المؤلفون: Messier, Stephen P., Callahan, Leigh F., Losina, Elena, Mihalko, Shannon L., Guermazi, Ali, Ip, Edward, Miller, Gary D., Katz, Jeffrey N., Loeser, Richard F., Pietrosimone, Brian G., Soto, Sandra, Cook, James L., Newman, Jovita J., DeVita, Paul, Spindler, Kurt P., Runhaar, Jos, Armitano-Lago, Cortney, Duong, Vicky, Selzer, Faith, Hill, Ryan, Love, Monica, Beavers, Daniel P., Saldana, Santiago, Stoker, Aaron M., Rice, Paige E., Hunter, David J.

المصدر: Messier , S P , Callahan , L F , Losina , E , Mihalko , S L , Guermazi , A , Ip , E , Miller , G D , Katz , J N , Loeser , R F , Pietrosimone , B G , Soto , S , Cook , J L , Newman , J J , DeVita , P , Spindler , K P , Runhaar , J , Armitano-Lago , C , Duong , V , Selzer , F , Hill , R , Love , M , Beavers , D P , ....

مصطلحات موضوعية: /dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_being, name=SDG 3 - Good Health and Well-being

الوصف: Background: Osteoarthritis (OA), the leading cause of disability among adults, has no cure and is associated with significant comorbidities. The premise of this randomized clinical trial is that, in a population at risk, a 48-month program of dietary weight loss and exercise will result in less incident structural knee OA compared to control. Methods/design: The Osteoarthritis Prevention Study (TOPS) is a Phase III, assessor-blinded, 48-month, parallel 2 arm, multicenter randomized clinical trial designed to reduce the incidence of structural knee OA. The study objective is to assess the effects of a dietary weight loss, exercise, and weight-loss maintenance program in preventing the development of structural knee OA in females at risk for the disease. TOPS will recruit 1230 ambulatory, community dwelling females with obesity (Body Mass Index (BMI) ≥ 30 kg/m 2 ) and aged ≥50 years with no radiographic (Kellgren-Lawrence grade ≤1) and no magnetic resonance imaging (MRI) evidence of OA in the eligible knee, with no or infrequent knee pain. Incident structural knee OA (defined as tibiofemoral and/or patellofemoral OA on MRI) assessed at 48-months from intervention initiation using the MRI Osteoarthritis Knee Score (MOAKS) is the primary outcome. Secondary outcomes include knee pain, 6-min walk distance, health-related quality of life, knee joint loading during gait, inflammatory biomarkers, and self-efficacy. Cost effectiveness and budgetary impact analyses will determine the value and affordability of this intervention. Discussion: This study will assess the efficacy and cost effectiveness of a dietary weight loss, exercise, and weight-loss maintenance program designed to reduce incident knee OA. Trial registration: ClinicalTrials.gov Identifier: NCT05946044.

وصف الملف: application/pdf

العلاقة: https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test

الإتاحة: https://doi.org/10.1016/j.ocarto.2023.100418Test
https://pure.eur.nl/en/publications/4f47dedb-a38f-4ef4-8b6f-9146d78ba487Test
https://pure.eur.nl/ws/files/124162103/The_osteoarthritis_prevention_study_TOPS_-_A_randomized_controlled_trial_of_diet_and_exercise_to_prevent_Knee_Osteoarthritis.pdfTest
http://www.scopus.com/inward/record.url?scp=85179044965&partnerID=8YFLogxKTest

المؤلفون: Cabre, Hannah E., Ladan, Alex N., Moore, Sam R., Joniak, Kelly E., Blue, Malia N. M., Pietrosimone, Brian G., Hackney, Anthony C., Smith-Ryan, Abbie E.

المصدر: Journal of Strength & Conditioning Research ; ISSN 1064-8011

الوصف: Cabre, HE, Ladan, AN, Moore, SR, Joniak, KE, Blue, MNM, Pietrosimone, BG, Hackney, AC, and Smith-Ryan, AE. Effects of hormonal contraception and the menstrual cycle on fatigability and recovery from an anaerobic exercise test. J Strength Cond Res XX(X): 000–000, 2024—This study sought to evaluate the effects of oral contraceptive (OC) and hormonal intrauterine device (H-IUD) use, compared with a eumenorrheic (EUM) cycle, on fatigability and recovery between hormone the phases. Peak power (PP), average power (AP), fatigue index (FI), blood lactate, vessel diameter, and blood flow (BF) were measured from a repeated sprint cycle test (10 × 6 seconds) in 60, healthy, active women (mean ± SD ; age: 26.5 ± 7.0 years, BMI: 22.5 ± 3.7 kg·m −2 ) who used monophasic OC (≥6 months; n = 21), had a H-IUD (≥6 months; n = 20), or had regular naturally occurring menstrual cycle (≥3 months) or had a nonhormonal IUD (EUM; n = 19). Subjects were randomly assigned to begin in either the low-hormone phase (LHP) or high-hormone phase (HHP) and were tested once in each phase. Separate univariate analyses of covariances assessed the change from HHP to LHP between the groups, covaried for progesterone, with significance set at p ≤ 0.05. All groups demonstrated similar changes in PP, AP, FI, blood lactate, vessel diameter, and BF between the phases ( p > 0.05). Although not significant, AP was higher in LHP for OC (Δ −248.2 ± 1,301.4 W) and EUM (Δ −19.5 ± 977.7 W) and higher in HHP for H-IUD (Δ 369.3 ± 1,123.0 W). Oral contraceptive group exhibited a higher FI (Δ 2.0%) and reduced blood lactate clearance (Δ 2.5%) in HHP. In recreationally active women, hormonal contraception and hormone phases may minimally impact fatigue and recovery. Individual elite female athletes may benefit from understanding hormonal contraception type as performance and recovery may slightly vary across the cycle.

الإتاحة: https://doi.org/10.1519/jsc.0000000000004764Test

المؤلفون: Nilius, Alex, Dewig, Derek R., Johnston, Christopher D., Pietrosimone, Brian G., Blackburn, J. Troy

المصدر: Clinical Biomechanics ; volume 114, page 106229 ; ISSN 0268-0033

مصطلحات موضوعية: Orthopedics and Sports Medicine, Biophysics

الإتاحة: https://doi.org/10.1016/j.clinbiomech.2024.106229Test
https://api.elsevier.com/content/article/PII:S0268003324000615?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0268003324000615?httpAccept=text/plainTest

المؤلفون: Jang, Jaeho, Franz, Jason R., Pietrosimone, Brian G., Wikstrom, Erik A.

المصدر: Journal of Biomechanics ; volume 163, page 111926 ; ISSN 0021-9290

مصطلحات موضوعية: Rehabilitation, Biomedical Engineering, Orthopedics and Sports Medicine, Biophysics

الإتاحة: https://doi.org/10.1016/j.jbiomech.2024.111926Test
https://api.elsevier.com/content/article/PII:S0021929024000034?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0021929024000034?httpAccept=text/plainTest

المؤلفون: Keil, Lukas G., Onuscheck, Douglas S., Pratson, Lincoln F., Kamath, Ganesh V., Creighton, Robert A., Nissman, Daniel B., Pietrosimone, Brian G., Spang, Jeffrey T.

المصدر: Journal of Experimental Orthopaedics ; volume 9, issue 1 ; ISSN 2197-1153

الوصف: Purpose Anterior cruciate ligament rupture is associated with characteristic bone contusions in approximately 80% of patients, and these have been correlated with higher pain scores. Bone bruising may indicate joint damage that increases inflammation and the likelihood of posttraumatic osteoarthritis. We sought to characterize the severity of bone bruising following acute anterior cruciate ligament injury and determine if it correlates with synovial fluid and serum levels of the proinflammatory chemokine monocyte chemoattractant protein-1 associated with posttraumatic osteoarthritis. Methods This was a retrospective analysis of data collected prospectively from January 2014 through December 2016. All patients who sustained an acute ligament rupture were evaluated within 15 days of injury, obtained a magnetic resonance imaging study, and underwent bone-patellar-tendon-bone autograft reconstruction were offered enrollment. The overall severity of bone bruising on magnetic resonance imaging was graded (sum of 0–3 grades in 13 sectors of the articular surfaces). Serum and synovial fluid levels of monocyte chemoattractant protein-1 were measured within 14 days of injury, and serum levels were again measured 6 and 12 months following surgery. Separate univariate linear regression models were constructed to determine the association between monocyte chemoattractant protein-1 and bone bruising severity at each time point. Results Forty-eight subjects were included in this study. They had a mean age of 21.4 years and were 48% female. Median overall bone bruising severity was 5 (range 0–14). Severity of bone bruising correlated with higher synovial fluid concentrations of monocyte chemoattractant protein-1 preoperatively (R 2 = 0.18, p = 0.009) and with serum concentrations at 12 months post-reconstruction (R 2 = 0.12, p = 0.04). Conclusions The severity of bone bruising following anterior cruciate ligament rupture is associated with higher levels of the proinflammatory cytokine monocyte chemoattractant protein-1 ...

الإتاحة: https://doi.org/10.1186/s40634-022-00478-8Test

المؤلفون: Dewig, Derek R., Mills, Hallie R., Evans-Pickett, Alyssa, Pietrosimone, Brian G., Troy Blackburn, J.

المصدر: Journal of Biomechanics ; volume 134, page 110989 ; ISSN 0021-9290

مصطلحات موضوعية: Rehabilitation, Biomedical Engineering, Orthopedics and Sports Medicine, Biophysics

الإتاحة: https://doi.org/10.1016/j.jbiomech.2022.110989Test
https://api.elsevier.com/content/article/PII:S002192902200046X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S002192902200046X?httpAccept=text/plainTest

المؤلفون: Ryan, Eric D., Laffan, Megan R., Trivisonno, Abigail J., Gerstner, Gena R., Mota, Jacob A., Giuliani, Hayden K., Pietrosimone, Brian G.

المصدر: Applied Ergonomics ; volume 98, page 103555 ; ISSN 0003-6870

مصطلحات موضوعية: Physical Therapy, Sports Therapy and Rehabilitation, Engineering (miscellaneous), Safety, Risk, Reliability and Quality, Human Factors and Ergonomics

الإتاحة: https://doi.org/10.1016/j.apergo.2021.103555Test
https://api.elsevier.com/content/article/PII:S0003687021002027?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0003687021002027?httpAccept=text/plainTest

المؤلفون: Kiefer, Adam W., Armitano-Lago, Cortney, Sathyan, Anoop, Longobardi, Lara, Loeser, Richard, Spang, Jeffrey T., Cohen, Kelly, Pietrosimone, Brian G.

المصدر: Medicine & Science in Sports & Exercise ; volume 53, issue 8S, page 114-114 ; ISSN 1530-0315 0195-9131

الإتاحة: https://doi.org/10.1249/01.mss.0000760460.97900.6eTest

المؤلفون: Gerstner, Gena R., Laffan, Megan R., Trivisonno, Abigail J., Giuliani, Hayden K., Mota, Jacob A., Register-Mihalik, Johna, Smith-Ryan, Abbie, Pietrosimone, Brian G., Weir, Joseph P., Ryan, Eric D.

المصدر: Medicine & Science in Sports & Exercise ; volume 52, issue 7S, page 957-957 ; ISSN 1530-0315 0195-9131

الإتاحة: https://doi.org/10.1249/01.mss.0000685960.51789.bdTest

المؤلفون: Dewig, Derek R., Evans-Pickett, Alyssa, Pietrosimone, Brian G., Blackburn, J. Troy

المصدر: Gait & Posture ; volume 100, page 261-267 ; ISSN 0966-6362

مصطلحات موضوعية: Rehabilitation, Orthopedics and Sports Medicine, Biophysics

الإتاحة: https://doi.org/10.1016/j.gaitpost.2023.01.012Test
https://api.elsevier.com/content/article/PII:S0966636223000127?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0966636223000127?httpAccept=text/plainTest