المؤلفون: Camus, Christophe, Locher, Clara, Saliba, Faouzi, Goubaux, Bernard, Bonadona, Agnes, Lavayssiere, Laurence, Paugam, Catherine, Quinart, Alice, Barbot, Olivier, Dharancy, Sebastien, Delafosse, Bertrand, Pichon, Nicolas, Barraud, Helene, Galbois, Arnaud, Veber, Benoit, Cayot, Sophie, Souche, Bruno

المساهمون: CHU Lille, Inserm, Université de Lille, Service des maladies infectieuses et réanimation médicale Rennes = Infectious Disease and Intensive Care Rennes, Centre Hospitalier Universitaire de Rennes CHU Rennes = Rennes University Hospital Ponchaillou, Centre d'Investigation Clinique Rennes CIC, Centre Hépato-Biliaire Hôpital Paul Brousse CHB, Hôpital l'Archet, Hôpital la Tronche, Centre Hospitalier Universitaire de Toulouse CHU Toulouse, Hôpital Beaujon AP-HP, Service Anesthésie - Réanimation Bordeaux, Centre Hospitalier Régional Universitaire de Besançon CHRU Besançon, Institute for Translational Research in Inflammation - U 1286 INFINITE (Ex-Liric), Service de Réanimation Polyvalente CHU Limoges, CHU Limoges, Service d'Hépato-gastro-entérologie CHRU Nancy, CHU Saint-Antoine AP-HP, Hôpital Charles Nicolle Rouen, CHU Estaing Clermont-Ferrand, Hôpital Saint Eloi CHRU Montpellier

مصطلحات موضوعية: MARS albumin dialysis, liver transplantation, retrospective study, outcome

الوصف: The molecular adsorbent recirculating system (MARS) is the most widely used device to treat liver failure. Nevertheless, data from widespread real-life use are lacking. This was a retrospective multicenter study conducted in all French adult care centers that used MARS between 2004 and 2009. The primary objective was to evaluate patient survival according to the liver disease and listing status. Factors associated with mortality were the secondary objectives. A total of 383 patients underwent 393 MARS treatments. The main indications were acute liver failure (ALF, 32.6%), and severe cholestasis (total bilirubin >340 μmol/L) (37.2%), hepatic encephalopathy (23.7%), and/or acute kidney injury-hepatorenal syndrome (22.9%) most often among patients with chronic liver disease. At the time of treatment, 34.4% of the patients were listed. Overall, the hospital survival rate was 49% (95% CI: 44-54%) and ranged from 25% to 81% depending on the diagnosis of the liver disease. In listed patients versusvsvsvsP Our study suggests that MARS should be mainly used as a bridge to liver transplantation. Survival was correlated with being listed for most etiologies and with the intensity of treatment in ALF.

وصف الملف: application/rdf+xml; charset=utf-8; application/pdf

العلاقة: Journal of Gastroenterology and Hepatology; JGH Open; http://hdl.handle.net/20.500.12210/40677Test

الإتاحة: https://doi.org/20.500.12210/40677Test
https://hdl.handle.net/20.500.12210/40677Test

المؤلفون: Chelly, Jonathan, Plantefève, Gaetan, Kamel, Toufik, Bruel, Cédric, Nseir, Saad, Lai, Christopher, Cirillo, Giulia, Skripkina, Elena, Ehrminger, Sébastien, Berdaguer-Ferrari, Fernando-Daniel, Le Marec, Julien, Paul, Marine, Autret, Aurélie, Deye, Nicolas, Arnal, Jean-Michel, Badie, Julio, Berric, Audrey, Brunet, Jennifer, Bertrand, Thibault, Carpentier, Dorothée, Chaoui, Karim, Chapelle, Anaïs, Chelha, Riad, Corno, Gaëlle, Daubin, Cédric, Descamps, Richard, Demoule, Alexandre, Deryckere, Stéphanie, Donati, Stephane-Yannis, Ducros, Laurent, Embriaco, Nathalie, Engrand, Nicolas, Foucault, Camille, Freeman, Sean Anthony, Freita Ramos, Santiago, Galbois, Arnaud, Garnero, Aude, Geay, Cyrille, Guérin, Laurent, Hong Tuan Ha, Vivien, Hullin, Thomas, Jochmans, Sébastien, Kaidomar, Michel, Kelway, Charlotte, Labruyere, Marie, Larcher, Romaric, Legriel, Stéphane, Leloup, Maxime, Lesieur, Olivier, Malissin, Isabelle, Mazerand, Sandie, Mégarbane, Bruno, Mélone, Marie-Anne, Menoret, Edouard, Metzelard, Matthieu, Mongardon, Nicolas, Vong, Ly Van Phack, Persichini, Romain, Pichon, Nicolas, Picos Gil, Santiago, Quenot, Jean-Pierre, Roux, Damien, Schnell, David, Sigaud, Florian, Suply, Clement, Sztrymf, Benjamin, Terzi, Nicolas, Thevenin, Didier, Voicu, Sebastian

المساهمون: Université de Lille, CNRS, Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576

مصطلحات موضوعية: In‑hospital cardiac arrest, Intensive care unit, SARS‑CoV‑2, COVID‑19

الوصف: Background Initial reports have described the poor outcome of unexpected cardiac arrest (CA) in intensive care unit (ICU) among COVID-19 patients in China and the USA. However, there are scarce data on characteristics and outcomes of such CA patients in Europe. Methods Prospective registry in 35 French ICUs, including all in-ICU CA in COVID-19 adult patients with cardiopulmonary resuscitation (CPR) attempt. Favorable outcome was defined as modified Rankin scale ranging from 0 to 3 at day 90 after CA. Results Among the 2425 COVID-19 patients admitted to ICU from March to June 2020, 186 (8%) experienced in-ICU CA, of whom 146/186 (78%) received CPR. Among these 146 patients, 117 (80%) had sustained return of spontaneous circulation, 102 (70%) died in the ICU, including 48 dying within the first day after CA occurrence and 21 after withdrawal of life-sustaining therapy. Most of CA were non-shockable rhythm (90%). At CA occurrence, 132 patients (90%) were mechanically ventilated, 83 (57%) received vasopressors and 75 (51%) had almost three organ failures. Thirty patients (21%) had a favorable outcome. Sepsis-related organ failure assessment score > 9 before CA occurrence was the single parameter constantly associated with unfavorable outcome in multivariate analysis. Conclusions In-ICU CA incidence remains high among a large multicenter cohort of French critically ill adults with COVID-19. However, 21% of patients with CPR attempt remained alive at 3 months with good functional status. This contrasts with other recent reports showing poor outcome in such patients. Trial registration: This study was retrospectively registered in ClinicalTrials.gov (NTC04373759) in April 2020 (https://www.clinicaltrials.gov/ct2/show/NCT04373759?term=acicovid&draw=2&rank=1Test). ; 11;1

وصف الملف: application/rdf+xml; charset=utf-8; application/octet-stream

العلاقة: Annals of Intensive Care; Ann. Intensive Care; http://hdl.handle.net/20.500.12210/107887Test

الإتاحة: https://doi.org/20.500.12210/107887Test
https://hdl.handle.net/20.500.12210/107887Test

المؤلفون: Lascarrou, Jean Baptiste, Bougouin, Wulfran, Chelly, Jonathan, Bourenne, Jeremy, Daubin, Cedric, Lesieur, Olivier, Asfar, Pierre, Colin, Gwenhael, Paul, Marine, Chudeau, Nicolas, Muller, Gregoire, Geri, Guillaume, Jacquier, Sophier, Pichon, Nicolas, Klein, Thomas, Sauneuf, Bertrand, Klouche, Kada, Cour, Martin, Sejourne, Caroline, Annoni, Filippo, Raphalen, Jean-Herle, Galbois, Arnaud, Bruel, Cedric, Mongardon, Nicolas, Aissaoui, Nadia, Deye, Nicolas, Maizel, Julien, Dumas, Florence, Legriel, Stephane, Cariou, Alain, Peres, Noémie, Le Saux, Audrey, Bellal, Mathieu, Leloup, Maxime, Jaubert, Paul, Henry-Lagarrigue, Matthieu, Alezra, Nina, Meunier, Juliette, Nay, Mai-Anh, Salmon-Gandonnière, Charlotte, Mons, Sandrine, Levy, Bruno, Souloy, Xavier, Platon, Laura, Argaud, Laurent, Taccone, Fabio, Vimpere, Damien, Chelha, Riad, de Roux, Quentin, Berlemont, Caroline Hauw, Megarbane, Bruno, Benghanem, Sarah, Lemarie, Jeremie, Goulenok, Cyril

المساهمون: Motricité, interactions, performance UR 4334 / Movement - Interactions - Performance (MIP), Le Mans Université (UM)-Nantes Université - UFR des Sciences et Techniques des Activités Physiques et Sportives (Nantes Univ - UFR STAPS), Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ)-Nantes Université - pôle Santé, Nantes Université (Nantes Univ)-Nantes Université (Nantes Univ), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), AfterROSC Network Group Paris, Paris-Centre de Recherche Cardiovasculaire (PARCC (UMR_S 970/ U970)), Hôpital Européen Georges Pompidou APHP (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité), Hôpital Privé Jacques Cartier Massy, Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse, Hôpital de la Timone CHU - APHM (TIMONE), Service de Soins Intensifs CHU Caen, Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN), Groupe hospitalier de La Rochelle, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier Départemental - Hôpital de La Roche-sur-Yon (CHD Vendée), Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier Le Mans (CH Le Mans), Centre Hospitalier Régional d'Orléans (CHRO), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Hôpital Ambroise Paré AP-HP, Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Centre Hospitalier de Brive-la-Gaillarde (CH Brive), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service d'Anesthésie et Réanimation CHRU Nancy, Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), CH Centre Hospitalier Public du Cotentin (CHPC), Physiologie & médecine expérimentale du Cœur et des Muscles U 1046 (PhyMedExp), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Montpellier (UM), Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Hospices Civils de Lyon (HCL), Centre Hospitalier de Béthune (CH Béthune), GHT de l'Artois, Hôpital Erasme Bruxelles, Hôpital Necker - Enfants Malades AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre Hospitalier Privé Claude Galien - Ramsay Santé, Groupe Hospitalier Paris Saint-Joseph (hpsj), Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), Hôpital Lariboisière-Fernand-Widal APHP, CHU Amiens-Picardie, Mécanismes physiopathologiques et conséquences des calcifications vasculaires - UR UPJV 7517 (MP3CV), Université de Picardie Jules Verne (UPJV)-CHU Amiens-Picardie, Hôpital Cochin AP-HP

المصدر: ISSN: 2110-5820 ; Annals of Intensive Care ; https://u-picardie.hal.science/hal-04247479Test ; Annals of Intensive Care, 2023, 13 (1), pp.100. ⟨10.1186/s13613-023-01195-w⟩.

مصطلحات موضوعية: Cardiac arrest, Functional outcome, Neurological prognosis, Outcome prediction, Score, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology

الوصف: International audience ; Background Out-of-hospital cardiac arrest (OHCA) is a heterogeneous entity with multiple origins and prognoses. An early, reliable assessment of the prognosis is useful to adapt therapeutic strategy, tailor intensity of care, and inform relatives. We aimed primarily to undertake a prospective multicentric study to evaluate predictive performance of the Cardiac Arrest Prognosis (CAHP) Score as compare to historical dataset systematically collected after OHCA (Utstein style criteria). Our secondary aim was to evaluate other dedicated scores for predicting outcome after OHCA and to compare them to Utstein style criteria. Methods We prospectively collected data from 24 French and Belgium Intensive Care Units (ICUs) between August 2020 and June 2022. All cases of non-traumatic OHCA (cardiac and non-cardiac causes) patients with stable return of spontaneous circulation (ROSC) and comatose at ICU admission (defined by Glasgow coma score ≤ 8) on ICU admission were included. The primary outcome was the modified Rankin scale (mRS) at day 90 after cardiac arrest, assessed by phone interviews. A wide range of developed scores (CAHP, OHCA, CREST, C-Graph, TTM, CAST, NULL-PLEASE, and MIRACLE2) were included, and their accuracies in predicting poor outcome at 90 days after OHCA (defined as mRS ≥ 4) were determined using the area under the receiving operating characteristic curve (AUROC) and the calibration belt. Results During the study period, 907 patients were screened, and 658 were included in the study. Patients were predominantly male (72%), with a mean age of 61 ± 15, most having collapsed from a supposed cardiac cause (64%). The mortality rate at day 90 was 63% and unfavorable neurological outcomes were observed in 66%. The performance (AUROC) of Utstein criteria for poor outcome prediction was moderate at 0.79 [0.76–0.83], whereas AUROCs from other scores varied from 0.79 [0.75–0.83] to 0.88 [0.86–0.91]. For each score, the proportion of patients for whom individual values could not be ...

العلاقة: hal-04247479; https://u-picardie.hal.science/hal-04247479Test; https://u-picardie.hal.science/hal-04247479/documentTest; https://u-picardie.hal.science/hal-04247479/file/s13613-023-01195-w.pdfTest

الإتاحة: https://doi.org/10.1186/s13613-023-01195-wTest
https://u-picardie.hal.science/hal-04247479Test
https://u-picardie.hal.science/hal-04247479/documentTest
https://u-picardie.hal.science/hal-04247479/file/s13613-023-01195-w.pdfTest

المؤلفون: Jolly, Florian, Jacquier, Marine, Pecqueur, Delphine, Labruyère, Marie, Vinsonneau, Christophe, Fournel, Isabelle, Quenot, Jean-Pierre, Mégarbane, Bruno, Lesieur, Olivier, Leloup, Maxime, Weiss, Nicolas, Tamion, Fabienne, Beuret, Pascal, Monchi, Mehran, Delcourte, Claire, Hayon, Jan, Klouche, Kada, Stoclin, Annabelle, Gibot, Sébastien, Peigne, Vincent, Mezher, Chaouki, Martino, Frédéric, Nguyen, Maxime, Kuteifan, Khaldoun, Louis, Guillaume, Rigault, Guillaume, Masuccio, Michel, Garin, Aude, Asfar, Pierre, Andrieu, Maude, Auchabie, Johann, Daviet, Florence, Lacave, Guillaume, Benhamida, Hotman, Vivet, Bérengère, Chaignat, Claire, Desgrouas, Maxime, La Combe, Béatrice, Plouvier, Fabienne, Richard, Jean-Christophe, Haddadi, Clément, Czolnowski, Dorian, Lau, Nicolas, Jacobs, Frédéric, Thirion, Marina, Pons, Antoine, Pichon, Nicolas, Patrigeon, René-Gilles, Vieillard-Baron, Antoine, Uhel, Fabrice, Rigaud, Jean-Philippe, Bouhake, Yannis, Zagozda, Dominique, Arrestier, Romain, Vinclair, Camille, Fedou, Anne-Laure, Dargent, Auguste, Dellamonica, Jean, Rey, Brice, Gachet, Alexandre, Serie, Mathieu, Bruel, Cédric, Troger, Antoine, Berthoud, Vivien, Delbove, Agathe, Goulenok, Cyril, Bouguoin, Wulfran, Osman, David, Anguel, Nadia, Guérin, Laurent, Foucault, Camille, Préau, Sébastien, Saura, Ouriel, Boué, Yvonnick, Sédillot, Nicholas, Covin, Laetitia, Lambiotte, Fabien, Guignon, Carole, Perinel-Ragey, Sophie, Souloy, Xavier, Defaux-Chevillard, Cécile, Renault, Anne, Mme-Ngapmen, Nadège, Jourdain, Mercedes, van Der Linden, Thierry, Levy, Clémentine, Thouy, François, Degouy, Guillaume

المساهمون: CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Equipe LIPNESS (LNC - U1231) (LIPNESS), Lipides - Nutrition - Cancer Dijon - U1231 (LNC), Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Université de Bourgogne (UB)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Institut Agro Dijon, Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro)-Institut national d'enseignement supérieur pour l'agriculture, l'alimentation et l'environnement (Institut Agro), Centre d'Investigation Clinique 1432 (Dijon) - Epidemiologie Clinique/Essais Cliniques (CIC-EC), Université de Bourgogne (UB)-Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon)-Institut National de la Santé et de la Recherche Médicale (INSERM), Centre Hospitalier de Béthune (CH Béthune), GHT de l'Artois, Hôpital Lariboisière, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Lariboisière-Fernand-Widal APHP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Groupe hospitalier de La Rochelle, CHU Pitié-Salpêtrière AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Rouen, Normandie Université (NU), Centre Hospitalier de Roanne, Centre Hospitalier de Melun (CHM), Centre Hospitalier Régional Universitaire CHU Lille (CHRU Lille), Centre hospitalier intercommunal de Poissy/Saint-Germain-en-Laye - CHIPS Poissy, Centre Hospitalier Régional Universitaire Montpellier (CHRU Montpellier), Institut Gustave Roussy (IGR), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Métropole Savoie Chambéry, Hôpital Nord Franche-Comté Hôpital de Trévenans (HNFC), CHU Pointe-à-Pitre/Abymes Guadeloupe, Service de Réanimation Médicale (CHU de Dijon), Groupe hospitalier de la région de Mulhouse et Sud-Alsace, CHR de Metz-Thionville, Centre Hospitalier Universitaire CHU Grenoble (CHUGA), Centre Hospitalier Universitaire Strasbourg (CHU Strasbourg), Les Hôpitaux Universitaires de Strasbourg (HUS), Centre Hospitalier Victor Jousselin Dreux, Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Centre Hospitalier de Dax, Centre Hospitalier de Cholet (CH Cholet), Hôpital Nord CHU - APHM, Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier de Vesoul (CH Vesoul), Groupe Hospitalier de La Haute-Saône (GH70), Centre Hospitalier Régional d'Orléans (CHRO), Centre Hospitalier de Lorient (CH Lorient), Groupe Hospitalier Bretagne Sud (GHBS), Centre Hospitalier Agen-Nérac, Hôpital de la Croix-Rousse CHU - HCL, Hospices Civils de Lyon (HCL), Groupe Hospitalier Nord Essonne Longjumeau, AP-HP - Hôpital Antoine Béclère Clamart, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Hôpitaux du Bassin de Thau, Centre Hospitalier de Brive-la-Gaillarde (CH Brive), Centre hospitalier d'Auxerre (CHA), Hôpital Ambroise Paré AP-HP, Hôpital Louis Mourier - AP-HP Colombes, Centre hospitalier de Dieppe, Centre Hospitalier Jura Sud Lons-le-Saunier (CH Jura Sud), Centre Hospitalier de la Région de Saint Omer (CH St Omer), Partenaires INRAE, Hôpital Henri Mondor, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Henri Mondor-Université Paris-Est Créteil Val-de-Marne - Paris 12 (UPEC UP12), Centre Hospitalier de la Côte Basque (CHCB), CHU Limoges, Hôpital Edouard Herriot CHU - HCL, Hôpital l'Archet, Centre Hospitalier Pierre Bérégovoy Nevers, CHU Mont de Marsan, Centre hospitalier territorial Gaston-Bourret Dumbea (CHT), Centre hospitalier territorial Gaston-Bourret Nouméa, Centre hospitalier Saint-Joseph Paris, Centre hospitalier Bretagne Atlantique (Morbihan) (CHBA), Hôpital Privé Jacques Cartier Massy, Hôpital Bicêtre AP-HP, Le Kremlin-Bicêtre, Centre Hospitalier Cahors, Centre Hospitalier de Mayotte, Centre Hospitalier de Bourg en Bresse, CHU Amiens-Picardie, Centre hospitalier Valenciennes, Nord, Centre hospitalier universitaire de Poitiers = Poitiers University Hospital (CHU de Poitiers La Milétrie ), Centre Hospitalier Universitaire de Saint-Etienne CHU Saint-Etienne (CHU ST-E), Auteur indépendant, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Hôpital Saint Philibert Lomme, Groupement des Hôpitaux de l'Institut Catholique de Lille (GHICL), Université catholique de Lille (UCL)-Université catholique de Lille (UCL), CHU Clermont-Ferrand, Centre Hospitalier de Lens

المصدر: EISSN: 2667-100X ; Journal of Intensive Medicine ; https://hal.science/hal-04102288Test ; Journal of Intensive Medicine, 2023, 3 (2), pp.147-154. ⟨10.1016/j.jointm.2022.10.005⟩

مصطلحات موضوعية: Acute kidney injury, Bedside, Intensive care unit, Practice evaluation, Renal replacement therapy, [SDV]Life Sciences [q-bio]

الوصف: International audience ; BackgroundThis study aimed to investigate renal replacement therapy (RRT) practices in a representative nationwide sample of French intensive care units (ICUs).MethodsFrom July 1 to October 5 2021, 67 French ICUs provided data regarding their ICU and RRT implementation. We used an online questionnaire to record general data about each participating ICU, including the type of hospital, number of beds, staff ratios, and RRT implementation. Each center then prospectively recorded RRT parameters from 5 consecutive acute kidney injury (AKI) patients, namely the indication, type of dialysis catheter used, type of catheter lock used, type of RRT (continuous or intermittent), the RRT parameters initially prescribed (dose, blood flow, and duration), and the anticoagulant agent used for the circuit.ResultsA total of 303 patients from 67 ICUs were analyzed. Main indications for RRT were oligo-anuria (57.4%), metabolic acidosis (52.1%), and increased plasma urea levels (47.9%). The commonest insertion site was the right internal jugular (45.2%). In 71.0% of cases, the dialysis catheter was inserted by a resident. Ultrasound guidance was used in 97.0% and isovolumic connection in 90.1%. Citrate, unfractionated heparin, and saline were used as catheter locks in 46.9%, 24.1%, and 21.1% of cases, respectively.ConclusionsPractices in French ICUs are largely compliant with current national guidelines and international literature. The findings should be interpreted in light of the limitations inherent to this type of study.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/37188118; hal-04102288; https://hal.science/hal-04102288Test; https://hal.science/hal-04102288/documentTest; https://hal.science/hal-04102288/file/2023%20%20Jolly%20%20et%20al.,%20Management%20of.pdfTest; PUBMED: 37188118; PUBMEDCENTRAL: PMC10175733

الإتاحة: https://doi.org/10.1016/j.jointm.2022.10.005Test
https://hal.science/hal-04102288Test
https://hal.science/hal-04102288/documentTest
https://hal.science/hal-04102288/file/2023%20%20Jolly%20%20et%20al.,%20Management%20of.pdfTest

المؤلفون: Salvetti, Marie, Schnell, Guillaume, Pichon, Nicolas, Schenck, Maleka, Cronier, Pierrick, Perbet, Sébastien, Lascarrou, Jean Baptiste, Guitton, Christophe, Lesieur, Olivier, Argaud, Laurent, Colin, Gwenhael, Cholley, Bernard P., Quenot, Jean-Pierre, Merdji, Hamid, Geeraerts, T., Piagnerelli, Michaël, Jacq, Gwenaelle, Paul, Marine, Chelly, Jonathan, de Charentenay, Louise, Deye, Nicolas, Danguy des Déserts, Marc, Thiery, Guillaume, Simon, Marc, Das, Vincent, Jacobs, Frédéric, Cerf, Charles, Mayaux, Julien, Beuret, Pascal, Ouchenir, Abdelkader, Lafarge, Antoine, Sauneuf, Bertrand, Daubin, Cedric, Cariou, Alain, Silva, S., Legriel, Stéphane

المصدر: Frontiers in neurology, 14

مصطلحات موضوعية: Neurologie, cardiopulmonary resuscitation, coma/therapy, intensive care unit, near-hanging, outcome

الوصف: Background: Cardiac arrest is the most life-threatening complication of attempted suicide by hanging. However, data are scarce on its characteristics and outcome predictors. Methods: This retrospective observational multicentre study in 31 hospitals included consecutive adults admitted after cardiac arrest induced by suicidal hanging. Factors associated with in-hospital mortality were identified by multivariate logistic regression with multiple imputations for missing data and adjusted to the temporal trends over the study period. Results: Of 450 patients (350 men, median age, 43 [34–52] years), 305 (68%) had a psychiatric history, and 31 (6.9%) attempted hanging while hospitalized. The median time from unhanging to cardiopulmonary resuscitation was 0 [0–5] min, and the median time to return of spontaneous circulation (ROSC) was 20 [10–30] min. Seventy-nine (18%) patients survived to hospital discharge. Three variables were independently associated with higher in-hospital mortality: time from collapse or unhanging to ROSC>20 min (odds ratio [OR], 4.71; 95% confidence intervals [95%CIs], 2.02–10.96; p = 0.0004); glycaemia >1.4 g/L at admission (OR, 6.38; 95%CI, 2.60–15.66; p < 0.0001); and lactate >3.5 mmol/L at admission (OR, 6.08; 95%CI, 1.71–21.06; p = 0.005). A Glasgow Coma Scale (GCS) score of >5 at admission was associated with lower in-hospital mortality (OR, 0.009; 95%CI, 0.02–0.37; p = 0.0009). Conclusion: In patients with hanging-induced cardiac arrest, time from collapse or unhanging to return of spontaneous circulation, glycaemia, arterial lactate, and coma depth at admission were independently associated with survival to hospital discharge. Knowledge of these risk factors may help guide treatment decisions in these patients at high risk of hospital mortality. ; SCOPUS: ar.j ; info:eu-repo/semantics/published

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.3389/fneur.2023.1240383; uri/info:scp/85173915048; https://dipot.ulb.ac.be/dspace/bitstream/2013/370807/1/doi_354451.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/370807Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/370807Test

المؤلفون: Fleuriet, Jérôme, Heming, Nicholas, Meziani, Ferhat, Reignier, Jean, Declerq, Pierre-Louis, Mercier, Emmanuelle, Muller, Grégoire, Colin, Gwenhaël, Monnet, Xavier, Robine, Adrien, Siami, Shidasp, Uhel, Fabrice, Quenot, Jean-Pierre, Plantefeve, Gaetan, Badie, Julio, Schneider, Francis, Cerf, Charles, Troché, Gilles, Monchi, Mehran, Mira, Jean-Paul, Francois, Bruno, Lamiae, Grimaldi, Chevret, Sylvie, Annane, Djillali, RECORDS consortium, CRICS TRIGGERSEP network, Antigoni, Alexandrou, Djillali, Annane, Birte, Arlt, Julio, Badie, Sarah, Benghanem, Fernando, Berdaguer Ferrari, Charles, Cerf, Zaineb, Chelly Dagdia, Sylvie, Chevret, Gwenhaël, Colin, Christel, Daniel, Pierre-Louis, Declercq, Agathe, Delbove, Philippe, Devillier, Jérome, Fleuriet, Bruno, Francois, Henri-Jean, Garchon, Véronique, Godot, Stanislas, Grassin-Delyle, Mathieu, Grisolia, Christophe, Guitton, Julie, Helms, Nicholas, Heming, Marielle, Herzog, Toufik, Kamel, Zoubida, Kedad, Philippe, Lassalle, Guillaume, Lhermite, Bruno, Megarbane, Armand, Mekontso Dessap, Emmanuelle, Mercier, Ferhat, Meziani, Jean-Paul, Mira, Mehran, Monchi, Xavier, Monnet, Grégoire, Muller, Jean-Pierre, Quenot, Jean, Reignier, Adrien, Robine, Martin, Rottman, Anne-Laure, Roux, Francis, Schneider, Shidasp, Siami, Pierre, Tissieres, Gilles, Troché, Fabrice, Uhel, Karine, Zeitouni, Gaëtan, Plantefève, Nawal, Derridj, Bodet-Contentin, Laetitia, Darwiche, Walid, Ehrmann, Stephan, Garot, Denis, Guillon, Antoine, Jouan, Youenn, Legras, Annick, Mankikian, Julie, Morisseau, Marlene, Perez, Yonatan, Rouve, Emmanuelle, Salmon-Gandonniere, Charlotte, Helms, Julie, Rahmani, Hassene, Monnier, Alexandra, Merdji, Hamid, Clere-Jehl, Raphael, Stiel, Laure, Studer, Antoine, Andreu, Pascal, Roudaut, Jean-Baptiste, Labruyere, Marie, Jacquier, Marine, Barbier, Francois, Benzekri, Dalila, Boulain, Thierry, Jacquier, Sophie, Mathonnet, Armelle, Muller, Gregoire, Nai, Mai-Anh, Runge, Isabelle, Tollec, Sophie, Roux, Damien, Messika, Jonathan, Vuillard, Constance, Dumont, Louis-Marie, Federici, Laura, Zucman, Noemie, Amouretti, Marc, Moine, Pierre, Meng, Paris, Bounab, Rania, Fartoukh, Muriel-Sarah, Djibre, Michel, Elabbadi, Alexandre, Azais, Marie-Ange, Bachoumas, Konstantinos, Bailly, Arthur, Bernardon, Remi, Blonz, Gauthier, Desmedt, Luc, Emonet, Brian, Fiancette, Maud, Henry, Matthieu, Lacherade, Jean-Claude, Lascarrou, Jean-Baptiste, Lebert, Christine, Lorber, Julien, Martin-Lefevre, Laurent, Pouplet, Caroline, Vinatier, Isabelle, Yehia, Aihem, Benghanem, Sarah, Charpentier, Julien, Vigneron, Clara, Pichon, Nicolas, Fedou, Anne-Laure, Mancia, Claire, Begot, Emmanuelle, Daix, Thomas, Vignon, Philippe, Galy, Antoine, Gonzalez, Celine, Goudelin, Marine, Evrard, Bruno, Desachy, Arnaud, Vaidie, Julien, Gilbert, Guillaume, Darreau, Cedric, Derrien, Benoit, Saint-Martin, Marjorie, Tirot, Patrice, Landais, Mickael, Chudeau, Nicolas, Callahan, Jean Christophe, Vivier, Dominique, Moal, Charlene Le, Olivier, Pierre-Yves, Marnai, Remy, Sedillot, Nicolas, Tchenio, Xavier, Poncelin, Yves, Bruyere, Remi

مصطلحات موضوعية: Intensive care

الوصف: Introduction Corticosteroids affect variably survival in sepsis trials, suggesting heterogeneity in patients’ response to corticosteroids. The RECORDS (Rapid rEcognition of COrticosteRoiD resistant or sensitive Sepsis) trial aimed at defining endotypes associated with adults with sepsis responsiveness to corticosteroids. Methods and analysis RECORDS, a multicentre, placebo-controlled, biomarker-guided, adaptive Bayesian design basket trial, will randomly assign to a biomarker stratum 1800 adults with community-acquired pneumonia, vasopressor-dependent sepsis, septic shock or acute respiratory distress syndrome. In each stratum, patients will be randomly assigned to receive a 7-day course of hydrocortisone and fludrocortisone or their placebos. Patients with COVID-19 will be treated with a 10-day standard course of dexamethasone and randomised to fludrocortisone or its placebo. Primary outcome will be 90-day death or persistent organ dysfunction. Large simulation study will be performed across a range of plausible scenarios to foresee power to detect a 5%–10% absolute difference with corticosteroids. We will assess subset-by-treatment interaction by estimating in a Bayesian framework two quantities: (1) measure of influence, relying on the value of the estimation of corticosteroids’ effect in each subset, and (2) measure of interaction. Ethics and dissemination The protocol was approved by the Ethics Committee ( Comit e ´ de Protection des Personnes, Dijon, France), on 6 April 2020. Trial results will be disseminated at scientific conferences and results will be published in peer-reviewed journals. Trial registration number ClinicalTrials.gov Registry ( NCT04280497 ).

وصف الملف: text/html

العلاقة: http://bmjopen.bmj.com/cgi/content/short/13/3/e066496Test; http://dx.doi.org/10.1136/bmjopen-2022-066496Test

الإتاحة: https://doi.org/10.1136/bmjopen-2022-066496Test
http://bmjopen.bmj.com/cgi/content/short/13/3/e066496Test

المؤلفون: Boulain, Thierry, Nay, Mai-Anh, Dequin, Pierre-François, Lascarrou, Jean-Baptiste, Vignon, Philippe, Kamel, Toufik, Muller, Grégoire, Ehrmann, Stephan, Baudin, Olivier, Calvat, Sylvie, Cracco, Christophe, Desachy, Arnault, Lafon, Charles, Boitrou, Emmanuelle, Follin, Arnaud, Mentec, Hervé, Pajot, Olivier, Plantefève, Gaëtan, Thirion, Marina, Bruyère, Rémi, Quenot, Jean-Pierre, Bachoumas, Konstantinos, Fiancette, Maud, Lacherade, Jean Claude, Lebert, Christine, Martin-Lefèvre, Laurent, Reignier, Jean, Vinatier, Isabelle, Yehia, Aihem, Begot, Emmanuelle, Bellier, Remy, Clavel, Marc, François, Bruno, Galy, Antoine, Pichon, Nicolas, Bardou, Patrick, Bellec, Frédéric, Bonnivard, Michel, Marco, Anne, Roustan, Jérôme, Vimeux, Sylvie, Bretagnol, Anne, Mathonnet, Armelle, Bercault, Nicolas, Réminiac, François, Runge, Isabelle, Skarzynski, Marie, Chatellier, Delphine

المصدر: Australian Critical Care ; volume 36, issue 3, page 307-312 ; ISSN 1036-7314

مصطلحات موضوعية: Critical Care Nursing, Emergency Nursing

الإتاحة: https://doi.org/10.1016/j.aucc.2022.03.010Test
https://api.elsevier.com/content/article/PII:S103673142200042X?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S103673142200042X?httpAccept=text/plainTest

المؤلفون: Jacq, Gwenaëlle, Chelly, Jonathan, Quenot, Jean Pierre, Soulier, Pauline, Lesieur, Olivier, Beuret, Pascal, Holleville, Mathilde, Bruel, Cédric, Bailly, Pierre, Sauneuf, Bertrand, Sejourne, Caroline, Rigaud, Jean Philippe, Galbois, Arnaud, Arrayago, Marine, Plantefeve, Gaétan, Stoclin, Annabelle, Schnell, David, Fontaine, Candice, Perier, François, Bougouin, Wulfran, Pichon, Nicolas, Mongardon, Nicolas, Ledoux, Didier, Lascarrou, Jean Baptiste, Legriel, Stéphane

المساهمون: Centre Hospitalier de Versailles André Mignot (CHV), Centre Hospitalier Intercommunal Toulon-La Seyne sur Mer - Hôpital Sainte-Musse, CHU Dijon, Centre Hospitalier Universitaire de Dijon - Hôpital François Mitterrand (CHU Dijon), Groupe Hospitalier Sud Ile-de-France (GHSIF), Groupe hospitalier de La Rochelle, Centre Hospitalier de Roanne, Hôpitaux Universitaires Paris Nord Val de Seine (HUPNVS), Hôpital Beaujon AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Centre hospitalier Saint-Joseph Paris, Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Service de Réanimation Polyvalente CHPC - Site Louis Pasteur, Site Louis Pasteur CHPC, CH Centre Hospitalier Public du Cotentin (CHPC)-CH Centre Hospitalier Public du Cotentin (CHPC), Centre Hospitalier de Béthune (CH Béthune), GHT de l'Artois, Centre hospitalier de Dieppe, Centre Hospitalier Privé Claude Galien - Ramsay Santé, Centre Hospitalier de Cannes, Centre hospitalier Argenteuil (CH Argenteuil), Institut Gustave Roussy (IGR), Département de soins aigus Gustave Roussy (DSA), Centre Hospitalier d'Angoulême (CH Angoulême), Hôpital Privé Jacques Cartier Massy, Hôpital de Brive, Hôpital Henri Mondor, Centre Hospitalier Universitaire de Liège (CHU-Liège), Centre Hospitalier Universitaire de Nantes = Nantes University Hospital (CHU Nantes), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, Acknowledgements We thank A Wolfe MD (Chaumont, France) for helping to prepare the manuscript. The study was supported by the French public funding agency Délégation à la Recherche Clinique et à l’Innovation (DRCI), Versailles, France.

المصدر: ISSN: 2044-6055 ; BMJ Open ; https://hal.science/hal-03604089Test ; BMJ Open, 2022, 12 (2), ⟨10.1136/bmjopen-2021-059675⟩.

مصطلحات موضوعية: adult intensive & critical care, adult neurology, epidemiology, [SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie

الوصف: International audience ; Introduction Status epilepticus (SE) is a common life-threatening neurological emergency that can cause long-term impairments. Overall outcomes remain poor. Major efforts are required to clarify the epidemiology of SE and the determinants of outcomes, thereby identifying targets for improved management. Methods and analysis ICTAL Registry is a multicentre open cohort of critically ill patients with convulsive, non-convulsive or psychogenic non-epileptic SE. Observational methods are applied to collect uniform data. The goal of the ICTAL Registry is to collect high-quality information on a large number of patients, thereby allowing elucidation of the pathophysiological mechanisms involved in mortality and morbidity. The registry structure is modular, with a large core data set and the opportunity for research teams to create satellite data sets for observational or interventional studies (eg, cohort multiple randomised controlled trials, cross-sectional studies and short-term and long-term longitudinal outcome studies). The availability of core data will hasten patient recruitment to studies, while also decreasing costs. Importantly, the vast amount of data from a large number of patients will allow valid subgroup analyses, which are expected to identify patient populations requiring specific treatment strategies. The results of the studies will have a broad spectrum of application, particularly given the multidisciplinary approach used by the IctalGroup research network. Ethics and dissemination The ICTAL Registry protocol was approved by the ethics committee of the French Intensive Care Society (#CE_SRLF 19-68 and 19-68a). Patients or their relatives/proxies received written information to the use of the retrospectively collected and pseudonymised data, in compliance with French law. Prospectively included patients receive written consent form as soon as they recover decision-making competency; if they refuse consent, they are excluded from the registry. Data from the registry will be ...

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/35168989; hal-03604089; https://hal.science/hal-03604089Test; https://hal.science/hal-03604089/documentTest; https://hal.science/hal-03604089/file/bmjopen-2021-059675.pdfTest; PUBMED: 35168989; PUBMEDCENTRAL: PMC8852755

الإتاحة: https://doi.org/10.1136/bmjopen-2021-059675Test
https://hal.science/hal-03604089Test
https://hal.science/hal-03604089/documentTest
https://hal.science/hal-03604089/file/bmjopen-2021-059675.pdfTest

المؤلفون: Grimaldi, David, Legriel, Stéphane, Pichon, Nicolas, Colardelle, Philippe, Leblanc, Sina, Canouï-Poitrine, Florence, Salem, Omar O.B.H., Muller, Grégoire, de Prost, Nicolas, Herrmann, S., Marque, Sophie, Baron, Audrey, Sauneuf, Bertrand, Messika, Jonathan, Dior, Marie, Creteur, Jacques, Bedos, Jean Pierre, Boutin, Emmanuelle, Cariou, Alain

المصدر: Critical care, 26 (1

مصطلحات موضوعية: Soins intensifs réanimation, Cardiac arrest, Gastrointestinal tract, Gastroscopy, Gut, Ischemia/reperfusion, Mesenteric ischemia, Organ failure

الوصف: Background: The consequences of cardiac arrest (CA) on the gastro-intestinal tract are poorly understood. We measured the incidence of ischemic injury in the upper gastro-intestinal tract after Out-of-hospital CA (OHCA) and determined the risk factors for and consequences of gastrointestinal ischemic injury according to its severity. Methods: Prospective, non-controlled, multicenter study in nine ICUs in France and Belgium conducted from November 1, 2014 to November 30, 2018. Included patients underwent an esophago-gastro-duodenoscopy 2 to 4 d after OHCA if still intubated and the presence of ischemic lesions of the upper gastro-intestinal tract was determined by a gastroenterologist. Lesions were a priori defined as severe if there was ulceration or necrosis and moderate if there was mucosal edema or erythema. We compared clinical and cardiac arrest characteristics of three groups of patients (no, moderate, and severe lesions) and identified variables associated with gastrointestinal ischemic injury using multivariate regression analysis. We also compared the outcomes (organ failure during ICU stay and neurological status at hospital discharge) of the three groups of patients. Results: Among the 214 patients included in the analysis, 121 (57%, 95% CI 50–63%) had an upper gastrointestinal ischemic lesion, most frequently on the fundus. Ischemic lesions were severe in 55/121 (45%) patients. In multivariate regression, higher adrenaline dose during cardiopulmonary resuscitation (OR 1.25 per mg (1.08–1.46)) was independently associated with increased odds of severe upper gastrointestinal ischemic lesions; previous proton pump inhibitor use (OR 0.40 (0.14–1.00)) and serum bicarbonate on day 1 (OR 0.89 (0.81–0.97)) were associated with lower odds of ischemic lesions. Patients with severe lesions had a higher SOFA score during the ICU stay and worse neurological outcome at hospital discharge. Conclusions: More than half of the patients successfully resuscitated from OHCA had upper gastrointestinal tract ischemic ...

وصف الملف: 1 full-text file(s): application/pdf

العلاقة: uri/info:doi/10.1186/s13054-022-03939-9; uri/info:pmid/35287719; uri/info:scp/85126651710; https://dipot.ulb.ac.be/dspace/bitstream/2013/341642/1/doi_325286.pdfTest; http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/341642Test

الإتاحة: http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/341642Test

المؤلفون: Blanc, Alexiane, Colin, Gwenhael, Cariou, Alain, Merdji, Hamid, Grillet, Guillaume, Girardie, Patrick, Coupez, Elisabeth, Dequin, Pierre-François, Boulain, Thierry, Frat, Jean-Pierre, Asfar, Pierre, Pichon, Nicolas, Landais, Mickael, Plantefeve, Gaëtan, Quenot, Jean-Pierre, Chakarian, Jean-Charles, Sirodot, Michel, Legriel, Stéphane, Massart, Nicolas, Thevenin, Didier, Desachy, Arnaud, Delahaye, Arnaud, Botoc, Vlad, Vimeux, Sylvie, Martino, Frederic, Reignier, Jean, Taccone, F.S., Lascarrou, J.B.

المصدر: Chest ; volume 162, issue 2, page 356-366 ; ISSN 0012-3692

مصطلحات موضوعية: Cardiology and Cardiovascular Medicine, Critical Care and Intensive Care Medicine, Pulmonary and Respiratory Medicine

الإتاحة: https://doi.org/10.1016/j.chest.2022.02.056Test
https://api.elsevier.com/content/article/PII:S0012369222004913?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0012369222004913?httpAccept=text/plainTest