المؤلفون: Prestel, Jürgen, Volkers, Peter, Linster, E., Blaes, F., Krämer, H., Guthke, K., Schmidt, H., Krumpolt, H., Schiess, D., Roth, M., Fuchs, H. H., Schneider, E., Wohlfarth, K., Langel, S., Müller, T., Sick, W., Schwandt, D., Wellach, I., Töpper, R. F., Koehler, J., Rosenkranz, T., Knepel, S., Duwe, T., Stiller, M., Bößenecker, W., Rieke, K., Baas, H., Brunotte, P., Tümmler, J., Heidenreich, F., Stangel, M., Stift, T., Ringleb, P., Kaendler, S., Humbroich, K., Bamberg, C., Plöger, H., Sitzer, M., Dieter, J., Dietz, M., Eicke, M., Ochs, G., Güldenring, A., Hagemann, G., Zinke, J., Fetter, M., Gerlach, R., Herath, H., Escheu, G., Stingele, R., Berthold, A., Schmitt, E., Haupt, W. F., Petereit, H. F., Limmroth, V., von Giesen, H. J., Kirsch, B., Reckhardt, M., Heckmann, J. G., Beuche, W., Schattenfroh, C., Tampier-Pohl, C., Friedl, R., Oberwittler, C., Schlenker, M., Trillenberg, P., Abushammala, A., Schabet, M., Borak, P., Eßer, M., Thümen, A., Lins, H., Vielhaber, S., Bayerl, J., Tackenberg, B., Hachgenei, A., Meisenheim, G. K., Philipps, J., Tings, T., Braun, H., Franz, O., Jauß, M., Berthele, A., München, T. U., Hupfer, W., Nagi, M., Dziewas, R., Kusch, W., Lobenstein, S., Fischer, V., Harzheim, M., Syed, N., Bitsch, A., Jahnke, U., Allendörfer, J., Dietrich, W., Görtzen, A., Stark, E., Wenning, W., Neumann, F., Petrick, M., Isenhardt, K., Kaiser, R., Niehoff, T., Deymann, R., Hartmann, R., Christe, W., Görlitz, C., Hotz, M., Buchner, H., Balzer, K., Braune, H. J., Mentzer, Dirk, Bader, P., Kindl, H. J., Leschnik, O., Lohner, H., Zettl, U., Kiefer, R., Krauth, S., Hansberg, T., Matrisch, H., Vetter, T., Schepelmann, K., Glocker, F., Schade, B., Nguento, A., Fortwängler, T., Hartnack, F., Neuhaus, O., Wennrich, M., Leopold, H. C., Tebben, J., Polzer, U., Sieb, P., Reimers, C. D., Huss, G. P., Kuhl, V., Gawlitza, M., Freudenberger, T., Rieder, G., Schröder, K., Bös, M., Krüger, T., Rechlin, M., Bufler, J., Riesterer-Hemm, G., Angerer, M., Möller, P., Eppinger, B., Dömges, F., Albrecht, P., Kotterba, S., Stolz, E., Schmidt, N., Trottenberg, T., Feige, P., Trabold, R., Hufschmidt, A., Svrakova, L., Haensch, C. A., Kastrau, F., Schmidt, P., Reiners, K., Weinmann, E., Merkelbach, S., Bachhuber, A., Hermann, W., Homberg, V., Häusler, M., Toth, M., Weiß, B. M., Stein, D., Klepper, J., Hirsch, T., von Moers, A., Brandes, H., Botsch, M., Köhler, C., Klee, R., Franke, I., Kössel, H., Kauffmann, B., Schwalm, H., Kirschstein, M., Tribukait, U., Mandl, M., Böhmann, H., Schaetz, K., Hebing, B., von Rosen, F., Steinert, M., Eichholz, S., von Lilien-Waldau, T., Karenfort, M., Kretzschmar, B., Trollmann, R., Schmiedel, G., Dördelmann, M., Kieslich, M., Mause, U., Daffertshofer, M., Grüber, C., Korinthenberg, R., Heubner, G., Mattes, J., Radlow, U., Repp, R., Klinge, J., Genseke, R., Gsinn, S., Gebhardt, B., Hofler, D., Papsch, M., Mutlak, S., Brockmann, K., Koch, G., Mandelkow, F., v Blanckenburg, P., Bertram, U., Vieker, S., Peltner, H. U., Sander, M., Lehmann, Helmar C., Hofstadt, U., Shamdeen, M. G., Nowka, S., Koch, W., Walkenhorst, H., Rubens, T., Westerbeck, K., Rübo, J., Wiater, A., Pflumm, K., Bensch, J., Baumsteiger, C., Engelhardt, H., Deja, M., Borte, M., Tibussek, D., Bosse, H., Rinschen, K., Härtel, C., Gaude-Wagener, M., Beyer, U., Pädiatrie, A., Dreger, J., Peters, H., Kowalzik, F., Seipelt, P., Zippel, S., Pargac, K. N., Schobeß, A., Müller, W., Baethmann, M., Leiz, S., Gehrmann, A., Stachulski, F., Makowski, C., Fiedler, B., Böswald, M., Weisbrod, T., Kintzel, K., Franz, C., Feickert, H. J., Kühl, P. G., Schneider, M., Raab, K., Harms, H., Beyer, P., Kauther, K. D., Reiter, H. L., Behl, E. S., Trefz, F. K., Hoffmann, H. G., Buss, M., Olbertz, D. M., Hempel, L., Kauert, A., Agricola, G., Horneff, G., Augustin, K. S., Mihatsch, W., Kurre, A., Colling, S., Burghard, R., Soditt, V., Feierfeil, K., Hornbrook, D., Haas, J., Kellner, L., Pernice, W., Schirmer, D., Alber, M., Geerken, S., Kratz, M., Köhler, A., Knuf, M., Repinska, T., Buller, M., von Brevern, M., Becker, J. C., Niesytto, C., Skopnik, H., Borusiak, P., Verbeek, T., Gabler, I., Winkelmann, T., Völzke, E., Ducke, F., Hartung, Hans-Peter, Böhme, H., Koennecke, H. C., Ecke, A., Bähr, D., Nabavi, D. G., Hopmann, D., Porz, D., Neumayer, B., Keller-Stanislawski, Brigitte, Kitzrow, M., Börnke, C., Schröder, A., Kowalski, T., Günther, J., Boeckler, D., Reinshagen, A., Sarholz, M., Böhm, K. D., Weiland, T., GBS Study Group, Kuhlmann, R. J., Heide, W., Heider, S., Schüler, O., Claus, D., Kunesch, E., Yaretskyy, G., Spieker, S., Jung, S., Gerber, J., Spitzer, C., Busch, A., Schneider, H., Machetanz, J., Grehl, H., Nolden-Koch, M., Wilmsen, H., Lehmann, H., Seitz, R., Griese, M., Heyden, M., Schmitt, H. M., Dietze, C., Holz, J., Leinisch, E., Derfuß, T., Linker, R., Reinhardt, F. M., Krämer, M., Koeppen, S., Gerhard, H., Klötzsch, C., Bauer, H., Stolze, H., Jost, V., Steinmetz, H., Schütz, H., Böhm, J., Rauer, S., Klotz, J. M., Schneider, A., Biemann, M.

المصدر: Pharmacoepidemiology and drug safety 23(11), 1192-1204 (2014). doi:10.1002/pds.3638

جغرافية الموضوع: DE

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000345076200011; info:eu-repo/semantics/altIdentifier/issn/1053-8569; info:eu-repo/semantics/altIdentifier/issn/1099-1557; info:eu-repo/semantics/altIdentifier/pmid/pmid:24817531; https://publications.rwth-aachen.de/record/462580Test; https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-090997%22Test

الإتاحة: https://doi.org/10.1002/pds.3638Test
https://publications.rwth-aachen.de/record/462580Test
https://publications.rwth-aachen.de/search?p=id:%22RWTH-CONV-090997%22Test

المؤلفون: Merkelbach, S., Schulz, H., Kölmel, H. W., Gora, G., Klingelhöfer, J., Dietzel, J., Dachsel, R., Hoffmann, F., Daume, L., Polzer, U., Renner, R.

المصدر: Journal of Sleep Research ; volume 15, issue 1, page 105-106 ; ISSN 0962-1105 1365-2869

الإتاحة: https://doi.org/10.1111/j.1365-2869.2006.00508.xTest

المؤلفون: Kappos L., Bar-Or A., Cree B. A. C., Fox R. J., Giovannoni G., Gold R., Vermersch P., Arnold D. L., Arnould S., Scherz T., Wolf C., Wallstrom E., Dahlke F., Achiron A., Achtnichts L., Agan K., Akman-Demir G., Allen A. B., Antel J. P., Antiguedad A. R., Apperson M., Applebee A. M., Ayuso G. I., Baba M., Bajenaru O., Balasa R., Balci B. P., Barnett M., Bass A., Becker V. U., Bejinariu M., Bergh F. T., Bergmann A., Bernitsas E., Berthele A., Bhan V., Bischof F., Bjork R. J., Blevins G., Boehringer M., Boerner T., Bonek R., Bowen J. D., Bowling A., Boyko A. N., Boz C., Bracknies V., Braune S., Brescia Morra V., Brochet B., Brola W., Brownstone P. K., Brozman M., Brunet D., Buraga I., Burnett M., Buttmann M., Butzkueven H., Cahill J., Calkwood J. C., Camu W., Cascione M., Castelnovo G., Centonze D., Cerqueira J., Chan A., Cimprichova A., Cohan S., Comi G., Conway J., Cooper J. A., Corboy J., Correale J., Costell B., Cottrell D. A., Coyle P. K., Craner M., Cui L., Cunha L., Czlonkowska A., da Silva A. M., de Sa J., de Seze J., Debouverie M., Debruyne J., Decoo D., Defer G., Derfuss T., Deri N. H., Dihenia B., Dioszeghy P., Donath V., Dubois B., Duddy M., Duquette P., Edan G., Efendi H., Elias S., Emrich P. J., Estruch B. C., Evdoshenko E. P., Faiss J., Fedyanin A. S., Feneberg W., Fermont J., Fernandez O. F., Ferrer F. C., Fink K., Ford H., Ford C., Francia A., Freedman M., Frishberg B., Galgani S., Garmany G. P., Gehring K., Gitt J., Gobbi C., Goldstick L. P., Gonzalez R. A., Grandmaison F., Grigoriadis N., Grigorova O., Grimaldi L. M. E., Gross J., Gross-Paju K., Gudesblatt M., Guillaume D., Haas J., Hancinova V., Hancu A., Hardiman O., Harmjanz A., Heidenreich F. R., Hengstman G. J. D., Herbert J., Herring M., Hodgkinson S., Hoffmann O. M., Hofmann W. E., Honeycutt W. D., Hua L. H., Huang D., Huang Y., Hupperts R., Imre P., Jacobs A. K., Jakab G., Jasinska E., Kaida K., Kalnina J., Kaprelyan A., Karelis G., Karussis D., Katz A., Khabirov F. A., Khatri B., Kimura T., Kister I., Kizlaitiene R., Klimova E., Koehler J., Komatineni A., Kornhuber A., Kovacs K., Koves A., Kozubski W., Krastev G., Krupp L. B., Kurca E., Lassek C., Laureys G., Lee L., Lensch E., Leutmezer F., Li H., Linker R. A., Linnebank M., Liskova P., Llanera C., Lu J., Lutterotti A., Lycke J., Macdonell R., Maciejowski M., Maeurer M., Magzhanov R. V., Maida E. -M., Malciene L., Mao-Draayer Y., Marfia G. A., Markowitz C., Mastorodimos V., Matyas K., Meca-Lallana J., Merino J. A. G., Mihetiu I. G., Milanov I., Miller A. E., Millers A., Mirabella M., Mizuno M., Montalban X., Montoya L., Mori M., Mueller S., Nakahara J., Nakatsuji Y., Newsome S., Nicholas R., Nielsen A. S., Nikfekr E., Nocentini U., Nohara C., Nomura K., Odinak M. M., Olsson T., van Oosten B. W., Oreja-Guevara C., Oschmann P., Overell J., Pachner A., Panczel G., Pandolfo M., Papeix C., Patrucco L., Pelletier J., Piedrabuena R., Pless M., Polzer U., Pozsegovits K., Rastenyte D., Rauer S., Reifschneider G., Rey R., Rizvi S. A., Robertson D., Rodriguez J. M., Rog D., Roshanisefat H., Rowe V., Rozsa C., Rubin S., Rusek S., Sacca F., Saida T., Salgado A. V., Sanchez V. E. F., Sanders K., Satori M., Sazonov D. V., Scarpini E. A., Schlegel E., Schluep M., Schmidt S., Scholz E., Schrijver H. M., Schwab M., Schwartz R., Scott J., Selmaj K., Shafer S., Sharrack B., Shchukin I. A., Shimizu Y., Shotekov P., Siever A., Sigel K. -O., Silliman S., Simo M., Simu M., Sinay V., Siquier A. E., Siva A., Skoda O., Solomon A., Stangel M., Stefoski D., Steingo B., Stolyarov I. D., Stourac P., Strassburger-Krogias K., Strauss E., Stuve O., Tarnev I., Tavernarakis A., Tello C. R., Terzi M., Ticha V., Ticmeanu M., Tiel-Wilck K., Toomsoo T., Tubridy N., Tullman M. J., Tumani H., Turcani P., Turner B., Uccelli A., Urtaza F. J. O., Vachova M., Valikovics A., Walter S., Van Wijmeersch B., Vanopdenbosch L., Weber J. R., Weiss S., Weissert R., West T., Wiendl H., Wiertlewski S., Wildemann B., Willekens B., Visser L. H., Vorobeychik G., Xu X., Yamamura T., Yang Y. N., Yelamos S. M., Yeung M., Zacharias A., Zelkowitz M., Zettl U., Zhang M., Zhou H., Zieman U., Ziemssen T.

المساهمون: Kappos, L., Bar-Or, A., Cree, B. A. C., Fox, R. J., Giovannoni, G., Gold, R., Vermersch, P., Arnold, D. L., Arnould, S., Scherz, T., Wolf, C., Wallstrom, E., Dahlke, F., Achiron, A., Achtnichts, L., Agan, K., Akman-Demir, G., Allen, A. B., Antel, J. P., Antiguedad, A. R., Apperson, M., Applebee, A. M., Ayuso, G. I., Baba, M., Bajenaru, O., Balasa, R., Balci, B. P., Barnett, M., Bass, A., Becker, V. U., Bejinariu, M., Bergh, F. T., Bergmann, A., Bernitsas, E., Berthele, A., Bhan, V., Bischof, F., Bjork, R. J., Blevins, G., Boehringer, M., Boerner, T., Bonek, R., Bowen, J. D., Bowling, A., Boyko, A. N., Boz, C., Bracknies, V., Braune, S., Brescia Morra, V., Brochet, B., Brola, W., Brownstone, P. K., Brozman, M., Brunet, D., Buraga, I., Burnett, M., Buttmann, M., Butzkueven, H., Cahill, J., Calkwood, J. C., Camu, W., Cascione, M., Castelnovo, G., Centonze, D., Cerqueira, J., Chan, A., Cimprichova, A., Cohan, S., Comi, G., Conway, J., Cooper, J. A., Corboy, J., Correale, J., Costell, B., Cottrell, D. A., Coyle, P. K., Craner, M., Cui, L., Cunha, L., Czlonkowska, A., da Silva, A. M., de Sa, J., de Seze, J., Debouverie, M., Debruyne, J., Decoo, D., Defer, G., Derfuss, T., Deri, N. H., Dihenia, B., Dioszeghy, P., Donath, V., Dubois, B., Duddy, M., Duquette, P., Edan, G., Efendi, H., Elias, S., Emrich, P. J., Estruch, B. C.

الوصف: Background No treatment has consistently shown efficacy in slowing disability progression in patients with secondary progressive multiple sclerosis (SPMS). We assessed the effect of siponimod, a selective sphingosine 1-phosphate (S1P) receptor 1,5 modulator, on disability progression in patients with SPMS.Methods This event-driven and exposure-driven, double-blind, phase 3 trial was done at 292 hospital clinics and specialised multiple sclerosis centres in 31 countries. Using interactive response technology to assign numbers linked to treatment arms, patients (age 18-60 years) with SPMS and an Expanded Disability Status Scale score of 3.0-6.5 were randomly assigned (2: 1) to once daily oral siponimod 2 mg or placebo for up to 3 years or until the occurrence of a prespecified number of confirmed disability progression (CDP) events. The primary endpoint was time to 3-month CDP. Efficacy was assessed for the full analysis set (ie, all randomly assigned and treated patients); safety was assessed for the safety set. This trial is registered with ClinicalTrials. gov, number NCT01665144.Findings 1651 patients were randomly assigned between Feb 5, 2013, and June 2, 2015 (1105 to the siponimod group, and 546 to the placebo group). One patient did not sign the consent form, and five patients did not receive study drug, all of whom were in the siponimod group. 1645 patients were included in the analyses (1099 in the siponimod group and 546 in the placebo). At baseline, the mean time since first multiple sclerosis symptoms was 16.8 years (SD 8.3), and the mean time since conversion to SPMS was 3.8 years (SD 3.5); 1055 (64%) patients had not relapsed in the previous 2 years, and 918 (56%) of 1651 needed walking assistance. 903 (82%) patients receiving siponimod and 424 (78%) patients receiving placebo completed the study. 288 (26%) of 1096 patients receiving siponimod and 173 (32%) of 545 patients receiving placebo had 3-month CDP (hazard ratio 0.79, 95% CI 0.65-0.95; relative risk reduction 21%; p=0.013). Adverse events ...

وصف الملف: STAMPA

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/29576505; info:eu-repo/semantics/altIdentifier/wos/WOS:000428791600025; volume:391 (10127); firstpage:1263; lastpage:1273; numberofpages:11; journal:THE LANCET; http://hdl.handle.net/11567/977935Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85044304126

الإتاحة: https://doi.org/10.1016/S0140-6736Test(18)30475-6
http://hdl.handle.net/11567/977935Test

المؤلفون: Odin, P, Oehlwein, C, Storch, A, Polzer, U, Werner, G, Renner, R, Shing, M, Ludolph, A, Schüler, P

المصدر: Aktuelle Neurologie; 20240101, Issue: Preprints

المؤلفون: Merkelbach, S, Schulz, H, Kölmel, HW, Gora, G, Klingelhöfer, J, Dachsel, R, Hoffmann, F, Polzer, U

المصدر: Aktuelle Neurologie; 20240101, Issue: Preprints

المؤلفون: Merkelbach, S., Schulz, H., Kölmel, H. W., Gora, G., Klingelhöfer, J., Dachsel, R., Hoffmann, F., Polzer, U.

المصدر: Journal of Neurology ; volume 258, issue 1, page 74-79 ; ISSN 0340-5354 1432-1459

مصطلحات موضوعية: Neurology (clinical), Neurology

الإتاحة: https://doi.org/10.1007/s00415-010-5684-3Test

المؤلفون: Merkelbach, S., Schulz, H., Kölmel, H.W., Gora, G., Klingelhöfer, J., Dachsel, R., Hoffmann, F., Polzer, U.

المصدر: Der Nervenarzt ; volume 80, issue S1, page 50-51 ; ISSN 0028-2804 1433-0407

مصطلحات موضوعية: Psychiatry and Mental health, Neurology (clinical), Neurology, General Medicine

الإتاحة: https://doi.org/10.1007/s00115-009-2771-8Test

المؤلفون: Schelhorn, J., Höfer, L., Syrbe, G., Polzer, U.

المصدر: Der Nervenarzt ; volume 79, issue 6, page 696-698 ; ISSN 0028-2804 1433-0407

مصطلحات موضوعية: Psychiatry and Mental health, Neurology (clinical), Neurology, General Medicine

الإتاحة: https://doi.org/10.1007/s00115-008-2437-yTest

المؤلفون: Merkelbach, S, Schulz, H, Kölmel, HW, Gora, G, Klingelhöfer, J, Dachsel, R, Hoffmann, F, Polzer, U

المصدر: Aktuelle Neurologie ; volume 34, issue S 2 ; ISSN 0302-4350 1438-9428

الإتاحة: https://doi.org/10.1055/s-2007-987989Test

المؤلفون: Storch, Alexander, Trenkwalder, Claudia, Oehlwein, C., Winkelmann, Juliane, Polzer, U., Hundemer, H. P., Schwarz, J.

الوصف: Motor complications arising after long-term treatment with levodopa remain one of the main challenges in the treatment of patients with Parkinson's disease (PD). Monotherapy with dopamine agonists may delay the onset of motor complications or reduce their severity when added to levodopa treatment. Here, we retrospectively analyzed data from 62 patients with advanced PD who presented with moderate to severe response fluctuations in whom we increased the dose of oral treatment with pergolide beyond 4.5 mg daily. Patients had been treated with levodopa for 10.7 +/- 4.8 years. Pergolide was increased to 8.2 +/- 4.3 mg per day over a median titration period of 13.5 weeks. Mean daily dose of levodopa prior to pergolide high-dose treatment was 733 +/- 468 mg and decreased to 348 +/- 186 mg after pergolide fitration. The duration of OFF times decreased from 7.3 +/- 3.8 to 1.7 +/- 0.9 h per day (p < 0.001) measured by patients' diaries. Dyskinesias, present for 5.0 +/- 3.3 h per day at baseline, were reduced to 1.4 +/- 0.8 h per day (p < 0.001) and the total daily duration of motor fluctuations (off-time duration plus dyskinesia duration) decreased from 10.5 +/- 7.0 to 2.8 +/- 2.2 h (p < 0.00 1). There was a significant improvement in parkinsonian symptoms (baseline to endpoint reduction of UPDRS III from a median of 36 to 8; p < 0.001). To reduce gastrointestinal side effects 23 patients required concomitant treatment with domperidone. Seven patients developed hallucinations during the titration period, six patients required treatment with clozapine. Our data indicate that increasing the dose of pergolide above 5 mg per day can dramatically reduce the need for levodopa, motor fluctuations and severity of clinical symptoms. Controlled trials are needed to further substantiate the efficacy and safety of this treatment strategy. (c) 2005 Elsevier Ltd. All rights reserved.

العلاقة: https://resolver.sub.uni-goettingen.de/purl?gro-2/20413Test; 000232420400009

الإتاحة: https://doi.org/10.1016/j.parkreldis.2005.03.005Test
https://resolver.sub.uni-goettingen.de/purl?gro-2/20413Test