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1دورية أكاديمية
المؤلفون: Uhe, Tobias, Wasser, Katrin, Prettin, Christiane, Probst, Mareike, Essa, Hisham, Frank, Benedikt, Stolte, Benjamin, Milles, Lennart, Soda, Hassan, Hiermann, Erich, Rascher, Renate Weinhardt Alexandra, Stan, Marius, Kääb, Stefan, Michalski, Dominik, Kellert, Lars, Dimitriadis, Konstantinos, Kopczak, Anna, Küster, Bettina, Sinner, Moritz, Steiger, Ignaz, Kaffe, Maria, Clauß, Sebastian, Janowitz, Daniel, Thaler, Raffael, Kraft, Andrea, Schellinger, Peter, Glahn, Jörg, Schubert, Jan, Jenniges, Simone, Markmann-Boenke, Silke, Putzer, Anne-Sophie, Straeten, Michael Schwarze Vera, Wiemer, Marcus, Kallmünzer, Bernd, Macha, Kosmas, Etgen, Thorleif, Haupenthal, David, Balk, Stefanie, Kossel, Clara-Sophie, Häusler, Georg, Lehrieder, Dominik, Cidlinsky, Peter, Hametner, Christian, Vogl, Christine, Fischer, Thomas, Huttelmaier, Moritz, Schellinger, Peter D., Nordbeck, Octavian Maniuc Peter, von Hardenberg, Albrecht, Jünemann, Martin, Braun, Tobias, Viard, Maxime, Gerner, Stefan, Omar, AlHaj, Genau, Sonja, Olbricht, Linus, Wassenberg, Matthias, Langguth, Niklas, Fräbel, Christian, Baumgart, Romy, Kalra, Love-Preet, Diel, Norma, Hoffmann, Frank, Schönmuth, Bettine, Giebler, Anja, Weber, Lorenz, Bethke, Florian, Grond, Martin, Birringer, Jan, Lichte-Schneider, Sandra, Hütwohl, Daniela, Krause, Lars Udo, Petersen, Martina, Althaus, Katharina, Kirchmeier, Konstantin, Novikova, Liubov, Müller, Susanne, Ertl, Michael, Schellong, Sebastian, Brudzinski, Mirko, Gerk, Ulrich, Palisch, Holger, Heinzel, Frank R., Fett, Jana, Suntha, Avinash, Burian, Katja, Schmitz, Bettina, Gutwinski, Anna, Angermüller, Veronika, Alhammoud, Tameem, Cakiroglu, Hüsniye, Bach, Ullrich, Nabavi, Darius, Offermann, Jens, Crome, Olaf, Dimitrijeski, Boris, Meincke, Carsten, Hamann, Gerhard, Alber, Burkhard, Müller, Robert, Pallesen, Lars-Peder, Pütz, Volker, Hartmann, Christian, Berrouschot, Jörg, Stoll, Anett, Keilitz, Janina, Klunk, Dietrich, Voigt, Roman, Weber-Krüger, Mark, Kastrup, Andreas, Schröter, Andreas, Schmucker, Johannes, Pfeilschifter, Waltraud, Krämer, Christoffer, Wiemers, Milena, Simon, Micha, Finke, Alexander, Weiß, Christian, Hobohm, Carsten, Hamann, Gerhard F., Naupold, Katrin, Bley-Renning, Karen, Winter, Sabrina, Poli, Sven, Mengel, Annerose, Poli, Khouloud, Expósito, Alexandra Gómez, Mbroh, Joshua, Tieck, Maria, Rosenkranz, Michael, Mende, Meinhard, Boskamp, Stefan, Ritter, Nicolas, Seibel, Lena, Schöps, Christian, Ketzler, Rebecca, Nägele, Herbert, Sydow, Karsten, Kurka, Natalia, Schäfer, Jan Hendrik, Charisse, Daniel, Wagner, Marcus, Gruber, Katharina, Kohlhase, Konstantin, Lieschke, Franziska, Operhalski, Felix, Seiler, Alexander, Petzold, Gabor, Bode, Felix Jürgen, Stösser, Sebastian, Meißner, Julius, Ebrahimi, Taraneh, Gröschel, Sonja, Nordsiek, Julia, Beckonert, Niklas, Weissenborn, Karin, Große, Gerrit Maximilian, Worthmann, Hans, Hennemann, Ann-Katrin, Jochmann, Svenja, Gründahl, Julius, Al-Ayoubi, Jana, Ernst, Johanna, Uphaus, Timo, Bähr, Oliver, Gruber, Herbert, Benesch, Sonka, Pollinger, Thomas, Alachkar, Nawar, Busch, Sonia, Butz, Steffi, Forkmann, Mathias, Mahnkopf, Christian, Mischke, Thomas, Gröschel, Klaus, Schnupp, Steffen, Thomalla, Götz, Deb-Chatterji, Milani, Cheng, Bastian, Gelderblom, Mathias, Hoppe, Julia, Jensen, Märit, Schell, Maximilian, Schlemm, Eckhard, Marquardt, Lars, Wachter, Rolf, Kazarians, Haiko, Rheingans, Pia Franziska, Hötzer, Kai, Rose, Dietmar, Neumann-Haefelin, Tobias, Berthel, Jörg, Alijaj, Lirim, Krug, Joachim, Niethammer, Margit, Szöllösi, Géza-Attila, Wachter , Rolf, Obermann, Marc, Adochitei, Nicoletta, Strik, Herwig, Lenz, Arne, Steigerwald, Frank, Müller, Jörg, Honermann, Martin, Burgstaller, Marian Christoph, Kollmar, Rainer, Rashid, Maryam, Ganai, Ahmad Ajaz, Ossendorf, Saric, Majda, Tischer, Karl-Heinz, Toluli, Adela, Wollenweber, Frank Arne, Rahban, Laya, Silva, Thais Portugal, Lee, Miri, Grosch, Matthias Julius, Schäbitz, Wolf-Rüdiger, Minnerup, Jens, Liman, Jan, Nückel, Martin, Böhm, Magdalena, Uhe , Tobias, Köhrmann, Martin, Dichgans, Martin, Hahn, Marianne, Zuhorn, Frederic, Wulff, Leonard, Plümer, Jorge, Kok, Lena, Janz, Marcel, Kitsiou, Alkisti, Gehmeyr, Julian, Dabbagh, Alhuda, Huber, Charlotte, Pelz, Johann, Wartenberg, Katja, Brachmann, Johannes, Seidel, Mirko, Flissakowski, Oscar, Goschenhofer, Anna, Hussain, Rabia-Basari, Kim, Ina, Kinze, Stephan, Kroneberger, Christian, Lingnau, Michale, Lischewski, Dennis, Muhn, Florian, Laufs, Ulrich, Rogge, Witold, Schieffer, Miriam, Setayesh-Roonizi, Anuscheh, Sparenberg, Paul, Schertel, Jill Marie, Ringleb, Peter, Purrucker, Jan, Berberich, Anne, Heyse, Miriam, Ungerer, Matthias, Bauer, Gregor, Reichardt, Christine, Ebel, Bernhard, Milanković-Eberl, Dragana, Schwarte, Olav, Höcherl, Constanze, Asch, Eric-Manuel, Bojtschuk, Luisa, Frey, Maximilian, Gelbrich, Götz, Dlouhy, Tomas, Zickler, Philipp Patrick, Beier, Barbara, Braadt, Lino-Dominic, Gabrielyan, Inessa, Kermer, Pawel, Kaste, Matthias, Anter, Ahmed, Stirbulescu, Corina, Petroff, David, Meleshchenco, Nataliia, Burgholte, Friederike, Lüers, Claus, Steiner, Thorsten, Cierpinski, Mari-Carmen, Lichti, Bonowski, Lars, Eid, Hassan Abou, Vajda-Medina, Esteban
المصدر: American heart journal 265, 66 - 76 (2023). doi:10.1016/j.ahj.2023.06.016
مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Humans, Infant, Atrial Fibrillation: complications, Atrial Fibrillation: diagnosis, Ischemic Stroke, Furylfuramide, Prospective Studies, Stroke: etiology, Stroke: prevention & control, Stroke: diagnosis, Electrocardiography, Ambulatory: methods, Embolism: diagnosis, Embolism: etiology, Embolism: prevention & control
جغرافية الموضوع: DE
الوصف: Atrial fibrillation (AF) is one of the most frequent causes of stroke. Several randomized trials have shown that prolonged monitoring increases the detection of AF, but the effect on reducing recurrent cardioembolism, ie, ischemic stroke and systemic embolism, remains unknown. We aim to evaluate whether a risk-adapted, intensified heart rhythm monitoring with consequent guideline conform treatment, which implies initiation of oral anticoagulation (OAC), leads to a reduction of recurrent cardioembolism.Find-AF 2 is a randomized, controlled, open-label parallel multicenter trial with blinded endpoint assessment. 5,200 patients ≥ 60 years of age with symptomatic ischemic stroke within the last 30 days and without known AF will be included at 52 study centers with a specialized stroke unit in Germany. Patients without AF in an additional 24-hour Holter ECG after the qualifying event will be randomized in a 1:1 fashion to either enhanced, prolonged and intensified ECG-monitoring (intervention arm) or standard of care monitoring (control arm). In the intervention arm, patients with a high risk of underlying AF will receive continuous rhythm monitoring using an implantable cardiac monitor (ICM) whereas those without high risk of underlying AF will receive repeated 7-day Holter ECGs. The duration of rhythm monitoring within the control arm is up to the discretion of the participating centers and is allowed for up to 7 days. Patients will be followed for at least 24 months. The primary efficacy endpoint is the time until recurrent ischemic stroke or systemic embolism occur.The Find-AF 2 trial aims to demonstrate that enhanced, prolonged and intensified rhythm monitoring results in a more effective prevention of recurrent ischemic stroke and systemic embolism compared to usual care.
العلاقة: info:eu-repo/semantics/altIdentifier/pmid/pmid:37422010; info:eu-repo/semantics/altIdentifier/issn/0002-8703; info:eu-repo/semantics/altIdentifier/issn/1097-6744; https://pub.dzne.de/record/259702Test; https://pub.dzne.de/search?p=id:%22DZNE-2023-00774%22Test
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2دورية أكاديمية
المؤلفون: Probst Mareike, Schmidt Martin, Weitschies Werner, Seidlitz Anne
المصدر: Current Directions in Biomedical Engineering, Vol 2, Iss 1, Pp 383-386 (2016)
مصطلحات موضوعية: biorelevant, flow-through-cell, intramuscular injection, in vitro dissolution, Medicine
الوصف: There is an urgent need for in vitro dissolution test setups for intramuscularly applied dosage forms. Especially biorelevant methods are needed to predict the in vivo behavior of newly developed dosage forms in a realistic way. There is a lack of knowledge regarding critical in vivo parameters influencing the release and absorption behavior of an intramuscularly applied drug. In the presented work the focus was set on the simulation of blood perfusion and muscle tissue. A solid agarose gel, being incorporated in an open-pored foam, was used to mimic the gel phase of muscle tissue and implemented in a flow through cell. An aqueous solution of fluorescein sodium was injected. Compared to recently obtained in vivo results the distribution of the model substance was very slow. Furthermore an agarose gel of lower viscosity an open-pored foam and phosphate buffer saline pH 7.4 were implemented in a multi-channel-ceramic membrane serving as a holder for the muscle imitating material. Blood simulating release medium was perfused through the ceramic membrane including filling materials. Transport of the dissolved fluorescein sodium was, in case of the gel, not only determined by diffusion but also by convective transport processes. The more realistic the muscle simulating materials were constituted the less reproducible results were obtained with the designed test setups.
وصف الملف: electronic resource
العلاقة: https://doaj.org/toc/2364-5504Test
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3دورية أكاديمية
المؤلفون: Probst, Mareike, Kühn, Jens-Peter, Modeß, Christiane, Scheuch, Eberhard, Seidlitz, Anne, Hosten, Norbert, Siegmund, Werner, Weitschies, Werner
المساهمون: German Federal Ministry of Education and Research
المصدر: Drug Safety - Case Reports ; volume 4, issue 1 ; ISSN 2199-1162 2198-977X
مصطلحات موضوعية: Pharmacology (medical)
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المؤلفون: Probst, Mareike
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6دورية أكاديمية
المؤلفون: Probst, Mareike, Schmidt, Martin, Tietz, Katharina, Klein, Sandra, Weitschies, Werner, Seidlitz, Anne
المساهمون: Bundesministerium für Bildung und Forschung
المصدر: International Journal of Pharmaceutics ; volume 532, issue 1, page 519-527 ; ISSN 0378-5173
مصطلحات موضوعية: Pharmaceutical Science
الإتاحة: https://doi.org/10.1016/j.ijpharm.2017.09.052Test
https://api.elsevier.com/content/article/PII:S0378517317309183?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0378517317309183?httpAccept=text/plainTest -
7رسالة جامعية
المؤلفون: Probst, Mareike
مصطلحات موضوعية: In vitro, In vivo, Freisetzung, ddc:540
الوصف: In der Arzneimitteltherapie nehmen parenteral zu applizierende Arzneimittel einen immer größer werdenden Stellenwert ein. Diese Entwicklung beruht vor allem auf der steigenden Anzahl von Peptiden und Proteinen als Wirkstoffe, deren perorale Applikation aufgrund unzureichender Resorptionsraten aus dem Gastrointestinaltrakt unmöglich ist, aber auch auf der Möglichkeit Depotformulierungen anzuwenden, die Wirkstoffe nach subkutaner oder intramuskulärer Injektion über einen langen Zeitraum freisetzen können. Dennoch sind Arzneimitteltransportwege nach subkutaner oder intramuskulärer Applikation im Detail weitestgehend unerforscht. In der vorliegenden Arbeit wurde der Fokus auf die intramuskuläre Applikation gelegt. Im ersten Teil der Arbeit wurde eine tierexperimentelle Studie an Ratten durchgeführt, die es zum Ziel hatte, ausgewählte physiologische Einflussparameter auf die Wirkstoffresorption nach intramuskulärer Injektion zu untersuchen. Die Tiere erhielten sowohl wässrige Lösungen als auch ölige Suspensionen von Paracetamol, Prednisolon und Diclofenac-Natrium in die rechte Oberschenkelmuskulatur und das jeweilige Placebo in den Muskel des linken Oberschenkels. Anschließend wurde das intramuskuläre Arzneistoffdepot erstmals mittels Magnetresonanztomographie (MRT) als bildgebendes Verfahren zeitabhängig untersucht und parallel die Anflutungskinetik der Wirkstoffe ins Blut bestimmt. Die Volumina und Oberflächen der Depots sowie die Zeit bis zu deren Abtransport aus dem Muskelgewebe wurden mit den Blutspiegelkurven verglichen. Allen Formulierungen war gemein, dass der Wirkstoff deutlich schneller resorbiert wurde als das Depot. Daraus lässt sich schließen, dass die Wirkstoffaufnahme nicht über die Resorption des Depots erfolgte. Ein schnelleres Verschwinden der Depots führte nicht zu höheren Blutspiegelmaxima oder zu einer beschleunigten systemischen Wirkstoffresorption. Es wurde keine Korrelation zwischen dem Volumen und der Oberfläche der Depots und den Blutspiegelkurven gefunden. Ein weiterer Aspekt, der während ...
وصف الملف: application/pdf
العلاقة: https://epub.ub.uni-greifswald.de/frontdoor/index/index/docId/1849Test; urn:nbn:de:gbv:9-002681-7; https://nbn-resolving.org/urn:nbn:de:gbv:9-002681-7Test; https://epub.ub.uni-greifswald.de/files/1849/diss_Probst_Mareike.pdf.pdfTest
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8دورية أكاديمية
المؤلفون: Probst, Mareike, Kühn, Jens-Peter, Scheuch, Eberhard, Seidlitz, Anne, Hadlich, Stefan, Evert, Katja, Oswald, Stefan, Siegmund, Werner, Weitschies, Werner
المساهمون: Bundesministerium für Bildung und Forschung
المصدر: Journal of Controlled Release ; volume 227, page 1-12 ; ISSN 0168-3659
مصطلحات موضوعية: Pharmaceutical Science
الإتاحة: https://doi.org/10.1016/j.jconrel.2016.02.029Test
https://api.elsevier.com/content/article/PII:S016836591630092X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S016836591630092X?httpAccept=text/plainTest -
9دورية أكاديمية
المؤلفون: Berg, Daniela, Seppi, Klaus, Godau, Jana, Huber, Heiko, Srulijes, Karin, Kiechl, Stefan, Bentele, Marianna, Gasperi, Arno, Schubert, Teresa, Hiry, Teresa, Probst, Mareike, Schneider, Vera, Behnke, Stefanie, Klenk, Jochen, Sawires, Martin, Willeit, Johann, Maetzler, Walter, Fassbender, Klaus, Gasser, Thomas, Poewe, Werner, Liepelt, Inga, Schweitzer, Katherine, Stockner, Heike, Wollenweber, Frank, Gaenslen, Alexandra, Mahlknecht, Philipp, Spiegel, Jörg
المصدر: JAMA neurology 68(7), 932 (2011). doi:10.1001/archneurol.2011.141
مصطلحات موضوعية: info:eu-repo/classification/ddc/610, Aged, 80 and over, Brain Mapping, Female, Humans, Longitudinal Studies, Male, Middle Aged, Neurologic Examination, Parkinson Disease: diagnostic imaging, Parkinson Disease: etiology, Parkinson Disease: pathology, Risk Factors, Substantia Nigra: diagnostic imaging, Substantia Nigra: pathology, Ultrasonography, Doppler, Transcranial: methods
جغرافية الموضوع: DE
الوصف: To evaluate whether enlarged substantia nigra hyperechogenicity (SN+) is associated with an increased risk for Parkinson disease (PD) in a healthy elderly population.Longitudinal 3-center observational study with 37 months of prospective follow-up.Individuals 50 years or older without evidence of PD or any other neurodegenerative disease.Of 1847 participants who underwent a full medical history, neurological assessment, and transcranial sonography at baseline, 1535 could undergo reassessment.Incidence of new-onset PD in relation to baseline transcranial sonography status.There were 11 cases of incident PD during the follow-up period. In participants with SN+ at baseline, the relative risk for incident PD was 17.37 (95% confidence interval, 3.71-81.34) times higher compared with normoechogenic participants.In this prospective study, we demonstrate for the first time a highly increased risk for PD in elderly individuals with SN+. Transcranial sonography of the midbrain may therefore be a promising primary screening procedure to define a risk population for imminent PD.
العلاقة: info:eu-repo/semantics/altIdentifier/issn/2330-9644; info:eu-repo/semantics/altIdentifier/issn/0003-9942; info:eu-repo/semantics/altIdentifier/pmid/pmid:21747034; info:eu-repo/semantics/altIdentifier/issn/2168-6157; info:eu-repo/semantics/altIdentifier/issn/1538-3687; info:eu-repo/semantics/altIdentifier/issn/2168-6149; info:eu-repo/semantics/altIdentifier/issn/0375-8540; https://pub.dzne.de/record/136260Test; https://pub.dzne.de/search?p=id:%22DZNE-2020-02582%22Test
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10دورية أكاديمية
المؤلفون: Wollenweber, Frank Arne, Schomburg, Robert, Probst, Mareike, Schneider, Vera, Hiry, Teresa, Ochsenfeld, Annika, Mueller, Martin, Dillmann, Ulrich, Fassbender, Klaus, Behnke, Stefanie
المصدر: Psychiatry Research: Neuroimaging ; volume 191, issue 3, page 212-216 ; ISSN 0925-4927
الإتاحة: https://doi.org/10.1016/j.pscychresns.2010.09.010Test
https://api.elsevier.com/content/article/PII:S0925492710003215?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0925492710003215?httpAccept=text/plainTest
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