المؤلفون: Yahong Shi, Chuqiao Jiao, Xi Lu, Yifeng Nie, Xiang Li, Dong Han

المصدر: Orphanet Journal of Rare Diseases, Vol 17, Iss 1, Pp 1-7 (2022)

مصطلحات موضوعية: Pulmonary lymphangiomyomatosis (PLAM), Rapamycin, Intervaginal space injection (ISI), LC–MS, Medicine

الوصف: Abstract Background Pulmonary lymphangiomyomatosis (PLAM) is a rare interstitial lung disease characterized by diffuse cystic changes caused by the destructive proliferation of smooth muscle-like cells or LAM cells. PLAM is more common in young women than other people, and a consensus is lacking regarding PLAM treatment. The clinical treatment of PLAM is currently dominated by rapamycin. By inhibiting the mTOR signaling pathway, rapamycin can inhibit and delay PLAM’s occurrence and development. However, the application of rapamycin also has shortcomings, including the drug’s low oral bioavailability and a high binding rate to hemoglobin, thus significantly decreasing the amount of drug distributed to the lungs. Methods and results Here, we developed a new mode of rapamycin administration in which the drug was injected into the intrathecal space after being nanosized; the directional flow characteristics of the liquid in the intrathecal space were exploited to increase the drug content in the interstitial fluid to the greatest extent possible. We studied the rapamycin content in the interstitial fluid and blood after intervaginal space injection (ISI). Compared with oral administration, ISI significantly increased the drug concentration in the lung interstitial fluid. Conclusions These results provided new ideas for treating PLAM and optimizing the dosing regimens of drugs with similar characteristics to rapamycin.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1750-1172Test

الوصول الحر: https://doaj.org/article/066c8493da8746fc905fa5cd9bfaa36aTest

المؤلفون: El Ismaili, Asmae, Serraj, Mouni A, Amara, Bouchra, Benjelloun, M. C.

المصدر: International Journal of Health and Biological Sciences; Vol. 3 No. 02 (2020): International Journal of Health and Biological Sciences; 06-08 ; 2590-3357 ; 2590-3365

مصطلحات موضوعية: Bilateral pneumothorax, Bourneville’s Tuberoussclerosis, Pulmonary lymphangiomyomatosis, Subependymal Cerebral nodules

الوصف: Lymphangiomyomatosisis a rare disease characterized by a proliferation of abnormal smooth muscle cells responsible for infiltration with the destruction of tissue architecture and genesis of cystic lung and lymphatic lesions. In addition to lung damage, Bourneville’s tuberous sclerosis (BTS) also affects the skin, brain, retina, kidneys, and, less frequently, the heart and bone. We report the case of a young patient with bilateral pneumothorax revealing pulmonary lymphangiomyomatosis in the context of Bourneville’stuberoussclerosis BTS.

وصف الملف: application/pdf

العلاقة: https://ijhbs.com/index.php/ijhbs/article/view/32/24Test; https://ijhbs.com/index.php/ijhbs/article/view/32Test

الإتاحة: https://ijhbs.com/index.php/ijhbs/article/view/32Test

المؤلفون: Asmae El ismail, M. Serraj

المصدر: Visual Journal of Emergency Medicine. 23:101029

مصطلحات موضوعية: Tuberous sclerosis, medicine.medical_specialty, business.industry, Bilateral pneumothorax, Emergency Medicine, Medicine, Context (language use), Radiology, business, medicine.disease, Pulmonary lymphangiomyomatosis

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::5d41d4514e570ecdc03932c2d716d509Test
https://doi.org/10.1016/j.visj.2021.101029Test

المؤلفون: Arata Azuma, Hiroshi Ono, 吾妻安良太, 小野啓資

المصدر: 気管支学 / The Journal of the Japan Society for Respiratory Endoscopy. 2005, 27(1):37

المؤلفون: Akira Murata, Hisanobu Niitani, Jirou Usuki, Kiyoshi Koizumi, Ouichi Kawanami, Seiryuu Kamoi, Tasuku Syouji, Tsutomu Araki, Yuichirou Takeda

المصدر: The Japanese journal of thoracic diseases. 1989, 27(9):1106

المؤلفون: Hideyasu Mishima, Katsuaki Nishimiya, Naomi Suematsu, Ryuichi Yamada, Satoshi Kumazaki, Takeshi Uzawa, Teruo Ishihara

المصدر: The Japanese journal of thoracic diseases. 1989, 27(7):860

المؤلفون: Akio Ishii, Bunichi Umeda, Eitetu Lee, Hiroko Sakamoto, Hironobu Iwasaki, Hiroyuki Shirane, Hitoshi Nakai, Hitoya Ota, Kyosuke Ishihara, Nobuyuki Katakami

المصدر: The Japanese journal of thoracic diseases. 1988, 26(2):179

المؤلفون: Gengo Mabuti, Kimio Konno, Makiko Toyooka, Masahiko Kawakami, Mitsuko Konno, Ryuko Endo, Takao Takizawa

المصدر: The Japanese journal of thoracic diseases. 1988, 26(1):75

المؤلفون: Hirki Hara, Toshiaki Manabe, Toshiharu Matsushima, Yoshihiko Tono

المصدر: The Japanese journal of thoracic diseases. 1987, 25(8):918

المؤلفون: Akira Sakamoto, Katsurou Taketomi, Kiyotaka Komori, Kouhei Hara, Kouji Tobinaga, Masao Kishikawa, Shigeru Kohno, Takashige Miyazaki, 岡 三喜男

المصدر: The Japanese journal of thoracic diseases. 1992, 30(8):1532