نتائج البحث - "Peter J. Mullen"

21

Clonal Heterogeneity Supports Mitochondrial Metabolism in Pancreatic Cancer

المؤلفون: Abigail S. Krall, Costas A. Lyssiotis, Ji Zhang, Ben Z. Stanger, Sandeep Batra, Peter Sajjakulnukit, Christopher J. Halbrook, Andrea Viale, Galloway Thurston, Claus Jørgensen, Marina Pasca di Magliano, Barbara S. Nelson, Peter J. Mullen, Li Zhang, Amy McCarthy, Heather R Cristofk

مصطلحات موضوعية: Cell type, education.field_of_study, Cell, Population, Biology, medicine.disease, Crosstalk (biology), medicine.anatomical_structure, Pancreatic tumor, Pancreatic cancer, Cancer cell, medicine, Extracellular, Cancer research, education

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::666b3d1e09e2b3c97c6406c4282b9adcTest
https://doi.org/10.1101/2020.05.15.098368Test

22

Asparagine signals mitochondrial respiration and can be targeted to impair tumour growth

المؤلفون: Steven D. Mittelman, Ernst W. Schmid, Milica Momcilovic, Peter J. Mullen, Christopher J. Halbrook, Apisadaporn Thambundit, Costas A. Lyssiotis, Simon R.V. Knott, Felicia Surjono, Heather R. Christofk, David B. Shackelford, Abigail S. Krall

مصطلحات موضوعية: 0303 health sciences, Asparaginase, Anabolism, Cell growth, Context (language use), mTORC1, Cell biology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, chemistry, 030220 oncology & carcinogenesis, Respiration, Asparagine, Intracellular, 030304 developmental biology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15a9a296bf3b0a046d2f79606bfa5690Test
https://doi.org/10.1101/2020.03.17.995670Test

23

Statin-Induced Cancer Cell Death Can Be Mechanistically Uncoupled from Prenylation of RAS Family Proteins

المؤلفون: Peter J. Mullen, Rosemary Yu, Jenna E. van Leeuwen, Wail Ba-alawi, Joseph Longo, Linda Z. Penn, Benjamin Haibe-Kains

المصدر: Cancer Research. 78:1347-1357

مصطلحات موضوعية: 0301 basic medicine, Cancer Research, Epithelial-Mesenchymal Transition, Statin, medicine.drug_class, Protein Prenylation, Farnesyl pyrophosphate, Mevalonic Acid, Apoptosis, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Polyisoprenyl Phosphates, Prenylation, Neoplasms, Biomarkers, Tumor, Tumor Cells, Cultured, medicine, Humans, HRAS, Fluvastatin, Cell Proliferation, Zinc Finger E-box-Binding Homeobox 1, 3. Good health, 030104 developmental biology, Oncology, chemistry, Drug Resistance, Neoplasm, 030220 oncology & carcinogenesis, Cancer cell, ras Proteins, Cancer research, Protein prenylation, lipids (amino acids, peptides, and proteins), Ras superfamily, Sesquiterpenes, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::172d0af6f57cd0142de641e82bd842fdTest
https://doi.org/10.1158/0008-5472.can-17-1231Test

24

Asparagine couples mitochondrial respiration to ATF4 activity and tumor growth

المؤلفون: David B. Shackelford, Steven D. Mittelman, Ernst W. Schmid, Peter J. Mullen, Milica Momcilovic, Simon R.V. Knott, Abigail S. Krall, Apisadaporn Thambundit, Heather R. Christofk, Felicia Surjono, Costas A. Lyssiotis, Christopher J. Halbrook

المصدر: Cell metabolism, vol 33, iss 5

مصطلحات موضوعية: 0301 basic medicine, Physiology, cancer metabolism, mTORC1, Medical Biochemistry and Metabolomics, Mice, chemistry.chemical_compound, 0302 clinical medicine, Mice, Inbred NOD, Neoplasms, Asparagine, Cancer, Tumor, Nucleotides, Chemistry, asparagine, Metformin, Mitochondria, Survival Rate, Biochemistry, Intracellular, Asparaginase, Context (language use), Mechanistic Target of Rapamycin Complex 1, cancer treatment, Cell Line, Endocrinology & Metabolism, 03 medical and health sciences, Cell Line, Tumor, Respiration, Animals, Humans, Molecular Biology, Cell Proliferation, Aspartic Acid, Cell growth, ATF4, dietary restriction, Cell Biology, asparaginase, Activating Transcription Factor 4, Diet, 030104 developmental biology, Electron Transport Chain Complex Proteins, Inbred NOD, Biochemistry and Cell Biology, respiration, 030217 neurology & neurosurgery

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7ff698e1ed01342f983891c97c95357Test
https://doi.org/10.1016Test/j.cmet.2021.02.001

25

The interplay between cell signalling and the mevalonate pathway in cancer

المؤلفون: Peter J. Mullen, Rosemary Yu, Michael C. Archer, Joseph Longo, Linda Z. Penn

المصدر: Nature Reviews Cancer. 16:718-731

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44579fb2e893e634174ba9ab66ffe337Test
https://doi.org/10.1038/nrc.2016.76Test

26

An actionable sterol-regulated feedback loop modulates statin sensitivity in prostate cancer

المؤلفون: Eric Chen, Mehdi Masoomian, Peter J. Mullen, Joan Sweet, Theodorus van der Kwast, Joseph Longo, Neil E. Fleshner, Rosemary Yu, Linda Z. Penn, Jenna E. van Leeuwen, Yuzhuo Wang, Robert J. Hamilton, Dixon T.S. Woon

المصدر: Molecular Metabolism
Molecular Metabolism, Vol 25, Iss, Pp 119-130 (2019)

مصطلحات موضوعية: 0301 basic medicine, Male, Mevalonate pathway, Drug repurposing, Apoptosis, Mice, SCID, Prostate cancer, Mice, 0302 clinical medicine, Mice, Inbred NOD, Medicine, Dipyridamole, 3. Good health, Sterols, lipids (amino acids, peptides, and proteins), Original Article, medicine.drug, Sterol Regulatory Element Binding Protein 2, lcsh:Internal medicine, Programmed cell death, Statin, medicine.drug_class, Cell Survival, Mevalonic Acid, 030209 endocrinology & metabolism, Antineoplastic Agents, 03 medical and health sciences, Downregulation and upregulation, Cell Line, Tumor, Animals, Viability assay, lcsh:RC31-1245, Fluvastatin, Molecular Biology, Tumor metabolism, business.industry, Drug Repositioning, Statins, Prostatic Neoplasms, Cell Biology, medicine.disease, Lipid Metabolism, Xenograft Model Antitumor Assays, Sterol regulatory element-binding protein, 030104 developmental biology, Cancer research, Hydroxymethylglutaryl CoA Reductases, Hydroxymethylglutaryl-CoA Reductase Inhibitors, business

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b2157c71470c4e70e8e94eed012f71aTest
https://pubmed.ncbi.nlm.nih.gov/31023626Test

27

Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization

المؤلفون: William J. Sullivan, Milica Momcilovic, Daniel Braas, Utpal Banerjee, Andrew E. Whiteley, Ernst W. Schmid, David Jelinek, William E. Lowry, Peter J. Mullen, Matthew B. Maxwell, Mark S. Sharpley, Hilary A. Coller, Donald E. Ayer, David B. Shackelford, Thomas Q. de Aguiar Vallim, Blake R. Wilde, Aimee Flores, Heather R. Christofk

المصدر: Cell, vol 175, iss 1

مصطلحات موضوعية: 0301 basic medicine, cell migration, extracellular matrix, glucose metabolism, 1.1 Normal biological development and functioning, Hyaluronoglucosaminidase, hyaluronidase, Biology, Medical and Health Sciences, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, receptor tyrosine kinase signaling, Extracellular matrix, 03 medical and health sciences, Tristetraprolin, Underpinning research, Cell Line, Tumor, cell biology, Humans, Glycolysis, Hyaluronic Acid, ZFP36, Cancer, Glucose Transporter Type 1, Tumor, Glucose transporter, Cell migration, Biological Sciences, Cell biology, Extracellular Matrix, 030104 developmental biology, Glucose, GLUT1 trafficking, mRNA degradation, biology.protein, Intercellular Signaling Peptides and Proteins, Carbohydrate Metabolism, GLUT1, Signal transduction, Carrier Proteins, TXNIP, Signal Transduction, Developmental Biology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06c96199e1b89ffdcbcc9314a9aa530bTest
https://escholarship.org/uc/item/3x99h8gqTest

28

Genome-wide RNAi analysis reveals that simultaneous inhibition of specific mevalonate pathway genes potentiates tumor cell death

المؤلفون: Karl S. Lang, Janice T. Pong, Peter J. Mullen, Elke Ericson, Jason Moffat, Corey Nislow, Kevin R. Brown, Rosemary Yu, Traver Hart, Aleksandra A. Pandyra, Piyush Sharma, Marinella Gebbia, Manpreet Kalkat, Guri Giaever, Carolyn A. Goard, Linda Z. Penn

المصدر: Oncotarget

مصطلحات موضوعية: Hydroxymethylglutaryl-CoA Synthase, Indoles, Lung Neoplasms, Medizin, Mevalonic Acid, Antineoplastic Agents, Apoptosis, Breast Neoplasms, Mevalonic acid, Biology, Real-Time Polymerase Chain Reaction, statins, Small hairpin RNA, Fatty Acids, Monounsaturated, chemistry.chemical_compound, feedback inhibition, RNA interference, Cell Line, Tumor, Neoplasms, Farnesyltranstransferase, Humans, RNA, Small Interfering, Fluvastatin, Transcription factor, Cell Proliferation, Gene knockdown, mevalonate pathway, Geranyltranstransferase, Dimethylallyltranstransferase, Molecular biology, Gene Expression Regulation, Neoplastic, Oncology, chemistry, Cancer research, lipids (amino acids, peptides, and proteins), tumor metabolism, Female, Hydroxymethylglutaryl CoA Reductases, RNA Interference, GGPS1, Mevalonate pathway, SREBP2, Research Paper, Sterol Regulatory Element Binding Protein 2

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461f085c99e7d15a9c40fd98cab6e0ccTest
http://europepmc.org/articles/PMC4694962Test

29

MYC Interacts with the G9a Histone Methyltransferase to Drive Transcriptional Repression and Tumorigenesis

المؤلفون: Peter J. Mullen, Ahmed Aman, Linda Z. Penn, Benjamin Haibe-Kains, Aaliya Tamachi, Wail Ba-alawi, Rima Al-awar, David W. Cescon, Cornelia Redel, Cheryl H. Arrowsmith, Yu-Jia Shiah, Dharmendra Dingar, Brian Raught, William B. Tu, Corey Lourenco, Paul C. Boutros

المصدر: Cancer cell. 34(4)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4f0fd34332be5f88813a6d939006c6aTest
https://pubmed.ncbi.nlm.nih.gov/30367118Test

30

Immediate Utility of Two Approved Agents to Target Both the Metabolic Mevalonate Pathway and Its Restorative Feedback Loop

المؤلفون: Rosemary Yu, Suzanne Trudel, Aleksandra A. Pandyra, Janice T. Pong, Manpreet Kalkat, Peter J. Mullen, Karl S. Lang, Aaron D. Schimmer, Mark D. Minden, Linda Z. Penn, Zhihua Li

المصدر: Cancer Research. 74:4772-4782

مصطلحات موضوعية: Hydroxymethylglutaryl-CoA Synthase, Male, Cancer Research, Statin, medicine.drug_class, Medizin, Mevalonic Acid, Antineoplastic Agents, Apoptosis, Mevalonic acid, Pharmacology, Biology, Mice, chemistry.chemical_compound, In vivo, Cell Line, Tumor, Antineoplastic Combined Chemotherapy Protocols, medicine, Animals, Humans, Dipyridamole, Potentiator, medicine.disease, Leukemia, Myeloid, Acute, Leukemia, Oncology, chemistry, Leukocytes, Mononuclear, lipids (amino acids, peptides, and proteins), Mevalonate pathway, Sterol regulatory element-binding protein 2, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Multiple Myeloma, Sterol Regulatory Element Binding Protein 2, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2261eae78d1bfa3221fb79891532d0bTest
https://doi.org/10.1158/0008-5472.can-14-0130Test

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