المؤلفون: Kutchartt, E., Pedron, M., Pirotti, F.

المصدر: eISSN: 2194-9050

الوصف: Active remote sensing systems orbiting the Earth are only a small portion of the current constellation of satellites and will increase in number and advance in technology in the future. The launch of the GEDI sensor in December 2018, for an expected life-span period of about 2 years, is a fundamental step of this revolution, as it is the first spaceborne full-waveform lidar specifically designed for measuring the structure of ecosystems, providing information of the vertical profile of forests. Accuracy assessment of GEDI height metrics in the context of an Alpine forest environment in steep terrain scenarios has been conducted in this study. We used discrete return lidar from a recent aerial laser scanner survey as reference to analyse differences of heights of terrain elevation and maximum canopy height of the vegetation detected in each GEDI footprint. The height metrics differences between the discrete lidar and the GEDI data were then analysed to verify any correlation with the following factors: morphology (terrain slope), land cover (land cover type, fraction of canopy cover, vegetation density), GEDI laser beam characteristics (day/night-time acquisition, full power vs coverage laser beam, beam ID, laser sensitivity). Further analysis involved shifting the footprints’ location in 8 different direction and 4 distances to assess the impact of geolocation errors on accuracy and precision. Results show that what most influences accuracy in this study is the terrain slope, very likely linked to the uncertainty of geolocation of the GEDI footprints, suggesting caution in using single GEDI footprints if located in steep environments. Other than slope, terrain height accuracy varies mostly with forest type (conifer vs broadleaves), but not significantly with other factors. Canopy height instead is affected by most factors; high vegetation canopy is overestimated by ∼3 m in GEDI, and underestimated by 3 m over heath and bushes (median difference). Higher sensitivity pulses and night-time pulses provide better ...

وصف الملف: application/pdf

العلاقة: https://isprs-annals.copernicus.org/articles/V-3-2022/431/2022Test/

الإتاحة: https://doi.org/10.5194/isprs-annals-V-3-2022-431-2022Test
https://isprs-annals.copernicus.org/articles/V-3-2022/431/2022Test/

المؤلفون: Garrigós-Pedrón, M., Segura-Ortí, E., Gracia-Naya, M., La Touche, R.

المصدر: Neurología ; volume 37, issue 2, page 101-109 ; ISSN 0213-4853

مصطلحات موضوعية: Neurology (clinical)

الإتاحة: https://doi.org/10.1016/j.nrl.2018.11.004Test
https://api.elsevier.com/content/article/PII:S0213485319300143?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0213485319300143?httpAccept=text/plainTest

المؤلفون: Garrigós-Pedrón, M., Segura-Ortí, E., Gracia-Naya, M., La Touche, R.

المصدر: Neurología (English Edition) ; volume 37, issue 2, page 101-109 ; ISSN 2173-5808

الإتاحة: https://doi.org/10.1016/j.nrleng.2018.11.009Test
https://api.elsevier.com/content/article/PII:S2173580821000110?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2173580821000110?httpAccept=text/plainTest

المؤلفون: Re A. M., Benavides-Varela S., Pedron M., De Gennaro M. A., Lucangeli D.

المساهمون: Re A.M., Benavides-Varela S., Pedron M., De Gennaro M.A., Lucangeli D.

مصطلحات موضوعية: app, digital training, home training, mathematical difficulty, students

الوصف: The present study evaluated the effectiveness of a shortened, specialized, and digitally supported training program for enhancing numerical skills in primary and secondary school children with mathematical difficulty (MD). The participants (n = 57) were randomly assigned to two groups: for the experimental group, the tasks were differentiated and adapted to each student’s learning profile. Moreover, children of this group used a Web App (i.e., “I bambini contano” or “Children count” in English) for improving arithmetic fact retrieval at home; for the control group, the difficulty of the activities was graded according to the school curriculum, and this group did not use the Web App. Pre‐ to post-training measurements showed that children of the experimental group had an improvement significantly higher than the control group, in particular in arithmetic facts and written calculation. Moreover, a follow-up evaluation indicated that the efficacy of the experimental training program lasted up to 2 months after the intervention. The results indicate that a specialized face-to-face intervention along with a digitally supported training at home can benefit children with mathematical learning difficulties.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32982850; info:eu-repo/semantics/altIdentifier/wos/WOS:000570569100001; volume:11; firstpage:1; lastpage:11; numberofpages:11; journal:FRONTIERS IN PSYCHOLOGY; http://hdl.handle.net/2318/1786675Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85090929951

الإتاحة: https://doi.org/10.3389/fpsyg.2020.02039Test
http://hdl.handle.net/2318/1786675Test

المؤلفون: Hochstoeger, T., Al Said, T., Maestre, D., Walter, F., Vilceanu, A., Pedron, M., Cushion, T., Snider, W., Nimpf, S., Nordmann, G., Landler, L., Edelman, N., Kruppa, L., Duernberger, G., Mechtler, K., Schuechner, S., Ogris, E., Malkemper, E., Weber, S., Schleicher, E., Keays, D.

المصدر: Science Advances

الوصف: The biophysical and molecular mechanisms that enable animals to detect magnetic fields are unknown. It has been proposed that birds have a light-dependent magnetic compass that relies on the formation of radical pairs within cryptochrome molecules. Using spectroscopic methods, we show that pigeon cryptochrome clCRY4 is photoreduced efficiently and forms long-lived spin-correlated radical pairs via a tetrad of tryptophan residues. We report that clCRY4 is broadly and stably expressed within the retina but enriched at synapses in the outer plexiform layer in a repetitive manner. A proteomic survey for retinal-specific clCRY4 interactors identified molecules that are involved in receptor signaling, including glutamate receptor-interacting protein 2, which colocalizes with clCRY4. Our data support a model whereby clCRY4 acts as an ultraviolet-blue photoreceptor and/or a light-dependent magnetosensor by modulating glutamatergic synapses between horizontal cells and cones.

وصف الملف: application/pdf

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32851187; http://hdl.handle.net/21.11116/0000-0006-F847-3Test; http://hdl.handle.net/21.11116/0000-0006-F849-1Test

الإتاحة: https://doi.org/10.1126/sciadv.abb9110Test
http://hdl.handle.net/21.11116/0000-0006-F847-3Test
http://hdl.handle.net/21.11116/0000-0006-F849-1Test

المؤلفون: Pedron, M., Legnani, L., Chiacchio, M.A., Caramella, P., Tejero, T., Merino, P.

الوصف: The ruthenium tetroxide-mediated oxidation of cyclopentane, tetrahydrofuran, tetrahydrothiophene and N-substituted pyrrolidines has been studied computationally by DFT and topological (analysis of the electron localization function, ELF) methods. In agreement with experimental observations and previous DFT calculations, the rate-limiting step of the reaction takes place through a highly asynchronous (3 + 2) concerted cycloaddition through a single transition structure (one kinetic step). The ELF analysis identifies the reaction as a typical one-step-two-stages process and corroborates the existence of a transient carbocation. In the case of pyrrolidines, the carbocation is completely stabilized as an energy minimum in the form of an iminium ion and the reaction takes place in two steps.

وصف الملف: application/pdf

العلاقة: info:eu-repo/grantAgreement/ES/DGA-FEDER/E34-R17; info:eu-repo/grantAgreement/ES/MINECO/CTQ2016-76155-R; http://zaguan.unizar.es/record/96808Test

الإتاحة: https://doi.org/10.3762/bjoc.15.158Test
http://zaguan.unizar.es/record/96808Test

المؤلفون: Garrigós-Pedrón M, Elizagaray-García I, Domínguez-Gordillo AA, Del-Castillo-Pardo-de-Vera JL, Gil-Martínez A

المصدر: Journal of Multidisciplinary Healthcare, Vol Volume 12, Pp 803-804 (2019)

مصطلحات موضوعية: Medicine (General), R5-920

الوصف: Garrigós-Pedrón M, Elizagaray-García I, Domínguez-Gordillo AA, Del-Castillo-Pardo-de-Vera JL, Gil-Martínez A. J Multidiscip Healthc. 2019;12:733–747. The authors of this paper have advised that during the finalcorrection stage of the production process of this manuscript,abbreviations for DDwR and DDwoR were changed in thewrong places against their advice. On page 738, the paragraph: ContraindicationsSplints should not be used in patients with morning intermittentlocking or in small symptomatic DDwoR that canpromote its progression or blockade. If their use is essential,it must be included in the consent document; however,it should be remembered that asymptomatic DDwoR cases(no pain, no blockage) do not require treatment. Splints arealso not indicated in patients with short-term DDwR forwhom recapturing is possible (an anterior replacementsplint will be indicated).75 Should instead read: ContraindicationsSplints should not be used in patients with morning intermittentlocking or in small symptomatic DDwR that canpromote its progression or blockade. If their use is essential,it must be included in the consent document; however,it should be remembered that asymptomatic DDwR cases(no pain, no blockage) do not require treatment. Splints arealso not indicated in patients with short-term DDwoR forwhom recapturing is possible (an anterior replacementsplint will be indicated).75 Read the original article

العلاقة: https://www.dovepress.com/httpswwwdovepresscomerratum-temporomandibular-disorders-imp-peer-reviewed-article-JMDHTest; https://doaj.org/toc/1178-2390Test; https://doaj.org/article/dc2bff22b2bc4013beb962f252cb48f5Test

الإتاحة: https://doaj.org/article/dc2bff22b2bc4013beb962f252cb48f5Test

المؤلفون: Peeters S. A., Engelen L., Buijs J., Chaturvedi N., Fuller J. H., Schalkwijk C. G., Stehouwer C. D., Karamanos B., Kofinis A., Petrou K., Giorgino F., Picca G., Angarano A., de Pergola. G., Laviola L., Giorgino R., Ionescu-Tirgoviste C., Coszma A., Guja C., Songini M., Casu A., Pedron M., Pintus S., Fossarello M., Ferriss J. B., Grealy G., O'Keefe D., Toeller M., Arden C., Rottiers R., Tuyttens C., Priem H., Ebeling P., Kylliainen M., Koivisto V. A., Idzior-Walus B., Sieradzki J., Cyganek K., Solnica B., Lemkes H. H. P. J., Lemkes-Stuffken J. C., Nunes-Correa J., Rogado M. C., Gardete-Correia L., Cardoso M. C., Silva A., Boavida J., Machado Sa Marques M., Michel G., Wirion R., Cardillo S., Pozza G., Mangili R., Asnaghi V., Standl E., Schaffler B., Brand H., Harms A., Ben Soussan M., Verier-Mine O., Fallas P., Fallas M. C., Holloway J., Asbury L., Betteridge D. J., Cathelineau G., Bouallouche A., Villatte Cathelineau B., Santeusanio F., Rosi G., D'Alessandro V., Cagini C., Bottini P., Reboldi G. P., Navalesi R., Penno G., Bandinelli S., Miccoli R., Nannipieri M., Ghirlanda G., Saponara C., Cotroneo P., Manto A., Minnella A., Ward J. D., Tesfaye S., Eaton S., Mody C., Borra M., Cavallo Perin P., Giunti S., Grassi G., Pagano G. F., Porta M., Sivieri R., Vitelli F., Veglio M., Papazoglou N., Manes G., Muggeo M., Iagulli M., Cacciatori V., Cattedra di Malattie del Metabolismo V., Irsigler K., Abrahamian H., Walford S., Sinclair J., Hughes S., McLelland V., Ward J., Roglic G., Metelko Z., Pepeonik Z. R.

المساهمون: Peeters, S. A., Engelen, L., Buijs, J., Chaturvedi, N., Fuller, J. H., Schalkwijk, C. G., Stehouwer, C. D., Karamanos, B., Kofinis, A., Petrou, K., Giorgino, F., Picca, G., Angarano, A., Pergola. G., De, Laviola, L., Giorgino, R., Ionescu-Tirgoviste, C., Coszma, A., Guja, C., Songini, M., Casu, A., Pedron, M., Pintus, S., Fossarello, M., Ferriss, J. B., Grealy, G., O'Keefe, D., Toeller, M., Arden, C., Rottiers, R., Tuyttens, C., Priem, H., Ebeling, P., Kylliainen, M., Koivisto, V. A., Idzior-Walus, B., Sieradzki, J., Cyganek, K., Solnica, B., Lemkes, H. H. P. J., Lemkes-Stuffken, J. C., Nunes-Correa, J., Rogado, M. C., Gardete-Correia, L., Cardoso, M. C., Silva, A., Boavida, J., Machado Sa Marques, M., Michel, G., Wirion, R., Cardillo, S., Pozza, G., Mangili, R., Asnaghi, V., Standl, E., Schaffler, B., Brand, H., Harms, A., Ben Soussan, M., Verier-Mine, O., Fallas, P., Fallas, M. C., Holloway, J., Asbury, L., Betteridge, D. J., Cathelineau, G., Bouallouche, A., Villatte Cathelineau, B., Santeusanio, F., Rosi, G., D'Alessandro, V., Cagini, C., Bottini, P., Reboldi, G. P., Navalesi, R., Penno, G., Bandinelli, S., Miccoli, R., Nannipieri, M., Ghirlanda, G., Saponara, C., Cotroneo, P., Manto, A., Minnella, A., Ward, J. D., Tesfaye, S., Eaton, S., Mody, C., Borra, M., Cavallo Perin, P., Giunti, S., Grassi, G., Pagano, G. F., Porta, M., Sivieri, R., Vitelli, F., Veglio, M., Papazoglou, N., Manes, G.

مصطلحات موضوعية: Albuminuria, Cardiovascular disease, Matrix metalloproteinase, Retinopathy, Tissue inhibitor of metalloproteinase, Type 1 diabete, Adult, Biomarker, Cohort Studie, Cross-Sectional Studie, Diabetes Complication, Diabetes Mellitus, Type 1, Europe, Female, Human, Male, Matrix Metalloproteinase 10, Matrix Metalloproteinase 2, Matrix Metalloproteinase 3, Middle Aged, Prospective Studie, Tissue Inhibitor of Metalloproteinase-1, Vascular Diseases

الوصف: Impaired regulation of extracellular matrix remodeling by matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinase (TIMP) may contribute to vascular complications in patients with type 1 diabetes. We investigated associations between plasma MMP-1, -2, -3, -9, -10 and TIMP-1, and cardiovascular disease (CVD) or microvascular complications in type 1 diabetic patients. We also evaluated to which extent these associations could be explained by low-grade inflammation (LGI) or endothelial dysfunction (ED). Methods: 493 type 1 diabetes patients (39.5 ± 9.9 years old, 51% men) from the EURODIAB Prospective Complications Study were included. Linear regression analysis was applied to investigate differences in plasma levels of MMP-1, -2, -3, -9, -10, and TIMP-1 between patients with and without CVD, albuminuria or retinopathy. All analyses were adjusted for age, sex, duration of diabetes, Hba1c and additionally for other cardiovascular risk factors including LGI and ED. Results: Patients with CVD (n = 118) showed significantly higher levels of TIMP-1 [β = 0.32 SD (95%CI: 0.12; 0.52)], but not of MMPs, than patients without CVD (n = 375). Higher plasma levels of MMP-2, MMP-3, MMP-10 and TIMP-1 were associated with higher levels of albuminuria (p-trends were 0.028, 0.004, 0.005 and 0.001, respectively). Severity of retinopathy was significantly associated with higher levels of MMP-2 (p-trend = 0.017). These associations remained significant after further adjustment for markers of LGI and ED. Conclusions: These data support the hypothesis that impaired regulation of matrix remodeling by actions of MMP-2, -3 and-10 and TIMP-1 contributes to the pathogenesis of vascular complications in type 1 diabetes.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/25848912; info:eu-repo/semantics/altIdentifier/wos/WOS:000350726000001; volume:14; issue:1; firstpage:31; journal:CARDIOVASCULAR DIABETOLOGY; http://hdl.handle.net/11586/353539Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-84925234995

الإتاحة: https://doi.org/10.1186/s12933-015-0195-2Test
http://hdl.handle.net/11586/353539Test

المؤلفون: Tolias, Panagiotis, 1984, De Angeli, M., Riva, G., Ratynskaia, Svetlana V., Daminelli, G., Laguardia, L., Pedron, M., Ripamonti, D., Uccello, A., Vassallo, E.

المصدر: Nuclear Materials and Energy. 18:18-22

مصطلحات موضوعية: Dust adhesion, Pull-off force, Dust remobilization, Electrostatic detachment, Adsorbates, Sputtering

الوصف: The adhesion of tungsten dust is measured on plasma-exposed and non-exposed tungsten substrates with the electrostatic detachment method. Tungsten substrates of comparable surface roughness have been exposed to the deuterium plasmas of the GyM linear device and the argon plasmas of rf glow discharges under conditions which invariably modify the surface composition due to physical sputtering. The adhesion has been systematically characterized for different spherical nearly monodisperse dust populations. Independent of the dust size, an approximate 50% post-exposure reduction of the average and spread of the adhesive force has been consistently observed and attributed to surface chemistry modifications.

وصف الملف: print

الوصول الحر: https://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-247856Test

المؤلفون: Muroni A., Murru M. R., Sechi M., Ercoli T., Marrosu F., Bentivoglio A. R., Petracca M., Maria Scaglione C. L., Soliveri P., Cocco E., Pedron M., Murgia M., Deriu M., Cuccu S., Ulgheri L., Zuccato C., Defazio G.

المساهمون: Muroni, A., Murru, M. R., Sechi, M., Ercoli, T., Marrosu, F., Bentivoglio, A. R., Petracca, M., Maria Scaglione, C. L., Soliveri, P., Cocco, E., Pedron, M., Murgia, M., Deriu, M., Cuccu, S., Ulgheri, L., Zuccato, C., Defazio, G.

مصطلحات موضوعية: Huntington's disease, Prevalence

الوصف: Background: The frequency of Huntington's disease (HD) may vary considerably, with higher estimates in non Asian populations. In Italy, two recent studies performed in Ferrara county and Molise provided different prevalence estimates, varying from 4.2 × 105 to 10.8 × 105. Here we present a study performed in the Southern part of Sardinia, a large Italian mediterranean island that is considered a genetic isolate. Methods: The study area included the two neighbouring counties of South Sardinia and Cagliari with 353,830 and 431,955 inhabitants respectively on December 31st, 2017 (prevalence date). Case-patients were ascertained through multiple sources in Sardinia and Italy. Results: We identified 54 individuals with HD, of whom 47 were alive on prevalence date. The resulting prevalence rate was 5.98 × 105 in the overall study area, however with marked variations between South Sardinia and Cagliari (9.6 × 105 vs. 3.0 × 105, p = 0.02). In the two study areas, we found similar CAG repeat length in normal alleles (17.5 ± 2.1 vs. 17.7 ± 2.2, p = 0.5). Conclusions: The overall prevalence of HD in Sardinia is close to the correspondent estimates in Europeans. Our findings also highlighted the possibility of local microgeographic variations in the epidemiology of HD.

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/32956974; info:eu-repo/semantics/altIdentifier/wos/WOS:000602944600014; volume:80; firstpage:54; lastpage:57; numberofpages:4; journal:PARKINSONISM & RELATED DISORDERS; http://hdl.handle.net/11584/298430Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85091228528

الإتاحة: https://doi.org/10.1016/j.parkreldis.2020.09.011Test
http://hdl.handle.net/11584/298430Test