يعرض 1 - 10 نتائج من 44 نتيجة بحث عن '"Platelet to albumin ratio"', وقت الاستعلام: 0.88s تنقيح النتائج
  1. 1
    دورية أكاديمية

    المصدر: Journal of the Egyptian National Cancer Institute, Vol 36, Iss 1, Pp 1-8 (2024)

    الوصف: Abstract Background Esophageal cancer has a poor survival outcome with 5-year OS at 16.7% despite treatment. Some inflammation-based prognostic indicators like the neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) have been previously studied as potential biomarker for predicting outcome in esophageal cancer. Recently, platelet-to-albumin ratio (PAR) has been reported as a promising prognostic factor in gastrointestinal malignancies. Methods We performed a retrospective analysis of prospectively treated patients of carcinoma esophagus to evaluate the prognostic significance of inflammation-based prognostic indicators—neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and a composite inflammation-nutrition index: platelet-to-albumin ratio (PAR) in esophageal cancer. Based on previous studies, the optimal cut-off value of PAR was kept at 5.7 × 10^9, and 2.62 for NLR. Results A total of 71 patients of locally advanced esophageal cancer treated between 2019 and 2022, with either neoadjuvant or definitive chemoradiotherapy, were included. Median follow-up time was 19 months [range: 7–44 months]. Median OS and PFS in our study cohort were 11.3 months [range: 7–23 months] and 7.8 months [range: 3–17 months], respectively. In univariate analysis, lower PAR was found to be significantly correlated with shorter survival time (HR = 2.41; 1.3–4.76; p = 0.047). There was no association found between the OS and the NLR [HR = 1.09; 0.95–1.26; p = 0.222]. Univariate and multivariate linear and logistic regressions found no association between V15, V10, V5, or V2 of spleen and nadir lymphocyte count or between Dmax or Dmean and nadir lymphocyte counts. Conclusion Present analysis found a trend toward an inverse association between PAR and OS. PAR, in the not-so-distant future, may evolve as a novel, convenient, and inexpensive prognostic indicator in esophageal cancer.

    وصف الملف: electronic resource

  2. 2
    دورية أكاديمية

    المؤلفون: Jun Huang, Jie Lu, Feiyu Jiang, Tiejun Song

    المصدر: BMC Gastroenterology, Vol 23, Iss 1, Pp 1-11 (2023)

    الوصف: Abstract Background Endoscopy is currently recognized as the gold standard for assessing inflammatory bowel disease (IBD) severity. However, because the procedure is costly and invasive, endoscopy is not suitable for frequently monitoring intestinal inflammation. In this study, our aim was to identify noninvasive, low cost, and convenient biomarkers for identifying endoscopic IBD activity. Methods In total, 246 patients with IBD (131 with Ulcerative colitis (UC) and 115 with Crohn’s disease (CD)) and 369 healthy controls were recruited for this retrospective study. IBD activity was evaluated using endoscopic and clinical examinations. The potential of several inflammatory biomarkers, including platelets (PLT), plateletcrit (PCT), albumin (ALB), highly sensitive C-reactive protein (hs-CRP), erythrocyte sedimentation rate (ESR), and platelet-to-albumin ratio (PLT/ALB) to assess endoscopic IBD activity was evaluated using receiver operating characteristic (ROC) analyses. Results PLT/ALB ratio, PLT, ALB, and hs-CRP levels were correlated with Mayo scores in UC patients, while PCT, PLT, fibrinogen (FIB), PLT/ALB ratio, hs-CRP, and ESR levels were correlated with Simple Endoscopic Scores for CD (SES-CD) in CD patients. ROC analyses showed that the area under the curve (AUC) value for the PLT/ALB ratio (0.705) was greater than hs-CRP (0.607) and ESR (0.552) values in UC patients. The AUC value for PCT (0.779) was greater than hs-CRP (0.698) and ESR (0.746) values in CD patients. Conclusion PLT/ALB ratio and PCT biomarkers were the most appropriate of all tested inflammatory biomarkers for assessing endoscopic IBD activity in UC and CD patients, respectively.

    وصف الملف: electronic resource

  3. 3
    دورية أكاديمية

    المؤلفون: Xu H, Zheng L, Wang L, Gao H, Wei Y, Chen J

    المصدر: Neuropsychiatric Disease and Treatment, Vol Volume 19, Pp 2027-2037 (2023)

    الوصف: Haiting Xu,1 Lina Zheng,2 Leilei Wang,1 Huanqin Gao,1 Yanyan Wei,1 Jingxu Chen1 1Psychology and Psychiatric Department, Beijing Hui-Long-Guan Hospital, Peking University, Beijing, People’s Republic of China; 2Psychology and Psychiatric Department, Liaocheng People’s Hospital, Liaocheng, People’s Republic of ChinaCorrespondence: Jingxu Chen, Email chenjx1110@163.comBackground: Inflammation is relevant to the pathophysiology of severe neuropsychiatric disorders, schizophrenia (SCZ) and bipolar disorders (BD). Multiple pathophysiological biomarkers are valuable for the study of inflammatory processes. This study investigated albumin-related biomarkers in SCZ and BD to explore their roles in disease.Methods: A total of 5,577 SCZ, 3442 BD-manic (BD-M) and 1405 BD-depression (BD-D) in acute stage and 5000 health controls (HCs) were enrolled. The differences in these biomarker levels among different groups were compared, and the contributing factors for the occurrence of SCZ, BD, and subgroups of BD were analyzed.Results: Both SCZ and BD exhibit lower prognostic nutritional index (PNI), but higher neutrophil percentage-to-albumin ratio (NPAR) and creatinine–albumin ratio (CRA) compared with HC. Compared with BD-D, BD-M had higher NPAR and platelet-to-albumin ratio (PAR) and lower CRA. In logistic regression, lower prognostic nutritional index (PNI) and higher CRA were associated with both SCZ and BD, while higher NPAR was associated with BD. In the subgroup of BD, higher NPAR, CRA and lower PNI were associated with BD-M; lower PAR, PNI and higher CRA were associated with BD-D.Conclusion: Our study reaffirmed the role of inflammation in the pathophysiology of SCZ and BD. Diagnostic value has been demonstrated in NPAR, PAR, PNI and CRA for BD and SCZ.Keywords: schizophrenia, bipolar disorder, inflammation, albumin, neutrophil percentage-to-albumin ratio, platelet to albumin ratio, prognostic nutritional index

    وصف الملف: electronic resource

    العلاقة: https://www.dovepress.comTest/albumin-and-associated-biomarkers-in-severe-neuropsychiatric-disorders-peer-reviewed-fulltext-article-NDT; https://doaj.org/toc/1178-2021Test

  4. 4
    دورية أكاديمية

    المصدر: BMC Anesthesiology, Vol 23, Iss 1, Pp 1-9 (2023)

    الوصف: Abstract Background The aim of this study was to investigate the prognostic role of platelet to albumin ratio (PAR) and in persistent acute kidney injury (pAKI) of patients admitted to the intensive care unit (ICU). Methods We involved pAKI patients from the Medical Information Mart for Intensive Care-IV (MIMIC-IV) database and eICU Collaborative Research Database (eICU-CRD). Receiver operating curve (ROC) analysis was performed to evaluate the optimal cut-off PAR. Results A total of 7,646 patients were finally included in the present study. The optimal cut-off value of PAR was 7.2. The high-PAR group was associated with pAKI (hazard ratio [HR]: 3.25, 95% CI: 2.85–3.72, P

    وصف الملف: electronic resource

  5. 5
    دورية أكاديمية

    المصدر: Journal of Clinical Medicine, Vol 13, Iss 4, p 991 (2024)

    الوصف: Background: IgA nephropathy (IgAN) is associated with chronic inflammation. Platelet-related parameters, such as the platelet (PLT) count, platelet-to-albumin ratio (PAR), and platelet-to-lymphocyte ratio (PLR), were examined as potential prognostic indicators for renal and cardiovascular (CV) outcomes in IgAN. We were interested in whether platelet-related parameters are risk factors for ESKD and CV events in IgAN patients. Methods: In a monocentric retrospective study, 124 IgAN patients were divided into two groups based on the cut-off value of the PAR. All-cause mortality, major CV events, and end-stage renal disease were the primary combined endpoints. Secondary endpoints, such as CV or renal endpoints, were also analyzed separately. Results: The patients’ mean age was 43.7 ± 13.5 years, and the follow-up time was 124 ± 67 months. The K-M curve showed that the PLR, PAR, and PLT were strongly associated with primary combined (p = 0.002, p = 0.004, p = 0.001) and renal outcomes (p < 0.001, p < 0.001, p < 0.001), but not with CV outcomes in IgAN. However, when combined with left ventricular hypertrophy (LVH) or metabolic syndrome (MetS), the PAR was found to be a significant predictor of both primary (p < 0.001, p < 0.001) and secondary outcomes (p = 0.001 and p = 0.038; p = 0.001 and p = 0.015). Additionally, the PLR correlated with albuminuria (r = −0.165, p = 0.033) and LVH (r = −0.178, p = 0.025), while PLT correlated with eGFR (r = 0.158, p = 0.040). Conclusions. Elevated PARs and PLRs may predict progression to end-stage kidney disease, but in combination with LVH and MetS, they were related to CV events in IgAN. The determination of PARs and PLRs can be useful and cost-effective parameters for assessing both cardiovascular and renal risks in IgAN.

    وصف الملف: electronic resource

  6. 6
    دورية أكاديمية

    المؤلفون: He Z, Wang H, Wang S, Li L

    المصدر: International Journal of General Medicine, Vol Volume 15, Pp 8315-8326 (2022)

    الوصف: Zhenshuo He,1,* Haizhi Wang,2,* Shan Wang,3,* Lu Li4 1Department of Laboratory Medicine, The Sixth People’s Hospital of Hengshui City, Hengshui, 053099, People’s Republic of China; 2Department of Laboratory Medicine, The People’s Hospital of Hengshui City, Hengshui, 053099, People’s Republic of China; 3Department of Laboratory Medicine, The People’s Hospital of Huangmei, Huanggang, 435599, People’s Republic of China; 4Department of Nephrology, The First People’s Hospital of Jiangxia District, Wuhan, 430299, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lu Li, Department of Nephrology, The first People’s hospital of jiangxia district, No. 1 of Cultural Avenue, Wuhan, 430299, People’s Republic of China, Tel +86027-87958740, Email 307034153@qq.comBackground: We wanted to demonstrate whether the initial platelet-to-albumin ratio (PAR) had predictive value for cardiac surgery-associated acute kidney injury (CSA-AKI) and prognosis of critical care patients.Methods: This is an observational and multi-center study from the MIMIC-IV database, the eICU-CRD database as well as CS patients at our institution. Logistic regression and Cox regression analyses were applied to determine the predictive value for CSA-AKI and in-hospital mortality. LASSO and SVM-RFE models were then employed to discover the coincident variables connected with CSA-AKI. The main objective of this research was the incidence of CSA-AKI, whereas the secondary endpoint was in-hospital death.Results: The higher PAR value (≥ 4.67) had a higher risk of CSA-AKI (adjusted OR = 4.02, 95% CI 3.41– 4.75, P < 0.001) and in-hospital mortality (HR = 2.41 95% CI 1.44– 4.03, P = 0.001) after adjusted for other confounding factors including patients with or without chronic kidney disease. The proposed nomogram based on PAR and others clinical factors selected by LASSO and SVM-RFE models for CSA-AKI had the C-index 0.821 (95% CI 0.807– 0.834), 0.808 (95% CI 0.787– 0.829), 0.745 (95% CI 0.728– 0.762), and 0.826 (95% CI 0.753– 0.899) in these cohorts, respectively. The nomogram exhibited both remarkable calibration capacity and therapeutic helpfulness in all groups.Conclusion: PAR is a relative excellent measure for the event AKI and prognosis of ICU patients who undergone CS. The suggested nomogram based on PAR resulted in an accurate prediction for the detection of critical care patients with CSA-AKI.Keywords: platelet to albumin ratio, cardiac surgery, acute kidney injury, nomograms, prognosis

    وصف الملف: electronic resource

    العلاقة: https://www.dovepress.com/predictive-value-ofTest-platelet-to-albumin-ratio-par-for-the-cardiac-asso-peer-reviewed-fulltext-article-IJGM; https://doaj.org/toc/1178-7074Test

  7. 7
    دورية أكاديمية

    المصدر: Therapeutics and Clinical Risk Management, Vol Volume 18, Pp 421-428 (2022)

    الوصف: Ahmet Kucuk,1 Erkan Topkan,2 Ugur Selek,3,4 Veysel Haksoyler,5 Huseyin Mertsoylu,6 Ali Ayberk Besen,6 Berrin Pehlivan7 1Clinic of Radiation Oncology, Mersin Education and Research Hospital, Mersin, Turkey; 2Department of Radiation Oncology, Baskent University Medical Faculty, Adana, Turkey; 3Department of Radiation Oncology, Koc University School of Medicine, Istanbul, Turkey; 4Division of Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; 5Clinics of Medical Oncology, Medline Hospital, Adana, Turkey; 6Department of Medical Oncology, Baskent University Medical Faculty, Adana, Turkey; 7Department of Radiation Oncology, Bahcesehir University, Istanbul, TurkeyCorrespondence: Erkan Topkan, Department of Radiation Oncology, Baskent University Medical Faculty, Adana, Turkey, Tel +90-533-7381069, Fax +90-322-3444452, Email docdretopkan@gmail.comPurpose: In a lack of similar research, we meant to retrospectively investigate the prognostic significance of pre-chemoradiotherapy (C-CRT) platelet-to-albumin ratio (PAR) on the survival results of locally advanced unresectable pancreatic adenocarcinoma (LAPC) patients.Patients and Methods: The present analysis included 139 LAPC patients who received C-CRT in total. The utility of pre-C-CRT cutoff(s) reshaping survival data was explored using receiver operating characteristic (ROC) curve analysis. The primary and secondary objectives were the associations between PAR levels and overall survival (OS) and progression-free survival (PFS) outcomes.Results: At a median follow-up of 15.7 months (95% CI: 11.6– 19.8), the overall cohort’s median and 5-year OS rates were 14.4 months (95% CI: 11.8– 17) and 14.7%, respectively, while the corresponding PFS rates were 7.8 months (95% CI: 6.5– 9.1) and 11.2%. Because the ROC curve analysis found 4.9 as the optimal PAR cutoff for both OS and PFS [area under the curve (AUC): 75.4%; sensitivity: 72.4%; specificity: 70.3%], we divided the patients into two PAR cohorts: PAR< 4.9 (N=60) and PAR≥ 4.9 (N=79). Comparative analysis per PAR group exhibited significantly worse OS (11.2 vs 18.6 months, and 9.8% vs 20.9% at 5 years, P=0.003) and DFS (7 vs 14.3 months, and 7.6% vs 16.2% at 5 years, P=0.001) with PAR≥ 4.9 versus PAR< 4.9, respectively. In multivariate analysis, the N0 nodal status, CA 19– 9≤ 90 U/mL, and PAR< 4.9 were found to be independent predictors of improved OS and PFS.Conclusion: The pre-C-CRT high PAR (≥ 4.9) robustly and independently prognosticated significantly worse OS and PFS results in inoperable LAPC patients who underwent definitive C-CRT.Keywords: pancreas cancer, prognosis, platelet-to-albumin ratio, concurrent chemoradiotherapy, survival outcomes

    وصف الملف: electronic resource

    العلاقة: https://www.dovepress.com/high-measures-of-pre-chemoradiotherapyTest-platelet-to-albumin-ratio-indic-peer-reviewed-fulltext-article-TCRM; https://doaj.org/toc/1178-203XTest

  8. 8
    دورية أكاديمية

    المصدر: Journal of Cardiovascular Development and Disease; Volume 10; Issue 6; Pages: 241

    الوصف: Background: The platelet-to-albumin ratio (PAR), leucocyte-to-albumin ratio (LAR), neutrophil percentage-to-albumin ratio (NPAR), and monocyte-to-albumin ratio (MAR) represent easily reproducible markers, which may predict the outcomes in various diseases. Early postoperative complications might appear after heart transplantation, such as infections, diabetes mellitus type 2 (DM2), acute graft rejection, and atrial fibrillation (AFib). Objective: The aim of our study was to investigate the PAR, LAR, NPAR, and MAR values before and after heart transplantation, and the associations of the preoperative levels of these markers with the presence of postoperative complications in first two months after surgery. Methods: Our retrospective research was directed from May 2014 to January 2021, with a total number of 38 patients being included. We used cut-off values for the ratios from previously published studies, as well as our own determination of these levels by using a receiver operating characteristic (ROC) curve. Results: By ROC analysis, the optimal preoperative PAR cut-off value was 38.84 (AUC: 0.771, p = 0.0039), with 83.3% sensitivity, and 75.0% specificity. Applying a Chi square (χ2) test, PAR > 38.84 represented an independent risk factor for complications, regardless of cause, and postoperative infections. Conclusions: Preoperative PAR > 38.84 was a risk factor of developing complications of any cause, and postoperative infections in the first two months after heart transplantation.

    وصف الملف: application/pdf

  9. 9
    دورية أكاديمية

    المصدر: BMC Cancer, Vol 22, Iss 1, Pp 1-11 (2022)

    الوصف: Abstract Background This retrospective study investigated biomarkers that can reflect coagulation, inflammation, and lipid abnormalities: platelet-to-albumin ratio (PAR), platelet-to lymphocyte ratio (PLR), low-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (LDL-C/HDL-C), apolipoprotein B-to-apolipoprotein ratio (ApoB/ApoA1) whether may be viable prognostic predictors in children and adolescents with osteosarcoma. Methods The retrospective review has enrolled a total of 118 children and adolescent patients diagnosed with osteosarcoma. Analyses with a receiver operating characteristic (ROC) curve were performed to evaluate the optimal cut-off values and to compare the area under curves (AUC). Kaplan–Meier curves were used to visualize survival outcome and a Cox proportional hazards model were used to confirm independent prognostic factors. Results Osteosarcoma patients in high PAR group (> 4.41) and high ApoB/ApoA1 group (> 0.82) experienced significantly shorter overall survival compared with those in low PAR group (≤ 4.41) and low ApoB/ApoA1 group (≤ 0.82). In univariate and multivariable analyses, preoperative PAR and ApoB/ApoA1 were identified as independent prognostic factors for OS in children and adolescents with osteosarcoma. Conclusion Preoperative PAR and ApoB/ApoA1 can be used as promising predictors in children and adolescents with osteosarcoma to help clinicians recognize patients with an increased risk of poor prognosis.

    وصف الملف: electronic resource

  10. 10
    دورية أكاديمية

    المؤلفون: Gui Y, Xu Y, Yang P

    المصدر: Journal of Inflammation Research, Vol Volume 14, Pp 5647-5652 (2021)

    الوصف: Yonghui Gui,1 Yuanhong Xu,2 Peng Yang1 1Department of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaCorrespondence: Peng YangDepartment of Blood Transfusion, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaEmail yangpeng00812@163.comYuanhong XuDepartment of Clinical Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, 230022, Anhui, People’s Republic of ChinaEmail xyhong1964@163.comObjective: The purpose of this study was to evaluate the predictive value of the platelet-to-albumin ratio (PAR) on the risk of death in patients with severe fever with thrombocytopenia syndrome.Methods: Between Jan 2019 and June 2021, 127 cases which were admitted to the First Affiliated Hospital of Anhui Medical University have been included in this study. The laboratory data were selected at the time of admission. To identify the potential independent risk factors for severe fever associated with thrombocytopenia syndrome, multivariate logistic regression analysis was performed. Receiver operating characteristic (ROC) curve analysis was used to evaluate the prediction accuracy of PAR in identifying patients exhibiting severe fever with thrombocytopenia syndrome.Results: Multiple logistic regression analysis showed that PAR could potentially serve as an independent risk factor for the death in patients with SFTS (OR = 4.023, 95% CI 1.204– 13.436, P=0.024). The prediction of the risk of death in patients with SFTS was assessed using the AUC. The AUC for the PAR was 0.729 (95% CI, 0.637– 0.82, P < 0.001), whereas the optimal cut-off value of PAR was found to be 1.43, with 54.9% sensitivity and 86.1% specificity.Conclusion: Our study demonstrated for the first time that PAR could act as an independent predictor for mortality in adult patients with SFTS.Keywords: severe fever with thrombocytopenia syndrome, risk factors, platelet-to-albumin ratio

    وصف الملف: electronic resource

    العلاقة: https://www.dovepress.com/predictive-value-of-theTest-platelet-to-albumin-ratio-par-on-the-risk-of-d-peer-reviewed-fulltext-article-JIR; https://doaj.org/toc/1178-7031Test