المؤلفون: Sofia Lachiondo-Ortega, Claudia M. Rejano-Gordillo, Jorge Simon, Fernando Lopitz-Otsoa, Teresa C. Delgado, Krystyna Mazan-Mamczarz, Naroa Goikoetxea-Usandizaga, L. Estefanía Zapata-Pavas, Ana García-del Río, Pietro Guerra, Patricia Peña-Sanfélix, Natalia Hermán-Sánchez, Ruba Al-Abdulla, Carmen Fernandez-Rodríguez, Mikel Azkargorta, Alejandro Velázquez-Cruz, Joris Guyon, César Martín, Juan Diego Zalamea, Leire Egia-Mendikute, Arantza Sanz-Parra, Marina Serrano-Maciá, Irene González-Recio, Monika Gonzalez-Lopez, Luis Alfonso Martínez-Cruz, Patrizia Pontisso, Ana M. Aransay, Rosa Barrio, James D. Sutherland, Nicola G.A. Abrescia, Félix Elortza, Amaia Lujambio, Jesus M. Banales, Raúl M. Luque, Manuel D. Gahete, Asís Palazón, Matias A. Avila, Jose J. G. Marin, Supriyo De, Thomas Daubon, Antonio Díaz-Quintana, Irene Díaz-Moreno, Myriam Gorospe, Manuel S. Rodríguez, María Luz Martínez-Chantar

المصدر: Cell Reports, Vol 43, Iss 3, Pp 113924- (2024)

مصطلحات موضوعية: CP: Cancer, CP: Molecular biology, Biology (General), QH301-705.5

الوصف: Summary: The posttranslational modification of proteins critically influences many biological processes and is a key mechanism that regulates the function of the RNA-binding protein Hu antigen R (HuR), a hub in liver cancer. Here, we show that HuR is SUMOylated in the tumor sections of patients with hepatocellular carcinoma in contrast to the surrounding tissue, as well as in human cell line and mouse models of the disease. SUMOylation of HuR promotes major cancer hallmarks, namely proliferation and invasion, whereas the absence of HuR SUMOylation results in a senescent phenotype with dysfunctional mitochondria and endoplasmic reticulum. Mechanistically, SUMOylation induces a structural rearrangement of the RNA recognition motifs that modulates HuR binding affinity to its target RNAs, further modifying the transcriptomic profile toward hepatic tumor progression. Overall, SUMOylation constitutes a mechanism of HuR regulation that could be potentially exploited as a therapeutic strategy for liver cancer.

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S2211124724002523Test; https://doaj.org/toc/2211-1247Test

الوصول الحر: https://doaj.org/article/ac05448b67bf43d08eefd6737eb5e995Test

المؤلفون: Pietro Guerra, Andrea Martini, Patrizia Pontisso, Paolo Angeli

المصدر: Cancers, Vol 15, Iss 14, p 3629 (2023)

مصطلحات موضوعية: hepatocellular carcinoma, hypoxia, immunotherapy, SerpinB3, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Hepatocellular carcinoma (HCC) is a common and aggressive cancer with a high mortality rate. The incidence of HCC is increasing worldwide, and the lack of effective screening programs often results in delayed diagnosis, making it a challenging disease to manage. Immunotherapy has emerged as a promising treatment option for different kinds of cancers, with the potential to stimulate the immune system to target cancer cells. However, the current immunotherapeutic approaches for HCC have shown limited efficacy. Since HCC arises within a complex tumour microenvironment (TME) characterized by the presence of various immune and stromal cell types, the understanding of this interaction is crucial for the identification of effective therapy. In this review, we highlight recent advances in our understanding of the TME of HCC and the immune cells involved in anti-tumour responses, including the identification of new possible targets for immunotherapy. We illustrate a possible classification of HCC based on the tumour immune infiltration and give evidence about the role of SerpinB3, a serine protease inhibitor involved in the regulation of the immune response in different cancers.

وصف الملف: electronic resource

العلاقة: https://www.mdpi.com/2072-6694/15/14/3629Test; https://doaj.org/toc/2072-6694Test

الوصول الحر: https://doaj.org/article/788932b63c4d41f0a609ac7612a96471Test

المؤلفون: Francesco Tovoli, Pietro Guerra, Massimo Iavarone, Letizia Veronese, Matteo Renzulli, Stefania De Lorenzo, Francesca Benevento, Giovanni Brandi, Federico Stefanini, Fabio Piscaglia

المصدر: Liver Cancer, Vol 9, Iss 6, Pp 744-755 (2020)

مصطلحات موضوعية: cholangiocellular carcinoma, intrahepatic cholangiocarcinoma, screening, outcomes, liver cirrhosis, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Background: Due to its poor survival, intrahepatic cholangiocarcinoma (ICC) is held to be a much more aggressive cancer than hepatocellular carcinoma (HCC). In most published series, patients were diagnosed when symptomatic. However, ICC is now increasingly being discovered during the surveillance for HCC in cirrhosis. Whether this earlier detection of ICC is associated with an equally dismal prognosis or not is unknown. Methods: This is amulticenter retrospective study of consecutive ICC patients. Patients were stratified into subgroups according to the absence/presence of cirrhosis. A propensity score matching was performed to reduce the potential biases. Cirrhotic patients were further stratified according to their surveillance status. The lead-time bias and its potential effects were also estimated. Results: We gathered 184 patients. Eighty-five patients (46.2%) were cirrhotic. Liver cirrhosis was not related to a worse overall survival (33.0 vs. 32.0 months, p = 0.800) even after the propensity score analysis (43.0 in vs. 44.0 months in 54 pairs of patients, p = 0.878). Among the cirrhotic population, 47 (55.3%) patients had received a diagnosis of ICC during a surveillance programme. The 2 subgroups differed in maximum tumour dimensions (30 vs. 48 mm in surveyed and non-surveyed patients, respectively). Surveyed patients were more likely to receive surgical treatments (59.8 vs. 28.9%, p = 0.003). Overall survival was higher in surveyed patients (51.0 vs. 21.0 months, p < 0.001). These benefits were confirmed after correcting for the lead-time bias. Conclusions: Cirrhotic patients have different clinical presentation and outcomes of ICC according to their surveillance status. In our series, ICC in cirrhosis was not associated with worse OS. Cirrhosis itself should not discourage either surgical or non-surgical treatments.

وصف الملف: electronic resource

العلاقة: https://www.karger.com/Article/FullText/509059Test; https://doaj.org/toc/2235-1795Test; https://doaj.org/toc/1664-5553Test

الوصول الحر: https://doaj.org/article/2787c0f6745b4fef9eddc50a54657d43Test

المؤلفون: Letizia Veronese, Fabio Piscaglia, Federico Stefanini, Giovanni Brandi, Stefania De Lorenzo, Massimo Iavarone, Francesca Benevento, Francesco Tovoli, Pietro Guerra, Matteo Renzulli

المساهمون: Tovoli F., Guerra P., Iavarone M., Veronese L., Renzulli M., De Lorenzo S., Benevento F., Brandi G., Stefanini F., Piscaglia F.

المصدر: Liver Cancer
Liver Cancer, Vol 9, Iss 6, Pp 744-755 (2020)

مصطلحات موضوعية: medicine.medical_specialty, Cirrhosis, liver cirrhosis, Population, cholangiocellular carcinoma, outcomes, lcsh:RC254-282, Gastroenterology, Liver cirrhosi, 03 medical and health sciences, 0302 clinical medicine, intrahepatic cholangiocarcinoma, Internal medicine, Overall survival, Medicine, education, Intrahepatic Cholangiocarcinoma, Outcome, Original Paper, education.field_of_study, Hepatology, business.industry, screening, Aggressive cancer, Retrospective cohort study, lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens, medicine.disease, Oncology, 030220 oncology & carcinogenesis, Hepatocellular carcinoma, Propensity score matching, 030211 gastroenterology & hepatology, business

الوصف: Background: Due to its poor survival, intrahepatic cholangiocarcinoma (ICC) is held to be a much more aggressive cancer than hepatocellular carcinoma (HCC). In most published series, patients were diagnosed when symptomatic. However, ICC is now increasingly being discovered during the surveillance for HCC in cirrhosis. Whether this earlier detection of ICC is associated with an equally dismal prognosis or not is unknown. Methods: This is amulticenter retrospective study of consecutive ICC patients. Patients were stratified into subgroups according to the absence/presence of cirrhosis. A propensity score matching was performed to reduce the potential biases. Cirrhotic patients were further stratified according to their surveillance status. The lead-time bias and its potential effects were also estimated. Results: We gathered 184 patients. Eighty-five patients (46.2%) were cirrhotic. Liver cirrhosis was not related to a worse overall survival (33.0 vs. 32.0 months, p = 0.800) even after the propensity score analysis (43.0 in vs. 44.0 months in 54 pairs of patients, p = 0.878). Among the cirrhotic population, 47 (55.3%) patients had received a diagnosis of ICC during a surveillance programme. The 2 subgroups differed in maximum tumour dimensions (30 vs. 48 mm in surveyed and non-surveyed patients, respectively). Surveyed patients were more likely to receive surgical treatments (59.8 vs. 28.9%, p = 0.003). Overall survival was higher in surveyed patients (51.0 vs. 21.0 months, p < 0.001). These benefits were confirmed after correcting for the lead-time bias. Conclusions: Cirrhotic patients have different clinical presentation and outcomes of ICC according to their surveillance status. In our series, ICC in cirrhosis was not associated with worse OS. Cirrhosis itself should not discourage either surgical or non-surgical treatments.

وصف الملف: ELETTRONICO

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f12e3873fd3db5b7ffb989143c776769Test
https://doi.org/10.1159/000509059Test

المؤلفون: Francesco Tovoli, Pietro Guerra, Massimo Iavarone, Letizia Veronese, Matteo Renzulli, Stefania De Lorenzo, Giovanni Brandi, Federico Stefanini, Fabio Piscaglia

المصدر: Journal of Hepatology. 73:S389

مصطلحات موضوعية: Hepatology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::097b5a645899927e8a60389107ed3522Test
https://doi.org/10.1016/s0168-8278Test(20)31268-x

المؤلفون: DE VITA, Giovanni

المساهمون: GIOVANNI DE VITA, PIETRO GUERRA, DE VITA, Giovanni

العلاقة: info:eu-repo/semantics/altIdentifier/isbn/9788884312617; ispartofbook:Gente del Gargano. Uomini e mestieri nella fototeca Tancredi di Monte Sant'Angelo; firstpage:9; lastpage:23; http://hdl.handle.net/11580/73Test

الإتاحة: http://hdl.handle.net/11580/73Test