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1دورية أكاديمية
المؤلفون: Grant, Igor, Krupitsky, Evgeny, Vetrova, Marina, Umlauf, Anya, Heaton, Robert K, Hauger, Richard L, Toussova, Olga, Franklin, Donald R, Letendre, Scott L, Woody, George, Blokhina, Elena, Lioznov, Dmitry, Zvartau, Edwin
المصدر: Viruses. 16(1)
مصطلحات موضوعية: Microbiology, Biological Sciences, Clinical Research, Mind and Body, Substance Misuse, Mental Health, Behavioral and Social Science, Infectious Diseases, Drug Abuse (NIDA only), Brain Disorders, Clinical Trials and Supportive Activities, HIV/AIDS, Good Health and Well Being, Humans, Analgesics, Opioid, Dehydroepiandrosterone Sulfate, Hydrocortisone, Hypothalamo-Hypophyseal System, Interleukin-6, Lipopolysaccharide Receptors, Pituitary-Adrenal System, HIV Infections, HIV, opioid, withdrawal, Russia
الوصف: ObjectiveMany persons with opioid use disorders (OUDs) have HIV disease and experience clinically significant stress after they enroll in abstinence-based treatment and undergo medically assisted withdrawal. We examined whether opioid withdrawal affects virologic control, inflammatory markers, cognition, and mood in persons with an OUD and HIV, and explored whether measures of withdrawal stress, such as activation of the HPA axis, contribute to alterations in immune function, cognition, and mood.Method and participantsStudy participants were 53 persons with HIV who were admitted for OUD treatment at the City Addiction Hospital in Saint Petersburg, Russian Federation. Participants were examined at admission, at the anticipated peak of withdrawal 3 to 7 days after the last day of a clonidine-based withdrawal process lasting 7 to 14 days, and 3 to 4 weeks after completing withdrawal. At these times, participants received medical exams and were evaluated for symptoms of withdrawal, as well as cognition and mood. Viral load, plasma cortisol, DHEA sulfate ester (DHEA-S), interleukin-6 (IL-6), and soluble CD14 (sCD14) were determined. Multivariable models examined the relationships between markers of HPA activation and the other parameters over time.ResultsHPA activation as indexed by cortisol/DHEA-S ratio increased during withdrawal, as did markers of immune activation, IL-6 and sCD14. There were no significant associations between viral load and indicators of HPA activation. In longitudinal analyses, higher cortisol/DHEA sulfate was related to worse cognition overall, and more mood disturbance. Increase in IL-6 was associated with worse cognitive performance on a learning task. There were no significant associations with sCD14.ConclusionsWorsening of cognition and measures of mood disturbance during withdrawal were associated with activation of the HPA axis and some measures of inflammation. Whether repeated episodes of opioid withdrawal have a cumulative impact on long-term HIV outcomes and neurocognition is a topic for further investigation.
وصف الملف: application/pdf
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2دورية أكاديمية
المؤلفون: de Mendonça Filho, Euclides, Pokhvisneva, Irina, Maalouf, Christina, Parent, Carine, Mliner, Shanna, Slopen, Natalie, Williams, David, Boyce, William, Levitt, Pat, Nelson, Charles, Gunnar, Megan, Meaney, Michael, Shonkoff, Jack, Silveira, Patricia, Bush, Nicole
المصدر: Pediatric Research. 94(2)
مصطلحات موضوعية: Humans, Child, Hydrocortisone, Cortisone, Tumor Necrosis Factor-alpha, Stress, Psychological, Saliva, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Dehydroepiandrosterone
الوصف: BACKGROUND: Although investigations have begun to differentiate biological and neurobiological responses to a variety of adversities, studies considering both endocrine and immune function in the same datasets are limited. METHODS: Associations between proximal (family functioning, caregiver depression, and anxiety) and distal (SES-D; socioeconomic disadvantage) early-life adversities with salivary inflammatory biomarkers (IL-1β, IL-6, IL-8, and TNF-α) and hair HPA markers (cortisol, cortisone, and dehydroepiandrosterone) were examined in two samples of young U.S. children (N = 142; N = 145). RESULTS: Children exposed to higher SES-D had higher levels of TNF-α (B = 0.13, p = 0.011), IL-1β (B = 0.10, p = 0.033), and DHEA (B = 0.16, p = 0.011). Higher family dysfunction was associated with higher cortisol (B = 0.08, p = 0.033) and cortisone (B = 0.05, p = 0.003). An interaction between SES-D and family dysfunction was observed for cortisol levels (p = 0.020) whereby children exposed to lower/average levels of SES-D exhibited a positive association between family dysfunction and cortisol levels, whereas children exposed to high levels of SES-D did not. These findings were partially replicated in the second sample. CONCLUSIONS: Our results indicate that these biological response systems may react differently to different forms of early-life adversity. IMPACT: Different forms of early-life adversity have varied stress signatures, and investigations of early-life adversities with inflammation and HPA markers are lacking. Children with higher socioeconomic disadvantage had higher TNF-α, IL-1β, and DHEA. Higher family dysfunction was associated with higher hair cortisol and cortisone levels, and the association between family dysfunction and cortisol was moderated by socioeconomic disadvantage. Biological response systems (immune and endocrine) were differentially associated with distinct forms of early-life adversities.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/4q03w2dqTest
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3دورية أكاديمية
المؤلفون: Coccaro, Emil, Meruelo, Alejandro, Timmins, Matthew, Irwin, Michael
مصطلحات موضوعية: Aggression, C-reactive protein, Cortisol, IED, Impulsivity, Adult, Humans, Hydrocortisone, Hypothalamo-Hypophyseal System, Interleukin-6, Pituitary-Adrenal System, Disruptive, Impulse Control, and Conduct Disorders, Aggression, Inflammation, Research Subjects
الوصف: BACKGROUND: The role of the hypothalamic-pituitary-adrenal (HPA) axis in human aggressive behavior is poorly characterized, though some studies report that, unlike depression, circulating or salivary levels of cortisol are low compared with controls. METHODS: In this study, we collected three salivary cortisol levels (two in the morning and one in the evening) on three separate days in 78 adult study participants with (n = 28) and without (n = 52) prominent histories of impulsive aggressive behavior. Plasma C-Reactive Protein (CRP) and Interleukin-6 (IL-6) were also collected in most study participants. Aggressive study participants meet DSM-5 criteria for Intermittent Explosive Disorder (IED) while non-aggressive participants either had a history of a psychiatric disorder or no such history (Controls). RESULTS: Morning, but not evening, salivary cortisol levels were significantly lower in IED (p
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/80k09131Test
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4دورية أكاديمية
المؤلفون: Keeton, Victoria F, Hoffmann, Thomas J, Goodwin, Kalisha Moneé, Powell, Bree, Tupuola, Sophia, Weiss, Sandra J
المصدر: Stress. 27(1)
مصطلحات موضوعية: Reproductive Medicine, Biomedical and Clinical Sciences, Pediatric, Behavioral and Social Science, Mental Health, Conditions Affecting the Embryonic and Fetal Periods, Perinatal Period - Conditions Originating in Perinatal Period, Mind and Body, Violence Research, Pediatric Research Initiative, Clinical Research, 2.3 Psychological, social and economic factors, Aetiology, Reproductive health and childbirth, Good Health and Well Being, Infant, Infant, Newborn, Pregnancy, Humans, Female, Child, Hydrocortisone, Longitudinal Studies, Prenatal Exposure Delayed Effects, Hypothalamo-Hypophyseal System, Social Alienation, Stress, Psychological, Pituitary-Adrenal System, Saliva, Social adversity, infant cortisol, prenatal stress, fetal programming, economic hardship, biomarkers, Clinical Sciences, Neurology & Neurosurgery, Clinical sciences, Neurosciences
الوصف: Exposure to social adversity has been associated with cortisol dysregulation during pregnancy and in later childhood; less is known about how prenatal exposure to social stressors affects postnatal cortisol of infants. In a secondary analysis of data from a longitudinal study, we tested whether a pregnant woman's reports of social adversity during the third trimester were associated with their infant's resting cortisol at 1, 6, and 12 months postnatal. Our hypothesis was that prenatal exposure to social adversity would be associated with elevation of infants' cortisol. Measures included prenatal survey reports of social stressors and economic hardship, and resting cortisol levels determined from infant saliva samples acquired at each postnatal timepoint. Data were analyzed using linear mixed effects models. The final sample included 189 women and their infants (46.56% assigned female sex at birth). Prenatal economic hardship was significantly associated with infant cortisol at 6 months postnatal; reports of social stressors were not significantly associated with cortisol at any time point. Factors associated with hardship, such as psychological distress or nutritional deficiencies, may alter fetal HPA axis development, resulting in elevated infant cortisol levels. Developmental changes unique to 6 months of age may explain effects at this timepoint. More work is needed to better comprehend the complex pre- and post-natal physiologic and behavioral factors that affect infant HPA axis development and function, and the modifying role of environmental exposures.
الوصول الحر: https://escholarship.org/uc/item/3jf5m6ctTest
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5دورية أكاديمية
المؤلفون: N.A.D. RAZLAN, M. KAPITONOVA, R.N. ALYAUTDIN, S.B. TALIP, N. RAMLI, T.M. NWE
المصدر: Паёми Сино, Vol 26, Iss 1, Pp 57-66 (2024)
مصطلحات موضوعية: depression, hypothalamic-pituitary-adrenal system, corticosterone, immune system, mice., Public aspects of medicine, RA1-1270
الوصف: Objective: To study the effect of modelled depression not associated with stress on the hypothalamic-pituitary-adrenal system (HPAS) in mice. Methods: The experiment was conducted on the twenty-four C57BL/6 mice weighing 20-25 g, divided into two groups: an experimental one, involving animals with reserpine-induced depression, and a control one, the animals of which were administered normal saline instead of reserpine solution. At the end of the experiment, behavioral tests were performed (open field, sucrose preference, forced swimming), and the corticosterone concentration in blood was measured using ELISA. Image analysis of histological changes in the adrenal gland and thymus was performed. All results were statistically processed using SPSS 27.0.1 software, with p
وصف الملف: electronic resource
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6دورية أكاديمية
المصدر: International Journal of Environmental Research and Public Health. 20(7)
مصطلحات موضوعية: Clinical and Health Psychology, Psychology, Basic Behavioral and Social Science, Behavioral and Social Science, Mental Health, Humans, Hydrocortisone, Circadian Rhythm, Hypothalamo-Hypophyseal System, Ecological Momentary Assessment, Pituitary-Adrenal System, Saliva, Wakefulness, affectionate touch, cortisol awakening response, ecological momentary assessment, hugging, Toxicology
الوصف: Previous research suggests that affectionate touch such as hugs might downregulate stress systems such as the hypothalamic pituitary adrenal (HPA) axis. However, the current literature lacks in generalizability beyond the laboratory setting and outside the context of romantic relationships. The cortisol awakening response (CAR) is a measure of the HPA axis and is responsive to daily fluctuations in stress and social information. However, associations between affectionate touch and the CAR have never been assessed. This study used ecological momentary assessment (EMA) to measure daily hugging behaviors in 104 first-year college students and salivary cortisol to assess the CAR. Participants who reported more daily hugs in their social interactions had significantly smaller CARs the next morning compared to days they reported fewer hugs. This study contributes to the literature on social interactions and stress responsive systems and emphasizes the importance of assessing affectionate touch behaviors such as hugs that can be exchanged outside the context of romantic relationships.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/2q28072xTest
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7دورية أكاديمية
المؤلفون: Jobe, Alan H, Caplan, Michael S, Polin, Richard A, Laptook, Abbot R, Hensman, Angelita M, Vieira, Elisa, Little, Emilee, Johnson, Katharine, Alksninis, Barbara, Keszler, Mary Lenore, Knoll, Andrea M, Leach, Theresa M, McGowan, Elisabeth C, Watson, Victoria E, Walsh, Michele C, Fanaroff, Avroy A, Payne, Allison, Wilson-Costello, Deanne E, Newman, Nancy S, Siner, Bonnie S, Zadell, Arlene, DiFiore, Julie, Bhola, Monika, Friedman, Harriet G, Yalcinkaya, Gulgun, Goldberg, Ronald N, Cotten, C Michael, Gustafson, Kathryn E, Goldstein, Ricki F, Ashley, Patricia, Auten, Kathy J, Fisher, Kimberley A, Foy, Katherine A, Freedman, Sharon F, Lohmeyer, Melody B, Malcolm, William F, Wallace, David K, Carlton, David P, Stoll, Barbara J, Adams-Chapman, Ira, Buchter, Susie, Piazza, Anthony J, Carter, Sheena, Fritz, Sobha, Hale, Ellen C, Hutchinson, Amy K, LaRossa, Maureen Mulligan, Loggins, Yvonne, Bottcher, Diane, Higgins, Rosemary D, Archer, Stephanie Wilson, Poindexter, Brenda B, Sokol, Gregory M, Harmon, Heidi M, Papile, Lu-Ann, Hines, Abbey C, Wilson, Leslie D, Herron, Dianne E, Smiley, Lucy, Granger, Douglas A, Kennedy, Kathleen A, Tyson, Jon E, Duncan, Andrea F, Dempsey, Allison G, John, Janice, Jones, Patrick M, Lillie, M Layne, Siddiki, Saba, Sperry, Daniel K, Blaisdell, Carol J, Das, Abhik, Wallace, Dennis, Gantz, Marie G, O’Donnell Auman, Jeanette, Hammond, Jane A, Newman, Jamie E, Poole, W Kenneth, Van Meurs, Krisa P, Stevenson, David K, Ball, M Bethany, DeAnda, Maria Elena, Goodlin, Gabrielle T, Frantz, Ivan D, Fiascone, John M, Kurfiss, Anne, MacKinnon, Brenda L, Nylen, Ellen, Brussa, Ana, Sibley, Cecelia, Carlo, Waldemar A, Ambalavanan, Namasivayam, Collins, Monica V, Cosby, Shirley S, Phillips, Vivien A, Domanovich, Kristy, Whitley, Sally, Smith, Leigh Ann, Kiser, Carin R, Finer, Neil N
المصدر: Pediatric Research. 93(3)
مصطلحات موضوعية: Paediatrics, Biomedical and Clinical Sciences, Basic Behavioral and Social Science, Behavioral and Social Science, Mind and Body, Mental Health, Neurosciences, Clinical Research, Pediatric, 2.3 Psychological, social and economic factors, Aetiology, Mental health, Child, Female, Humans, Infant, Newborn, Executive Function, Hydrocortisone, Hypothalamo-Hypophyseal System, Infant, Extremely Premature, Pituitary-Adrenal System, SUPPORT NEURO School-Age Study Subcommittee of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, Paediatrics and Reproductive Medicine, Public Health and Health Services, Pediatrics
الوصف: BackgroundExtremely preterm (EPT) birth has been related to dysregulation of stress responses and behavioral/learning problems at school age. Early adverse experiences can blunt HPA axis reactivity. We hypothesized that an attenuated cortisol awakening response would be associated with developmental and behavioral problems at school age in EPT children.MethodsThis secondary analysis of a sub-cohort of the SUPPORT study included children born between 24 and 27 weeks, evaluated at 6-7 years with a neurodevelopmental battery and cortisol measures. Differences were tested between EPT and a term-born group. Relationships of cortisol awakening response to test scores were analyzed.ResultsCortisol was measured in 110 EPT and 29 term-born 6-7 year olds. Unadjusted WISC-IV and NEPSY-II scores were significantly worse among EPT children only. Conners Parent Rating Scale behavior scores were significantly worse among EPT children. After adjusting for covariates, blunted cortisol awakening responses were found to be associated with poorer scores on memory tests and greater problems with inattention for the EPT group (p
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/0q87324jTest
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8دورية أكاديمية
مصطلحات موضوعية: Paediatrics, Reproductive Medicine, Biomedical and Clinical Sciences, Women's Health, Minority Health, Prevention, Conditions Affecting the Embryonic and Fetal Periods, Clinical Research, Perinatal Period - Conditions Originating in Perinatal Period, Pregnancy, Preterm, Low Birth Weight and Health of the Newborn, Behavioral and Social Science, Health Disparities, Pediatric, Basic Behavioral and Social Science, Reproductive health and childbirth, Good Health and Well Being, Infant, Infant, Newborn, Humans, Female, Hydrocortisone, Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Premature Birth, Infant, Premature, Adrenal Cortex Hormones, Stress, Psychological, Corticosteroids, HPA axis, Cortisol, Fetal programming, Medical and Health Sciences, Psychology and Cognitive Sciences, Psychiatry, Biomedical and clinical sciences, Psychology
الوصف: Administration of antenatal corticosteroids (AC) is the standard of care during pregnancy for women who are at risk of early delivery. Evidence indicates that AC improve survival and reduce morbidity for preterm infants. However, research suggests that infants whose mothers receive AC have an altered hypothalamic-pituitary-axis (HPA) response to stressors in early life. Results are mixed regarding the nature of these effects, with studies showing both suppressed and augmented HPA activity. In addition, research is very limited beyond the 4th month of life. The purpose of this study was to determine if AC exposure was associated with infant cortisol levels in a resting state or in response to a stressor at 1, 6 and 12 months postnatal. We also evaluated the moderating role of preterm birth in this association. 181 women and their infants participated in the study. Women were recruited during the 3rd trimester of pregnancy; at this time, they completed the Perceived Stress Scale and provided 8 salivary samples over a 2-day period for cortisol assay. They provided these data again at 6 and 12 months postnatal. At 1, 6, and 12 months postnatal, salivary samples were collected from infants to examine their cortisol levels before and after participation in a 'stressor protocol'. Data were extracted from the medical record on AC exposure, gestational age, maternal obstetric risk, and neonatal morbidity. Mixed effects multilevel regression modeling was used to examine the aims. Infants whose mothers received AC had significantly lower resting state (B = -2.47, CI: -3.691, -0.0484) and post-stressor (B = -2.51, CI: -4.283, -0.4276) cortisol levels across the first year of life than infants whose mothers did not receive AC. There was no moderating effect of preterm birth on the relationship between AC exposure and cortisol. Results indicate a state of dampened HPA activation and cortisol hypo-arousal that persists across the first year of life among infants who were exposed to corticosteroids in utero. Further research is needed to examine mechanisms responsible for any alterations that occur during development of the fetal HPA axis, including epigenetic and biochemical factors that control hormonal secretion, negative feedback, and glucocorticoid receptor function throughout the HPA axis. Findings warrant careful consideration by obstetric clinicians of the benefits and risks of prescribing AC.
وصف الملف: application/pdf
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9دورية أكاديمية
المؤلفون: Larauche, Muriel, Erchegyi, Judit, Miller, Charleen, Sim, Myung Shin, Rivier, Jean, Behan, Dominic, Taché, Yvette
مصطلحات موضوعية: Pharmacology and Pharmaceutical Sciences, Biomedical and Clinical Sciences, Neurosciences, Clinical Sciences, Chronic Pain, Pain Research, Behavioral and Social Science, Digestive Diseases, Development of treatments and therapeutic interventions, 5.1 Pharmaceuticals, Animals, Corticotropin-Releasing Hormone, Diarrhea, Female, Hyperalgesia, Hypothalamo-Hypophyseal System, Male, Peptide Fragments, Pituitary-Adrenal System, Rats, Rats, Sprague-Dawley, Receptors, Corticotropin-Releasing Hormone, Stress, Psychological, Visceral Pain, Astressin, CRF antagonists, Peripheral CRF, Sex difference, Visceral pain, Medical and Health Sciences, Endocrinology & Metabolism, Medical biochemistry and metabolomics, Medicinal and biomolecular chemistry
الوصف: Peptide CRF antagonists injected peripherally alleviate stress-induced visceral hypersensitivity (SIVH) to colorectal distension (CRD) in rodents. Here we further evaluated the dose and time-dependent inhibitory activity of several long-acting peptide CRF receptor antagonists related to astressin on SIVH, focusing on astressin C (AstC), which previously showed high efficacy on stress-related alterations of HPA axis and gut secretomotor functions. Male and female Sprague-Dawley rats pretreated subcutaneously (SC) with AstC were injected intraperitoneally (IP) with CRF 15 min later. The visceromotor responses (VMR) to graded phasic CRD (10, 20, 40 and 60 mmHg) were monitored at basal, 15 min and up to 1-8 days after pretreatment. Two other astressin analogs, hexanoyl-astressin D (Hex-AstD) and [CαMeVal19,32]-AstC, were also tested. The response to IP CRF was sex-dependent with female rats requiring a higher dose to exhibit visceral hyperalgesia. Pretreatment with AstC (30-1000 µg/kg) resulted in a dose-related inhibition of IP CRF-induced SIVH and diarrhea in both sexes. The highest dose prevented SIVH and diarrhea up to 5-7 days after a single SC injection and was lost on day 7 (females) and day 8 (males) but reinstated after a second injection of AstC on day 8 or 9 respectively. [CαMeVal19,32]-AstC and Hex-AstD (1000 µg/kg in males) also prevented SIVH. These data show the potent long-lasting anti-hyperalgesic effect of AstC in an acute model of SIVH in both male and female rats. This highlights the potential of long-acting peripheral CRF antagonists to treat stress-sensitive irritable bowel syndrome.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/4j22z8mmTest
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10دورية أكاديميةMaternal stress and mental health before pregnancy and offspring diurnal cortisol in early childhood
المؤلفون: Guardino, Christine M, Rahal, Danny, Rinne, Gabrielle R, Mahrer, Nicole E, Davis, Elysia Poggi, Adam, Emma K, Shalowitz, Madeleine U, Ramey, Sharon L, Schetter, Christine Dunkel
المصدر: Developmental Psychobiology. 64(7)
مصطلحات موضوعية: Clinical and Health Psychology, Psychology, Pediatric, Mental Health, Post-Traumatic Stress Disorder (PTSD), Prevention, Behavioral and Social Science, Brain Disorders, Depression, Clinical Research, Conditions Affecting the Embryonic and Fetal Periods, Reproductive health and childbirth, Mental health, Good Health and Well Being, Pregnancy, Child, Female, Child, Preschool, Humans, Hydrocortisone, Pituitary-Adrenal System, Hypothalamo-Hypophyseal System, Saliva, Mothers, Stress, Psychological, depression, HPA axis, preconception, PTSD, stress, Cognitive Sciences, Behavioral Science & Comparative Psychology, Applied and developmental psychology, Biological psychology
الوصف: The current study investigates whether prepregnancy maternal posttraumatic stress disorder (PTSD) symptoms, depressive symptoms, and stress predict children's cortisol diurnal slopes and cortisol awakening responses (CARs) adjusting for relevant variables. Mothers were enrolled after delivering a baby and followed through their subsequent pregnancy with 5 years of longitudinal data on their subsequent child. This prospective design allowed assessment of PTSD symptoms, depressive symptoms, and perceived stress prior to pregnancy. Children provided three saliva samples per day on three consecutive days at two timepoints in early childhood (M age = 3.7 years, SD = 0.38; M age = 5.04 years, SD = 0.43). Mothers' PTSD symptoms prior to pregnancy were significantly associated with flatter child diurnal cortisol slopes at 4 and 5 years, but not with child CAR. Findings at the age of 4 years, but not 5 years, remained statistically significant after adjustment for maternal socioeconomic status, race/ethnicity, child age, and other covariates. In contrast, maternal prepregnancy depressive symptoms and perceived stress did not significantly predict cortisol slopes or CAR. Results suggest that maternal prepregnancy PTSD symptoms may contribute to variation in early childhood physiology. This study extends earlier work demonstrating risk of adverse outcomes among children whose mothers experienced trauma but associations cannot be disentangled from effects of prenatal mental health of mothers on children's early childhood.
وصف الملف: application/pdf
الوصول الحر: https://escholarship.org/uc/item/0gc0p678Test
