المؤلفون: Biermann, Jana, Melms, Johannes C, Amin, Amit Dipak, Wang, Yiping, Caprio, Lindsay A, Karz, Alcida, Tagore, Somnath, Barrera, Irving, Ibarra-Arellano, Miguel A, Andreatta, Massimo, Fullerton, Benjamin T, Gretarsson, Kristjan H, Sahu, Varun, Mangipudy, Vaibhav S, Nguyen, Trang TT, Nair, Ajay, Rogava, Meri, Ho, Patricia, Koch, Peter D, Banu, Matei, Humala, Nelson, Mahajan, Aayushi, Walsh, Zachary H, Shah, Shivem B, Vaccaro, Daniel H, Caldwell, Blake, Mu, Michael, Wünnemann, Florian, Chazotte, Margot, Berhe, Simon, Luoma, Adrienne M, Driver, Joseph, Ingham, Matthew, Khan, Shaheer A, Rapisuwon, Suthee, Slingluff, Craig L, Eigentler, Thomas, Röcken, Martin, Carvajal, Richard, Atkins, Michael B, Davies, Michael A, Agustinus, Albert, Bakhoum, Samuel F, Azizi, Elham, Siegelin, Markus, Lu, Chao, Carmona, Santiago J, Hibshoosh, Hanina, Ribas, Antoni, Canoll, Peter, Bruce, Jeffrey N, Bi, Wenya Linda, Agrawal, Praveen, Schapiro, Denis, Hernando, Eva, Macosko, Evan Z, Chen, Fei, Schwartz, Gary K, Izar, Benjamin

المصدر: Cell. 185(14)

مصطلحات موضوعية: Cancer, Biotechnology, Neurosciences, Aetiology, 2.1 Biological and endogenous factors, Brain Neoplasms, CD8-Positive T-Lymphocytes, Ecosystem, Humans, Melanoma, RNA-Seq, brain metastasis, chromosomal instability, melanoma, neuronal-like cell state, single-cell genomics, spatial transcriptomics, tumor-microenvironment, Biological Sciences, Medical and Health Sciences, Developmental Biology

الوصف: Melanoma brain metastasis (MBM) frequently occurs in patients with advanced melanoma; yet, our understanding of the underlying salient biology is rudimentary. Here, we performed single-cell/nucleus RNA-seq in 22 treatment-naive MBMs and 10 extracranial melanoma metastases (ECMs) and matched spatial single-cell transcriptomics and T cell receptor (TCR)-seq. Cancer cells from MBM were more chromosomally unstable, adopted a neuronal-like cell state, and enriched for spatially variably expressed metabolic pathways. Key observations were validated in independent patient cohorts, patient-derived MBM/ECM xenograft models, RNA/ATAC-seq, proteomics, and multiplexed imaging. Integrated spatial analyses revealed distinct geography of putative cancer immune evasion and evidence for more abundant intra-tumoral B to plasma cell differentiation in lymphoid aggregates in MBM. MBM harbored larger fractions of monocyte-derived macrophages and dysfunctional TOX+CD8+ T cells with distinct expression of immune checkpoints. This work provides comprehensive insights into MBM biology and serves as a foundational resource for further discovery and therapeutic exploration.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3087t3dxTest

المؤلفون: Beek, Nina van, Eming, Rüdiger, Reuss, Alexander, Zillikens, Detlef, Sárdy, Miklós, Günther, Claudia, Kiritsi, Dimitra, Benoit, Sandrine, Beissert, Stefan, Gläser, Regine, Gollnick, Harald, Horváth, Orsolya N., Pfeiffer, Christiane, Röcken, Martin, Schauer, Franziska, Schreml, Stephan, Steinbrink, Kerstin, Zink, Alexander, Schade-Brittinger, Carmen, Hertl, Michael, Schmidt, Enno

المصدر: British journal of dermatology. - 190, 5 (2024) , 657-667, ISSN: 1365-2133

الوصف: Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially life-threatening autoimmune blistering diseases. Treatment is based on long-term immunosuppression with high doses of glucocorticosteroids in combination with potentially corticosteroid-sparing agents and/or rituximab. Immunoadsorption (IA) has emerged as a fast-acting adjuvant treatment option. Objectives To assess the clinical efficacy of IA in addition to best medical treatment (BMT). Methods We conducted a multicentre (26 centres from Germany and Austria) randomized controlled trial in 72 patients with newly diagnosed, relapsed or chronic active PV or PF (34 female patients and 38 male patients, aged 42–72 years) comparing BMT (prednisolone 1.0 mg kg−1 per day plus azathioprine or mycophenolate) with adjuvant IA (BMT + IA). Central 1 : 1 randomization was done at the coordinating centre for clinical trials (KKS Marburg). The primary endpoint was analysed using Kaplan–Meier and Cox regression methods. Results The study was ended prematurely owing to safety concerns after random allocation of 72 patients to BMT + IA (n = 34) or BMT (n = 38). The primary endpoint, time to complete remission on therapy, was not significantly different for the two groups [hazard ratio (HR) 1.35, 95% confidence interval (CI) 0.68–2.69; P = 0.39]. The cumulative dose of prednisolone was significantly lower in the BMT + IA group compared with BMT alone (difference −1214, 95% CI −2225 to −70; P = 0.03). In a post hoc analysis, patients with more extensive PV/PF showed a tendency towards a shorter time to remission in the BMT + IA group compared with the BMT group (HR 1.87, P = 0.17 in patients with baseline Pemphigus Disease Area Index ≥ 15). While more adverse events were observed in patients in the BMT group (29 vs. 25), severe adverse events were more frequent in patients in the BMT + IA group (17 events in 10 patients vs. 11 events in 8 patients). Conclusions In this study, adjuvant IA did not demonstrate a shorter time to clinical remission, but a ...

وصف الملف: pdf

العلاقة: https://freidok.uni-freiburg.de/data/242856Test

الإتاحة: https://doi.org/10.1093/bjd/ljad489Test
https://freidok.uni-freiburg.de/data/242856Test
https://nbn-resolving.org/urn:nbn:de:bsz:25-freidok-2428565Test
https://freidok.uni-freiburg.de/dnb/download/242856Test

المؤلفون: Rogava, Meri, Aprati, Tyler J, Chi, Wei-Yu, Melms, Johannes C, Hug, Clemens, Davis, Stephanie H, Earlie, Ethan M, Chung, Charlie, Deshmukh, Sachin K, Wu, Sharon, Sledge, George, Tang, Stephen, Ho, Patricia, Amin, Amit Dipak, Caprio, Lindsay, Gurjao, Carino, Tagore, Somnath, Ngo, Bryan, Lee, Michael J, Zanetti, Giorgia, Wang, Yiping, Chen, Sean, Ge, William, Melo, Luiza Martins Nascentes, Allies, Gabriele, Rösler, Jonas, Gibney, Goeffrey T, Schmitz, Oliver J, Sykes, Megan, Creusot, Rémi J, Tüting, Thomas, Schadendorf, Dirk, Röcken, Martin, Eigentler, Thomas K, Molotkov, Andrei, Mintz, Akiva, Bakhoum, Samuel F, Beyaz, Semir, Cantley, Lewis C, Sorger, Peter K, Meckelmann, Sven W, Tasdogan, Alpaslan, Liu, David, Laughney, Ashley M, Izar, Benjamin

مصطلحات موضوعية: cancer, diseases & disorders, Investigative techniques and equipment, CRISPR-Cas9, liver, metastasis, organs types and functions, organs, tissues, organelles, cell types and functions

الوصف: Liver metastasis (LM) confers poor survival and therapy resistance across cancer types, but the mechanisms of liver-metastatic organotropism remain unknown. Here, through in vivo CRISPR-Cas9 screens, we found that Pip4k2c loss conferred LM but had no impact on lung metastasis or primary tumor growth. Pip4k2c-deficient cells were hypersensitized to insulin-mediated PI3K/AKT signaling and exploited the insulin-rich liver milieu for organ-specific metastasis. We observed concordant changes in PIP4K2C expression and distinct metabolic changes in 3,511 patient melanomas, including primary tumors, LMs and lung metastases. We found that systemic PI3K inhibition exacerbated LM burden in mice injected with Pip4k2c-deficient cancer cells through host-mediated increase in hepatic insulin levels; however, this circuit could be broken by concurrent administration of an SGLT2 inhibitor or feeding of a ketogenic diet. Thus, this work demonstrates a rare example of metastatic organotropism through co-optation of physiological metabolic cues and proposes therapeutic avenues to counteract these mechanisms.

وصف الملف: application/pdf

العلاقة: https://repository.cshl.edu/id/eprint/41428/1/s43018-023-00704-x.pdfTest; Rogava, Meri, Aprati, Tyler J, Chi, Wei-Yu, Melms, Johannes C, Hug, Clemens, Davis, Stephanie H, Earlie, Ethan M, Chung, Charlie, Deshmukh, Sachin K, Wu, Sharon, Sledge, George, Tang, Stephen, Ho, Patricia, Amin, Amit Dipak, Caprio, Lindsay, Gurjao, Carino, Tagore, Somnath, Ngo, Bryan, Lee, Michael J, Zanetti, Giorgia, Wang, Yiping, Chen, Sean, Ge, William, Melo, Luiza Martins Nascentes, Allies, Gabriele, Rösler, Jonas, Gibney, Goeffrey T, Schmitz, Oliver J, Sykes, Megan, Creusot, Rémi J, Tüting, Thomas, Schadendorf, Dirk, Röcken, Martin, Eigentler, Thomas K, Molotkov, Andrei, Mintz, Akiva, Bakhoum, Samuel F, Beyaz, Semir, Cantley, Lewis C, Sorger, Peter K, Meckelmann, Sven W, Tasdogan, Alpaslan, Liu, David, Laughney, Ashley M, Izar, Benjamin (January 2024) Loss of Pip4k2c confers liver-metastatic organotropism through insulin-dependent PI3K-AKT pathway activation. Nature Cancer. ISSN 2662-1347 (Public Dataset)

الإتاحة: https://doi.org/10.1038/s43018-023-00704-xTest
https://repository.cshl.edu/id/eprint/41428Test/
https://repository.cshl.edu/id/eprint/41428/1/s43018-023-00704-x.pdfTest
https://www.ncbi.nlm.nih.gov/pubmed/38286827Test

المؤلفون: Knopf, Philipp, Stowbur, Dimitri, Hoffmann, Sabrina H. L., Hermann, Natalie, Maurer, Andreas, Bucher, Valentina, Poxleitner, Marilena, Tako, Bredi, Sonanini, Dominik, Krishnamachary, Balaji, Sinharay, Sanhita, Fehrenbacher, Birgit, Gonzalez-Menendez, Irene, Reckmann, Felix, Bomze, David, Flatz, Lukas, Kramer, Daniela, Schaller, Martin, Forchhammer, Stephan, Bhujwalla, Zaver M., Quintanilla-Martinez, Leticia, Schulze-Osthoff, Klaus, Pagel, Mark D., Fransen, Marieke F., Röcken, Martin, Martins, André F., Pichler, Bernd J., Ghoreschi, Kamran, Kneilling, Manfred

المصدر: Knopf , P , Stowbur , D , Hoffmann , S H L , Hermann , N , Maurer , A , Bucher , V , Poxleitner , M , Tako , B , Sonanini , D , Krishnamachary , B , Sinharay , S , Fehrenbacher , B , Gonzalez-Menendez , I , Reckmann , F , Bomze , D , Flatz , L , Kramer , D , Schaller , M , Forchhammer , S , Bhujwalla , Z M , Quintanilla-Martinez , L , Schulze-Osthoff , K , Pagel , M D , Fransen , M ....

الوصف: Immune checkpoint inhibitors have revolutionized cancer therapy, yet the efficacy of these treatments is often limited by the heterogeneous and hypoxic tumor microenvironment (TME) of solid tumors. In the TME, programmed death-ligand 1 (PD-L1) expression on cancer cells is mainly regulated by Interferon-gamma (IFN-γ), which induces T cell exhaustion and enables tumor immune evasion. In this study, we demonstrate that acidosis, a common characteristic of solid tumors, significantly increases IFN-γ-induced PD-L1 expression on aggressive cancer cells, thus promoting immune escape. Using preclinical models, we found that acidosis enhances the genomic expression and phosphorylation of signal transducer and activator of transcription 1 (STAT1), and the translation of STAT1 mRNA by eukaryotic initiation factor 4F (elF4F), resulting in an increased PD-L1 expression. We observed this effect in murine and human anti-PD-L1-responsive tumor cell lines, but not in anti-PD-L1-nonresponsive tumor cell lines. In vivo studies fully validated our in vitro findings and revealed that neutralizing the acidic extracellular tumor pH by sodium bicarbonate treatment suppresses IFN-γ-induced PD-L1 expression and promotes immune cell infiltration in responsive tumors and thus reduces tumor growth. However, this effect was not observed in anti-PD-L1-nonresponsive tumors. In vivo experiments in tumor-bearing IFN-γ−/− mice validated the dependency on immune cell-derived IFN-γ for acidosis-mediated cancer cell PD-L1 induction and tumor immune escape. Thus, acidosis and IFN-γ-induced elevation of PD-L1 expression on cancer cells represent a previously unknown immune escape mechanism that may serve as a novel biomarker for anti-PD-L1/PD-1 treatment response. These findings have important implications for the development of new strategies to enhance the efficacy of immunotherapy in cancer patients.

العلاقة: https://research.vumc.nl/en/publications/feb921f5-4968-4186-bc8d-462fd52c73f2Test

الإتاحة: https://doi.org/10.1186/s12943-023-01900-0Test
https://research.vumc.nl/en/publications/feb921f5-4968-4186-bc8d-462fd52c73f2Test
https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85179703345&origin=inwardTest
https://www.ncbi.nlm.nih.gov/pubmed/38102680Test

المؤلفون: Stratigos, Alexander J., Garbe, Claus, Dessinioti, Clio, Lebbe, Célèste, van Akkooi, Alexander J.C., Bataille, Véronique A., Bastholt, Lars, Dreno, Brigitte, Dummer, Reinhard G., Fargnoli, Maria Concetta, Forsea, Ana Maria, Harwood, Catherine Anne, Hauschild, Axel, Hoeller, Christoph, Kandolf-Sekulovic, Lidija O., Kaufmann, Roland, Kelleners-Smeets, Nicole W.J., Lallas, Aimilios, Leiter, Ulrike, Malvehy, Josep, del Marmol, Véronique, Moreno-Ramirez, David, Pellacani, Giovanni, Peris, Ketty, Saiag, Phillippe, Tagliaferri, Luca, Trakatelli, Myrto Georgia, Ioannides, Demetrios, Vieira, Ricardo José David Costa, Zalaudek, Iris, Arenberger, Petr, Eggermont, Alexander M.M., Röcken, Martin, Grob, Jean Jacques, Lorigan, Paul C.

المساهمون: Sénopole Hopital Saint Louis, Hopital Saint-Louis AP-HP (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Immunology and New Concepts in ImmunoTherapy (INCIT), Université d'Angers (UA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes)-Nantes Université - UFR de Médecine et des Techniques Médicales (Nantes Univ - UFR MEDECINE), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Biomarqueurs et essais cliniques en Cancérologie et Onco-Hématologie (BECCOH), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Saclay, Assistance Publique - Hôpitaux de Marseille (APHM), The development of the current set of guidelines wassupported solely by funds of the EADO which were usedto mainly support the consensus meeting without honoraria and without reimbursement of travel costs.

المصدر: ISSN: 0959-8049 ; European Journal of Cancer ; https://hal.science/hal-04229549Test ; European Journal of Cancer, 2023, 193, ⟨10.1016/j.ejca.2023.113251⟩.

مصطلحات موضوعية: Advanced, Diagnosis, High-risk, Immunosuppression, Invasive cutaneous squamous cell carcinoma, Locally advanced cSCC, Metastatic cSCC, Prevention, Prognosis, Staging, [SDV.CAN]Life Sciences [q-bio]/Cancer

الوصف: International audience ; Invasive cutaneous squamous cell carcinoma (cSCC) is one of the most common cancers in white populations, accounting for 20% of all cutaneous malignancies. Overall, cSCC mostly has very good prognosis after treatment, with 5-year cure rates greater than 90%. Despite the overall favourable prognosis and the proportionally rare deaths, cSCC is associated with a high total number of deaths due to its high incidence. A collaboration of multidisciplinary experts from the European Association of Dermato-Oncology (EADO), the European Dermatology Forum (EDF), the European Society for Radiotherapy and Oncology (ESTRO), the European Union of Medical Specialists (UEMS), the European Academy of Dermatology and Venereology (EADV) and the European Organization of Research and Treatment of Cancer (EORTC), was formed to update recommendations on cSCC, based on current literature and expert consensus. Part 1 of the guidelines addresses the updates on classification, epidemiology, diagnosis, risk stratification, staging and prevention in immunocompetent as well as immunosuppressed patients.

العلاقة: hal-04229549; https://hal.science/hal-04229549Test

الإتاحة: https://doi.org/10.1016/j.ejca.2023.113251Test
https://hal.science/hal-04229549Test

المؤلفون: Sinnberg, Tobias, Lichtensteiger, Christa, Hasan Ali, Omar, Pop, Oltin T, Jochum, Ann-Kristin, Risch, Lorenz, Brugger, Silvio D, Velic, Ana, Bomze, David, Kohler, Philipp, Vernazza, Pietro, Albrich, Werner C, Kahlert, Christian R, Abdou, Maire-Therese, Wyss, Nina, Hofmeister, Kathrin, Niessner, Heike, Zinner, Carl, Gilardi, Mara, Tzankov, Alexandar, Röcken, Martin, Dulovic, Alex, Mairpady Shambat, Srikanth, Ruetalo, Natalia, Buehler, Philipp K, Scheier, Thomas C, Jochum, Wolfram, Kern, Lukas, Henz, Samuel, Schneider, Tino, Kuster, Gabriela M, Lampart, Maurin, Siegemund, Martin, Bingisser, Roland, Schindler, Michael, Schneiderhan-Marra, Nicole, Kalbacher, Hubert, McCoy, Kathy D, Spengler, Werner, Brutsche, Martin H, Macek, Boris, Twerenbold, Raphael, Penninger, Josef M, Matter, Matthias S, Flatz, Lukas

المصدر: Sinnberg, Tobias; Lichtensteiger, Christa; Hasan Ali, Omar; Pop, Oltin T; Jochum, Ann-Kristin; Risch, Lorenz; Brugger, Silvio D; Velic, Ana; Bomze, David; Kohler, Philipp; Vernazza, Pietro; Albrich, Werner C; Kahlert, Christian R; Abdou, Maire-Therese; Wyss, Nina; Hofmeister, Kathrin; Niessner, Heike; Zinner, Carl; Gilardi, Mara; Tzankov, Alexandar; . (2023). Pulmonary Surfactant Proteins are Inhibited by IgA Autoantibodies in Severe COVID-19. American journal of respiratory and critical care medicine, 207(1), pp. 38-49. American Lung Association 10.1164/rccm.202201-0011OC

مصطلحات موضوعية: 610 Medicine & health

الوصف: RATIONALE Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress syndrome with fatal outcomes. Evidence suggests that dysregulated immune responses, including autoimmunity, are key pathogenic factors. OBJECTIVES To assess whether IgA autoantibodies target lung-specific proteins and contribute to disease severity. METHODS We collected 147 blood, 9 lung tissue, and 36 bronchoalveolar lavage fluid samples from three tertiary hospitals in Switzerland and one in Germany. Severe COVID-19 was defined by the need to administer oxygen. We investigated the presence of IgA autoantibodies and their effects on pulmonary surfactant in COVID-19 using the following methods: immunofluorescence on tissue samples, immunoprecipitations followed by mass spectrometry on bronchoalveolar lavage fluid samples, enzyme-linked immunosorbent assays on blood samples, and surface tension measurements with medical surfactant. MEASUREMENTS AND MAIN RESULTS IgA autoantibodies targeting pulmonary surfactant proteins B and C were elevated in patients with severe COVID-19, but not in patients with influenza or bacterial pneumonia. Notably, pulmonary surfactant failed to reduce surface tension after incubation with either plasma or purified IgA from patients with severe COVID-19. CONCLUSIONS Our data suggest that patients with severe COVID-19 harbor IgA against pulmonary surfactant proteins B and C and that these antibodies block the function of lung surfactant, potentially contributing to alveolar collapse and poor oxygenation. This article is open access and distributed under the terms of the Creative Commons Attribution Non-Commercial No Derivatives License 4.0 (http://creativecommons.org/licenses/by-nc-nd/4.0Test/).

وصف الملف: application/pdf

العلاقة: https://boris.unibe.ch/171756Test/

الإتاحة: https://doi.org/10.1164/rccm.202201-0011OCTest
https://boris.unibe.ch/171756/1/rccm.202201-0011oc.pdfTest
https://boris.unibe.ch/171756Test/

المؤلفون: van Beek, Nina, Eming, Rüdiger, Reuss, Alexander, Zillikens, Detlef, Sárdy, Miklós, Günther, Claudia, Kiritsi, Dimitra, Benoit, Sandrine, Beissert, Stefan, Gläser, Regine, Gollnick, Harald, Horváth, Orsolya N, Pfeiffer, Christiane, Röcken, Martin, Schauer, Franziska, Schreml, Stephan, Steinbrink, Kerstin, Zink, Alexander, Schade-Brittinger, Carmen, Hertl, Michael, Schmidt, Enno

المساهمون: German Research Foundation, Care

المصدر: British Journal of Dermatology ; volume 190, issue 5, page 657-667 ; ISSN 0007-0963 1365-2133

الوصف: Background Pemphigus vulgaris (PV) and pemphigus foliaceus (PF) are potentially life-threatening autoimmune blistering diseases. Treatment is based on long-term immunosuppression with high doses of glucocorticosteroids in combination with potentially corticosteroid-sparing agents and/or rituximab. Immunoadsorption (IA) has emerged as a fast-acting adjuvant treatment option. Objectives To assess the clinical efficacy of IA in addition to best medical treatment (BMT). Methods We conducted a multicentre (26 centres from Germany and Austria) randomized controlled trial in 72 patients with newly diagnosed, relapsed or chronic active PV or PF (34 female patients and 38 male patients, aged 42–72 years) comparing BMT (prednisolone 1.0 mg kg−1 per day plus azathioprine or mycophenolate) with adjuvant IA (BMT + IA). Central 1 : 1 randomization was done at the coordinating centre for clinical trials (KKS Marburg). The primary endpoint was analysed using Kaplan–Meier and Cox regression methods. Results The study was ended prematurely owing to safety concerns after random allocation of 72 patients to BMT + IA (n = 34) or BMT (n = 38). The primary endpoint, time to complete remission on therapy, was not significantly different for the two groups [hazard ratio (HR) 1.35, 95% confidence interval (CI) 0.68–2.69; P = 0.39]. The cumulative dose of prednisolone was significantly lower in the BMT + IA group compared with BMT alone (difference −1214, 95% CI −2225 to −70; P = 0.03). In a post hoc analysis, patients with more extensive PV/PF showed a tendency towards a shorter time to remission in the BMT + IA group compared with the BMT group (HR 1.87, P = 0.17 in patients with baseline Pemphigus Disease Area Index ≥ 15). While more adverse events were observed in patients in the BMT group (29 vs. 25), severe adverse events were more frequent in patients in the BMT + IA group (17 events in 10 patients vs. 11 events in 8 patients). Conclusions In this study, adjuvant IA did not demonstrate a shorter time to clinical remission, ...

الإتاحة: https://doi.org/10.1093/bjd/ljad489Test
https://academic.oup.com/bjd/article-pdf/190/5/657/57262114/ljad489.pdfTest

المؤلفون: Schwenck, Johannes, Sonanini, Dominik, Seyfried, Dominik, Ehrlichmann, Walter, Kienzle, Gabriele, Reischl, Gerald, Krezer, Pascal, Wilson, Ian, Korn, Ron, Gonzalez-Menendez, Irene, Quintanilla-Martinez, Leticia, Seith, Ferdinand, Forschner, Andrea, Eigentler, Thomas, Zender, Lars, Röcken, Martin, Pichler, Bernd J, Flatz, Lukas, Kneilling, Manfred, Fougere, Christian la

المصدر: Theranostics ; volume 13, issue 8, page 2408-2423 ; ISSN 1838-7640

مصطلحات موضوعية: Pharmacology, Toxicology and Pharmaceutics (miscellaneous), Medicine (miscellaneous)

الإتاحة: https://doi.org/10.7150/thno.79976Test
https://www.thno.org/v13p2408.htmTest

المؤلفون: Stratigos, Alexander J., Garbe, Claus, Dessinioti, Clio, Lebbe, Celeste, van Akkooi, Alexander, Bataille, Veronique, Bastholt, Lars, Dreno, Brigitte, Dummer, Reinhard, Fargnoli, Maria Concetta, Forsea, Ana Maria, Harwood, Catherine A., Hauschild, Axel, Hoeller, Christoph, Kandolf-Sekulovic, Lidija, Kaufmann, Roland, Kelleners-Smeets, Nicole WJ, Lallas, Aimilios, Leiter, Ulrike, Malvehy, Josep, del Marmol, Veronique, Moreno-Ramirez, David, Pellacani, Giovanni, Peris, Ketty, Saiag, Philippe, Tagliaferri, Luca, Trakatelli, Myrto, Ioannides, Dimitrios, Vieira, Ricardo, Zalaudek, Iris, Arenberger, Petr, Eggermont, Alexander M.M., Röcken, Martin, Grob, Jean-Jacques, Lorigan, Paul

المصدر: European Journal of Cancer ; volume 193, page 113252 ; ISSN 0959-8049

مصطلحات موضوعية: Cancer Research, Oncology

الإتاحة: https://doi.org/10.1016/j.ejca.2023.113252Test
https://api.elsevier.com/content/article/PII:S0959804923003544?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0959804923003544?httpAccept=text/plainTest

المؤلفون: Chatziioannou, Eftychia, Roßner, Jana, Aung, Thazin New, Rimm, David L., Niessner, Heike, Keim, Ulrike, Serna-Higuita, Lina Maria, Bonzheim, Irina, Kuhn Cuellar, Luis, Westphal, Dana, Steininger, Julian, Meier, Friedegund, Pop, Oltin Tiberiu, Forchhammer, Stephan, Flatz, Lukas, Eigentler, Thomas, Garbe, Claus, Röcken, Martin, Amaral, Teresa, Sinnberg, Tobias

المصدر: eBioMedicine ; volume 93, page 104644 ; ISSN 2352-3964

الإتاحة: https://doi.org/10.1016/j.ebiom.2023.104644Test
https://api.elsevier.com/content/article/PII:S2352396423002098?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2352396423002098?httpAccept=text/plainTest