المؤلفون: Mader R., Demay C., Jouvin-Marche E., Ploy M. -C., Barraud O., Bernard S., Lacotte Y., Pulcini C., Weinbach J., Berling C., Bouqueau M., Hlava A., Habl C., Kernstock E., Strauss R., Muchl R., Buhmann V., Versporten A., Ingenbleek A., Vandael E., Haelterman G., De Raedt L., Hunjak B., Raickovic B., Mackova B., Niklova E., Zemlickova H., Hrivnakova L., Jindrak V., Kristensen B., Lyndrup M., Skovgaard S., Wolf Sonksen U., Aasmae B., Ruut J., Linnik L., Sadikova O., Martin P., Zanuzdana A., Kizilkaya-Guneser G., Oezcelik N., Eckmanns T., Lambrou A., Kontopidou F., Papadaki M., Tsana M., Maroulis N., Vatopoulos A., Papadogiannakis E., Kontarini M., Gikas A., Magkanaraki A., Cozza A., Martinelli D., Fortunato F., Prato R., Marella A. M., Pantosti A., Prestinaci F., Busani L., Pezzoti P., Creti R., Martoccia R. M., Brusaferro S., Vilde A., Jakovela A., Langusa E., Grudule L., Grinsteine M., Dumpis U., Dambrauskiene A., Vitkauskiene A., Tirvaite D., Cemnalianskis L., Kazenaite E., Lozoraitiene I., Adomaitiene R., Ambrazaitiene R., Kiveryte S., Maciulaityte A., Kuklyte J., Petrene J., Valinteliene R., Kanapeckiene V., Razmiene A., Kairiene B., Aleksiene G., Valinciute G., Petraitis R., Elsemulder A., Nakched A., Claessen J., Gui L., Kort M. D., Peran R., Van Leeuwen A., Smeets E., Mennen M., Spruijt P., Westerhof R., Skulberg A., Bakka E. Ro., Miard K., Henricsen S. Ho., Pellerud A., Kallberg C., Ardal C., Eriksen H. -M., Kranstad K., Molvik M., Kacelnik O., Sollund P., Samuelsen R., Bakke T., Urdahl A. M., Norstrom M., Olczak-Pienkowska A., Skoczynska A., Zabicka D., Bysiek J., Rekawek J., Lebre A., Falcao E., Scripcaru G., Neves I., Gomes S., Pereira N., Malutan A. M., Iuhas C., Szakacs L., Kissiedou-Bob M., Ciortea R., Grilc E., Klavs I., Turk K., Subelj M., Vrdelja M., Serdt M., Jemec N., Glavan U., Simonovic Z., Tamayo A. N., Lopez Navas A., Munoz Madero C., Alonso Lebrero J. L., Alonso Irujo L., Santacreu Garcia M., Crespo Robledo P., Oliva G., Massanes M., Oliver Palomo A., Garcia Pineda A., Ferragut E., Rojo E., Castano E., Perianez L., Torres Cantero A. M., Jimenez Guillen C., Hukelova H., Alcaraz M., Carlos M. A., Lopez Acuna M. D. P., Gil Setas A., Ibarrola Segura A., Ezpeleta C., Gahigiro Merino C., Portillo Bordonabe M. E., Fragoso M., Beristain Rementeria X., Penalva G., Cisneros J. M., Estevez M., Monteau S., Del Rio L., Gonzalez De Suso M. J., Gallego Berciano P., Aranguren Oyarzabal A., Alioto D., Izquierdo Palomares J. M., Calvo Alcantara M. J., Gonzalez Perez R., Havarria T., Hulth A., Carlin K., Edman L., Grape M., Aspevall O., Haggar A., Lindal E., Burgos A., Ottoson J., Ostman M., Egervarn M., Nordenfelt A., Bengtsson B., Soderman I., Bjers A., Jonsson J. -I., Starborg M., Laine M., Fagerstedt P., Metcalfe A., Soder J., Lytsy B., Madec J. Y., Collineau L., Berger-Carbonne A., Colomb-Cotinat M., Bourely C., Amat J. -P., Broens E. M., Callens B., Crespo-Robledo P., Damborg P., Filippitzi M. -E., Fitzgerald W., Gronthal T., Haenni M., Heuvelink A., Van Hout J., Kaspar H., Pedersen K., Pokludova L., Dal Pozzo F., Slowey R., Zafeiridis C., Madec J. -Y.

المساهمون: Mader, R., Demay, C., Jouvin-Marche, E., Ploy, M. -C., Barraud, O., Bernard, S., Lacotte, Y., Pulcini, C., Weinbach, J., Berling, C., Bouqueau, M., Hlava, A., Habl, C., Kernstock, E., Strauss, R., Muchl, R., Buhmann, V., Versporten, A., Ingenbleek, A., Vandael, E., Haelterman, G., De Raedt, L., Hunjak, B., Raickovic, B., Mackova, B., Niklova, E., Zemlickova, H., Hrivnakova, L., Jindrak, V., Kristensen, B., Lyndrup, M., Skovgaard, S., Wolf Sonksen, U., Aasmae, B., Ruut, J., Linnik, L., Sadikova, O., Martin, P., Zanuzdana, A., Kizilkaya-Guneser, G., Oezcelik, N., Eckmanns, T., Lambrou, A., Kontopidou, F., Papadaki, M., Tsana, M., Maroulis, N., Vatopoulos, A., Papadogiannakis, E., Kontarini, M., Gikas, A., Magkanaraki, A., Cozza, A., Martinelli, D., Fortunato, F., Prato, R., Marella, A. M., Pantosti, A., Prestinaci, F., Busani, L., Pezzoti, P., Creti, R., Martoccia, R. M., Brusaferro, S., Vilde, A., Jakovela, A., Langusa, E., Grudule, L., Grinsteine, M., Dumpis, U., Dambrauskiene, A., Vitkauskiene, A., Tirvaite, D., Cemnalianskis, L., Kazenaite, E., Lozoraitiene, I., Adomaitiene, R., Ambrazaitiene, R., Kiveryte, S., Maciulaityte, A., Kuklyte, J., Petrene, J., Valinteliene, R., Kanapeckiene, V., Razmiene, A., Kairiene, B., Aleksiene, G., Valinciute, G., Petraitis, R., Elsemulder, A., Nakched, A., Claessen, J., Gui, L., Kort, M. D., Peran, R., Van Leeuwen, A., Smeets, E., Mennen, M., Spruijt, P., Westerhof, R.

مصطلحات موضوعية: Animal, Anti-Bacterial Agent, Bacteria, Cat, Cattle, Chicken, Dog, Drug Resistance, Bacterial, Female, Swine, One Health

الوصف: Background: Building the European Antimicrobial Resistance Surveillance network in Veterinary medicine (EARS-Vet) was proposed to strengthen the European One Health antimicrobial resistance (AMR) surveillance approach. Objectives: To define the combinations of animal species/production types/age categories/bacterial species/specimens/antimicrobials to be monitored in EARS-Vet. Methods: The EARS-Vet scope was defined by consensus between 26 European experts. Decisions were guided by a survey of the combinations that are relevant and feasible to monitor in diseased animals in 13 European countries (bottom-up approach). Experts also considered the One Health approach and the need for EARS-Vet to complement existing European AMR monitoring systems coordinated by the ECDC and the European Food Safety Authority (EFSA). Results: EARS-Vet plans to monitor AMR in six animal species [cattle, swine, chickens (broilers and laying hens), turkeys, cats and dogs], for 11 bacterial species (Escherichia coli, Klebsiella pneumoniae, Mannheimia haemolytica, Pasteurella multocida, Actinobacillus pleuropneumoniae, Staphylococcus aureus, Staphylococcus pseudintermedius, Staphylococcus hyicus, Streptococcus uberis, Streptococcus dysgalactiae and Streptococcus suis). Relevant antimicrobials for their treatment were selected (e.g. tetracyclines) and complemented with antimicrobials of more specific public health interest (e.g. carbapenems). Molecular data detecting the presence of ESBLs, AmpC cephalosporinases and methicillin resistance shall be collected too. Conclusions: A preliminary EARS-Vet scope was defined, with the potential to fill important AMR monitoring gaps in the animal sector in Europe. It should be reviewed and expanded as the epidemiology of AMR changes, more countries participate and national monitoring capacities improve.

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000759761100041; volume:77; issue:3; firstpage:816; lastpage:826; numberofpages:11; journal:JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY; http://hdl.handle.net/11390/1225038Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85125212615

الإتاحة: https://doi.org/10.1093/jac/dkab462Test
http://hdl.handle.net/11390/1225038Test

المؤلفون: Béraud, Guillaume, Tubiana, Sarah, Erpelding, Marie-Line, Le-Moing, Vincent, Chirouze, Catherine, Gorenne, Isabelle, Manchon, Pauline, Tattevin, Pierre, Vernet-Garnier, Véronique, Varon, Emmanuelle, Hoen, Bruno, Duval, Xavier, Obadia, J., Leport, C., Poyart, C., Revest, M., Selton-Suty, C., Strady, C., Vandenesch, F., Bernard, Y., Chocron, S., Plesiat, P., Abouliatim, I., de Place, C., Donnio, P., Alla, F., Carteaux, J., Doco-Lecompte, T., Lion, C., Aissa, N., Baehrel, B., Jaussaud, R., Nazeyrollas, P., Cambau, E., Iung, B., Nataf, P., Chidiac, C., Celard, M., Delahaye, F., Aumaître, H., Frappier, J., Oziol, E., Sotto, A., Sportouch, C., Bouvet, A., Bes, M., Abassade, P., Abrial, E., Acar, C., Alexandra, J., Amireche, N., Amrein, D., Andre, P., Appriou, M., Arnould, M., Atoui, A., Aziza, F., Baille, N., Bajolle, N., Battistella, P., Baumard, S., Ben Ali, A., Bertrand, J., Bialek, S., Bois Grosse, M., Boixados, M., Borlot, F., Bouchachi, A., Bouche, O., Bouchemal, S., Bourdon, J., Brasme, L., Bruntz, J., Cailhol, J., Caplan, M.P., Carette, B., Cartry, O., Cazorla, C., Chamagne, H., Champagne, H., Chanques, G., Chevalier, B., Chometon, F., Christophe, C., Colin de Verdiere, N., Daneluzzi, V., David, L., Danchin, N., de Lentdecker, P., Delcey, V., Deleuze, P., Deroure, B., Descotes-Genon, V., Didier Petit, K., Dinh, A., Doat, V., Duchene, F., Duhoux, F., Dupont, M., Ederhy, S., Epaulard, O., Evest, M., Faucher, J., Fauveau, E., Ferry, T., Fillod, M., Floch, T., Fraisse, T., Frapier, J., Freysz, L., Fumery, B., Gachot, B., Gallien, S., Garcon, P., Gaubert, A., Genoud, J., Ghiglione, S., Godreuil, C., Gandjbakhch, I., Grentzinger, A., Groben, L., Gherissi, D., Hagege, A., Hammoudi, N., Heliot, F., Henry, P., Houriez, P., Hustache-Mathieu, L., Huttin, O., Imbert, S., Jaureguiberry, S., Kaaki, M., Konate, A., Kuhn, J., Kural Menasche, S., Lafitte, A., Lafon, B., Lanternier, F., Le Chenault, V., Lechiche, C., Lefevre Thibaut, S., Lefort, A., Lemoine, J., Lepage, L., Lepousé, C., Leroy, J., Lesprit, P., Letranchant, L., Loncar, G., Lorentz, C., Magnin-Poull, I., Makinson, A., Man, H., Mansouri, M., Marçon, O., Maroni, J., Masse, V., Maurier, F., Mechaï, F., Merceron, O., Messika-Zeitoun, D., Metref, Z., Meyssonnier, V., Mezher, C., Micheli, S., Monsigny, M., Mouly, S., Mourvillier, B., Nallet, O., Nazerollas, P., Noel, V., Payet, B., Pelletier, A., Perez, P., Petit, J., Philippart, F., Piet, E., Plainvert, C., Popovic, B., Porte, J., Pradier, P., Ramadan, R., Richemond, J., Rodermann, M., Roncato, M., Roigt, I., Ruyer, O., Saada, M., Schwartz, J., Simon, M., Simorre, B., Skalli, S., Spatz, F., Sudrial, J., Tartiere, L., Terrier de La Chaize, A., Thiercelin, M., Thomas, D., Thomas, M., Toko, L., Tournoux, F., Tristan, A., Trouillet, J., Tual, L., Verdier, F., Vernet Garnier, V., Vidal, V., Weyne, P., Wolff, M., Wynckel, A., Zannad, N., Zinzius, P., Ploy, M.-C., Caron, F., Bollaert, P.-E., Gaillot, O., Taha, M.-K., Bonacorsi, S., Lecuit, M., Gravet, A., Frachet, B., Debroucker, T., Levy-Bruhl, D., Raffi, F., Preau, M., Anguel, N., Argaud, L., Arista, S., Armand-Lefevre, L., Balavoine, S., Baraduc, R., Barnaud, G., Bernard, L., Bernars, G., Bertei, D., Bessede, E., Billard Pomares, T., Biron, C., Bland, S., Boileau, J., Boubeau, P., Bourdon, S., Bousquet, A., Boyer, S., Bozorg-Grayeli, A., Bret, L., Bretonniere, C., Bricaire, F., Brocas, E., Brun, M., Buret, J., Burucoa, C., Cabalion, J., Cabon, M., Camuset, G., Canevet, C., Carricajo, A., Castan, B., Caumes, E., Cazanave, C., Chabrol, A., Challan-Belval, T., Chanteperdrix-Marillier, V., Chaplain, C., Charlier-Woerther, C., Chaussade, H., Clair, B., Colot, J., Conil, J.-M., Cordel, H., Cormier, P., Cousson, J., Cronier, P., Cua, E., Dao-Dubremetz, A., Dargere, S., Degand, N., Dekeyser, S., Delaune, D., Denes, E., Dequin, P.-F., Descamps, D., Descloux, E., Desmaretz, J.-L., Diehl, J.-L., Dimet, J., Escaut, L., Fabe, C., Faibis, F., Flateau, C., Fonsale, N., Forestier, E., Fortineau, N., Gagneux-Brunon, A., Garandeau, C., Garcia, M., Garot, D., Gaudry, S., Goehringer, F., Gregoire-Faucher, V., Grosset, M., Gubavu, C., Gueit, I., Guelon, D., Guimard, T., Guinard, J., Hadou, T., Helene, J.-P., Henard, S., Henry, B., Hochart, A.-C., Illes, G., Jaffuel, S., Jarrin, I., Jaureguy, F., Joseph, C., Juvin, M.-E., Kayal, S., Kerneis, S., Lacassin, F., Lamaury, I., Lanotte, P., Laurens, E., Laurichesse, H., Le Brun, C., Le Turnier, P., Lecuyer, H., Ledru, S., Legrix, C., Lemaignen, A., Lemble, C., Lemee, L., Lesens, O., Levast, M., Lhommet, C., Males, S., Malpote, E., Martin-Blondel, G., Marx, M., Masson, R., Matray, O., Mbadi, A., Mellon, G., Merens, A., Meyohas, M.-C., Michon, A., Mootien Yoganaden, J., Morquin, D., Mrozek, N., Nguyen, S., Nguyen, Y., Ogielska, M., Page, B., Patrat-Delon, S., Patry, I., Pechinot, A., Picot, S., Pierrejean, D., Piroth, L., Plassart, C., Plessis, P., Portel, L., Poubeau, P., Poupard, M., Prazuck, T., Quaesaet, L., Ramanantsoa, A., Rapp, C., Raskine, L., Raymond, J., Riche, A., Robaday-Voisin, S., Robin, F., Romaszko, J.-P., Rousseau, F., Roux, A.-L., Royer, C., Salmon, D., Saroufim, C., Schmit, J.-L., Sebire, M., Segonds, C., Sivadon-Tardy, V., Soismier, N., Son, O., Sunder, S., Suy, F., Tande, D., Tankovic, J., Valin, N., van Grunderbeeck, N., Verdon, R., Vergnaud, M., Vernet-Garnier, V., Vidal, M., Vitrat, V., Vittecoq, D., Vuotto, F., Laouenan, C., Marcault, E., Mentre, F., Pasquet, B., Roy, C.

المساهمون: Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Centre d'investigation Clinique CHU Bichat - Épidémiologie clinique (CIC 1425), AP-HP - Hôpital Bichat - Claude Bernard Paris, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre d'investigation clinique - Epidémiologie clinique Nancy (CIC-EC), Centre d'investigation clinique Nancy (CIC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL)-Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département Maladies Infectieuses et Tropicales, Hôpital Universitaire, Montpellier, France, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Recherches Translationnelles sur le VIH et les maladies infectieuses endémiques et émergentes (TransVIHMI), Institut de Recherche pour le Développement (IRD)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Laboratoire Chrono-environnement (UMR 6249) (LCE), Centre National de la Recherche Scientifique (CNRS)-Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté COMUE (UBFC)-Université Bourgogne Franche-Comté COMUE (UBFC), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Hôpital universitaire Robert Debré Reims (CHU Reims), CHU Henri Mondor Créteil, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre

المصدر: ISSN: 2193-8229.

مصطلحات موضوعية: Austrian syndrome, Bacterial meningitis, Echocardiography, Infective endocarditis, Staphylococcus, Streptococcus, [SDV]Life Sciences [q-bio], [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

الوصف: Auteurs groupes collaboratifs AEPEI study group & the COMBAT study group ; International audience ; Introduction: We aimed to describe patients with coexisting infective endocarditis (IE) and bacterial meningitis (BM).Methods: We merged two large prospective cohorts, an IE cohort and a BM cohort, with only cases of definite IE and community-acquired meningitis. We compared patients who had IE and BM concurrently to patients with IE only and BM only.Results: Among the 1030 included patients, we identified 42 patients with IE-BM (4.1%). Baseline characteristics of patients with IE-BM were mostly similar to those of patients with IE, but meningitis was the predominant presentation at admission (39/42, 92.3%). Causative pathogens were predominantly Streptococcus pneumoniae (18/42, 42.9%) and Staphylococcus aureus (14/42, 33.3%). All pneumococcal IE were associated with BM (18/18). BM due to oral and group D streptococci, Streptococcus agalactiae, and S. aureus were frequently associated with IE (14/30, 46.7%). Three-month mortality was 28.6% in patients with IE-BM, 20.5% in patients with IE, and 16.6% in patients with BM.Conclusions: Patients with pneumococcal IE or altered mental status during IE must be investigated for BM. Patients with S. aureus, oral and group D streptococcal or enterococcal BM, or unfavorable outcome in pneumococcal meningitis would benefit from an echocardiography. Patients with the dual infection have the worst prognosis. Their identification is mandatory to initiate appropriate treatment.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35618954; hal-03680022; https://hal.science/hal-03680022Test; https://hal.science/hal-03680022/documentTest; https://hal.science/hal-03680022/file/2022%20B%C3%A9raud%20et%20al.,%20Combined.pdfTest; PUBMED: 35618954; PUBMEDCENTRAL: PMC9334461; WOS: 000805464100002

الإتاحة: https://doi.org/10.1007/s40121-022-00651-7Test
https://hal.science/hal-03680022Test
https://hal.science/hal-03680022/documentTest
https://hal.science/hal-03680022/file/2022%20B%C3%A9raud%20et%20al.,%20Combined.pdfTest

المؤلفون: Bataille, C., Venier, A.-G., Caire, F., Salle, H., Le Guyader, A., Pesteil, F., Chauvet, R., Marcheix, P.-S., Valleix, D., Fourcade, L., Aubry, K., Brie, J., Robert, P.-Y., Pefau, M., Ploy, M.-C., D’hollander-Pestourie, N., Couve-Deacon, E.

المساهمون: Service de Bactériologie, Virologie, Hygiène CHU Limoges, CHU Limoges, Centre régional de prévention Des Infections associées Aux Soins (CPias), Service de Neurochirurgie CHU Limoges, Service de chirurgie cardiaque CHU Limoges, Service de Chirurgie Thoracique et Vasculaire - Médecine vasculaire CHU Limoges, Service de Chirurgie orthopédique et traumatologique CHU Limoges, Service de Chirurgie digestive, endocrinienne et générale CHU Limoges, Service de chirurgie pédiatrique viscérale, orthopédique et plastique CHU Limoges, Service d'Oto-rhino-laryngologie (ORL) et chirurgie cervico-faciale CHU Limoges, Service de Chirurgie maxillo-faciale, réparatrice et stomatologie CHU Limoges, Service d'Ophtalmologie CHU Limoges

المصدر: ISSN: 0195-6701.

مصطلحات موضوعية: [CHIM.MATE]Chemical Sciences/Material chemistry, [SPI.MAT]Engineering Sciences [physics]/Materials

الوصف: International audience

العلاقة: hal-03390284; https://unilim.hal.science/hal-03390284Test; https://unilim.hal.science/hal-03390284/documentTest; https://unilim.hal.science/hal-03390284/file/S0195670121002759.pdfTest; PII: S0195-6701(21)00275-9

الإتاحة: https://doi.org/10.1016/j.jhin.2021.08.001Test
https://unilim.hal.science/hal-03390284Test
https://unilim.hal.science/hal-03390284/documentTest
https://unilim.hal.science/hal-03390284/file/S0195670121002759.pdfTest

المؤلفون: Tubiana, S., Varon, E., Biron, C., Ploy, M.-C., Mourvillier, B., Taha, Muhamed-Kheir, Revest, M., Poyart, C., Martin-Blondel, Guillaume, Lecuit, M., Cua, E., Pasquet, B., Préau, M., Hoen, B., Duval, X.

المساهمون: Infection, Anti-microbiens, Modélisation, Evolution (IAME (UMR_S_1137 / U1137)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, CIC - CHU Bichat, Institut National de la Santé et de la Recherche Médicale (INSERM), Centre National de Référence des Pneumocoques (CNRP), Assistance Publique - Hôpitaux de Paris, Département des Maladies Infectieuses CHU Nantes, Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), CHU Limoges, Centre Collaborateur de l'OMS pour les méningites bactériennes - WHO Collaborating Center Bacterial Meningitis (CC-OMS - WHO-CC), Institut Pasteur Paris (IP)-Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO), Service des maladies infectieuses et réanimation médicale Rennes = Infectious Disease and Intensive Care Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, ARN régulateurs bactériens et médecine (BRM), Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre national de Référence des Streptocoques (CNR), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service Maladies infectieuses et tropicales CHU Toulouse, Pôle Inflammation, infection, immunologie et loco-moteur CHU Toulouse (Pôle I3LM Toulouse), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Centre de Physiopathologie Toulouse Purpan (CPTP), Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Université Paris Descartes - Paris 5 (UPD5), Centre National de Référence Listeria - National Reference Center Listeria (CNRL), Institut Pasteur Paris (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre collaborateur de l'OMS Listeria / WHO Collaborating Centre Listeria (CC-OMS / WHO-CC), Service des Maladies infectieuses et tropicales CHU Necker, Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service d'infectiologie CHU Nice, Centre Hospitalier Universitaire de Nice (CHU Nice), AP-HP - Hôpital Bichat - Claude Bernard Paris, Groupe de Recherche en Psychologie Sociale (GRePS), Université Lumière - Lyon 2 (UL2), Service des Maladies Infectieuses et Tropicales CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), F-CRIN, Innovative clinical research network in vaccinology (I-REIVAC), This work was supported by the Assistance Publique Hopitaux de Paris, French Ministry of Health, Inserm, SPILF, and the Pfizer Pharmaceutical company, which also funded ORP. The study was endorsed by the following professional organizations: Association Pour l'enseignement de la Thérapeutique, Société de Pathologie Infectieuse de Langue Française, Société Française de Microbiologie, Société Nationale Française de Médecine Interne, Société de Réanimation de Langue Française, Société Française de Gérontologie, Société Française d'Anesthésie-Réanimation., COMBAT study group : Principal investigator: DUVAL Xavier. Steering Committee: HOEN Bruno, MOURVILLIER Bruno, PLOY Marie-Cécile, TUBIANA Sarah, VARON Emmanuelle. Scientific committee: steering committee and the following members CARON François, BOLLAERT Pierre-Edouard, GAILLOT Olivier, TAHA Muhamed-Kheir, POYART Claire, BONACORSI Stephane, VANDENESCH François, CAMBAU Emmanuelle, LECUIT Marc, GRAVET Alain, FRACHET Bruno, De BROUCKER Thomas, LEVY BRUHL Daniel, RAFFI François. COMBAT Clinical Centres: ANGUEL Nadia, ARGAUD Laurent, ARISTA Sophie, ARMAND-LEFEVRE Laurence, BALAVOINE Stéphanie, BARADUC Régine, BARNAUD Guilène, BERAUD Guillaume, BERNARD Louis, BERNARS Georges, BERTEI Dominique, BESSEDE Emilie, BILLARD POMARES Typhaine, BIRON Charlotte, BLAND Stéphane, BOILEAU Julien, BOUBEAU Patrice, BOURDON Sandra, BOUSQUET Aurore, BOYER Sophie, BOZORG-GRAYELI Alexis, BRET Laurent, BRETONNIERE Cédric, BRICAIRE François, BROCAS Elsa, BRUN Michel, BURET Jennifer, BURUCOA Christophe, CABALION Jean, CABON Mathieu, CAMBAU Emmanuelle, CAMUSET Guillaume, CANEVET Christophe, CARON François, CARRICAJO Anne, CASTAN Bernard, CAUMES Eric, CAZANAVE Charles, CHABROL Amélie, CHALLAN-BELVAL Thibaut, CHANTEPERDRIX-MARILLIER Vanessa, CHAPLAIN Chantal, CHARLIER-WOERTHER Caroline, CHAUSSADE Hélène CHIROUZE Catherine, CLAIR Bernard, COLOT Julien, CONIL Jean-Marie, CORDEL Hugues, CORMIER Philippe, COUSSON Joël, CRONIER Pierrick, CUA Eric, DAO-DUBREMETZ Anne, DARGERE Sylvie, DEGAND Nicolas, DEKEYSER Sophie, DELAUNE Deborah, DENES Eric, DEQUIN Pierre-Francois, DESCAMPS Diane, DESCLOUX Elodie, DESMARETZ Jean-Luc, DIEHL Jean-Luc, DIMET Jérôme, DINH Aurélien, DUVAL Xavier, ESCAUT Lelia, FABE Claude, FAIBIS Frédéric, FLATEAU Clara, FONSALE Nathalie, FORESTIER Emmanuel, FORTINEAU Nicolas, GAGNEUX-BRUNON Amandine, GARANDEAU, GARCIA Magali, GAROT Denis, GAUDRY Stéphane, GOEHRINGER François, GRAVET Alain, GREGOIRE-FAUCHER Valérie, GROSSET Marine, GUBAVU Camélia, GUEIT Isabelle, GUELON Dominique, GUIMARD Thomas, GUINARD Jérôme, HADOU Tahar, HELENE Jean-Pierre, HENARD Sandrine, HENRY Benoit, HOCHART Anne-Cécile, HOEN Bruno, ILLES Gabriela, JAFFUEL Sylvain, JARRIN Irène, JAUREGUY Françoise, JOSEPH Cédric, JUVIN Marie-Emmanuelle, KAYAL Samer, LACASSIN Flore, LAMAURY Isabelle, LANOTTE Philippe, LAURENS Etienne, LAURICHESSE Henri, LE BRUN Cécile, LE MOING Vincent, LE TURNIER Paul, LECUYER Hervé, LEDRU Sylvie, LEGRIX Céline, LEMAIGNEN Adrien, LEMBLE Chantal, LEMEE Ludovic, LESENS Olivier, LEVAST Marion, LHOMMET Claire, MALES Silvija, MALPOTE Edith, MARTIN-BLONDEL Guillaume, MARX Matthieu, MASSON Raphael, MATRAY Olivier, MBADI Aurore, MECHAI Frédéric, MELLON Guillaume, MERENS Audrey, MEYOHAS Marie Caroline, MICHON Adrien, MOOTIEN YOGANADEN Joy, MORQUIN David, MOULY Stéphane, MROZEK Natacha, NGUYEN Sophie, NGUYEN Yohan, OGIELSKA Maja, OZIOL Eric, PAGE Bernard, PATRAT-DELON Solène, PATRY Isabelle, PECHINOT André, PICOT Sandrine, PIERREJEAN, PIROTH Lionel, PLASSART Claire, PLESSIS Patrice, PLOY Marie-Cécile, PORTEL Laurent, POUBEAU Patrice, POUPARD Marie, POYART Claire, PRAZUCK Thierry, QUAESAET Luc, RAFFI François, RAMANANTSOA Adriatsiferana, RAPP Christophe, RASKINE Laurent, RAYMOND Josette, REVEST Matthieu, RICHE Agnès, ROBADAY-VOISIN Stéphanie, ROBIN Frédéric, ROMASZKO JP, ROUSSEAU Florence, ROUX Anne-Laure, ROYER Cecile, SAADA Matthieu, SALMON Dominique, SAROUFIM Carlo, SCHMIT Jean Luc, SEBIRE Manuela, SEGONDS Christine, SIVADON-TARDY Valérie, SOISMIER Nathalie, Solen KERNEIS, SON Olivia, SUNDER Simon, SUY Florence, TANDE Didier, TANKOVIC Jacques, VALIN Nadia, VAN GRUNDERBEECK Nicolas, VANDENESCH François, VARON Emmanuelle, VERDON Renaud, VERGNAUD Michel, VERNET-GARNIER Véronique, VIDAL Magali, VITRAT Virginie, VITTECOQ Daniel, VUOTTO Fanny. Coordination and statistical analyses (Clinical trial unit, Hôpitaux Universitaires Paris Nord Val de Seine, AP-HP, Paris): GORENNE Isabelle, LAOUENAN Cédric, MARCAULT Estelle, MENTRE France, PASQUET Blandine, ROY Carine, TUBIANA Sarah. Scientific partnership: SPLIF, CMIT, SRLF, SFM, REIVAC, SFORL, APNET, SPF. Partners: ORP (MC PLOY), GPIP/ACTIV (Corinne Levy).

المصدر: ISSN: 1198-743X.

مصطلحات موضوعية: Bacterial, Community-acquired, Determinants, Long-term outcome, Prognosis, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases

الوصف: International audience ; Objectives - To identify factors associated with unfavourable in-hospital outcome (death or disability) in adults with community-acquired bacterial meningitis (CABM). Methods - In a prospective multicentre cohort study (COMBAT; February 2013 to July 2015), all consecutive cases of CABM in the 69 participating centres in France were enrolled and followed up for 12 months. Factors associated with unfavourable outcome were identified by logistic regression and long-term disability was analysed. Results - Among the 533 individuals enrolled, (Streptococcus pneumoniae 53.8% (280/520 isolates identified), Neisseria meningitidis 21.3% (111/520), others 24.9% (129/520)), case fatality rate was 16.9% (90/533) and unfavourable outcome occurred in 45.0% (225/500). Factors independently associated with unfavourable outcome were: age >70 years (adjusted odds ratio (aOR) 4.64; 95% CI 1.93-11.15), male gender (aOR 2.11; 95% CI 1.25-3.57), chronic renal failure (aOR 6.65; 95% CI 1.57-28.12), purpura fulminans (aOR 4.37; 95% CI 1.38-13.81), localized neurological signs (aOR 3.72; 95% CI 2.29-6.05), disseminated intravascular coagulation (aOR 3.19; 95% CI 1.16-8.79), cerebrospinal fluid (CSF) white-cell count <1500 cells/μL (aOR 2.40; 95% CI 1.42-4.03), CSF glucose concentration (0.1-2.5 g/L: aOR 1.92; 95% CI 1.01-3.67; <0.1 g/L: aOR 2.24; 95% CI 1.01-4.97), elevated CSF protein concentration (aOR 1.09; 95% CI 1.03-1.17), time interval between hospitalization and lumbar puncture >1 day (aOR 2.94; 95% CI 1.32-6.54), and S. pneumoniae meningitis (aOR 4.99; 95% CI 1.98-12.56), or meningitis other than N. meningitidis (aOR 4.54; 95% CI 1.68-12.27). At 12 months, 26.7% (74/277) had hearing loss, 32.8% (87/265) depressive symptoms, 31.0% (86/277) persistent headache, and 53.4% had a physical health-related quality of life (142/266) <25th centile of the distribution of the score in the general French population (p < 0.0001). Conclusions - The burden of CABM (death, disability, depression, ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/31927117; pasteur-02618662; https://pasteur.hal.science/pasteur-02618662Test; https://pasteur.hal.science/pasteur-02618662/documentTest; https://pasteur.hal.science/pasteur-02618662/file/S1198743X19306792.pdfTest; PII: S1198-743X(19)30679-2; PUBMED: 31927117

الإتاحة: https://doi.org/10.1016/j.cmi.2019.12.020Test
https://pasteur.hal.science/pasteur-02618662Test
https://pasteur.hal.science/pasteur-02618662/documentTest
https://pasteur.hal.science/pasteur-02618662/file/S1198743X19306792.pdfTest

المؤلفون: Buelow, E, Rico, A, Gaschet, M, Lourenço, J, Kennedy, SP, Wiest, L, Ploy, M-C, Dagot, C

الوصف: Wastewaters (WW) are important sources for the dissemination of antimicrobial resistance (AMR) into the environment. Hospital WW (HWW) contain higher loads of micro-pollutants and AMR markers than urban WW (UWW). Little is known about the long-term dynamics of H and U WW and the impact of their joined treatment on the general burden of AMR. Here, we characterized the resistome, microbiota and eco-exposome signature of 126 H and U WW samples treated separately for three years, and then mixed, over one year. Multi-variate analysis and machine learning revealed a robust signature for each WW with no significant variation over time before mixing, and once mixed, both WW closely resembled Urban signatures. We demonstrated a significant impact of pharmaceuticals and surfactants on the resistome and microbiota of H and U WW. Our results present considerable targets for AMR related risk assessment of WW.

العلاقة: https://ora.ox.ac.uk/objects/uuid:4e9a25f5-f1c8-4dc0-a0b3-1314a83d1da1Test; https://doi.org/10.1016/j.wroa.2020.100045Test

الإتاحة: https://doi.org/10.1016/j.wroa.2020.100045Test
https://ora.ox.ac.uk/objects/uuid:4e9a25f5-f1c8-4dc0-a0b3-1314a83d1da1Test

المؤلفون: Crémieux, A.-C., Armand Lefèvre, L., Jarlier, V., Ploy, M.-C., Buisson, Y.

المصدر: Bulletin de l'Académie Nationale de Médecine ; volume 204, issue 9, page 955-960 ; ISSN 0001-4079

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.banm.2020.09.037Test
https://api.elsevier.com/content/article/PII:S0001407920305112?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0001407920305112?httpAccept=text/plainTest

المؤلفون: Danis, K, Ploy, M C, Varon, E, Levy-Bruhl, D, Gaillat, J

المصدر: European Journal of Public Health ; volume 29, issue Supplement_4 ; ISSN 1101-1262 1464-360X

مصطلحات موضوعية: Public Health, Environmental and Occupational Health

الوصف: Pneumococcal vaccine serotypes and host factors may increase the risk of severe invasive pneumococcal disease (IPD). In France, pneumococcal vaccination in adults is recommended for at-risk groups (immunosuppression or at-risk conditions/diseases). In 2014-2017, we conducted a study of IPD in adults to identify factors/serotypes associated with disease severity. We included IPD cases, excluding meningitis, in adults from 25 acute-care sentinel hospitals in six regions. Severe cases were IPD patients either admitted to an ICU or under mechanical ventilation or with severe sepsis or shock. Infectious disease specialists collected clinical/microbiological data on all cases. We calculated adjusted risk ratios (aRR) using binomial regression. In 2014-2017, 908 cases (median age 71 (range 18-101) years) were diagnosed; 48%(431/908) were severe and 84%(764/908) were at-risk. Compared with non-risk individuals, the risk of severe disease increased from 20% (aRR 1.2; 95%CI 1.0-1.4) in cases with 1-2 chronic diseases to 30% (aHR 1.3; 95%CI 1.0-7.0) in those with >2 chronic diseases. The risk of severe disease was 42% (aRR 1.4; 95%CI 1.2-1.6) higher for PCV13 serotypes compared with non-vaccine serotypes. Among cases infected with PCV13 serotypes, the risk of severe disease did not differ (aRR 0.96; 95%CI 1.2-23) between no-risk or at-risk cases. However, among cases infected with non-vaccine serotypes, the risk increased 49% (aRR 1.5; 95%CI 2.1-22) in at-risk compared with no-risk cases (homogeneity test p = 0.03). We observed a cumulative effect of concurrent comorbidities on severe IPD outcomes. The risk of severe IPD increased for vaccine serotypes regardless of risk status. However, non-vaccine serotypes increased the risk of severe outcomes only in risk groups, suggesting a different interplay between host factors and the pathogen in vulnerable groups. We recommend enhancing vaccination among risk groups and especially in those most at risk for poor IPD-related outcomes. Key messages Cumulative effect ...

الإتاحة: https://doi.org/10.1093/eurpub/ckz187.160Test
http://academic.oup.com/eurpub/article-pdf/29/Supplement_4/ckz187.160/32629952/ckz187.160.pdfTest

المؤلفون: Lacotte, Y., François, B., Brun-Buisson, C., Jouvin-Marche, E., Ploy, M.-C.

المصدر: Bulletin de l'Académie Nationale de Médecine ; volume 203, issue 3-4, page 179-185 ; ISSN 0001-4079

مصطلحات موضوعية: General Medicine

الإتاحة: https://doi.org/10.1016/j.banm.2019.02.007Test
https://api.elsevier.com/content/article/PII:S0001407919300615?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0001407919300615?httpAccept=text/plainTest

المؤلفون: Ploy, M. C.

الإتاحة: https://doi.org/10.15454/em2doaTest
https://ciag.hub.inrae.fr/media/revues/volume-66-juin-2018/8Test-ploy

المؤلفون: Robin, F., Beyrouthy, R., Bonacorsi, S., Aissa, N., Bret, L., Brieu, N., Cattoir, V., Chapuis, A., Chardon, H., Degand, N., Doucet-Populaire, F., Dubois, V., Fortineau, N., Grillon, A., Lanotte, P., Leyssene, D., Patry, I., Podglajen, I., Recule, C., Ros, A., Colomb-Cotinat, M., Ponties, V., Ploy, M. C., Bonnet, R.

مصطلحات موضوعية: Mechanisms of Resistance

الوصف: The objective of this study was to perform an inventory of the extended-spectrum-β-lactamase (ESBL)-producing Enterobacteriaceae isolates responsible for infections in French hospitals and to assess the mechanisms associated with ESBL diffusion. A total of 200 nonredundant ESBL-producing Enterobacteriaceae strains isolated from clinical samples were collected during a multicenter study performed in 18 representative French hospitals. Antibiotic resistance genes were identified by PCR and sequencing experiments. The clonal relatedness between isolates was investigated by the use of the DiversiLab system. ESBL-encoding plasmids were compared by PCR-based replicon typing and plasmid multilocus sequence typing. CTX-M-15, CTX-M-1, CTX-M-14, and SHV-12 were the most prevalent ESBLs (8% to 46.5%). The three CTX-M-type EBSLs were significantly observed in Escherichia coli (37.1%, 24.2%, and 21.8%, respectively), and CTX-M-15 was the predominant ESBL in Klebsiella pneumoniae (81.1%). SHV-12 was associated with ESBL-encoding Enterobacter cloacae strains (37.9%). qnrB, aac(6′)-Ib-cr, and aac(3)-II genes were the main plasmid-mediated resistance genes, with prevalences ranging between 19.5% and 45% according to the ESBL results. Molecular typing did not identify wide clonal diffusion. Plasmid analysis suggested the diffusion of low numbers of ESBL-encoding plasmids, especially in K. pneumoniae and E. cloacae. However, the ESBL-encoding genes were observed in different plasmid replicons according to the bacterial species. The prevalences of ESBL subtypes differ according to the Enterobacteriaceae species. Plasmid spread is a key determinant of this epidemiology, and the link observed between the ESBL-encoding plasmids and the bacterial host explains the differences observed in the Enterobacteriaceae species.

العلاقة: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328551Test/; http://www.ncbi.nlm.nih.gov/pubmed/27956424Test; http://dx.doi.org/10.1128/AAC.01911-16Test

الإتاحة: https://doi.org/10.1128/AAC.01911-16Test
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5328551Test/
http://www.ncbi.nlm.nih.gov/pubmed/27956424Test