المؤلفون: Pepe, Francesco, Russo, Gianluca, Venuta, Alessandro, Scimone, Claudia, Nacchio, Mariantonia, Pisapia, Pasquale, Goteri, Gaia, Barbisan, Francesca, Chiappetta, Caterina, Pernazza, Angelina, Campagna, Domenico, Giordano, Marco, Perrone, Giuseppe, Sabarese, Giovanna, Altimari, Annalisa, de Biase, Dario, Tallini, Giovanni, Calistri, Daniele, Chiadini, Elisa, Capelli, Laura, Santinelli, Alfredo, Gulini, Anna Elisa, Pierpaoli, Elisa, Badiali, Manuela, Murru, Stefania, Murgia, Riccardo, Guerini Rocco, Elena, Venetis, Konstantinos, Fusco, Nicola, Morotti, Denise, Gianatti, Andrea, Furlan, Daniela, Rossi, Giulio, Melocchi, Laura, Russo, Maria, De Luca, Caterina, Palumbo, Lucia, Simonelli, Saverio, Maffè, Antonella, Francia di Celle, Paola, Venesio, Tiziana, Scatolini, Maria, Grosso, Enrico, Orecchia, Sara, Fassan, Matteo, Balistreri, Mariangela, Zulato, Elisabetta, Reghellin, Daniela, Lazzari, Elena, Santacatterina, Maria

المساهمون: Regione Campania, Ministero della Salute

المصدر: Oncology and Therapy ; ISSN 2366-1070 2366-1089

مصطلحات موضوعية: Oncology

الإتاحة: https://doi.org/10.1007/s40487-023-00252-5Test

المؤلفون: Scimia, Mauro, Pepe, Francesco, Russo, Gianluca, Palumbo, Lucia, Malapelle, Umberto, Chuang, Rachel, Scimia, Simone, Sha, Michael, Tanaka, Hiromi, Shen, Shuo, Chen, David, Troncone, Giancarlo, Bianco, Maria Antonia

المساهمون: Diacarta

المصدر: Journal of Clinical Pathology ; page jcp-2024-209527 ; ISSN 0021-9746 1472-4146

الوصف: Cell-free DNA (cfDNA) has long been established as a useful diagnostic and prognostic tool in a variety of clinical settings, ranging from infectious to cardiovascular and neoplastic diseases. However, non-neoplastic diseases can act as confounders impacting on the amount of cfDNA shed in bloodstream and on technical feasibility of tumour derived free circulating nucleic acids selecting patients with cancer. Here, we investigated the potential impact of other pathological processes in the clinical stratification of 637 FIT+ patients. A single and multiple logistic regression yielded similar results. Crude sensitivity was 75.9% versus adjusted sensitivity of 74.1%, relative risk 0.9761 (0.8516 to 1.1188), risk difference 0.0181 (−0.0835 to 0.1199) and OR 0.9079 (0.5264 to 1.5658). Potential confounding effect from other source of cfDNA plays a pivotal role in the clinical stratification of FIT+ patients.

الإتاحة: https://doi.org/10.1136/jcp-2024-209527Test

المؤلفون: Buono, Mauro, Russo, Gianluca, Nardone, Valerio, Della Corte, Carminia Maria, Natale, Giovanni, Rubini, Dino, Palumbo, Lucia, Scimone, Claudia, Ciani, Giovanni, D'Onofrio, Ida, Grassi, Roberta, Fiorelli, Alfonso, Morgillo, Floriana, Reginelli, Alfonso, Troncone, Giancarlo, Cappabianca, Salvatore

المصدر: The Journal of Liquid Biopsy ; volume 5, page 100153 ; ISSN 2950-1954

الإتاحة: https://doi.org/10.1016/j.jlb.2024.100153Test
https://api.elsevier.com/content/article/PII:S2950195424000183?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2950195424000183?httpAccept=text/plainTest

المؤلفون: Scimone, Claudia, Pepe, Francesco, Russo, Gianluca, Palumbo, Lucia, Ball, Glyn, Morel, Pascale, Russo, Alessandro, Troncone, Giancarlo, Malapelle, Umberto

المصدر: The Journal of Liquid Biopsy ; volume 3, page 100133 ; ISSN 2950-1954

الإتاحة: https://doi.org/10.1016/j.jlb.2023.100133Test
https://api.elsevier.com/content/article/PII:S2950195423001339?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2950195423001339?httpAccept=text/plainTest

المؤلفون: Pepe, Francesco, Giordano, Claudia, Russo, Gianluca, Palumbo, Lucia, Vincenzi, Annamaria, Acanfora, Gennaro, Lisi, Dario, Picardi, Marco, Pane, Fabrizio, Troncone, Giancarlo, Vigliar, Elena

المصدر: Cytopathology ; volume 35, issue 2, page 182-187 ; ISSN 0956-5507 1365-2303

الوصف: Classic Hodgkin lymphoma (cHL) consists of a heterogeneous group of haematological disorders that covers undifferentiated B cell neoplasms originating from germinal centre B cells. The HL molecular characterization still represents an ongoing challenge due to the low fraction of tumour Hodgkin and Reed–Sternberg cells mixed with a plethora of non‐tumour haematological cells. In this scenario, next generation sequencing of liquid biopsy samples is emerging as a useful tool in HL patients' management. In this review, we aimed to overview the clinical and methodological topics regarding the implementation of molecular analysis in cHL, focusing on the role of liquid biopsy in diagnosis, follow‐up, and response prediction.

الإتاحة: https://doi.org/10.1111/cyt.13255Test

المؤلفون: Fiorito, Serena, Epifano, Francesco, Palumbo, Lucia, Collevecchio, Chiara, Spogli, Roberto, Genovese, Salvatore

المصدر: Food Research International ; volume 172, page 113094 ; ISSN 0963-9969

مصطلحات موضوعية: Food Science

الإتاحة: https://doi.org/10.1016/j.foodres.2023.113094Test
https://api.elsevier.com/content/article/PII:S0963996923006397?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S0963996923006397?httpAccept=text/plainTest

المؤلفون: de Luca, Caterina, Russo, Gianluca, Nacchio, Mariantonia, Ingenito, Maria, Palumbo, Lucia, Gragnano, Gianluca, Conticelli, Floriana, Russo, Maria, Rocco, Danilo, Gridelli, Cesare, Bianco, Roberto, Galetta, Domenico, Troncone, Giancarlo, Parente, Paola, Iaccarino, Antonino

المصدر: The Journal of Liquid Biopsy ; volume 2, page 100128 ; ISSN 2950-1954

الإتاحة: https://doi.org/10.1016/j.jlb.2023.100128Test
https://api.elsevier.com/content/article/PII:S2950195423001285?httpAccept=text/xmlTest
https://api.elsevier.com/content/article/PII:S2950195423001285?httpAccept=text/plainTest

المؤلفون: Fiorito, Serena, Palumbo, Lucia, Epifano, Francesco, Fraternale, Daniele, Collevecchio, Chiara, Genovese, Salvatore

المصدر: Biomass Conversion & Biorefinery; Jun2024, Vol. 14 Issue 12, p13187-13193, 7p

مستخلص: Previous and recent literature acquisitions suggested that cultured calli are an efficient and meaningful model to investigate the extent and fate of prenylation of phenylpropanoid cores in plants belonging to the Rutaceae and Apiaceae families upon administration of putative biosynthetic precursors. To this concern, in the present manuscript, we investigated the effect of supplementation of ferulic acid and umbelliferone on the biosynthesis of their oxyprenylated counterparts in Ferulago campestris (Besser) Grecescu (Fam. Apiaceae) cultured calli. Dried plant biomass material has been extracted by an ultrasound-assisted extraction with EtOH. O-prenyl secondary metabolites, namely 3,3-dimethylallyloxy, geranyloxy, and farnesyloxy derivatives of both ferulic acid and umbelliferone, were identified and quantified by HPLC/DAD analyses. Supplementation with ferulic acid was the only treatment providing appreciable results. Quite surprisingly, its addition to cultured calli did not affect the formation of its oxyprenylated phytochemicals but boosted the biosynthesis of umbelliferone and its farnesyloxy-derivative umbrelliprenin. The findings reported herein enforce and underline the role of ferulic acid as an elicitor of selected classes of secondary metabolites in apiaceous species, as recently observed. In addition to these results, a novel hitherto unknown metabolite from F. campestris, namely 7-[[(2E)-7-hydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-2H-1-benzopyran-2-one, was characterized by NMR and LC–MS analyses. [ABSTRACT FROM AUTHOR]

: Copyright of Biomass Conversion & Biorefinery is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Fiorito, Serena, Palumbo, Lucia, Epifano, Francesco, Fraternale, Daniele, Collevecchio, Chiara, Genovese, Salvatore

المصدر: Biomass Conversion and Biorefinery; June 2024, Vol. 14 Issue: 12 p13187-13193, 7p

مستخلص: Previous and recent literature acquisitions suggested that cultured calli are an efficient and meaningful model to investigate the extent and fate of prenylation of phenylpropanoid cores in plants belonging to the Rutaceae and Apiaceae families upon administration of putative biosynthetic precursors. To this concern, in the present manuscript, we investigated the effect of supplementation of ferulic acid and umbelliferone on the biosynthesis of their oxyprenylated counterparts in Ferulago campestris(Besser) Grecescu (Fam. Apiaceae) cultured calli. Dried plant biomass material has been extracted by an ultrasound-assisted extraction with EtOH. O-prenyl secondary metabolites, namely 3,3-dimethylallyloxy, geranyloxy, and farnesyloxy derivatives of both ferulic acid and umbelliferone, were identified and quantified by HPLC/DAD analyses. Supplementation with ferulic acid was the only treatment providing appreciable results. Quite surprisingly, its addition to cultured calli did not affect the formation of its oxyprenylated phytochemicals but boosted the biosynthesis of umbelliferone and its farnesyloxy-derivative umbrelliprenin. The findings reported herein enforce and underline the role of ferulic acid as an elicitor of selected classes of secondary metabolites in apiaceous species, as recently observed. In addition to these results, a novel hitherto unknown metabolite from F. campestris, namely 7-[[(2E)-7-hydroxy-3,7-dimethyl-2-octen-1-yl]oxy]-2H-1-benzopyran-2-one, was characterized by NMR and LC–MS analyses.

المؤلفون: Pepe, Francesco, Giordano, Claudia, Russo, Gianluca, Palumbo, Lucia, Vincenzi, Annamaria, Acanfora, Gennaro, Lisi, Dario, Picardi, Marco, Pane, Fabrizio, Troncone, Giancarlo, Vigliar, Elena

المصدر: Cytopathology; Mar2024, Vol. 35 Issue 2, p182-187, 6p

مصطلحات موضوعية: HODGKIN'S disease, NUCLEOTIDE sequencing, B cells, BIOPSY, LIQUIDS

مستخلص: Classic Hodgkin lymphoma (cHL) consists of a heterogeneous group of haematological disorders that covers undifferentiated B cell neoplasms originating from germinal centre B cells. The HL molecular characterization still represents an ongoing challenge due to the low fraction of tumour Hodgkin and Reed–Sternberg cells mixed with a plethora of non‐tumour haematological cells. In this scenario, next generation sequencing of liquid biopsy samples is emerging as a useful tool in HL patients' management. In this review, we aimed to overview the clinical and methodological topics regarding the implementation of molecular analysis in cHL, focusing on the role of liquid biopsy in diagnosis, follow‐up, and response prediction. [ABSTRACT FROM AUTHOR]

: Copyright of Cytopathology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)