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المساهمون: Redox Biology of Trypanosomes / Biología Redox de Tripanosomátidos Montevideo, Institut Pasteur de Montevideo, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP), Biochemie-Zentrum, Universität Heidelberg Heidelberg = Heidelberg University, Dipartimento di Scienze Chimiche, Università degli Studi di Padova = University of Padua (Unipd), Financial support by the Access to Research Infrastructures activity in the 7th Framework Programme of the EC (Project number: 261863, Bio-NMR) for conducting the research is gratefully acknowledged by Massimo Bellanda. Marcelo Comini acknowledges support from the Agencia Nacional de Investigacion e Innovacion (Grant Innova Uruguay, agreement No. DCI-ALA/2007/19.040 between Uruguay and the European Commission)

المصدر: ISSN: 1523-0864.

مصطلحات موضوعية: [SDV]Life Sciences [q-bio]

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/22978520; pasteur-00844780; https://riip.hal.science/pasteur-00844780Test; https://riip.hal.science/pasteur-00844780/documentTest; https://riip.hal.science/pasteur-00844780/file/ars_2E2012_2E4932.pdfTest; PUBMED: 22978520

الإتاحة: https://doi.org/10.1089/ars.2012.4932Test
https://riip.hal.science/pasteur-00844780Test
https://riip.hal.science/pasteur-00844780/documentTest
https://riip.hal.science/pasteur-00844780/file/ars_2E2012_2E4932.pdfTest

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35

دورية أكاديمية

High Throughput Screening against the Peroxidase Cascade of African Trypanosomes Identifies Antiparasitic Compounds That Inactivate Tryparedoxin

المؤلفون: Fueller, Florian, Jehle, Britta, Putzker, Kerstin, Lewis, Joe D., Krauth-Siegel, R. Luise

المصدر: Journal of Biological Chemistry ; volume 287, issue 12, page 8792-8802 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.m111.338285Test
https://api.elsevier.com/content/article/PII:S0021925820608432?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820608432?httpAccept=text/plainTest

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36

Natural Sesquiterpene Lactones of the 4,15-iso-Atriplicolide Type are Inhibitors of Trypanothione Reductase

المؤلفون: R. Luise Krauth-Siegel, Mairin Lenz, Thomas J. Schmidt

المصدر: Molecules
Volume 24
Issue 20
Molecules, Vol 24, Iss 20, p 3737 (2019)

مصطلحات موضوعية: Trypanosoma brucei, Stereochemistry, Trypanosoma cruzi, Trypanothione, Pharmaceutical Science, Sesquiterpene lactone, 01 natural sciences, Article, Analytical Chemistry, lcsh:QD241-441, 03 medical and health sciences, chemistry.chemical_compound, Lactones, Structure-Activity Relationship, lcsh:Organic chemistry, Drug Discovery, parasitic diseases, sesquiterpene lactone, Animals, Humans, NADH, NADPH Oxidoreductases, Physical and Theoretical Chemistry, Enzyme Inhibitors, antitrypanosomal activity, 030304 developmental biology, chemistry.chemical_classification, 0303 health sciences, biology, Dose-Response Relationship, Drug, Molecular Structure, 010405 organic chemistry, Organic Chemistry, irreversible inhibitor, Dithiol, trypanothione reductase, Trypanosoma brucei rhodesiense, biology.organism_classification, 0104 chemical sciences, Enzyme, chemistry, Chemistry (miscellaneous), 4,15-iso-atriplicolide ester, Molecular Medicine, Sesquiterpenes, Cysteine

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::616615d012ce1b6b2eadd6033fed41b4Test

37

Biological Evaluation and X-ray Co-crystal Structures of Cyclohexylpyrrolidine Ligands for Trypanothione Reductase, an Enzyme from the Redox Metabolism of Trypanosoma

المؤلفون: Elke Brodbeck-Persch, Steve Bryson, François Diederich, Raoul De Gasparo, R. Luise Krauth-Siegel, Marcel Kaiser, Emil F. Pai, Nina B. Hentzen

المصدر: ChemMedChem. 13:957-967

مصطلحات موضوعية: Models, Molecular, Trypanosoma, Pyrrolidines, Glutathione reductase, Trypanothione, Crystallography, X-Ray, Ligands, 010402 general chemistry, 01 natural sciences, Biochemistry, chemistry.chemical_compound, Non-competitive inhibition, Parasitic Sensitivity Tests, parasitic diseases, Drug Discovery, NADH, NADPH Oxidoreductases, Enzyme Inhibitors, General Pharmacology, Toxicology and Pharmaceutics, Binding site, Pharmacology, chemistry.chemical_classification, Molecular Structure, biology, 010405 organic chemistry, Chemistry, Organic Chemistry, Active site, Oxidoreductase inhibitor, biology.organism_classification, Trypanocidal Agents, 0104 chemical sciences, Enzyme, Solubility, biology.protein, Molecular Medicine, Oxidation-Reduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::565b0d4285fe4da01f36bc25c7ecfc1bTest
https://doi.org/10.1002/cmdc.201800067Test

38

دورية أكاديمية

Structural basis for a distinct catalytic mechanism in Trypanosoma brucei tryparedoxin peroxidase.

المؤلفون: Melchers, Johannes, Diechtierow, Michael, Fehér, Krisztina, Sinning, Irmgard, Tews, Ivo, Krauth-Siegel, R. Luise, Muhle-Goll, Claudia

المصدر: Journal of Biological Chemistry ; volume 286, issue 17, page 15618 ; ISSN 0021-9258

مصطلحات موضوعية: Cell Biology, Molecular Biology, Biochemistry

الإتاحة: https://doi.org/10.1074/jbc.a110.803563Test
https://api.elsevier.com/content/article/PII:S0021925820858451?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021925820858451?httpAccept=text/plainTest

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39

Bistacrines as potential antitrypanosomal agents

المؤلفون: August Stich, Ines Schmidt, Elena Katzowitsch, Heike Bruhn, Antje Fuß, Alexandra Miliu, Sarah Göllner, Tanja Schirmeister, Anna Kucharski, R. Luise Krauth-Siegel, Ulrike Holzgrabe

المصدر: Bioorganic & Medicinal Chemistry. 25:4526-4531

مصطلحات موضوعية: 0301 basic medicine, medicine.drug_class, Trypanosoma brucei brucei, Clinical Biochemistry, Pharmaceutical Science, Flavoprotein, Biochemistry, Cell Line, Mice, Structure-Activity Relationship, 03 medical and health sciences, Parasitic Sensitivity Tests, Oxidoreductase, parasitic diseases, Drug Discovery, medicine, Animals, African trypanosomiasis, Molecular Biology, Cell Proliferation, chemistry.chemical_classification, Dose-Response Relationship, Drug, Molecular Structure, biology, Chemistry, Organic Chemistry, Trypanosoma brucei rhodesiense, medicine.disease, biology.organism_classification, Trypanocidal Agents, Cysteine protease, Trypanosomiasis, African, 030104 developmental biology, Tacrine, Antiprotozoal, biology.protein, Molecular Medicine, Protozoa, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4044085813e651531a3dd560959511dTest
https://doi.org/10.1016/j.bmc.2017.06.051Test

40

دورية أكاديمية

The silicon trypanosome

المؤلفون: Bakker, Barbara M., Krauth-Siegel, R. Luise, Clayton, Christine, Matthews, Keith, Girolami, Mark, Westerhoff, Hans V., Michels, Paul A. M., Breitling, Rainer, Barrett, Michael P.

المصدر: Bakker , B M , Krauth-Siegel , R L , Clayton , C , Matthews , K , Girolami , M , Westerhoff , H V , Michels , P A M , Breitling , R & Barrett , M P 2010 , ' The silicon trypanosome ' , Parasitology , vol. 137 , no. 9 , pp. 1333-1341 . https://doi.org/10.1017/S0031182010000466Test

مصطلحات موضوعية: Trypanosoma brucei, metabolism, gene expression, differentiation, Silicon Cell, PENTOSE-PHOSPHATE PATHWAY, BLOOD-STREAM FORMS, GLYCOLYTIC-ENZYMES, SACCHAROMYCES-CEREVISIAE, AFRICAN TRYPANOSOMES, PARASITIC PROTOZOA, RNA INTERFERENCE, SYSTEMS BIOLOGY, LINLOG KINETICS, GENE-EXPRESSION

وصف الملف: application/pdf

العلاقة: https://research.rug.nl/en/publications/6da382ad-930a-45c5-be09-01400a3480d8Test

الإتاحة: https://doi.org/10.1017/S0031182010000466Test
https://hdl.handle.net/11370/6da382ad-930a-45c5-be09-01400a3480d8Test
https://research.rug.nl/en/publications/6da382ad-930a-45c5-be09-01400a3480d8Test
https://pure.rug.nl/ws/files/6749894/2010ParasitolBakker.pdfTest

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