المؤلفون: Paul Armstrong, Patrick Hayden, Michael Jeffers, Lisa Fitzpatrick, Aoife Mcknight, John Armstrong

المصدر: Case Reports in Oncology, Vol 16, Iss 1, Pp 1528-1535 (2023)

مصطلحات موضوعية: case report, pulmonary mucosa-associated lymphoid tissue lymphoma, mucosa-associated lymphoid tissue lymphoma, radiation therapy, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Introduction: Mucosa-associated lymphoid tissue lymphoma (MALT lymphoma or MALToma) is a prevalent type of primary pulmonary lymphoma. Typically, the primary therapeutic approaches involve surgery or chemotherapy, although there have been instances of radiation therapy being employed. Case Report: We present a case of pulmonary MALToma that exhibited progression despite rituximab therapy. Subsequently, the patient demonstrated a positive response to radiation therapy. Conclusion: This case highlights the potential efficacy of radiation therapy as a treatment option for pulmonary MALToma, especially in cases where other conventional treatments like rituximab have proven ineffective. Further research and studies are warranted to better understand the role of radiation therapy in managing pulmonary MALToma and to determine optimal treatment strategies for patients with this condition.

وصف الملف: electronic resource

العلاقة: https://beta.karger.com/Article/FullText/534802Test; https://doaj.org/toc/1662-6575Test

الوصول الحر: https://doaj.org/article/9530adbbaa9f4a98b98713d1fa46d74aTest

المؤلفون: Laurent Garderet, Luuk Gras, Linda Koster, Liesbeth de Wreede, Rovira Montserrat, Laure Vincent, Roland Fenk, Kamaraj Karunanithi, Dries Deeren, Martin Kaufmann, Jürgen Kuball, Hakan Ozdogu, Maria Jesus Pascual Cascon, Jakob Passweg, Adam Rye, Urpu Salmenniemi, John Snowden, Charlotte Toftmann Hansen, Xavier Leleu, Lauris Gastaud, Joanna Drozd Sokolowska, Kavita Raj, Meral Beksac, Stefan Schönland, Patrick Hayden, Donal McLornan

المصدر: Haematologica, Vol 999, Iss 1 (2024)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

الوصف: There is little long-term outcome data on the efficacy of autologous hematopoietic stem cell transplantation (ASCT) in light chain deposition disease (LCDD). We identified 51 LCDD patients in the EBMT registry who had undergone upfront ASCT between 1995 and 2021. The median serum creatinine was 280 μmol/L and 45% required renal replacement therapy (RRT) at time of transplant. The melphalan dose was 100mg/m2 in 23%, 140mg/m2 in 55% and 200 mg/m2 in 21%. The rate of very good partial response or better improved from 41% pre-transplant to 66% at Day +100 post-ASCT. In RRT-independent patients, there was a modest improvement in renal function within the first 3 months; the median eGFR increased from 44 to 51 ml/min/1.73 m2. There was no further change between 3 and 12 months post- ASCT. No patient who was RRT-independent at ASCT became RRT dependent by Day + 100 post-ASCT. Median follow-up post-ASCT was 84 months (IQR: 46-122). At 6-years post ASCT, overall survival (OS) was 88% (95% CI: 78-98%) and PFS was 44% (95% CI: 28-60%). The 2-year cumulative incidence of relapse and non-relapse mortality (NRM) was 17% (95% CI: 6-27%) and 2% (95% CI: 0-6%), respectively. The cumulative incidence of renal transplantation at 4 years after ASCT was 27% (95% CI 13-41) with renal transplantation performed between 6.3 and 52.9 months post-ASCT (median 24.7 months). ASCT represents a feasible option for LCDD patients even if RRT dependent at time of transplant. Outcomes are favourable with low NRM and good long-term OS.

وصف الملف: electronic resource

العلاقة: https://haematologica.org/article/view/11520Test; https://doaj.org/toc/0390-6078Test; https://doaj.org/toc/1592-8721Test

الوصول الحر: https://doaj.org/article/438f26de95374f69bac97c5f22505a12Test

المؤلفون: Marie Robin, Liesbeth C. de Wreede, Thomas Schroeder, Friedrich Stölzel, Nicolaus Kröger, Linda Koster, Uwe Platzbecker, Jürgen Finke, Arnold Ganser, Didier Blaise, Fabio Ciceri, Johan Maertens, Hélène Labussière Wallet, Junfeng Wang, Patrice Chevallier, Jakob Passweg, Jan J Cornelissen, Stéphanie Nguyen, Edouard Forcade, Amandine Charbonnier, Francesca Bonifazi, Patrick Hayden, Donal P. McLornan, Ibrahim Yakoub-Agha

المصدر: HemaSphere, Vol 7, Iss 4, p e851 (2023)

مصطلحات موضوعية: Diseases of the blood and blood-forming organs, RC633-647.5

وصف الملف: electronic resource

العلاقة: http://journals.lww.com/10.1097/HS9.0000000000000851Test; https://doaj.org/toc/2572-9241Test

الوصول الحر: https://doaj.org/article/e03e259b51fd42bdbcd057a17717db7bTest

المؤلفون: Zhaoyi Li, Isaac Kim, Patrick Hayden

المصدر: Quantum, Vol 7, p 1089 (2023)

مصطلحات موضوعية: Physics, QC1-999

الوصف: We investigate a family of fault-tolerant quantum error correction schemes based on the concatenation of small error detection or error correction codes with the three-dimensional cluster state. We propose fault-tolerant state preparation and decoding schemes that effectively convert every circuit-level error into an erasure error, leveraging the cluster state's high threshold against such errors. We find a set of codes for which such a conversion is possible, and study their performance against the standard circuit-level depolarizing model. Our best performing scheme, which is based on a concatenation with a classical code, improves the threshold by $16.5\%$ and decreases the spacetime overhead by $32\%$ compared to the scheme without concatenation, with each scheme subject to a physical error rate of $10^{-3}$ and achieving a logical error rate of $10^{-6}$.

وصف الملف: electronic resource

العلاقة: https://quantum-journal.org/papers/q-2023-08-22-1089/pdfTest/; https://doaj.org/toc/2521-327XTest

الوصول الحر: https://doaj.org/article/f73bacdc9b2942f3be98cc533dd84d0dTest

المؤلفون: Carlos Fernández de Larrea, Robert Kyle, Laura Rosiñol, Bruno Paiva, Monika Engelhardt, Saad Usmani, Jo Caers, Wilson Gonsalves, Fredrik Schjesvold, Giampaolo Merlini, Suzanne Lentzch, Enrique Ocio, Laurent Garderet, Philippe Moreau, Pieter Sonneveld, Ashraf Badros, Gösta Gahrton, Hartmut Goldschmidt, Sascha Tuchman, Hermann Einsele, Brian Durie, Baldeep Wirk, Pellegrino Musto, Patrick Hayden, Martin Kaiser, Jesús San Miguel, Joan Bladé, S. Vincent Rajkumar, Maria Victoria Mateos

المصدر: Blood Cancer Journal, Vol 11, Iss 12, Pp 1-5 (2021)

مصطلحات موضوعية: Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282

الوصف: Abstract Primary plasma cell leukemia (PCL) has a consistently ominous prognosis, even after progress in the last decades. PCL deserves a prompt identification to start the most effective treatment for this ultra-high-risk disease. The aim of this position paper is to revisit the diagnosis of PCL according to the presence of circulating plasma cells in patients otherwise meeting diagnostic criteria of multiple myeloma. We could identify two retrospective series where the question about what number of circulating plasma cells in peripheral blood should be used for defining PCL. The presence of ≥5% circulating plasma cells in patients with MM had a similar adverse prognostic impact as the previously defined PCL. Therefore, PCL should be defined by the presence of 5% or more circulating plasma cells in peripheral blood smears in patients otherwise diagnosed with symptomatic multiple myeloma.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2044-5385Test

الوصول الحر: https://doaj.org/article/316690c0ce52472eb67f8eef3f9e74a5Test

المؤلفون: Patrick Hayden, Onkar Parrikar, Jonathan Sorce

المصدر: Journal of High Energy Physics, Vol 2021, Iss 10, Pp 1-58 (2021)

مصطلحات موضوعية: AdS-CFT Correspondence, Gauge-gravity correspondence, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

الوصف: Abstract The reflected entropy S R (A : B) of a density matrix ρ AB is a bipartite correlation measure lower-bounded by the quantum mutual information I(A : B). In holographic states satisfying the quantum extremal surface formula, where the reflected entropy is related to the area of the entanglement wedge cross-section, there is often an order-N 2 gap between S R and I. We provide an information-theoretic interpretation of this gap by observing that S R − I is related to the fidelity of a particular Markov recovery problem that is impossible in any state whose entanglement wedge cross-section has a nonempty boundary; for this reason, we call the quantity S R − I the Markov gap. We then prove that for time-symmetric states in pure AdS3 gravity, the Markov gap is universally lower bounded by log(2)ℓ AdS /2G N times the number of endpoints of the cross-section. We provide evidence that this lower bound continues to hold in the presence of bulk matter, and comment on how it might generalize above three bulk dimensions. Finally, we explore the Markov recovery problem controlling S R − I using fixed area states. This analysis involves deriving a formula for the quantum fidelity — in fact, for all the sandwiched Rényi relative entropies — between fixed area states with one versus two fixed areas, which may be of independent interest. We discuss, throughout the paper, connections to the general theory of multipartite entanglement in holography.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1029-8479Test

الوصول الحر: https://doaj.org/article/a29cf3fab5874c88a7c018da80feb17fTest

المؤلفون: Johannes Schetelig, Henning Baldauf, Linda Koster, Michelle Kuxhausen, Falk Heidenreich, Liesbeth C. de Wreede, Stephen Spellman, Michel van Gelder, Benedetto Bruno, Francesco Onida, Vinzenz Lange, Carolin Massalski, Victoria Potter, Per Ljungman, Nicolaas Schaap, Patrick Hayden, Stephanie J. Lee, Nicolaus Kröger, Kathy Hsu, Alexander H. Schmidt, Ibrahim Yakoub-Agha, Marie Robin

المصدر: Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: KIR, KIR2DS1, KIR3DL1, hematopoietic stem cell transplantation, donor selection, unrelated donor, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fimmu.2021.813838/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/98cab44b6dfb4751a6cc5d0063c00727Test

المؤلفون: Patrick Hayden, Geoffrey Penington

المصدر: Journal of High Energy Physics, Vol 2019, Iss 12, Pp 1-55 (2019)

مصطلحات موضوعية: AdS-CFT Correspondence, Gauge-gravity correspondence, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798

الوصف: Abstract When the bulk geometry in AdS/CFT contains a black hole, boundary subregions may be sufficient to reconstruct certain bulk operators if and only if the black hole microstate is known, an example of state dependence. Reconstructions exist for any microstate, but no reconstruction works for all microstates. We refine this dichotomy, demonstrating that the same boundary operator can often be used for large subspaces of black hole microstates, corresponding to a constant fraction α of the black hole entropy. In the Schrödinger picture, the boundary subregion encodes the α-bits (a concept from quantum information) of a bulk region containing the black hole and bounded by extremal surfaces. These results have important consequences for the structure of AdS/CFT and for quantum information. Firstly, they imply that the bulk reconstruction is necessarily only approximate and allow us to place non-perturbative lower bounds on the error when doing so. Second, they provide a simple and tractable limit in which the entanglement wedge is state dependent, but in a highly controlled way. Although the state dependence of operators comes from ordinary quantum error correction, there are clear connections to the Papadodimas-Raju proposal for understanding operators behind black hole horizons. In tensor network toy models of AdS/CFT, we see how state dependence arises from the bulk operator being ‘pushed’ through the black hole itself. Finally, we show that black holes provide the first ‘explicit’ examples of capacity-achieving α-bit codes. Unintuitively, Hawking radiation always reveals the α-bits of a black hole as soon as possible. In an appendix, we apply a result from the quantum information literature to prove that entanglement wedge reconstruction can be made exact to all orders in 1/N.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/1029-8479Test

الوصول الحر: https://doaj.org/article/0a729269df2f41a49ceb090293d7a423Test

المؤلفون: Johannes Schetelig, Henning Baldauf, Linda Koster, Michelle Kuxhausen, Falk Heidenreich, Liesbeth C. de Wreede, Stephen Spellman, Michel van Gelder, Benedetto Bruno, Francesco Onida, Vinzenz Lange, Carolin Massalski, Victoria Potter, Per Ljungman, Nicolaas Schaap, Patrick Hayden, Stephanie J. Lee, Nicolaus Kröger, Kathy Hsu, Alexander H. Schmidt, Ibrahim Yakoub-Agha, Marie Robin

المصدر: Frontiers in Immunology, Vol 11 (2021)

مصطلحات موضوعية: KIR, KIR2DS1, KIR3DL1, hematopoietic stem cell transplantation, donor selection, unrelated donor, Immunologic diseases. Allergy, RC581-607

الوصف: Results from registry studies suggest that harnessing Natural Killer (NK) cell reactivity mediated through Killer cell Immunoglobulin-like Receptors (KIR) could reduce the risk of relapse after allogeneic Hematopoietic Cell Transplantation (HCT). Several competing models have been developed to classify donors as KIR-advantageous or disadvantageous. Basically, these models differ by grouping donors based on distinct KIR–KIR–ligand combinations or by haplotype motif assignment. This study aimed to validate different models for unrelated donor selection for patients with Myelodysplatic Syndromes (MDS) or secondary Acute Myeloid Leukemia (sAML). In a joint retrospective study of the European Society for Blood and Marrow Transplantation (EBMT) and the Center for International Blood and Marrow Transplant Research (CIBMTR) registry data from 1704 patients with secondary AML or MDS were analysed. The cohort consisted mainly of older patients (median age 61 years) with high risk disease who had received chemotherapy-based reduced intensity conditioning and anti-thymocyte globulin prior to allogeneic HCT from well-matched unrelated stem cell donors. The impact of the predictors on Overall Survival (OS) and relapse incidence was tested in Cox regression models adjusted for patient age, a modified disease risk index, performance status, donor age, HLA-match, sex-match, CMV-match, conditioning intensity, type of T-cell depletion and graft type. KIR genes were typed using high-resolution amplicon-based next generation sequencing. In univariable and multivariable analyses none of the models predicted OS and the risk of relapse consistently. Our results do not support the hypothesis that optimizing NK-mediated alloreactivity is possible by KIR-genotype informed selection of HLA-matched unrelated donors. However, in the context of allogeneic transplantation, NK-cell biology is complex and only partly understood. KIR-genes are highly diverse and current assignment of haplotype motifs based on the presence or absence of selected KIR genes is over-simplistic. As a consequence, further research is highly warranted and should integrate cutting edge knowledge on KIR genetics, and NK-cell biology into future studies focused on homogeneous groups of patients and treatment modalities.

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/articles/10.3389/fimmu.2020.584520/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/693c028224f942ae8e114564d060c6a0Test

المؤلفون: Kianna Wan, Soonwon Choi, Isaac H. Kim, Noah Shutty, Patrick Hayden

المصدر: PRX Quantum, Vol 2, Iss 4, p 040345 (2021)

مصطلحات موضوعية: Physics, QC1-999, Computer software, QA76.75-76.765

الوصف: With gate error rates in multiple technologies now below the threshold required for fault-tolerant quantum computation, the major remaining obstacle to useful quantum computation is scaling, a challenge greatly amplified by the huge overhead imposed by quantum error correction itself. We propose a fault-tolerant quantum computing scheme that can nonetheless be assembled from a small number of experimental components, potentially dramatically reducing the engineering challenges associated with building a large-scale fault-tolerant quantum computer. Our scheme has a threshold of 0.39% for depolarizing noise, assuming that memory errors are negligible. In the presence of memory errors, the logical error rate decays exponentially with sqrt[T/τ], where T is the memory coherence time and τ is the timescale for elementary gates. Our approach is based on a novel procedure for fault-tolerantly preparing three-dimensional cluster states using a single actively controlled qubit and a pair of delay lines. Although a circuit-level error may propagate to a high-weight error, the effect of this error on the prepared state is always equivalent to that of a constant-weight error. We describe how the requisite gates can be implemented using existing technologies in quantum photonic and phononic systems. With continued improvements in only a few components, we expect these systems to be promising candidates for demonstrating fault-tolerant quantum computation with a comparatively modest experimental effort.

وصف الملف: electronic resource

العلاقة: https://doaj.org/toc/2691-3399Test

الوصول الحر: https://doaj.org/article/1a36bfc4170d4e14af5484f25f35885bTest