, F., Chimienti, Cg, A., Lepri, Cozzi, Ch, A., Bachmann, Fb, S., Battegay, Fb, M., Bernasconi, Fb, E., Bucher, Fb, H., Bürgisser, Fb, P., Cattacin, Egger, Erb, Fierz, Fb, W., Fischer, Flepp, Fontana, Fb, A., Francioli, Furrer, H. J., Fb, Gorgievski, Günthard, Hirschel, Fb, B., Kaiser, Fb, L., Kind, Fb, C., Klimkait, Fb, T., Lauper, Fb, U., Opravil, Paccaud, Fb, F., Pantaleo, Fb, G., Perrin, Piffaretti, J. C., Fb, Rickenbach, Rudin, Schüpbach, Fb, J., Speck, Fb, R., Tarr, Telenti, Trkola, Vernazza, Yerly, Wolf, De, Ci, F., Van, Sighem, A. I., Ci, Van, Valkengoed, Ci, I., Gras, Ci, L., Bronsveld, Ci, W., Veldkamp, Ci, A., Prins, J. M., Cj, Bos, J. C., Cj, Schattenkerk, Eeftinck, J. K. M., Cj, Godfried, M. H., Cj, Lange, J. M. A., Cj, Lowe, S. H., Cj, van der Meer, J. T. M., Cj, Nellen, F. J. B., Cj, Pogany, Cj, K., van der Poll, Cj, T., Ruys, T. A., Cj, Sankatsing, Cj, S., van der Valk, Cj, M., Van, Vonderen, M. G. A., Cj, Wit, F. W. M. N., Cj, Van, Eeden, Cj, A., Ten, Veen, J. H., Cj, Van, Dam, P. S., Cj, Hillebrand, Haverkort, M. E., Cj, Brinkman, Frissen, P. H. J., Cj, Weigel, H. M., Cj, Mulder, J. W., Cj, Van, Gorp, E. C. M., Cj, Meenhorst, P. L., Cj, Mairuhu, A. T. A., Cj, Veenstra, Cj, J., Danner, S. A., Cj, Van, Agtmael, M. A., Cj, Claessen, F. A. P., Cj, Geerlings, S. E., Cj, Perenboom, R. M., Cj, Jurriaans, Back, N. K. T., Cj, Cuijpers, Rietra, P. J. G. M., Cj, Roozendaal, K. J., Cj, Pauw, Cj, W., Van, Zanten, A. P., Cj, Smits, P. H. M., Cj, Von, Blomberg, B. M. E., Cj, Savelkoul, Cj, P., Zaaijer, Cj, H., Beijnen, Crommentuyn, K. M. L., Cj, Huitema, A. D. R., Cj, Kappelhoff, Cj, B., Maat, De, M. M. R., Cj, Richter, Ck, C., van der Berg, Ck, J., Van, Leusen, Ck, R., Swanink, Vriesendorp, Cl, R., Jeurissen, F. J. F., Cl, Kauffmann, R. H., Cm, Koger, E. L. W., Cm, Franck, P. F. H., Cm, Lampe, A. S., Cm, Jansen, C. L., Cm, Bravenboer, Cn, B., Ten, Napel, C. H. H., Co, Mudrikova, Co, T., Hendriks, Co, R., Sprenger, H. G., Cp, Miesen, W. M. A. J., Cp, Schirm, Cp, J., Benne, Cp, D., Ten, Kate, R. W., Cq, Veenendaal, Cq, D., Van, Houte, D. P. F., Cr, Leemhuis, M. P., Cr, Pole, Cr, M., Storm, Cr, H., Van, Zeijl, J. H., Cr, Kroon, F. P., Cs, Schippers, E. F., Cs, Kroes, A. C. 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المساهمون: AII - Amsterdam institute for Infection and Immunity, APH - Amsterdam Public Health, Infectious diseases, Global Health, Other departments, Public and occupational health, General Internal Medicine, Center of Experimental and Molecular Medicine, Ledergerber, B, Lundgren, Jd, Walker, A, Sabin, C, Justice, A, Reiss, P, Mussini, C, Wit, F, Monforte, Ad, Weber, R, Fusco, G, Staszewski, S, Law, M, Hogg, R, Lampe, F, Gill, Mj, Castelli, F, Phillips, An, Fusco, Gp, Rooney, P, Taylor, S, Couldwell, D, Austin, D, Block, M, Clemons, J, Finlayson, R, Petoumenos, K, Quan, D, Smith, D, O'Connor, C, Gorton, C, Allen, D, Mulhall, B, Mutimer, K, Keeffe, N, Cooper, D, Carr, A, Miller, J, Pell, C, Ellis, D, Baker, D, Kidd, J, Mcfarlane, R, Liang, Mt, Brown, K, Huffam, S, Savage, J, Morgan, S, Knibbs, P, Sowden, D, Orth, D, Lister, G, Chuah, J, Fankhauser, W, Dickson, B, Bradford, D, Wilson, C, Ree, H, Magon, H, Anderson, J, Moore, R, Russell, D, Mcgovern, G, Mcnair, R, Bal, J, Fairley, K, Roth, N, Eu, B, Strecker, S, Wood, H, Mijch, A, Hoy, J, Pierce, A, Mccormack, C, Watson, K, Medland, N, Daye, J, Mallal, S, French, M, Skett, J, Maxwel, D, Cain, A, Montroni, M, Scalise, G, Costantini, A, Giacometti, A, Tirelli, U, Nasti, G, Pastore, G, Ladisa, N, Perulli, Ml, Suter, F, Arici, C, Chiodo, F, Gritti, Fm, Colangeli, V, Fiorini, C, Guerra, L, Carosi, G, Cadeo, Gp, Minardi, C, Vangi, D, Rizzardini, G, Migliorino, G, Manconi, Pe, Piano, P, Ferraro, T, Scerbo, A, Pizzigallo, E, Ricci, F, Santoro, D, Pusterla, L, Carnevale, G, Galloni, D, Vigano, P, Mena, M, Ghinelli, F, Sighinolfi, L, Leoncini, F, Mazzotta, F, Pozzi, M, Lo Caputo, S, Angarano, G, Grisorio, B, Ferrara, S, Grima, P, Tundo, P, Pagano, G, Piersantelli, N, Alessandrini, A, Piscopo, R, Toti, M, Chigiotti, S, Soscia, F, Taccooni, L, Orani, A, Perini, P, Scasso, A, Vincenti, A, Scalzini, A, Fibbia, G, Moroni, M, Lazzarin, A, Cargnel, A, Vigevani, Gm, Caggese, L, Tordato, F, Novati, R, Galli, A, Merli, S, Pastecchia, C, Moioli, C, Esposito, R, Abrescia, N, Chirianni, A, Izzo, C, Piazza, M, De Marco, M, Montesarchio, V, Manzillo, E, Nappa, S, Colomba, A, Abbadessa, V, Prestileo, T, Mancuso, S, Ferrari, C, Pzzaferri, P, Filice, G, Minoli, L, Bruno, R, Maserati, R, Pauluzzi, S, Baldelli, F, Petrelli, E, Cioppi, A, Alberici, F, Ruggieri, A, Menichetti, F, Martinelli, C, De Stefano, C, La Gala, A, Zauli, T, Ballardini, G, Magnani, G, Ursitti, Ma, Arlotti, M, Ortolani, P, Ortona, L, Dianzani, F, Ippolito, G, Antinori, A, Antonucci, G, D'Elia, S, Narciso, P, Petrosillo, N, Vullo, V, De Luca, A, Del Forno, L, Zaccarelli, M, De Longis, P, Ciardi, M, D'Offizi, G, Noto, P, Lichtner, M, Capobianchi, Mr, Girardi, E, Pezzotti, P, Rezza, G, Mura, M, Mannazzu, M, Caramello, P, Sinicco, A, Soranzo, Ml, Gennero, L, Sciandra, M, Salassa, B, Grossi, Pa, Basilico, C, Poggio, A, Bottari, G, Raise, E, Pasquinucci, S, De Lalla, F, Tositti, G, Resta, F, Chimienti, A, Lepri, Ac, Bachmann, S, Battegay, M, Bernasconi, E, Bucher, H, Burgisser, P, Cattacin, S, Egger, M, Erb, P, Fierz, W, Fischer, M, Flepp, M, Fontana, A, Francioli, P, Furrer, Hj, Gorgievski, M, Hirschel, B, Kaiser, L, Kind, C, Klimkait, T, Lauper, U, Opravil, M, Paccaud, F, Pantaleo, G, Perrin, L, Piffaretti, Jc, Rickenbach, M, Rudin, C, Schupbach, J, Speck, R, Tarr, P, Telenti, A, Trkola, A, Vernazza, P, Yerly, S, de Wolf, F, van Sighem, Ai, van Valkengoed, I, Gras, L, Bronsveld, W, Prins, Jm, Bos, Jc, Schattenkerk, Jkme, Godfried, Mh, Lange, Jma, Lowe, Sh, van der Meer, Jtm, Nellen, Fjb, Pogany, K, van der Poll, T, Ruys, Ta, Sankatsing, S, van der Valk, M, van Vonderen, Mga, Wit, Fwmn, van Eeden, A, ten Veen, Jh, van Dam, P, Hillebrand Haverkort, Me, Brinkman, K, Frissen, Phj, Weigel, Hm, Mulder, Jw, van Gorp, Ecm, Meenhorst, Pl, Mairuhu, Ata, Veenstra, J, Danner, Sa, Van Agtmael, Ma, Claessen, Fap, Geerlings, Se, Perenboom, Rm, Richter, C, van der Berg, J, van Leusen, R, Vriesendorp, R, Jeurissen, Fjf, Kauffmann, Rh, Koger, Elw, Bravenboer, B, ten Napel, Chh, Mudrikova, T, Sprenger, Hg, Miesen, Wmaj, ten Kate, Rw, van Houte, Dpf, Leemhuis, Mp, Pole, M, Kroon, Fp, Schippers, Ef, Schreij, G, van de Geest, S, Verbon, A, Koopmans, Pp, Telgt, M, van der Ven, Ajam, van der Ende, Me, Gyssens, Ic, de Marie, S, Nouwen, Jl, Juttmann, Jr, Schneider, Mme, Bonten, Mjm, Borleffs, Jcc, Hoepelman, Im, Jaspers, Cajj, Schouten, I, Schurink, Cam, Blok, Wl, Groenveld, Php, Jurriaans, S, Back, Nkt, Cuijpers, T, Rietra, Pjgm, Roozendaal, Kj, Pauw, W, van Zanten, Ap, Smits, Phm, von Blomberg, Bme, Savelkoul, P, Zaaijer, H, Swanink, C, Franck, Pfh, Lampe, A, Jansen, Cl, Hendriks, R, Schirm, J, Benne, D, Veenendaal, D, Storm, H, van Zeijl, Jh, Kroes, Acm, Claas, Hcj, Bruggeman, Camva, Goossens, Vj, Galama, Jmd, Poort, Yagm, Niesters, Mg, Osterhaus, Adme, Schutten, M, Buiting, Agm, Swaans, Cam, Boucher, Cab, Schuurman, R, Boel, E, Jansz, Af, Veldkamp, A, Beijnen, Jh, Crommentuyn, Kml, Huitema, Adr, Kappelhoff, B, de Maat, Mmr, Burger, 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المصدر: The Lancet, 364(9428), 51-62. ELSEVIER SCIENCE INC
Lancet, 364(9428), 51-62. Elsevier Limited

مصطلحات موضوعية: Male, HAART, Human immunodeficiency virus (HIV), CD4 cell count, HIV Infections, CLINICAL PROGRESSION, medicine.disease_cause, THERAPY, HAART REGIMEN, Cohort Studies, Risk Factors, Adult, Anti-Retroviral Agents, CD4 Lymphocyte Count, Cohort Studies, Female, Follow-Up Studies, HIV Infections, HIV Protease Inhibitors, HIV-1, Humans, Male, Middle Aged, Proportional Hazards Models, Reverse Transcriptase Inhibitors, Risk Factors, Treatment Failure, Viral Load, Medicine, Treatment Failure, Mortality rate, Medicine (all), INHIBITOR, General Medicine, Middle Aged, HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 (HIV-1), BLIND CONTROLLED-TRIAL, medicine.anatomical_structure, Anti-Retroviral Agents, Cohort, HUMAN-IMMUNODEFICIENCY-VIRUS, Reverse Transcriptase Inhibitors, Female, Off Treatment, Viral load, Cohort study, Adult, medicine.medical_specialty, Settore MED/17 - Malattie Infettive, T cell, Internal medicine, Humans, COHORT, Proportional Hazards Models, business.industry, Proportional hazards model, DISEASE PROGRESSION, HIV Protease Inhibitors, HIV-INFECTED INDIVIDUALS, CD4 Lymphocyte Count, VIRAL LOAD, Immunology, HIV-1, business, Follow-Up Studies

الوصف: Background Treatment strategies for patients in whom HIV replication is not suppressed after exposure to several drug classes remain unclear. We aimed to assess the inter-relations between viral load, CD4-cell count, and clinical outcome in patients who had experienced three-class virological failure.Methods We undertook collaborative joint analysis of 13 HIV cohorts from Europe, North America, and Australia, involving patients who had had three-class virological failure (viral load >1000 copies per mL for >4 months). Regression analyses were used to quantify the associations between CD4-cell-count slope, HIV-1 RNA concentration, treatment information, and demographic characteristics. Predictors of death were analysed by Cox's proportional-hazards models.Findings 2488 patients were included. 2118 (85%) had started antiretroviral therapy with single or dual therapy. During 5015 person-years of follow-up, 276 patients died (mortality rate 5.5 per 100 person-years; 3-year mortality risk 15.3% (95% Cl 13.5-17.3). Risk of death was strongly influenced by the latest CD4-cell count with a relative hazard of 15.8 (95% CI 9.28-27.0) for counts below 50 cells per muL versus above 200 cells per muL. The latest viral load did not independently predict death. For any given viral load, patients on treatment had more favourable CD4-cell-count slopes than those off treatment. For patients on treatment and with stable viral load, CD4-cell counts tended to be increasing at times when the current viral load was below 10 000 copies per mL or 1.5 log(10) copies per mL below off-treatment values.Interpretation In patients for whom viral-load suppression to below the level of detection is not possible, achievement and maintenance of a CD4-cell count above 200 per muL becomes the primary aim. Treatment regimens that maintain the viral load below 10 000 copies per mL or at least provide 1.5 log(10) copies per mL suppression below the off-treatment value do not seem to be associated with appreciable CD4-cell-count decline.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79fdc42ed7859d32f5f53138d76ef181Test
http://hdl.handle.net/2434/6284Test